Genetic alterations of lung cancer (Rattus norvegicus)
From WikiPathways
Description
Expression patterns of two major tumor suppressor pathways in lung cancer. These pathways are functionally linked to lung cancer and play role as a component of checkpoints and growth inhibitory pathways. Components which/who are activated in this pathway are given in red, those who are inactivated in blue. The dark blue ones are frequent and the light blue infreuquent inactivated. Both, the p14ARF/p53 and the p16INK4A/RB pathway lead to cell cycle arrest.
Quality Tags
Ontology Terms
Bibliography
- Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC; ''HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.''; Nat Cell Biol, 2001 PubMed Europe PMC Scholia
- Osada H, Takahashi T; ''Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.''; Oncogene, 2002 PubMed Europe PMC Scholia
- Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M; ''Repression of p15INK4b expression by Myc through association with Miz-1.''; Nat Cell Biol, 2001 PubMed Europe PMC Scholia
- Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, Roussel MF; ''Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.''; Genes Dev, 1998 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Akt1 | GeneProduct | ENSRNOG00000028629 (Ensembl Rat) | |
Atm | GeneProduct | ENSRNOG00000029773 (Ensembl Rat) | |
CBP | GeneProduct | ENSRNOG00000002167 (Ensembl Rat) | |
Cdk2 | GeneProduct | ENSRNOG00000006469 (Ensembl Rat) | |
Cdk4 | GeneProduct | ENSRNOG00000025602 (Ensembl Rat) | |
CyclinD | GeneProduct | ||
CyclinE | GeneProduct | ENSRNOG00000002167 (Ensembl Rat) | |
DP | GeneProduct | ENSRNOG00000025602 (Ensembl Rat) | |
Dmp1 | GeneProduct | ENSRNOG00000002167 (Ensembl Rat) | |
E2f1 | GeneProduct | ENSRNOG00000016708 (Ensembl Rat) | |
ERK | GeneProduct | ||
Egfr | GeneProduct | ENSRNOG00000004332 (Ensembl Rat) | |
Erbb2 | GeneProduct | ENSRNOG00000006450 (Ensembl Rat) | |
MEK | GeneProduct | ||
MYC | GeneProduct | ||
Mdm2 | GeneProduct | ENSRNOG00000006304 (Ensembl Rat) | |
PI3K | GeneProduct | ||
RB | GeneProduct | ENSRNOG00000025602 (Ensembl Rat) | |
Raf1 | GeneProduct | ENSRNOG00000010153 (Ensembl Rat) | |
Rasl11b | GeneProduct | ENSRNOG00000002097 (Ensembl Rat) | |
SMAD4_RAT | GeneProduct | ENSRNOG00000015634 (Ensembl Rat) | |
Smad2 | GeneProduct | ENSRNOG00000018140 (Ensembl Rat) | |
TGF-beta R1/2 | GeneProduct | ENSRNOG00000002418 (Ensembl Rat) | |
Tgfb1 | GeneProduct | ENSRNOG00000020652 (Ensembl Rat) | |
Tp53 | GeneProduct | ENSRNOG00000010756 (Ensembl Rat) | |
cell cycle arrest | |||
p14ARF | GeneProduct | ENSRNOG00000002167 (Ensembl Rat) | |
p15INK4B | GeneProduct | ||
p16INK4A | GeneProduct | ||
p21 | GeneProduct | ENSRNOG00000002167 (Ensembl Rat) | |
p300 | GeneProduct | ENSRNOG00000002167 (Ensembl Rat) |
Annotated Interactions
No annotated interactions