TNF-alpha signaling pathway (Bos taurus)

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AcetylationCY ->NUDemethylationInhibitionAutophosphorylationEnzyme complexMTCY ->NUPM(Protein-protein interaction)ControlPhosphorylationMolecular associationMolecule in the pathwayCYReaction through unknown mechanisms/moleculesRecruitmentGlycosylationUbiquitinationGONucleusActivationDephosphorylationCY ->NUCytoplasmMethylationExtracellularNUCY ->NUEndoplasmic reticulumGolgi apparatusDesumoylationProteins in a complex interactionPlasma membraneERProteolytic cleavageEndosomeECSumoylationENMitochondrionDeubiquitinationCY ->NUDPalmitoylationReceptorAccession Number: NetPath 9; cellmap:9TranslocationDeacetylationLigandRPL30PSMD6NFKB1TNFRSF1ABIRC3IQGAP2FBXW11TRAF6RELBRPS6KA5PTK2RPL4MAP3K3COPS3HDAC1G3BP2PFDN2PEBP1BTRCRPS11USP11SRCCRADDKIAA1967CASP2ALPLLOC100138545CREBBPNFKBIAPOLR2LTNFAIP3NFKB2NFKBIATNFRSF1BPSMC1RELRELPRKACALOC790559PDCD2RIPK1PSMD7DAPPSMB5BIRC3HSPB1GSK3BTNFRSF11AWDR68SUMO1PSMD13IKBKEUBE2IBCL7ACHUKCASP3KPNA3DDX3XPOLR1APKN1TNFCOMMD1KCNQ1MTIF2FLNAPOLR1ESMARCB1HSP90AB1NALP4RPL6TRADDBCL3CASP8NKIRAS2ZFAND5RIPK2TRAF1POLR1BRELANSMAFRELAMAP3K2NFKBIZMAP3K1YWHABMAP3K14NFKB1IKBKBIKBKGCASP10TNFPPP1R13LTNFBAG4GLG1GNB2L1PSMD3TXLNAGAB1CYLDPAPOLATNFTRPC4APMAP3K7IP1RASAL2RPS6KB1CD3EAPCASP8AP2MCM5MAP3K8ACTL6APIAS3PSMD12Gene SymbolYWHAQTNFRSF8GeneAKT1RNF216GeneKTN1FKBP5CASP7RNF25UBCH5CKPNA6MAP2K5CAPN3PSMC3MAP3K7IP2UBE2D2TNFSMARCE1RELBTRAF2POLR1DCUL1TNIP1TNFRSF1BHDAC2NR2C2YWHAZFANCD2TNFRSF1APSMC2NFKBIALOC509995TRAF4NFKB1SMARCC2AKAP8SMARCA4TRAF4TRAIPRIPK3EIF4A3TRAF1TNIP2KPNA2PTPN11HIST3H3TRAF3CHUKYWHAELOC511264GeneMCCPEG3YWHAGTANKMARK2BIRC2PRKCZGTF2IRIPK1TRAF5HDAC6GeneAZI2TRAF2TBK1HSPCATRAF2RELAIKBKAPMGC143170RELATBK1CSNK2A2LOC522045TRADDTNFRSF1BNKIRAS1USP2RPL8YWHAHNR2C2IKBKGCSNK2BRPS13AKT2CDC34FAF1CFLARPOLR2HSTAT1FBLMCM7CDC37NFKBIBMAP3K3DPF2CSNK2A1POLR1CPPP2CAFADDBIRC2CAV1TNFUNC5CLTNFRSF1ANFKBIEPSMD1


Description

No description

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 87% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116471view10:15, 7 May 2021EweitzModified title
89903view13:20, 6 October 2016EgonwModified description
80680view15:21, 30 June 2015Mkutmonhomology conversion
63380view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40552view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33791view00:12, 9 December 2009MaintBotAutomatic update of empty xrefs
32512view12:52, 17 August 2009MaintBotFixed text labels
32200view12:38, 15 August 2009MaintBotFixed text labels
31682view11:44, 14 August 2009MaintBotFixed group labels
31210view19:36, 13 August 2009MaintBotFixed text labels
30616view22:20, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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AKAP8GeneProduct522905 (Entrez Gene)
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BIRC2GeneProduct
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CAV1GeneProduct281040 (Entrez Gene)
CD3EAPGeneProduct617937 (Entrez Gene)
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CHUKGeneProduct281073 (Entrez Gene)
COMMD1GeneProduct534683 (Entrez Gene)
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FBLGeneProduct538548 (Entrez Gene)
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TNFRSF8GeneProduct614780 (Entrez Gene)
TNIP1GeneProduct526103 (Entrez Gene)
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YWHAQGeneProduct768311 (Entrez Gene)
YWHAZGeneProduct287022 (Entrez Gene)
ZFAND5GeneProduct404110 (Entrez Gene)

Annotated Interactions

No annotated interactions
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