G protein signaling pathways (Bos taurus)

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1, 2G betaTranscriptionAdenylate CyclasesGqGsGiCellResponseCytoskeletalChangesCellResponsePhosphatase 2BG12/13Protein Kinase AG gammacAMPPhosphodiesterasesAKAPsProtein Kinase CTranscriptionKRASAKAP12PRKAR2BGNAZcAMPARHGEF1AKAP9PDE8BPRKACGGNA15PRKCQPRKCEPDE1APRKACAPDE7APRKCGGNG5GNG7AKAP3AKAP11PRKAR1BPRKCHPPP3CCPDE7BPDE4DPRKCZPRKCAAKAP10PDE4BGNAO1PPP3CAPDE1CLOC505611ADCY4AKAP6CALM1ADCY6SLC9A1PRKACBHRASGNG3ITPR1AKAP5PDE8AIP3GNB5GNGT1LOC100139910AKAP7PRKD3ADCY7ADCY5AKAP4RHOAPDE4CPRKD1GNAI1GNAI1PPP3CCPDE1BGNB3GNB1DAGPRKAR1ANRASGNB2PRKCILOC517006GNAQGNAI3PRKCDADCY3GNAI2GNG10GNASADCY1Ca2+AKAP2GNA11KCNJ3GNAO1PDE4AADCY9RRASGNA14GNALGNG4ADCY8GNG11GNG12PLCB3AKAP8PRKCBGNGT2AKAP1AKAP13GNA12GNG8ADCY2


Description

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP35(r20751) with a 89% conversion rate.

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Bibliography

  1. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC Scholia
  2. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117517view11:06, 21 May 2021EweitzModified title
106003view11:53, 16 August 2019MaintBotHMDB identifier normalization
80727view15:23, 30 June 2015Mkutmonhomology conversion
71426view19:03, 17 October 2013MaintBotAutomated update of data sources
67258view10:27, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway' added !
63448view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
40582view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35321view08:21, 12 February 2010ThomasModified description
35320view08:21, 12 February 2010Thomasadded literature
33819view00:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32513view12:52, 17 August 2009MaintBotFixed text labels
32201view12:38, 15 August 2009MaintBotFixed text labels
31684view11:45, 14 August 2009MaintBotFixed group labels
31211view19:37, 13 August 2009MaintBotFixed text labels
30618view22:21, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY1GeneProduct281601 (Entrez Gene)
ADCY2GeneProduct510708 (Entrez Gene)
ADCY3GeneProduct535603 (Entrez Gene)
ADCY4GeneProduct788151 (Entrez Gene)
ADCY5GeneProduct505740 (Entrez Gene)
ADCY6GeneProduct509936 (Entrez Gene)
ADCY7GeneProduct281603 (Entrez Gene)
ADCY8GeneProduct535017 (Entrez Gene)
ADCY9GeneProduct525482 (Entrez Gene)
AKAP10GeneProduct513802 (Entrez Gene)
AKAP11GeneProduct533105 (Entrez Gene)
AKAP12GeneProduct513774 (Entrez Gene)
AKAP13GeneProduct504288 (Entrez Gene)
AKAP1GeneProduct532072 (Entrez Gene)
AKAP2GeneProduct
AKAP3GeneProduct281610 (Entrez Gene)
AKAP4GeneProduct281611 (Entrez Gene)
AKAP5GeneProduct281612 (Entrez Gene)
AKAP6GeneProduct537810 (Entrez Gene)
AKAP7GeneProduct613606 (Entrez Gene)
AKAP8GeneProduct522905 (Entrez Gene)
AKAP9GeneProduct520784 (Entrez Gene)
ARHGEF1GeneProduct513377 (Entrez Gene)
CALM1GeneProduct617095 (Entrez Gene)
Ca2+MetaboliteHMDB00464 (HMDB)
DAGMetaboliteC00165 (Kegg Compound)
GNA11GeneProduct281788 (Entrez Gene)
GNA12GeneProduct515159 (Entrez Gene)
GNA14GeneProduct281789 (Entrez Gene)
GNA15GeneProduct532029 (Entrez Gene)
GNAI1GeneProduct281790 (Entrez Gene)
GNAI2GeneProduct281791 (Entrez Gene)
GNAI3GeneProduct539521 (Entrez Gene)
GNALGeneProduct100124520 (Entrez Gene)
GNAO1GeneProduct281792 (Entrez Gene)
GNAQGeneProduct536654 (Entrez Gene)
GNASGeneProduct281793 (Entrez Gene)
GNAZGeneProduct281200 (Entrez Gene)
GNB1GeneProduct281201 (Entrez Gene)
GNB2GeneProduct281202 (Entrez Gene)
GNB3GeneProduct513340 (Entrez Gene)
GNB5GeneProduct535365 (Entrez Gene)
GNG10GeneProduct613930 (Entrez Gene)
GNG11GeneProduct788596 (Entrez Gene)
GNG12GeneProduct286850 (Entrez Gene)
GNG3GeneProduct281204 (Entrez Gene)
GNG4GeneProduct100125276 (Entrez Gene)
GNG5GeneProduct287018 (Entrez Gene)
GNG7GeneProduct618399 (Entrez Gene)
GNG8GeneProduct618470 (Entrez Gene)
GNGT1GeneProduct281796 (Entrez Gene)
GNGT2GeneProduct281797 (Entrez Gene)
HRASGeneProduct513012 (Entrez Gene)
IP3MetaboliteHMDB01143 (HMDB)
ITPR1GeneProduct317697 (Entrez Gene)
KCNJ3GeneProduct526088 (Entrez Gene)
KRASGeneProduct541140 (Entrez Gene)
LOC100139910GeneProduct100139910 (Entrez Gene)
LOC505611GeneProduct505611 (Entrez Gene)
LOC517006GeneProduct517006 (Entrez Gene)
NRASGeneProduct506322 (Entrez Gene)
PDE1AGeneProduct281969 (Entrez Gene)
PDE1BGeneProduct281970 (Entrez Gene)
PDE1CGeneProduct526211 (Entrez Gene)
PDE4AGeneProduct512222 (Entrez Gene)
PDE4BGeneProduct100124505 (Entrez Gene)
PDE4CGeneProduct524624 (Entrez Gene)
PDE4DGeneProduct539556 (Entrez Gene)
PDE7AGeneProduct
PDE7BGeneProduct522509 (Entrez Gene)
PDE8AGeneProduct506787 (Entrez Gene)
PDE8BGeneProduct539768 (Entrez Gene)
PLCB3GeneProduct515669 (Entrez Gene)
PPP3CAGeneProduct286852 (Entrez Gene)
PPP3CCGeneProduct533527 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PRKACBGeneProduct282323 (Entrez Gene)
PRKACGGeneProduct
PRKAR1AGeneProduct615074 (Entrez Gene)
PRKAR1BGeneProduct505370 (Entrez Gene)
PRKAR2BGeneProduct282463 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCEGeneProduct507041 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCIGeneProduct528478 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PRKD1GeneProduct533270 (Entrez Gene)
PRKD3GeneProduct538447 (Entrez Gene)
RHOAGeneProduct338049 (Entrez Gene)
RRASGeneProduct616503 (Entrez Gene)
SLC9A1GeneProduct317654 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions
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