Insulin signaling (Bos taurus)

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Review changes for Approved Revision 116790 of this pathway was approved for data analysis by Martina Kutmon.

Annotate nodes Comment: 2 out of 163 DataNodes have a missing external reference. Check DataNode table at the bottom of the page. Please help improve this pathway by annotating gene, protein and metabolite nodes.

Homology Converted Comment: Inferred from another species Revision {{{tag_revision}}} of this pathway has been inferred from another species (tagged by Maintenance bot). Expression error: Unrecognised punctuation character "{"

Ontology Terms

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Bibliography

1. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia
2. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia
3. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
AKT1	GeneProduct	280991 (Entrez Gene)
AKT2	GeneProduct	534923 (Entrez Gene)
ARF1	GeneProduct	338058 (Entrez Gene)
ARF6	GeneProduct	614161 (Entrez Gene)
CAP1	GeneProduct	504519 (Entrez Gene)
CBL	GeneProduct	527418 (Entrez Gene)
CBLB	GeneProduct	525906 (Entrez Gene)
CBLC	GeneProduct	615866 (Entrez Gene)
CRK	GeneProduct	512841 (Entrez Gene)
EGR1	GeneProduct	407125 (Entrez Gene)
EHD1	GeneProduct	511908 (Entrez Gene)
EHD2	GeneProduct	538348 (Entrez Gene)
EIF4E	GeneProduct	281751 (Entrez Gene)
EIF4EBP1	GeneProduct	509613 (Entrez Gene)
ELK1	GeneProduct	786886 (Entrez Gene)
ENPP1	GeneProduct	615535 (Entrez Gene)
FLOT1	GeneProduct	532573 (Entrez Gene)
FLOT2	GeneProduct	615679 (Entrez Gene)
FOS	GeneProduct	280795 (Entrez Gene)
FOXO3	GeneProduct	535530 (Entrez Gene)
GAB1	GeneProduct	540085 (Entrez Gene)
GRB14	GeneProduct	497029 (Entrez Gene)
GRB2	GeneProduct	535298 (Entrez Gene)
GSK3A	GeneProduct	536561 (Entrez Gene)
GSK3B	GeneProduct	790875 (Entrez Gene)
GYG1	GeneProduct	280812 (Entrez Gene)
GYS1	GeneProduct	786335 (Entrez Gene)
GYS2	GeneProduct	537451 (Entrez Gene)
Grb10	GeneProduct	407210 (Entrez Gene)
HRAS	GeneProduct	513012 (Entrez Gene)
IGF1R	GeneProduct	281848 (Entrez Gene)
IKBKB	GeneProduct	281854 (Entrez Gene)
INPP4A	GeneProduct	535487 (Entrez Gene)
INPPL1	GeneProduct	783833 (Entrez Gene)
INSR	GeneProduct	408017 (Entrez Gene)
IRS1	GeneProduct	538598 (Entrez Gene)
IRS2	GeneProduct
IRS4	GeneProduct	514607 (Entrez Gene)
JUN	GeneProduct	280831 (Entrez Gene)
KIF3A	GeneProduct	541246 (Entrez Gene)
KIF5B	GeneProduct	514261 (Entrez Gene)
LIPE	GeneProduct	286879 (Entrez Gene)
LOC100138040	GeneProduct	100138040 (Entrez Gene)
LOC100138102	GeneProduct	100138102 (Entrez Gene)
LOC100139219	GeneProduct	100139219 (Entrez Gene)
LOC100139988	GeneProduct	100139988 (Entrez Gene)
LOC506618	GeneProduct	506618 (Entrez Gene)
LOC513301	GeneProduct	513301 (Entrez Gene)
LOC537790	GeneProduct	537790 (Entrez Gene)
LOC615374	GeneProduct	615374 (Entrez Gene)
LOC789318	GeneProduct	789318 (Entrez Gene)
MAP2K1	GeneProduct	533199 (Entrez Gene)
MAP2K2	GeneProduct	510434 (Entrez Gene)
MAP2K3	GeneProduct	516039 (Entrez Gene)
MAP2K4	GeneProduct	526469 (Entrez Gene)
MAP2K5	GeneProduct
MAP2K6	GeneProduct	286883 (Entrez Gene)
MAP2K7	GeneProduct	787278 (Entrez Gene)
MAP3K10	GeneProduct	781037 (Entrez Gene)
MAP3K11	GeneProduct	514210 (Entrez Gene)
MAP3K12	GeneProduct	505427 (Entrez Gene)
MAP3K13	GeneProduct	505369 (Entrez Gene)
MAP3K14	GeneProduct	508367 (Entrez Gene)
MAP3K1	GeneProduct	523962 (Entrez Gene)
MAP3K2	GeneProduct	504592 (Entrez Gene)
MAP3K3	GeneProduct	508943 (Entrez Gene)
MAP3K4	GeneProduct	511779 (Entrez Gene)
MAP3K5	GeneProduct	537380 (Entrez Gene)
MAP3K6	GeneProduct	614598 (Entrez Gene)
MAP3K7	GeneProduct	529146 (Entrez Gene)
MAP3K8	GeneProduct	535622 (Entrez Gene)
MAP3K9	GeneProduct
MAP4K1	GeneProduct	522002 (Entrez Gene)
MAP4K2	GeneProduct	520058 (Entrez Gene)
MAP4K3	GeneProduct	507624 (Entrez Gene)
MAP4K4	GeneProduct
MAP4K5	GeneProduct	781335 (Entrez Gene)
MAPK10	GeneProduct	537631 (Entrez Gene)
MAPK11	GeneProduct	618906 (Entrez Gene)
MAPK12	GeneProduct	512943 (Entrez Gene)
MAPK1	GeneProduct	327672 (Entrez Gene)
MAPK13	GeneProduct	535327 (Entrez Gene)
MAPK14	GeneProduct	534492 (Entrez Gene)
MAPK3	GeneProduct	531391 (Entrez Gene)
MAPK4	GeneProduct	529183 (Entrez Gene)
MAPK6	GeneProduct	538094 (Entrez Gene)
MAPK7	GeneProduct	537703 (Entrez Gene)
MAPK8	GeneProduct	539941 (Entrez Gene)
MAPK9	GeneProduct	534125 (Entrez Gene)
MINK1	GeneProduct	519558 (Entrez Gene)
MYO1C	GeneProduct	281937 (Entrez Gene)
PFKL	GeneProduct	508683 (Entrez Gene)
PFKM	GeneProduct	506544 (Entrez Gene)
PIK3C3	GeneProduct	534815 (Entrez Gene)
PIK3CA	GeneProduct	282306 (Entrez Gene)
PIK3CB	GeneProduct	517948 (Entrez Gene)
PIK3CD	GeneProduct	504531 (Entrez Gene)
PIK3CG	GeneProduct	530001 (Entrez Gene)
PIK3R1	GeneProduct	282307 (Entrez Gene)
PIK3R2	GeneProduct	282308 (Entrez Gene)
PIK3R3	GeneProduct	286865 (Entrez Gene)
PIK3R4	GeneProduct	507414 (Entrez Gene)
PPP1R3A	GeneProduct	784877 (Entrez Gene)
PRKAA1	GeneProduct	540404 (Entrez Gene)
PRKAA2	GeneProduct	538954 (Entrez Gene)
PRKCA	GeneProduct	282001 (Entrez Gene)
PRKCB	GeneProduct	282325 (Entrez Gene)
PRKCD	GeneProduct	505708 (Entrez Gene)
PRKCH	GeneProduct	518542 (Entrez Gene)
PRKCI	GeneProduct	528478 (Entrez Gene)
PRKCQ	GeneProduct	505901 (Entrez Gene)
PRKCZ	GeneProduct	286877 (Entrez Gene)
PSCD3	GeneProduct
PTEN	GeneProduct	540786 (Entrez Gene)
PTPN11	GeneProduct	533590 (Entrez Gene)
PTPN1	GeneProduct	508658 (Entrez Gene)
PTPRF	GeneProduct	512072 (Entrez Gene)
RAB4A	GeneProduct	615849 (Entrez Gene)
RAC1	GeneProduct	281440 (Entrez Gene)
RAC2	GeneProduct	327671 (Entrez Gene)
RAF1	GeneProduct	521196 (Entrez Gene)
RAPGEF1	GeneProduct	520454 (Entrez Gene)
RHOJ	GeneProduct	540619 (Entrez Gene)
RPS6KA1	GeneProduct	533908 (Entrez Gene)
RPS6KA2	GeneProduct	517953 (Entrez Gene)
RPS6KA3	GeneProduct	511190 (Entrez Gene)
RPS6KA4	GeneProduct
RPS6KA5	GeneProduct	504408 (Entrez Gene)
RPS6KA6	GeneProduct	526227 (Entrez Gene)
RPS6KB1	GeneProduct	404181 (Entrez Gene)
RPS6KB2	GeneProduct	506083 (Entrez Gene)
RRAD	GeneProduct	505165 (Entrez Gene)
SGK1	GeneProduct	515854 (Entrez Gene)
SGK2	GeneProduct	517909 (Entrez Gene)
SGK3	GeneProduct	504480 (Entrez Gene)
SH2B2	GeneProduct	617840 (Entrez Gene)
SHC1	GeneProduct	507196 (Entrez Gene)
SHC2	GeneProduct	533455 (Entrez Gene)
SHC3	GeneProduct	512696 (Entrez Gene)
SLC2A1	GeneProduct	282356 (Entrez Gene)
SLC2A4	GeneProduct	282359 (Entrez Gene)
SNAP23	GeneProduct	522423 (Entrez Gene)
SNAP25	GeneProduct	540853 (Entrez Gene)
SNX26	GeneProduct
SOCS1	GeneProduct	518795 (Entrez Gene)
SOCS3	GeneProduct	282081 (Entrez Gene)
SORBS1	GeneProduct	504625 (Entrez Gene)
SOS1	GeneProduct	537682 (Entrez Gene)
SRF	GeneProduct	533039 (Entrez Gene)
STX4	GeneProduct	508675 (Entrez Gene)
STXBP1	GeneProduct	282378 (Entrez Gene)
STXBP2	GeneProduct	515618 (Entrez Gene)
STXBP3	GeneProduct	512490 (Entrez Gene)
STXBP4	GeneProduct	537963 (Entrez Gene)
TBC1D4	GeneProduct	534649 (Entrez Gene)
TRIB3	GeneProduct	538465 (Entrez Gene)
TSC1	GeneProduct	533440 (Entrez Gene)
TSC2	GeneProduct	504985 (Entrez Gene)
VAMP2	GeneProduct	282116 (Entrez Gene)
XBP1	GeneProduct	541236 (Entrez Gene)

Annotated Interactions