Insulin signaling (Bos taurus)
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Transcriptional Regulators & Immediate Early Genes
Metabolic Regulation
p90 Rsk Kinases
PDK/Akt Signaling
Ras-MAPK Signaling
Vesicular Trafficking
Tor Signaling
PI 3-Kinase
p70 S6 Kinases
Insulin Receptor Substrates
MEK/MAP Kinases
Translation Regulation
Glucose Transport
Modulators of Insulin Action
PFKL
GRB14
LOC513301
CBL
PRKAA2
IRS4
MAP3K10
MAP4K3
PRKCD
PIK3CB
SOS1
EIF4E
LIPE
GYS2
RPS6KA4
GSK3A
EGR1
MAPK7
SGK2
SH2B2
FLOT1
RPS6KA6
MAPK3
RPS6KA2
IRS1
INSR
SOCS1
SNAP23
RAPGEF1
RRAD
PTEN
CBLC
FLOT2
MAPK1
JUN
XBP1
SNX26
KIF3A
TRIB3
MAP4K1
MAP3K8
MAP3K2
LOC537790
MAP3K12
RPS6KA5
PIK3R3
CBLB
RPS6KB1
MAPK12
TBC1D4
RAC2
SHC3
LOC615374
PIK3CG
GSK3B
EHD2
FOXO3
RAC1
STXBP2
PTPN1
IGF1R
MAP2K2
MAP3K5
MAP2K1
AKT2
MAPK8
RAB4A
MAP2K3
STX4
MAPK6
STXBP3
LOC100138040
GAB1
CAP1
PRKCZ
HRAS
MAPK14
SGK1
PRKCB
GYG1
MAP3K7
INPPL1
MAPK9
MAP4K5
MAPK13
Grb10
IRS2
MAPK11
PIK3R1
PRKAA1
SORBS1
FOS
MAP4K2
RPS6KB2
TSC1
MAP2K6
MAP2K4
SLC2A1
SGK3
TSC2
VAMP2
EHD1
AKT1
PRKCH
RPS6KA3
LOC789318
STXBP1
EIF4EBP1
PIK3C3
SRF
MAP3K1
ARF1
MAP4K4
MAP3K4
MYO1C
RPS6KA1
MAP3K3
PIK3CD
MAPK10
MAP3K9
PTPN11
PPP1R3A
SHC2
MAP3K11
GYS1
SLC2A4
MAP2K5
GRB2
PSCD3
LOC100139988
ELK1
INPP4A
MAP2K7
RHOJ
LOC100138102
PFKM
LOC506618
SOCS3
PIK3R4
SHC1
MAP3K14
PRKCA
PRKCI
MINK1
PRKCQ
MAPK8
ARF6
RAF1
STXBP4
MAP3K13
LOC100139219
MAPK4
ENPP1
CRK
SNAP25
PIK3CA
KIF5B
MAP3K6
IKBKB
PTPRF
PIK3R2
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP481(r28132)
with a 92% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
Quality Tags
Ontology Terms
Saving...
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Bibliography
Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001
PubMed
Europe PMC
Scholia
Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991
PubMed
Europe PMC
Scholia
Bevan P; ''Insulin signalling.''; J Cell Sci, 2001
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
116790
view
09:59, 14 May 2021
Eweitz
Modified title
95776
view
14:28, 19 January 2018
Mkutmon
Homology conversion update
80882
view
15:29, 30 June 2015
Mkutmon
homology conversion
78838
view
23:00, 4 February 2015
Zari
Modified title
78837
view
22:58, 4 February 2015
Zari
Periodical save, work in progress
71280
view
04:14, 17 October 2013
MaintBot
Removed buggy complexes
63393
view
00:04, 10 May 2013
MaintBot
Updated to 2013 gpml schema
48134
view
05:52, 9 May 2012
MaintBot
Updating from human to fix xref duplication
40566
view
19:32, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33804
view
00:18, 9 December 2009
MaintBot
Automatic update of empty xrefs
33615
view
10:00, 1 December 2009
MaintBot
Removed group label
31628
view
22:21, 13 August 2009
MaintBot
Fixed text labels
30535
view
21:54, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
AKT1
GeneProduct
280991 (Entrez Gene)
AKT2
GeneProduct
534923 (Entrez Gene)
ARF1
GeneProduct
338058 (Entrez Gene)
ARF6
GeneProduct
614161 (Entrez Gene)
CAP1
GeneProduct
504519 (Entrez Gene)
CBL
GeneProduct
527418 (Entrez Gene)
CBLB
GeneProduct
525906 (Entrez Gene)
CBLC
GeneProduct
615866 (Entrez Gene)
CRK
GeneProduct
512841 (Entrez Gene)
EGR1
GeneProduct
407125 (Entrez Gene)
EHD1
GeneProduct
511908 (Entrez Gene)
EHD2
GeneProduct
538348 (Entrez Gene)
EIF4E
GeneProduct
281751 (Entrez Gene)
EIF4EBP1
GeneProduct
509613 (Entrez Gene)
ELK1
GeneProduct
786886 (Entrez Gene)
ENPP1
GeneProduct
615535 (Entrez Gene)
FLOT1
GeneProduct
532573 (Entrez Gene)
FLOT2
GeneProduct
615679 (Entrez Gene)
FOS
GeneProduct
280795 (Entrez Gene)
FOXO3
GeneProduct
535530 (Entrez Gene)
GAB1
GeneProduct
540085 (Entrez Gene)
GRB14
GeneProduct
497029 (Entrez Gene)
GRB2
GeneProduct
535298 (Entrez Gene)
GSK3A
GeneProduct
536561 (Entrez Gene)
GSK3B
GeneProduct
790875 (Entrez Gene)
GYG1
GeneProduct
280812 (Entrez Gene)
GYS1
GeneProduct
786335 (Entrez Gene)
GYS2
GeneProduct
537451 (Entrez Gene)
Grb10
GeneProduct
407210 (Entrez Gene)
HRAS
GeneProduct
513012 (Entrez Gene)
IGF1R
GeneProduct
281848 (Entrez Gene)
IKBKB
GeneProduct
281854 (Entrez Gene)
INPP4A
GeneProduct
535487 (Entrez Gene)
INPPL1
GeneProduct
783833 (Entrez Gene)
INSR
GeneProduct
408017 (Entrez Gene)
IRS1
GeneProduct
538598 (Entrez Gene)
IRS2
GeneProduct
IRS4
GeneProduct
514607 (Entrez Gene)
JUN
GeneProduct
280831 (Entrez Gene)
KIF3A
GeneProduct
541246 (Entrez Gene)
KIF5B
GeneProduct
514261 (Entrez Gene)
LIPE
GeneProduct
286879 (Entrez Gene)
LOC100138040
GeneProduct
100138040 (Entrez Gene)
LOC100138102
GeneProduct
100138102 (Entrez Gene)
LOC100139219
GeneProduct
100139219 (Entrez Gene)
LOC100139988
GeneProduct
100139988 (Entrez Gene)
LOC506618
GeneProduct
506618 (Entrez Gene)
LOC513301
GeneProduct
513301 (Entrez Gene)
LOC537790
GeneProduct
537790 (Entrez Gene)
LOC615374
GeneProduct
615374 (Entrez Gene)
LOC789318
GeneProduct
789318 (Entrez Gene)
MAP2K1
GeneProduct
533199 (Entrez Gene)
MAP2K2
GeneProduct
510434 (Entrez Gene)
MAP2K3
GeneProduct
516039 (Entrez Gene)
MAP2K4
GeneProduct
526469 (Entrez Gene)
MAP2K5
GeneProduct
MAP2K6
GeneProduct
286883 (Entrez Gene)
MAP2K7
GeneProduct
787278 (Entrez Gene)
MAP3K10
GeneProduct
781037 (Entrez Gene)
MAP3K11
GeneProduct
514210 (Entrez Gene)
MAP3K12
GeneProduct
505427 (Entrez Gene)
MAP3K13
GeneProduct
505369 (Entrez Gene)
MAP3K14
GeneProduct
508367 (Entrez Gene)
MAP3K1
GeneProduct
523962 (Entrez Gene)
MAP3K2
GeneProduct
504592 (Entrez Gene)
MAP3K3
GeneProduct
508943 (Entrez Gene)
MAP3K4
GeneProduct
511779 (Entrez Gene)
MAP3K5
GeneProduct
537380 (Entrez Gene)
MAP3K6
GeneProduct
614598 (Entrez Gene)
MAP3K7
GeneProduct
529146 (Entrez Gene)
MAP3K8
GeneProduct
535622 (Entrez Gene)
MAP3K9
GeneProduct
MAP4K1
GeneProduct
522002 (Entrez Gene)
MAP4K2
GeneProduct
520058 (Entrez Gene)
MAP4K3
GeneProduct
507624 (Entrez Gene)
MAP4K4
GeneProduct
MAP4K5
GeneProduct
781335 (Entrez Gene)
MAPK10
GeneProduct
537631 (Entrez Gene)
MAPK11
GeneProduct
618906 (Entrez Gene)
MAPK12
GeneProduct
512943 (Entrez Gene)
MAPK1
GeneProduct
327672 (Entrez Gene)
MAPK13
GeneProduct
535327 (Entrez Gene)
MAPK14
GeneProduct
534492 (Entrez Gene)
MAPK3
GeneProduct
531391 (Entrez Gene)
MAPK4
GeneProduct
529183 (Entrez Gene)
MAPK6
GeneProduct
538094 (Entrez Gene)
MAPK7
GeneProduct
537703 (Entrez Gene)
MAPK8
GeneProduct
539941 (Entrez Gene)
MAPK9
GeneProduct
534125 (Entrez Gene)
MINK1
GeneProduct
519558 (Entrez Gene)
MYO1C
GeneProduct
281937 (Entrez Gene)
PFKL
GeneProduct
508683 (Entrez Gene)
PFKM
GeneProduct
506544 (Entrez Gene)
PIK3C3
GeneProduct
534815 (Entrez Gene)
PIK3CA
GeneProduct
282306 (Entrez Gene)
PIK3CB
GeneProduct
517948 (Entrez Gene)
PIK3CD
GeneProduct
504531 (Entrez Gene)
PIK3CG
GeneProduct
530001 (Entrez Gene)
PIK3R1
GeneProduct
282307 (Entrez Gene)
PIK3R2
GeneProduct
282308 (Entrez Gene)
PIK3R3
GeneProduct
286865 (Entrez Gene)
PIK3R4
GeneProduct
507414 (Entrez Gene)
PPP1R3A
GeneProduct
784877 (Entrez Gene)
PRKAA1
GeneProduct
540404 (Entrez Gene)
PRKAA2
GeneProduct
538954 (Entrez Gene)
PRKCA
GeneProduct
282001 (Entrez Gene)
PRKCB
GeneProduct
282325 (Entrez Gene)
PRKCD
GeneProduct
505708 (Entrez Gene)
PRKCH
GeneProduct
518542 (Entrez Gene)
PRKCI
GeneProduct
528478 (Entrez Gene)
PRKCQ
GeneProduct
505901 (Entrez Gene)
PRKCZ
GeneProduct
286877 (Entrez Gene)
PSCD3
GeneProduct
PTEN
GeneProduct
540786 (Entrez Gene)
PTPN11
GeneProduct
533590 (Entrez Gene)
PTPN1
GeneProduct
508658 (Entrez Gene)
PTPRF
GeneProduct
512072 (Entrez Gene)
RAB4A
GeneProduct
615849 (Entrez Gene)
RAC1
GeneProduct
281440 (Entrez Gene)
RAC2
GeneProduct
327671 (Entrez Gene)
RAF1
GeneProduct
521196 (Entrez Gene)
RAPGEF1
GeneProduct
520454 (Entrez Gene)
RHOJ
GeneProduct
540619 (Entrez Gene)
RPS6KA1
GeneProduct
533908 (Entrez Gene)
RPS6KA2
GeneProduct
517953 (Entrez Gene)
RPS6KA3
GeneProduct
511190 (Entrez Gene)
RPS6KA4
GeneProduct
RPS6KA5
GeneProduct
504408 (Entrez Gene)
RPS6KA6
GeneProduct
526227 (Entrez Gene)
RPS6KB1
GeneProduct
404181 (Entrez Gene)
RPS6KB2
GeneProduct
506083 (Entrez Gene)
RRAD
GeneProduct
505165 (Entrez Gene)
SGK1
GeneProduct
515854 (Entrez Gene)
SGK2
GeneProduct
517909 (Entrez Gene)
SGK3
GeneProduct
504480 (Entrez Gene)
SH2B2
GeneProduct
617840 (Entrez Gene)
SHC1
GeneProduct
507196 (Entrez Gene)
SHC2
GeneProduct
533455 (Entrez Gene)
SHC3
GeneProduct
512696 (Entrez Gene)
SLC2A1
GeneProduct
282356 (Entrez Gene)
SLC2A4
GeneProduct
282359 (Entrez Gene)
SNAP23
GeneProduct
522423 (Entrez Gene)
SNAP25
GeneProduct
540853 (Entrez Gene)
SNX26
GeneProduct
SOCS1
GeneProduct
518795 (Entrez Gene)
SOCS3
GeneProduct
282081 (Entrez Gene)
SORBS1
GeneProduct
504625 (Entrez Gene)
SOS1
GeneProduct
537682 (Entrez Gene)
SRF
GeneProduct
533039 (Entrez Gene)
STX4
GeneProduct
508675 (Entrez Gene)
STXBP1
GeneProduct
282378 (Entrez Gene)
STXBP2
GeneProduct
515618 (Entrez Gene)
STXBP3
GeneProduct
512490 (Entrez Gene)
STXBP4
GeneProduct
537963 (Entrez Gene)
TBC1D4
GeneProduct
534649 (Entrez Gene)
TRIB3
GeneProduct
538465 (Entrez Gene)
TSC1
GeneProduct
533440 (Entrez Gene)
TSC2
GeneProduct
504985 (Entrez Gene)
VAMP2
GeneProduct
282116 (Entrez Gene)
XBP1
GeneProduct
541236 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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External references
DataNodes
Annotated Interactions
No annotated interactions