Eukaryotic translation termination (Homo sapiens)

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31, 23cytosolpolypeptideeRF3-GDP:eRF1:80S Ribosome:mRNA:tRNA ComplexeRF3-GTP:eRF1:80S Ribosome:mRNA:peptidyl-tRNA ComplexOrthophosphateGTP bound eRF3Eukaryotic peptide chain release factor subunit 1eRF3-GDP:eRF1:80S Ribosome:mRNA:peptidyl-tRNA Complex80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide


Description

The arrival of any of the three stop codons (UAA, UAG and UGA) into the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In eukaryotes, the RF is composed of two proteins, eRF1 and eRF3. eRF1 is responsible for the hydrolysis of the peptidyl-tRNA, while eRF3 provides a GTP-dependent function. The ribosome releases the mRNA and dissociates into its two complex subunits, which can reassemble on another molecule to begin a new round of protein synthesis. It should be noted that at present, there is no factor identified in eukaryotes that would be the functional equivalent of the bacterial ribosome release (or recycling) factor, RRF, that catalyzes dissociation of the ribosome from the mRNA following release of the polypeptide

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Ontology Terms

 

Bibliography

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  1. Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T.; ''The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.''; PubMed Europe PMC Scholia
  2. Frolova L, Le Goff X, Rasmussen HH, Cheperegin S, Drugeon G, Kress M, Arman I, Haenni AL, Celis JE, Philippe M.; ''A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor.''; PubMed Europe PMC Scholia
  3. Salas-Marco J, Bedwell DM.; ''GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination.''; PubMed Europe PMC Scholia
  4. Jones WM, Scaloni A, Bossa F, Popowicz AM, Schneewind O, Manning JM.; ''Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities.''; PubMed Europe PMC Scholia
  5. Erlandsson R, Boldog F, Persson B, Zabarovsky ER, Allikmets RL, Sümegi J, Klein G, Jörnvall H.; ''The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase.''; PubMed Europe PMC Scholia
  6. Figaro S, Scrima N, Buckingham RH, Heurgué-Hamard V.; ''HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.''; PubMed Europe PMC Scholia
  7. Hoshino S, Imai M, Mizutani M, Kikuchi Y, Hanaoka F, Ui M, Katada T.; ''Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.''; PubMed Europe PMC Scholia
  8. Ichikawa S, Kaji A.; ''Molecular cloning and expression of ribosome releasing factor.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117721view12:33, 22 May 2021EweitzModified title
115033view16:57, 25 January 2021ReactomeTeamReactome version 75
113477view11:55, 2 November 2020ReactomeTeamReactome version 74
112677view16:07, 9 October 2020ReactomeTeamReactome version 73
101594view11:46, 1 November 2018ReactomeTeamreactome version 66
101130view21:31, 31 October 2018ReactomeTeamreactome version 65
100658view20:05, 31 October 2018ReactomeTeamreactome version 64
100208view16:50, 31 October 2018ReactomeTeamreactome version 63
99759view15:16, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93873view13:42, 16 August 2017ReactomeTeamreactome version 61
93440view11:23, 9 August 2017ReactomeTeamreactome version 61
86531view09:20, 11 July 2016ReactomeTeamreactome version 56
83397view11:07, 18 November 2015ReactomeTeamVersion54
81591view13:08, 21 August 2015ReactomeTeamVersion53
77051view08:35, 17 July 2014ReactomeTeamFixed remaining interactions
76756view12:11, 16 July 2014ReactomeTeamFixed remaining interactions
76081view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75791view11:32, 10 June 2014ReactomeTeamReactome 48 Update
75141view14:08, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74832view10:05, 30 April 2014ReactomeTeamReactome46
74788view08:52, 30 April 2014ReactomeTeamReactome46
68957view17:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
45251view18:37, 7 October 2011AlexanderPicoOntology Term : 'translation termination pathway' added !
42036view21:52, 4 March 2011MaintBotAutomatic update
39839view05:52, 21 January 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
80S Ribosome:mRNA:

peptidyl-tRNA with elongating peptide

ComplexREACT_4835 (Reactome)
Eukaryotic peptide

chain release factor subunit 1

ProteinP62495 (UniProt)
GTP bound eRF3 ComplexREACT_5462 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
eRF3-GDP:eRF1:80S

Ribosome:mRNA: peptidyl-tRNA Complex

ComplexREACT_5057 (Reactome)
eRF3-GDP:eRF1:80S

Ribosome:mRNA:tRNA Complex

ComplexREACT_4303 (Reactome)
eRF3-GTP:eRF1:80S

Ribosome:mRNA: peptidyl-tRNA Complex

ComplexREACT_4059 (Reactome)
polypeptide UnknownREACT_3573 (Reactome)

Annotated Interactions

No annotated interactions

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