TCR signaling pathway (Bos taurus)

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ReceptorPMDMitochondrionNU->CYUbiquitinationENMethylationDeubiquitinationDeacetylationMTCY->NUReaction through unknown mechanisms/moleculesNucleus(Protein-protein interaction)ExtracellularDAccession Number: NetPath_11InhibitionAntigenProteolytic cleavagePhosphorylationAutophosphorylationPalmitoylationCY->PMControlCytoplasmCYDesumoylationMolecular associationEndoplasmic reticulumDemethylationActivationRecruitmentTranslocationGlycosylationPlasma membraneLigandGene SymbolSumoylationProteins in a complex interactionMolecule in the pathwayDephosphorylationNUERECEndosomeCY->NUEnzyme complexGOAcetylationGolgi apparatusUNC119LCP2FYNVASPSLARASA1CD3ELCKFYBNFAM1LYNMUC1LCP2STAT5ALOC533307GAB2CD5STAT1HOMER3WASTRA@SHC1SYKPIK3R2ABL1SKAP2WIPF1SKAP1JUNCD2EVLCD247VAV3CD247TRAT1NCK1ACP1SH2B3PTPN6CRKMAP4K1SHBLAX1WASF2PLCG1VAV2LIME1CD3GCTNNB1ITKSIT1PIK3R1BCL10FOSRAPGEF1DTX1PTK2SLA2CABIN1LOC100138040GRB2PRKD2PXNDEF6STAT5BCDC42CBLBTUBA4ASH2D2ADBNLLOC509843CARD11GRAPKHDRBS1CREBBPCBLSRCPAG1LOC527664MAPK3NEDD9BRAFLOC785291JAK3CRKLPRKCQMAP3K1PTPRCSTAT5BPSTPIP1RIPK2CEBPBDOCK2CD8AFCRL3SH3BP2MAP2K1CD3ENCLSTAT5APTPN3ARHGEF7CREB1ARHGEF6TXKSH2D3CENAHMAP2K2ARHGDIBCD4CISHPTPRHPTK2BGIT2SOS1NCK1TRB@ABI1PPP3CBVAV1AKT1RAP1AJUNMAPK7CD3DPTPN11LOC509843DUSP3LIME1MAPK1NFATC2PTPN12DNM2ZAP70GRAP2ITPR1PAK1PTPN22CD2APSTK39LATRAC2YWHAQRASGRP2FYB


Description

No description

Comments

GenMAPP notes 
NetPath_11 - T Cell Receptor Signaling Pathway NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP69(r20823) with a 86% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
117623view11:43, 21 May 2021EweitzModified title
89939view13:49, 6 October 2016MkutmonOntology Term : 'T cell receptor signaling pathway' added !
89938view13:49, 6 October 2016MkutmonModified description
80877view15:29, 30 June 2015Mkutmonhomology conversion
63335view21:13, 9 May 2013MaintBotUpdated to 2013 gpml schema
40515view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
33758view00:02, 9 December 2009MaintBotAutomatic update of empty xrefs
32490view12:46, 17 August 2009MaintBotFixed text labels
31188view19:29, 13 August 2009MaintBotFixed text labels
30580view22:08, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABI1GeneProduct540815 (Entrez Gene)
ABL1GeneProduct540876 (Entrez Gene)
ACP1GeneProduct785845 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
ARHGDIBGeneProduct327676 (Entrez Gene)
ARHGEF6GeneProduct533823 (Entrez Gene)
ARHGEF7GeneProduct524352 (Entrez Gene)
BCL10GeneProduct540824 (Entrez Gene)
BRAFGeneProduct536051 (Entrez Gene)
CABIN1GeneProduct530023 (Entrez Gene)
CARD11GeneProduct515377 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CBLBGeneProduct525906 (Entrez Gene)
CD247GeneProduct281056 (Entrez Gene)
CD2GeneProduct497022 (Entrez Gene)
CD2APGeneProduct533188 (Entrez Gene)
CD3DGeneProduct281053 (Entrez Gene)
CD3EGeneProduct281054 (Entrez Gene)
CD3GGeneProduct281055 (Entrez Gene)
CD4GeneProduct407098 (Entrez Gene)
CD5GeneProduct280745 (Entrez Gene)
CD8AGeneProduct281060 (Entrez Gene)
CDC42GeneProduct532712 (Entrez Gene)
CEBPBGeneProduct338319 (Entrez Gene)
CISHGeneProduct616753 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CREBBPGeneProduct505453 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CRKLGeneProduct
CTNNB1GeneProduct539003 (Entrez Gene)
DBNLGeneProduct514706 (Entrez Gene)
DEF6GeneProduct516457 (Entrez Gene)
DNM2GeneProduct511691 (Entrez Gene)
DOCK2GeneProduct281745 (Entrez Gene)
DTX1GeneProduct512873 (Entrez Gene)
DUSP3GeneProduct615432 (Entrez Gene)
ENAHGeneProduct513095 (Entrez Gene)
EVLGeneProduct506201 (Entrez Gene)
FCRL3GeneProduct515085 (Entrez Gene)
FOSGeneProduct280795 (Entrez Gene)
FYBGeneProduct535347 (Entrez Gene)
FYNGeneProduct527263 (Entrez Gene)
GAB2GeneProduct529346 (Entrez Gene)
GIT2GeneProduct516048 (Entrez Gene)
GRAP2GeneProduct522346 (Entrez Gene)
GRAPGeneProduct534491 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
HOMER3GeneProduct
ITKGeneProduct522311 (Entrez Gene)
ITPR1GeneProduct317697 (Entrez Gene)
JAK3GeneProduct
JUNGeneProduct280831 (Entrez Gene)
KHDRBS1GeneProduct538775 (Entrez Gene)
LATGeneProduct514735 (Entrez Gene)
LAX1GeneProduct540424 (Entrez Gene)
LCKGeneProduct508890 (Entrez Gene)
LCP2GeneProduct513244 (Entrez Gene)
LIME1GeneProduct
LOC100138040GeneProduct100138040 (Entrez Gene)
LOC509843GeneProduct509843 (Entrez Gene)
LOC527664GeneProduct527664 (Entrez Gene)
LOC533307GeneProduct533307 (Entrez Gene)
LOC785291GeneProduct785291 (Entrez Gene)
LYNGeneProduct534996 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP4K1GeneProduct522002 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK7GeneProduct537703 (Entrez Gene)
MUC1GeneProduct281333 (Entrez Gene)
NCK1GeneProduct536154 (Entrez Gene)
NCLGeneProduct497013 (Entrez Gene)
NEDD9GeneProduct504967 (Entrez Gene)
NFAM1GeneProduct512151 (Entrez Gene)
NFATC2GeneProduct530401 (Entrez Gene)
PAG1GeneProduct614460 (Entrez Gene)
PAK1GeneProduct533729 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PLCG1GeneProduct281987 (Entrez Gene)
PPP3CBGeneProduct790867 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKD2GeneProduct782793 (Entrez Gene)
PSTPIP1GeneProduct513924 (Entrez Gene)
PTK2GeneProduct506270 (Entrez Gene)
PTK2BGeneProduct541008 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN12GeneProduct531877 (Entrez Gene)
PTPN22GeneProduct518992 (Entrez Gene)
PTPN3GeneProduct511010 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
PTPRCGeneProduct407152 (Entrez Gene)
PTPRHGeneProduct521868 (Entrez Gene)
PXNGeneProduct517456 (Entrez Gene)
RAC2GeneProduct327671 (Entrez Gene)
RAP1AGeneProduct282031 (Entrez Gene)
RAPGEF1GeneProduct520454 (Entrez Gene)
RASA1GeneProduct282032 (Entrez Gene)
RASGRP2GeneProduct512056 (Entrez Gene)
RIPK2GeneProduct534407 (Entrez Gene)
SH2B3GeneProduct614726 (Entrez Gene)
SH2D2AGeneProduct530059 (Entrez Gene)
SH2D3CGeneProduct515820 (Entrez Gene)
SH3BP2GeneProduct
SHBGeneProduct538275 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SIT1GeneProduct512027 (Entrez Gene)
SKAP1GeneProduct506769 (Entrez Gene)
SKAP2GeneProduct616545 (Entrez Gene)
SLA2GeneProduct514398 (Entrez Gene)
SLAGeneProduct513589 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
STK39GeneProduct522103 (Entrez Gene)
SYKGeneProduct515515 (Entrez Gene)
TRA@GeneProduct511486 (Entrez Gene)
TRAT1GeneProduct614942 (Entrez Gene)
TRB@GeneProduct281547 (Entrez Gene)
TUBA4AGeneProduct777775 (Entrez Gene)
TXKGeneProduct504782 (Entrez Gene)
UNC119GeneProduct538501 (Entrez Gene)
VASPGeneProduct514902 (Entrez Gene)
VAV1GeneProduct617345 (Entrez Gene)
VAV2GeneProduct
VAV3GeneProduct521961 (Entrez Gene)
WASGeneProduct
WASF2GeneProduct504482 (Entrez Gene)
WIPF1GeneProduct540304 (Entrez Gene)
YWHAQGeneProduct768311 (Entrez Gene)
ZAP70GeneProduct504509 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1011"
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