Interferon alpha/beta signaling (Homo sapiens)

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1-428, 32-432, 9234, 20, 21223, 1314-1626, 273191, 5-1025, 264, 191, 7, 11, 12222428-3117, 18cytosolnucleoplasmmitochondrionendoplasmic reticulum lumenIFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1ISRE promoter elements in type I IFN-regulated genesInterferon alpha-inducible protein 6ATPIFNAR2c:UBP43Proteasome subunit beta type 8SHP2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2SOCS-1 and SOCS-3IP6K2Interferon alpha-inducible protein 27, mitochondrialInterferon-induced transmembrane protein 1UBP43H2OATPIFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2IFNAR2cXAF1IFIT3PTP1BSTAT2ISG15IFIT2ISGF3 bound to ISRE promotor elementsSHP-2/SHP-1OAS proteinsp-STAT2:p-STAT1ADPADPIFN alpha/beta (IFNA/B)EGR1p-STAT1:p-STAT1ATPp-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1ATPIFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2OrthophosphateIRF 1-9ATPIRF9Interferon-induced transmembrane protein 2IFNAR1:TYK2IFNA/B:IFNAR2:JAK1:STAT2RNASELIFIT1H2OClass I MHC heavy chain (MHC HC)Interferon-induced 35 kDa proteinOrthophosphateSHP1IFNAR2:JAK1:STAT2ADPISG20Mx GTPasesSTAT1-alphaInterferon-induced transmembrane protein 3GBP2IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2H2OIFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2ISGF3ISGF3STAT1OrthophosphateADPADAR1 proteinp-STAT1:p-STAT1


Description

Type I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, whereas there is only one IFNB gene. The large family of IFNA/B proteins all bind to a single receptor which is composed of two distinct chains: IFNAR1 and IFNAR2. The IFNA/B stimulation of the IFNA receptor complex leads to the formation of two transcriptional activator complexes: IFNA-activated-factor (AAF), which is a homodimer of STAT1 and IFN-stimulated gene factor 3 (ISGF3), which comprises STAT1, STAT2 and a member of the IRF family, IRF9/P48. AAF mediates activation of the IRF-1 gene by binding to GAS (IFNG-activated site), whereas ISGF3 activates several IFN-inducible genes including IRF3 and IRF7.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114797view16:29, 25 January 2021ReactomeTeamReactome version 75
113240view11:30, 2 November 2020ReactomeTeamReactome version 74
112460view15:41, 9 October 2020ReactomeTeamReactome version 73
101367view11:25, 1 November 2018ReactomeTeamreactome version 66
100905view21:00, 31 October 2018ReactomeTeamreactome version 65
100446view19:35, 31 October 2018ReactomeTeamreactome version 64
99995view16:19, 31 October 2018ReactomeTeamreactome version 63
99549view14:53, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99182view12:42, 31 October 2018ReactomeTeamreactome version 62
93744view13:33, 16 August 2017ReactomeTeamreactome version 61
93258view11:18, 9 August 2017ReactomeTeamreactome version 61
86337view09:15, 11 July 2016ReactomeTeamreactome version 56
83224view10:25, 18 November 2015ReactomeTeamVersion54
81620view13:09, 21 August 2015ReactomeTeamVersion53
77078view08:37, 17 July 2014ReactomeTeamFixed remaining interactions
76783view12:14, 16 July 2014ReactomeTeamFixed remaining interactions
76106view10:17, 11 June 2014ReactomeTeamRe-fixing comment source
75818view11:37, 10 June 2014ReactomeTeamReactome 48 Update
75168view14:11, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74815view08:54, 30 April 2014ReactomeTeamReactome46
44864view09:57, 6 October 2011MartijnVanIerselOntology Term : 'immune response pathway' added !
42055view21:53, 4 March 2011MaintBotAutomatic update
39861view05:53, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAR1 protein ProteinP55265 (UniProt)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Class I MHC heavy

chain (MHC HC)

ProteinREACT_26784 (Reactome)
EGR1 ProteinP18146 (UniProt)
GBP2 ProteinP32456 (UniProt)
H2O Metabolite15377 (ChEBI)
IFIT1 ProteinP09914 (UniProt)
IFIT2 ProteinP09913 (UniProt)
IFIT3 ProteinO14879 (UniProt)
IFN alpha/beta

(IFNA/B)

ProteinREACT_26595 (Reactome)
IFNA/B:IFNAR2:JAK1:

STAT2

ComplexREACT_26015 (Reactome)
IFNA/B:IFNAR2:JAK1:

STAT2:IFNAR1:TYK2

ComplexREACT_25725 (Reactome)
IFNA/B:IFNAR2:p-

JAK1:STAT2:IFNAR1: TYK2

ComplexREACT_26140 (Reactome)
IFNA/B:IFNAR2:p-

JAK1:STAT2:IFNAR1: p-TYK2

ComplexREACT_26001 (Reactome)
IFNA/B:IFNAR2:p-

JAK1:STAT2:p- IFNAR1:p-TYK2

ComplexREACT_26083 (Reactome)
IFNA/B:IFNAR2:p-

JAK1:STAT2:p- IFNAR1:p-TYK2: STAT2

ComplexREACT_25990 (Reactome)
IFNA/B:IFNAR2:p-

JAK1:STAT2:p- IFNAR1:p-TYK2:p- STAT2

ComplexREACT_26908 (Reactome)
IFNA/B:IFNAR2:p-

JAK1:STAT2:p- IFNAR1:p-TYK2:p- STAT2:STAT1

ComplexREACT_26740 (Reactome)
IFNA/B:IFNAR2:p-

JAK1:STAT2:p- IFNAR1:p-TYK2:p- STAT2:p-STAT1

ComplexREACT_26770 (Reactome)
IFNAR1:TYK2 ComplexREACT_25562 (Reactome)
IFNAR2:JAK1:STAT2 ComplexREACT_25438 (Reactome)
IFNAR2c ProteinP48551-2 (UniProt)
IFNAR2c:UBP43 ComplexREACT_26598 (Reactome)
IP6K2 ProteinQ9UHH9 (UniProt)
IRF 1-9 ProteinREACT_26465 (Reactome)
IRF9 ProteinQ00978 (UniProt)
ISG15 ProteinP05161 (UniProt)
ISG20 ProteinQ96AZ6 (UniProt)
ISGF3 ComplexREACT_25406 (Reactome)
ISGF3 ComplexREACT_25831 (Reactome)
ISGF3 bound to ISRE

promotor elements

ComplexREACT_25455 (Reactome)
ISRE promoter

elements in type I IFN-regulated genes

UnknownREACT_26432 (Reactome)
Interferon alpha-

inducible protein 27, mitochondrial

ProteinP40305 (UniProt)
Interferon alpha-

inducible protein 6

ProteinP09912 (UniProt)
Interferon-induced

35 kDa protein

ProteinP80217 (UniProt)
Interferon-induced

transmembrane protein 1

ProteinP13164 (UniProt)
Interferon-induced

transmembrane protein 2

ProteinQ01629 (UniProt)
Interferon-induced

transmembrane protein 3

ProteinQ01628 (UniProt)
Mx GTPases ProteinREACT_25553 (Reactome)
OAS proteins ProteinREACT_26755 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PTP1B ProteinP18031 (UniProt)
Proteasome subunit

beta type 8

ProteinP28062 (UniProt)
RNASEL ProteinQ05823 (UniProt)
SHP-2/SHP-1 ProteinREACT_20250 (Reactome)
SHP1 ProteinP29350 (UniProt)
SHP2 ProteinQ06124 (UniProt)
SOCS-1 and SOCS-3 ProteinREACT_25587 (Reactome)
STAT1 ProteinREACT_17621 (Reactome)
STAT1-alpha ProteinP42224-1 (UniProt)
STAT2 ProteinP52630 (UniProt)
UBP43 ProteinQ9UMW8 (UniProt)
XAF1 ProteinQ6GPH4 (UniProt)
p-STAT1:p-STAT1 ComplexREACT_26275 (Reactome)
p-STAT1:p-STAT1 ComplexREACT_26749 (Reactome)
p-STAT2:p-STAT1 ComplexREACT_27063 (Reactome)
p-TYK2:p-IFNAR1:

SOCS-1/SOCS-3: IFNA/B:IFNAR2:p- JAK1:STAT2

ComplexREACT_26646 (Reactome)

Annotated Interactions

No annotated interactions

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