L1CAM interactions (Homo sapiens)

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1-514, 16, 17322437, 3816, 2021-23137, 313318, 1936408153225-279-128293930283319, 321434, 3514clathrin-coated endocytic vesiclecytosolcytosolextracellular regionendosomenucleoplasmAxonin-1Neuropilin-1L1:FGFR1synapse-associated proteins (SAP)ADPL1:HNK-1pL1:CK-IIpL1:EzrinGDPATPPAK1 dimer (inactive/autoinhibited)L1:NCAM1 complexPAK1AnkyrinsNeurofascin:CNTN1:CASPR complexCHL1ATPADPNCAM1GTPNeurofascin:NrCAM:Ankyrin:spectrin based actin:Na+/K+ channelNrCAM:Ankyrin-GHeat Stable Antigen (HSA)Neuropilin-1ATPL1-EGFR trans-heterodimerunidentified protein tyrosine kinaseOrthophosphatepPAK1:Rac1-GTPNeuropilin-2 (NP2)ATPTyr phos L1:EPHB2p90rskATPCRMP-2:NUMB:alpha adaptinADPunidentified protein tyrosine kinaseEGFRSyntenin-1Neurofascin:NrCAM:Ankyrin:spectrin based actinspectrin based actinADPNeurofascinphospho-ERK-1:MEK1Neurofascin:Ankyrin-G complexATPHsc70NrCAM:NP-2CHL1:alpha1beta1/alpha2beta1 integrinsRAC1-GDPpL1:ERM:F-actinATPF-actinNrCAMALCAMShootin-1CHL1:CNTN6L1:AP-2 Clathrin complexContactin-6pNFASC:DoublecortinL1 trans-homodimerpL1 (Y1176)L1:NP-1ADPADPActivated ERK2Neurofascin:Syntenin-1 complexAnkyrin-GADPunknown proteinmicrotubuleMEK2:ERK-2Dynamin-1/2/3L1 dimer:Ankyrin:Spectrin:F-actinGDPMEK1:ERK-1DoublecortinTrans neurofascin dimer:ankyrin-GAP2 clathrin:L1:KIF4:microtubuleAxonin-1IntegrinsADPpL1 (S1204, 1248):ERK2:clathrin-dynamin complexADPL1:Axonin-1OrthophosphatepL1:Shootin-1:F-actinATPCHL1:Ankyrin-GL1:CNTN1RanBPML1:HSACasein kinase IIATPCNTN1alpha1beta1/alpha2beta1GTPL1CHL1:NP-1Clathrin-coated vesicleL1 homodimerunidentified protein tyrosine kinaseL1:clathrin-coated vesicleEPHB2pL1 (Y1229):L1CAML1:NUMB:CRMP-2:alpha-adaptinL1:AP-2 Clathrin complexL1ERM:PIP2L1NeurofascinKIF4 dimerATPF-actinSRCVAV2CHL1:Hsc70Neurofascin:NrCAM complexL1:Integrin complexL1:NeurocanNeurocanNrCAM:Axonin-1ADPNa+/K+ channel subunitsContactin1:CASPR complexphospho-ERK-2:MEK2L1:LamininATPpL1 (S1152):p90rsk:clathrin-dynamin complexL1L1:ALCAML1 trans-homodimer:AnkyrinRAC1-GTPEndophilinADPNFASC:pNFASCp-VAV2(Y172)L1:RanBPMADPLaminin-1 (EHS laminin)NrCAM:SAP membersFibroblast growth factor receptor 1c67


Description

The L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L1 (CHL1), NrCAM, and Neurofascin. These CAMs contain six Ig like domains, five or six fibronectin like repeats, a transmembrane region and a cytoplasmic domain. The L1CAM family has been implicated in processes integral to nervous system development, including neurite outgrowth, neurite fasciculation and inter neuronal adhesion.
L1CAM members are predominately expressed by neuronal, as well as some nonneuronal cells, during development. Except CHL1 all the other members of L1 family contain an alternatively spliced 12-nclueotide exon, encoding the amino acid residues RSLE in the neuronal splice forms but missing in the non-neuronal cells. The extracellular regions of L1CAM members are divergent and differ in their abilities to interact with extracellular, heterophilic ligands. The L1 ligands include other Ig-domain CAMs (such as NCAM, TAG-1/axonin and F11), proteoglycans type molecules (neurocan), beta1 integrins, and extra cellular matrix protein laminin, Neuropilin-1, FGF and EGF receptors. Some of these L1-interacting proteins also bind to other L1CAM members. For example TAG-1/axonin interact with L1 and NrCAM; L1, neurofascin and CHL1 binds to contactin family members. The cytoplasmic domains of L1CAM members are most highly conserved. Nevertheless, they have different cytoplasmic binding partners, and even those with similar binding partners may be involved in different signaling complexes and mechanisms. The most conserved feature of L1CAMs is their ability to interact with the actin cytoskeletal adapter protein ankyrin. The cytoplasmic ankyrin-binding domain, exhibits the highest degree of amino acid conservation throughout the L1 family.

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Bibliography

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  1. He Y, Jensen GJ, Bjorkman PJ.; ''Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1.''; PubMed Europe PMC Scholia
  2. Maness PF, Schachner M.; ''Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration.''; PubMed Europe PMC Scholia
  3. Tuvia S, Garver TD, Bennett V.; ''The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation.''; PubMed Europe PMC Scholia
  4. Jacob J, Haspel J, Kane-Goldsmith N, Grumet M.; ''L1 mediated homophilic binding and neurite outgrowth are modulated by alternative splicing of exon 2.''; PubMed Europe PMC Scholia
  5. Kulahin N, Li S, Hinsby A, Kiselyov V, Berezin V, Bock E.; ''Fibronectin type III (FN3) modules of the neuronal cell adhesion molecule L1 interact directly with the fibroblast growth factor (FGF) receptor.''; PubMed Europe PMC Scholia
  6. Schmid RS, Midkiff BR, Kedar VP, Maness PF.; ''Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling.''; PubMed Europe PMC Scholia
  7. Nagaraj K, Hortsch M.; ''Phosphorylation of L1-type cell-adhesion molecules--ankyrins away!''; PubMed Europe PMC Scholia
  8. Zhao X, Yip PM, Siu CH.; ''Identification of a homophilic binding site in immunoglobulin-like domain 2 of the cell adhesion molecule L1.''; PubMed Europe PMC Scholia
  9. Arthur JS, Ley SC.; ''Mitogen-activated protein kinases in innate immunity.''; PubMed Europe PMC Scholia
  10. Herron LR, Hill M, Davey F, Gunn-Moore FJ.; ''The intracellular interactions of the L1 family of cell adhesion molecules.''; PubMed Europe PMC Scholia
  11. Schmid RS, Maness PF.; ''L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth.''; PubMed Europe PMC Scholia
  12. Nishimura T, Fukata Y, Kato K, Yamaguchi T, Matsuura Y, Kamiguchi H, Kaibuchi K.; ''CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.''; PubMed Europe PMC Scholia
  13. Koroll M, Rathjen FG, Volkmer H.; ''The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity.''; PubMed Europe PMC Scholia
  14. Schaefer AW, Kamiguchi H, Wong EV, Beach CM, Landreth G, Lemmon V.; ''Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization.''; PubMed Europe PMC Scholia
  15. Wong EV, Schaefer AW, Landreth G, Lemmon V.; ''Casein kinase II phosphorylates the neural cell adhesion molecule L1.''; PubMed Europe PMC Scholia
  16. Kamiguchi H, Lemmon V.; ''Recycling of the cell adhesion molecule L1 in axonal growth cones.''; PubMed Europe PMC Scholia
  17. Whittard JD, Sakurai T, Cassella MR, Gazdoiu M, Felsenfeld DP.; ''MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth.''; PubMed Europe PMC Scholia
  18. Zhang X, Davis JQ, Carpenter S, Bennett V.; ''Structural requirements for association of neurofascin with ankyrin.''; PubMed Europe PMC Scholia
  19. Schmid RS, Pruitt WM, Maness PF.; ''A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis.''; PubMed Europe PMC Scholia
  20. Peretti D, Peris L, Rosso S, Quiroga S, Cáceres A.; ''Evidence for the involvement of KIF4 in the anterograde transport of L1-containing vesicles.''; PubMed Europe PMC Scholia
  21. Islam R, Kristiansen LV, Romani S, Garcia-Alonso L, Hortsch M.; ''Activation of EGF receptor kinase by L1-mediated homophilic cell interactions.''; PubMed Europe PMC Scholia
  22. Tomatis VM, Trenchi A, Gomez GA, Daniotti JL.; ''Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.''; PubMed Europe PMC Scholia
  23. Zhao X, Siu CH.; ''Colocalization of the homophilic binding site and the neuritogenic activity of the cell adhesion molecule L1 to its second Ig-like domain.''; PubMed Europe PMC Scholia
  24. Felding-Habermann B, Silletti S, Mei F, Siu CH, Yip PM, Brooks PC, Cheresh DA, O'Toole TE, Ginsberg MH, Montgomery AM.; ''A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins.''; PubMed Europe PMC Scholia
  25. Kadmon G, Kowitz A, Altevogt P, Schachner M.; ''The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions.''; PubMed Europe PMC Scholia
  26. Cheng L, Lemmon S, Lemmon V.; ''RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation.''; PubMed Europe PMC Scholia
  27. Gast D, Riedle S, Kiefel H, Müerköster SS, Schäfer H, Schäfer MK, Altevogt P.; ''The RGD integrin binding site in human L1-CAM is important for nuclear signaling.''; PubMed Europe PMC Scholia
  28. Kamiguchi H.; ''The mechanism of axon growth: what we have learned from the cell adhesion molecule L1.''; PubMed Europe PMC Scholia
  29. Volkmer H, Leuschner R, Zacharias U, Rathjen FG.; ''Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites.''; PubMed Europe PMC Scholia
  30. Kamiguchi H, Lemmon V.; ''Neural cell adhesion molecule L1: signaling pathways and growth cone motility.''; PubMed Europe PMC Scholia
  31. Kristiansen LV, Marques FA, Soroka V, Ronn LC, Kiselyov V, Pedersen N, Berezin V, Bock E.; ''Homophilic NCAM interactions interfere with L1 stimulated neurite outgrowth.''; PubMed Europe PMC Scholia
  32. Zheng CF, Guan KL.; ''Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.''; PubMed Europe PMC Scholia
  33. Castellani V, De Angelis E, Kenwrick S, Rougon G.; ''Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A.''; PubMed Europe PMC Scholia
  34. Roskoski R.; ''MEK1/2 dual-specificity protein kinases: structure and regulation.''; PubMed Europe PMC Scholia
  35. Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D.; ''Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.''; PubMed Europe PMC Scholia
  36. Kamiguchi H, Long KE, Pendergast M, Schaefer AW, Rapoport I, Kirchhausen T, Lemmon V.; ''The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.''; PubMed Europe PMC Scholia
  37. Panicker AK, Buhusi M, Erickson A, Maness PF.; ''Endocytosis of beta1 integrins is an early event in migration promoted by the cell adhesion molecule L1.''; PubMed Europe PMC Scholia
  38. Needham LK, Thelen K, Maness PF.; ''Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions.''; PubMed Europe PMC Scholia
  39. Nishimura K, Akiyama H, Komada M, Kamiguchi H.; ''betaIV-spectrin forms a diffusion barrier against L1CAM at the axon initial segment.''; PubMed Europe PMC Scholia
  40. Sakurai T, Gil OD, Whittard JD, Gazdoiu M, Joseph T, Wu J, Waksman A, Benson DL, Salton SR, Felsenfeld DP.; ''Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation.''; PubMed Europe PMC Scholia
  41. Nakata A, Kamiguchi H.; ''Serine phosphorylation by casein kinase II controls endocytic L1 trafficking and axon growth.''; PubMed Europe PMC Scholia
  42. Schaefer AW, Kamei Y, Kamiguchi H, Wong EV, Rapoport I, Kirchhausen T, Beach CM, Landreth G, Lemmon SK, Lemmon V.; ''L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1.''; PubMed Europe PMC Scholia
  43. Grumet M, Edelman GM.; ''Neuron-glia cell adhesion molecule interacts with neurons and astroglia via different binding mechanisms.''; PubMed Europe PMC Scholia
  44. Horstkorte R, Schachner M, Magyar JP, Vorherr T, Schmitz B.; ''The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with L1 and neurite outgrowth.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114936view16:45, 25 January 2021ReactomeTeamReactome version 75
113381view11:45, 2 November 2020ReactomeTeamReactome version 74
112586view15:55, 9 October 2020ReactomeTeamReactome version 73
101501view11:37, 1 November 2018ReactomeTeamreactome version 66
101038view21:17, 31 October 2018ReactomeTeamreactome version 65
100569view19:51, 31 October 2018ReactomeTeamreactome version 64
100118view16:36, 31 October 2018ReactomeTeamreactome version 63
99668view15:06, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93887view13:43, 16 August 2017ReactomeTeamreactome version 61
93457view11:24, 9 August 2017ReactomeTeamreactome version 61
86550view09:20, 11 July 2016ReactomeTeamreactome version 56
83082view09:54, 18 November 2015ReactomeTeamVersion54
81408view12:56, 21 August 2015ReactomeTeamVersion53
76876view08:15, 17 July 2014ReactomeTeamFixed remaining interactions
76581view11:56, 16 July 2014ReactomeTeamFixed remaining interactions
75914view09:56, 11 June 2014ReactomeTeamRe-fixing comment source
75614view10:47, 10 June 2014ReactomeTeamReactome 48 Update
74969view13:49, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74613view08:39, 30 April 2014ReactomeTeamReactome46
44884view10:11, 6 October 2011MartijnVanIerselOntology Term : 'cell adhesion signaling pathway' added !
42061view21:53, 4 March 2011MaintBotAutomatic update
39869view05:53, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
ALCAM ProteinQ13740 (UniProt)
AP2 clathrin:L1:KIF4:

microtubule

ComplexREACT_23331 (Reactome)
ATP Metabolite15422 (ChEBI)
Activated ERK2 ProteinP28482 (UniProt)
Ankyrin-G ProteinP16157 (UniProt)
Ankyrins ProteinREACT_22717 (Reactome)
Axonin-1 ProteinQ02246 (UniProt)
CHL1 ProteinO00533 (UniProt)
CHL1:

alpha1beta1/alpha2b eta1 integrins

ComplexREACT_22459 (Reactome)
CHL1:Ankyrin-G ComplexREACT_23311 (Reactome)
CHL1:CNTN6 ComplexREACT_23145 (Reactome)
CHL1:Hsc70 ComplexREACT_22887 (Reactome)
CHL1:NP-1 ComplexREACT_22777 (Reactome)
CNTN1 ProteinQ12860 (UniProt)
CRMP-2:NUMB:alpha

adaptin

ComplexREACT_22454 (Reactome)
Casein kinase II ComplexREACT_23098 (Reactome)
Clathrin-coated

vesicle

ComplexREACT_13103 (Reactome)
Contactin-6 ProteinQ9UQ52 (UniProt)
Contactin1:CASPR

complex

ComplexREACT_23146 (Reactome)
Doublecortin ProteinO43602 (UniProt)
Dynamin-1/2/3 ProteinREACT_22651 (Reactome)
EGFR ProteinP00533 (UniProt)
EPHB2 ProteinP29323 (UniProt)
ERM:PIP2 ComplexREACT_22835 (Reactome)
Endophilin ProteinQ99962 (UniProt)
F-actin UnknownREACT_20433 (Reactome)
Fibroblast growth

factor receptor 1c

ProteinP11362-1 (UniProt)
GDP Metabolite17552 (ChEBI)
GTP Metabolite15996 (ChEBI)
Heat Stable Antigen

(HSA)

ProteinP25063 (UniProt)
Hsc70 ProteinP31948 (UniProt)
Integrins ComplexREACT_23070 (Reactome)
KIF4 dimer ComplexREACT_23088 (Reactome)
L1 ProteinP32004 (UniProt)
L1 dimer:Ankyrin:

Spectrin:F-actin

ComplexREACT_22451 (Reactome)
L1 homodimer ComplexREACT_22876 (Reactome)
L1 trans-

homodimer:Ankyrin

ComplexREACT_22843 (Reactome)
L1 trans-homodimer ComplexREACT_22570 (Reactome)
L1-EGFR trans-

heterodimer

ComplexREACT_22956 (Reactome)
L1:ALCAM ComplexREACT_23036 (Reactome)
L1:AP-2 Clathrin

complex

ComplexREACT_22867 (Reactome)
L1:AP-2 Clathrin

complex

ComplexREACT_22916 (Reactome)
L1:Axonin-1 ComplexREACT_23324 (Reactome)
L1:CNTN1 ComplexREACT_23027 (Reactome)
L1:FGFR1 ComplexREACT_22912 (Reactome)
L1:HNK-1 ComplexREACT_23380 (Reactome)
L1:HSA ComplexREACT_22674 (Reactome)
L1:Integrin complex ComplexREACT_22722 (Reactome)
L1:Laminin ComplexREACT_23226 (Reactome)
L1:NCAM1 complex ComplexREACT_23047 (Reactome)
L1:NP-1 ComplexREACT_23153 (Reactome)
L1:NUMB:CRMP-2:

alpha-adaptin

ComplexREACT_22785 (Reactome)
L1:Neurocan ComplexREACT_23328 (Reactome)
L1:RanBPM ComplexREACT_23100 (Reactome)
L1:clathrin-coated

vesicle

ComplexREACT_22698 (Reactome)
Laminin-1 (EHS

laminin)

ComplexREACT_14571 (Reactome)
MEK1:ERK-1 ComplexREACT_5539 (Reactome)
MEK2:ERK-2 ComplexREACT_5435 (Reactome)
NCAM1 ProteinP13591 (UniProt)
NFASC:pNFASC ComplexREACT_22522 (Reactome)
Na+/K+ channel

subunits

ComplexREACT_23061 (Reactome)
Neurocan ProteinO14594 (UniProt)
Neurofascin ProteinO94856 (UniProt)
Neurofascin:

Syntenin-1 complex

ComplexREACT_23202 (Reactome)
Neurofascin:Ankyrin-

G complex

ComplexREACT_22462 (Reactome)
Neurofascin:CNTN1:

CASPR complex

ComplexREACT_22948 (Reactome)
Neurofascin:NrCAM

complex

ComplexREACT_22606 (Reactome)
Neurofascin:NrCAM:

Ankyrin:spectrin based actin

ComplexREACT_23030 (Reactome)
Neurofascin:NrCAM:

Ankyrin:spectrin based actin:Na+/K+ channel

ComplexREACT_22749 (Reactome)
Neuropilin-1 ProteinO14786-1 (UniProt)
Neuropilin-2 (NP2) ProteinO60462 (UniProt)
NrCAM ProteinQ92823 (UniProt)
NrCAM:Ankyrin-G ComplexREACT_23219 (Reactome)
NrCAM:Axonin-1 ComplexREACT_23383 (Reactome)
NrCAM:NP-2 ComplexREACT_22473 (Reactome)
NrCAM:SAP

members

ComplexREACT_23321 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PAK1 ProteinQ13153 (UniProt)
PAK1 dimer

(inactive/autoinhibited )

ComplexREACT_23136 (Reactome)
RAC1-GDP ComplexREACT_22018 (Reactome)
RAC1-GTP ComplexREACT_21594 (Reactome)
RanBPM ProteinQ96S59 (UniProt)
SRC ProteinP12931-1 (UniProt)
Shootin-1 ProteinA0MZ66 (UniProt)
Syntenin-1 ProteinO00560 (UniProt)
Trans neurofascin

dimer:ankyrin-G

ComplexREACT_22613 (Reactome)
Tyr phos L1:EPHB2 ComplexREACT_23011 (Reactome)
VAV2 ProteinP52735 (UniProt)
alpha1beta1/alpha2b

eta1

ComplexREACT_22630 (Reactome)
microtubule UnknownREACT_10446 (Reactome)
p-VAV2(Y172) ProteinP52735 (UniProt)
p90rsk ProteinREACT_23173 (Reactome)
pL1 (S1152):p90rsk:

clathrin-dynamin complex

ComplexREACT_23209 (Reactome)
pL1 (S1204, 1248):

ERK2:clathrin- dynamin complex

ComplexREACT_23286 (Reactome)
pL1 (Y1176) ProteinP32004 (UniProt)
pL1 (Y1229):L1CAM ComplexREACT_22871 (Reactome)
pL1:CK-II ComplexREACT_22634 (Reactome)
pL1:ERM:F-actin ComplexREACT_22519 (Reactome)
pL1:Ezrin ComplexREACT_22884 (Reactome)
pL1:Shootin-1:F-

actin

ComplexREACT_22531 (Reactome)
pNFASC:Doublecortin ComplexREACT_23013 (Reactome)
pPAK1:Rac1-GTP ComplexREACT_23376 (Reactome)
phospho-ERK-1:

MEK1

ComplexREACT_2796 (Reactome)
phospho-ERK-2:

MEK2

ComplexREACT_3199 (Reactome)
spectrin based actin ComplexREACT_22921 (Reactome)
synapse-associated

proteins (SAP)

ProteinREACT_23280 (Reactome)
unidentified protein

tyrosine kinase

UnknownREACT_22532 (Reactome)
unknown protein UnknownREACT_22919 (Reactome)

Annotated Interactions

No annotated interactions

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