Rap1 signaling (Homo sapiens)

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121, 4-62, 7, 89, 103111, 4-6cytosolCalDAG-GEFsRap1-GDPPKA catalytic subunits, PKG type IATPp(S7)-Rap1 GTPase-activating protein 23',5'-Cyclic AMPGTP14-3-3 beta, zetaRap1-GTPGDPRap1 GTPase-activating protein 2Rap1 cAMP-GEFs:cAMPpyrophosphateRap1-GTP:Raf1ADPRaf-1Rap1 cAMP-GEFsp(S7)-Rap1 GTPase-activating protein 2:14-3-3beta, zeta


Description

Rap1 (Ras-proximate-1) is a small G protein in the Ras superfamily. Like all G proteins, Rap1 is activated when bound GDP is exchanged for GTP. Rap1 is targeted to lipid membranes by the covalent attachment of lipid moieties to its carboxyl terminus. Movement of Rap1 from endosomal membranes to the plasma membrane upon activation has been reported in several cell types including Jurkat T cells and megakaryocytes. On activation, Rap1 undergoes conformational changes that facilitate recruitment of a variety of effectors, triggering it's participation in integrin signaling, ERK activation, and others.

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Bibliography

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  1. Stork PJ, Dillon TJ.; ''Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions.''; PubMed Europe PMC Scholia
  2. Schultess J, Danielewski O, Smolenski AP.; ''Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.''; PubMed Europe PMC Scholia
  3. Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP.; ''Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets.''; PubMed Europe PMC Scholia
  4. Polakis PG, Rubinfeld B, Evans T, McCormick F.; ''Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells.''; PubMed Europe PMC Scholia
  5. Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM.; ''A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.''; PubMed Europe PMC Scholia
  6. Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, Iwai K, Minato N.; ''Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product.''; PubMed Europe PMC Scholia
  7. Lafuente E, Boussiotis VA.; ''Rap1 regulation of RIAM and cell adhesion.''; PubMed Europe PMC Scholia
  8. Cook SJ, Rubinfeld B, Albert I, McCormick F.; ''RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.''; PubMed Europe PMC Scholia
  9. Hu CD, Kariya Ki, Kotani G, Shirouzu M, Yokoyama S, Kataoka T.; ''Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1.''; PubMed Europe PMC Scholia
  10. Crittenden JR, Bergmeier W, Zhang Y, Piffath CL, Liang Y, Wagner DD, Housman DE, Graybiel AM.; ''CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.''; PubMed Europe PMC Scholia
  11. Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA.; ''RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116417view09:09, 7 May 2021EweitzModified title
114768view16:25, 25 January 2021ReactomeTeamReactome version 75
113212view11:28, 2 November 2020ReactomeTeamReactome version 74
112436view15:38, 9 October 2020ReactomeTeamReactome version 73
101341view11:22, 1 November 2018ReactomeTeamreactome version 66
100879view20:56, 31 October 2018ReactomeTeamreactome version 65
100420view19:30, 31 October 2018ReactomeTeamreactome version 64
99970view16:14, 31 October 2018ReactomeTeamreactome version 63
99524view14:49, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99164view12:41, 31 October 2018ReactomeTeamreactome version 62
93990view13:49, 16 August 2017ReactomeTeamreactome version 61
93596view11:28, 9 August 2017ReactomeTeamreactome version 61
88130view10:18, 26 July 2016RyanmillerOntology Term : 'signaling pathway in the adaptive immune response' added !
88129view10:17, 26 July 2016RyanmillerOntology Term : 'Ras superfamily mediated signaling pathway' added !
88128view10:16, 26 July 2016RyanmillerOntology Term : 'signaling pathway' added !
86703view09:24, 11 July 2016ReactomeTeamreactome version 56
83370view11:01, 18 November 2015ReactomeTeamVersion54
81536view13:04, 21 August 2015ReactomeTeamVersion53
77004view08:29, 17 July 2014ReactomeTeamFixed remaining interactions
76709view12:07, 16 July 2014ReactomeTeamFixed remaining interactions
76035view10:09, 11 June 2014ReactomeTeamRe-fixing comment source
75744view11:23, 10 June 2014ReactomeTeamReactome 48 Update
75094view14:04, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74741view08:49, 30 April 2014ReactomeTeamReactome46
42111view21:57, 4 March 2011MaintBotAutomatic update
39921view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
14-3-3 beta,

zeta

ProteinREACT_24076 (Reactome)
3',5'-Cyclic AMP Metabolite17489 (ChEBI)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
CalDAG-GEFs ProteinREACT_18194 (Reactome) Rap1 can be activated by certain GEFs that respond to calcium and diacylglycerol (CalDAG-GEFs).
GDP Metabolite17552 (ChEBI)
GTP Metabolite15996 (ChEBI)
PKA catalytic

subunits, PKG type I

ProteinREACT_24087 (Reactome)
Raf-1 ProteinP04049 (UniProt)
Rap1 GTPase-

activating protein 2

ProteinQ684P5 (UniProt)
Rap1 cAMP-GEFs ProteinREACT_17998 (Reactome)
Rap1 cAMP-GEFs:

cAMP

ComplexREACT_24050 (Reactome)
Rap1-GDP ComplexREACT_15771 (Reactome)
Rap1-GTP ComplexREACT_16044 (Reactome)
Rap1-GTP:Raf1 ComplexREACT_24874 (Reactome)
p(S7)-Rap1 GTPase-

activating protein 2

ProteinQ684P5 (UniProt)
p(S7)-Rap1 GTPase-

activating protein 2: 14-3-3beta, zeta

ComplexREACT_24434 (Reactome)
pyrophosphate Metabolite29888 (ChEBI)

Annotated Interactions

No annotated interactions

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