Actin cytoskeleton regulation (Bos taurus)
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Actin polymerization
PI3K
GPCR
+p
Gene Expression
RTK
Focal complex
assembly
?
Stabilization
of actin
RAS
PI3K
Adherens junction
pathway
GF
Growth Factor (GF)
MAPK Signaling
pathway
RTK
Chemotactic factor
GPCR
-p
Focal adhesion
assembly
Lamellipodia
Actomyosin
assembly contraction
Focal adhesion
pathway
Actin
polymerization
stress fiber
Filipodia
RAS
Actin polymerization
stress fiber
Chemotatic factor
Focal adhesion
pathway
FGFR4
PIP5K1C
MAP2K2
WAS
CHRM5
CSK
NRAS
FGFR1
PFN1
LOC442775
LOC615374
PPP1R12A
LOC615374
FGF4
LOC615374
FGF9
MRAS
FGF20
PIP2
ARHGEF1
PDGFB
MSN
LOC505611
TMSB4X
MYL3
PIK3CG
PAK4
EGF
RAC1P4
RDX
IQGAP1
MYL1
MAPK1
CHRM3
FGF14
LOC537790
PIP5K1A
RHOA
FGF23
LOC615374
ACTB
FGF1
FGF11
LIMK1
C11orf13
SSH3
ARHGEF6
PIP4K2A
RAC3
PIK3CB
FGF16
VCL
PIK3R5
CDC42
ARPC5
ARPC5
MAP2K1
CRK
Bradykinin
PIK3R3
APC
FGF12
Apc2
LOC615374
SLC9A1
PXN
ABI2
LOC513301
PIK3R1
MYH10
ARHGEF7
MAPK4
FGF2
CHRM2
RRAS
LOC615374
PIP4K2A
PIP3
DOCK1
MAPK6
BAIAP2
ROCK1
PAK7
FGF17
SSH1
NCKAP1
PIK3CD
FGF18
FGFR2
F2R
FGF8
PTK2
FGF7
WASF2
PAK1
CYFIP2
FN1
EZR
BDKRB1
MYLK
GRLF1
FGF6
ITGA1
PIP2
GNG12
PDGFRA
GSN
FGF22
PIK3R2
LOC100138040
ACTG1
KRAS
Pik3c2b
ACTN1
LOC785576
CHRM1
PDGFRB
MAPK3
FGF5
BRAF
PDGFA
SOS1
SSH2
PFN1
Acetylcholine
PIK3C3
FGD1
EGFR
ACTB
CHRM4
GNA12
BAIAP2
PAK2
F2
VIL1
ACTB
RAC2
RAF1
PAK3
RAC1
PIP5K1B
ARHGEF4
PIP4K2C
GIT1
BDKRB2
LPS
MOS
WASF1
FGF13
CFL1
BCAR1
CFL2
FGF10
PIP5KL1
RRAS2
ARHGEF6
FGF3
FGFR3
PAK6
VCL
CD14
ACTG1
PIK3R4
PIK3CA
VAV1
ACTG1
ROCK2
PIP4K2B
ENAH
Description
No description
Comments
GenMAPP notes
http://www.genome.jp/kegg/pathway/hsa/hsa04810.html
GenMAPP remarks
Adapted from KEGG (right-click to see notes)
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP51(r20783)
with a 84% conversion rate.
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Bibliography
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Revision
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Time
User
Comment
120933
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09:05, 1 February 2022
Egonw
Made four pathways clickable
117595
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11:36, 21 May 2021
Eweitz
Modified title
80894
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15:30, 30 June 2015
Mkutmon
homology conversion
72126
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07:48, 25 October 2013
Mkutmon
added datasource for pathway datanodes
71429
view
19:03, 17 October 2013
MaintBot
Automated update of data sources
63458
view
17:18, 10 May 2013
MaintBot
Updated to 2013 gpml schema
48126
view
05:45, 9 May 2012
MaintBot
Updating from human to fix xref duplication
40593
view
19:33, 1 March 2011
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Removed redundant pathway information and comments
33830
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00:28, 9 December 2009
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Automatic update of empty xrefs
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12:56, 17 August 2009
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Fixed text labels
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12:41, 15 August 2009
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11:48, 14 August 2009
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Fixed group labels
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19:40, 13 August 2009
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Fixed text labels
30631
view
22:26, 29 July 2009
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New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ABI2
GeneProduct
537711 (Entrez Gene)
ACTB
GeneProduct
280979 (Entrez Gene)
ACTG1
GeneProduct
404122 (Entrez Gene)
ACTN1
GeneProduct
524770 (Entrez Gene)
APC
GeneProduct
533233 (Entrez Gene)
ARHGEF1
GeneProduct
513377 (Entrez Gene)
ARHGEF4
GeneProduct
505852 (Entrez Gene)
ARHGEF6
GeneProduct
533823 (Entrez Gene)
ARHGEF7
GeneProduct
524352 (Entrez Gene)
ARPC5
GeneProduct
614345 (Entrez Gene)
Acetylcholine
Metabolite
Apc2
GeneProduct
526572 (Entrez Gene)
BAIAP2
GeneProduct
507837 (Entrez Gene)
BCAR1
GeneProduct
527550 (Entrez Gene)
BDKRB1
GeneProduct
532119 (Entrez Gene)
BDKRB2
GeneProduct
538896 (Entrez Gene)
BRAF
GeneProduct
536051 (Entrez Gene)
Bradykinin
Metabolite
C11orf13
GeneProduct
CD14
GeneProduct
281048 (Entrez Gene)
CDC42
GeneProduct
532712 (Entrez Gene)
CFL1
GeneProduct
534553 (Entrez Gene)
CFL2
GeneProduct
539332 (Entrez Gene)
CHRM1
GeneProduct
281684 (Entrez Gene)
CHRM2
GeneProduct
522170 (Entrez Gene)
CHRM3
GeneProduct
281685 (Entrez Gene)
CHRM4
GeneProduct
512928 (Entrez Gene)
CHRM5
GeneProduct
281686 (Entrez Gene)
CRK
GeneProduct
512841 (Entrez Gene)
CSK
GeneProduct
509246 (Entrez Gene)
CYFIP2
GeneProduct
518833 (Entrez Gene)
DOCK1
GeneProduct
537203 (Entrez Gene)
EGF
GeneProduct
786061 (Entrez Gene)
EGFR
GeneProduct
407217 (Entrez Gene)
ENAH
GeneProduct
513095 (Entrez Gene)
EZR
GeneProduct
281574 (Entrez Gene)
F2
GeneProduct
280685 (Entrez Gene)
F2R
GeneProduct
526585 (Entrez Gene)
FGD1
GeneProduct
100124501 (Entrez Gene)
FGF10
GeneProduct
326285 (Entrez Gene)
FGF11
GeneProduct
613386 (Entrez Gene)
FGF12
GeneProduct
615823 (Entrez Gene)
FGF1
GeneProduct
281160 (Entrez Gene)
FGF13
GeneProduct
506924 (Entrez Gene)
FGF14
GeneProduct
FGF16
GeneProduct
540758 (Entrez Gene)
FGF17
GeneProduct
FGF18
GeneProduct
533929 (Entrez Gene)
FGF20
GeneProduct
539083 (Entrez Gene)
FGF22
GeneProduct
519657 (Entrez Gene)
FGF2
GeneProduct
281161 (Entrez Gene)
FGF23
GeneProduct
530239 (Entrez Gene)
FGF3
GeneProduct
618481 (Entrez Gene)
FGF4
GeneProduct
618474 (Entrez Gene)
FGF5
GeneProduct
536771 (Entrez Gene)
FGF6
GeneProduct
540317 (Entrez Gene)
FGF7
GeneProduct
616885 (Entrez Gene)
FGF8
GeneProduct
326284 (Entrez Gene)
FGF9
GeneProduct
FGFR1
GeneProduct
281768 (Entrez Gene)
FGFR2
GeneProduct
404193 (Entrez Gene)
FGFR3
GeneProduct
281769 (Entrez Gene)
FGFR4
GeneProduct
317696 (Entrez Gene)
FN1
GeneProduct
280794 (Entrez Gene)
GIT1
GeneProduct
515088 (Entrez Gene)
GNA12
GeneProduct
515159 (Entrez Gene)
GNG12
GeneProduct
286850 (Entrez Gene)
GRLF1
GeneProduct
540310 (Entrez Gene)
GSN
GeneProduct
535077 (Entrez Gene)
IQGAP1
GeneProduct
532715 (Entrez Gene)
ITGA1
GeneProduct
535951 (Entrez Gene)
KRAS
GeneProduct
541140 (Entrez Gene)
LIMK1
GeneProduct
535225 (Entrez Gene)
LOC100138040
GeneProduct
100138040 (Entrez Gene)
LOC442775
GeneProduct
LOC505611
GeneProduct
505611 (Entrez Gene)
LOC513301
GeneProduct
513301 (Entrez Gene)
LOC537790
GeneProduct
537790 (Entrez Gene)
LOC615374
GeneProduct
615374 (Entrez Gene)
LOC785576
GeneProduct
785576 (Entrez Gene)
LPS
Metabolite
C00338 (Kegg Compound)
MAP2K1
GeneProduct
533199 (Entrez Gene)
MAP2K2
GeneProduct
510434 (Entrez Gene)
MAPK1
GeneProduct
327672 (Entrez Gene)
MAPK3
GeneProduct
531391 (Entrez Gene)
MAPK4
GeneProduct
529183 (Entrez Gene)
MAPK6
GeneProduct
538094 (Entrez Gene)
MOS
GeneProduct
444869 (Entrez Gene)
MRAS
GeneProduct
540803 (Entrez Gene)
MSN
GeneProduct
540426 (Entrez Gene)
MYH10
GeneProduct
317655 (Entrez Gene)
MYL1
GeneProduct
317657 (Entrez Gene)
MYL3
GeneProduct
618352 (Entrez Gene)
MYLK
GeneProduct
338037 (Entrez Gene)
NCKAP1
GeneProduct
787496 (Entrez Gene)
NRAS
GeneProduct
506322 (Entrez Gene)
PAK1
GeneProduct
533729 (Entrez Gene)
PAK2
GeneProduct
PAK3
GeneProduct
534526 (Entrez Gene)
PAK4
GeneProduct
539742 (Entrez Gene)
PAK6
GeneProduct
539224 (Entrez Gene)
PAK7
GeneProduct
513432 (Entrez Gene)
PDGFA
GeneProduct
505908 (Entrez Gene)
PDGFB
GeneProduct
540106 (Entrez Gene)
PDGFRA
GeneProduct
282301 (Entrez Gene)
PDGFRB
GeneProduct
527165 (Entrez Gene)
PFN1
GeneProduct
781603 (Entrez Gene)
PIK3C3
GeneProduct
534815 (Entrez Gene)
PIK3CA
GeneProduct
282306 (Entrez Gene)
PIK3CB
GeneProduct
517948 (Entrez Gene)
PIK3CD
GeneProduct
504531 (Entrez Gene)
PIK3CG
GeneProduct
530001 (Entrez Gene)
PIK3R1
GeneProduct
282307 (Entrez Gene)
PIK3R2
GeneProduct
282308 (Entrez Gene)
PIK3R3
GeneProduct
286865 (Entrez Gene)
PIK3R4
GeneProduct
507414 (Entrez Gene)
PIK3R5
GeneProduct
614838 (Entrez Gene)
PIP2
Metabolite
C04637 (Kegg Compound)
PIP3
Metabolite
C05981 (Kegg Compound)
PIP4K2A
GeneProduct
533289 (Entrez Gene)
PIP4K2B
GeneProduct
539211 (Entrez Gene)
PIP4K2C
GeneProduct
540005 (Entrez Gene)
PIP5K1A
GeneProduct
100125224 (Entrez Gene)
PIP5K1B
GeneProduct
537654 (Entrez Gene)
PIP5K1C
GeneProduct
508819 (Entrez Gene)
PIP5KL1
GeneProduct
523736 (Entrez Gene)
PPP1R12A
GeneProduct
538606 (Entrez Gene)
PTK2
GeneProduct
506270 (Entrez Gene)
PXN
GeneProduct
517456 (Entrez Gene)
Pik3c2b
GeneProduct
537396 (Entrez Gene)
RAC1
GeneProduct
281440 (Entrez Gene)
RAC1P4
GeneProduct
RAC2
GeneProduct
327671 (Entrez Gene)
RAC3
GeneProduct
619066 (Entrez Gene)
RAF1
GeneProduct
521196 (Entrez Gene)
RDX
GeneProduct
517111 (Entrez Gene)
RHOA
GeneProduct
338049 (Entrez Gene)
ROCK1
GeneProduct
785911 (Entrez Gene)
ROCK2
GeneProduct
282041 (Entrez Gene)
RRAS2
GeneProduct
519269 (Entrez Gene)
RRAS
GeneProduct
616503 (Entrez Gene)
SLC9A1
GeneProduct
317654 (Entrez Gene)
SOS1
GeneProduct
537682 (Entrez Gene)
SSH1
GeneProduct
538233 (Entrez Gene)
SSH2
GeneProduct
512652 (Entrez Gene)
SSH3
GeneProduct
514643 (Entrez Gene)
TMSB4X
GeneProduct
781334 (Entrez Gene)
VAV1
GeneProduct
617345 (Entrez Gene)
VCL
GeneProduct
783645 (Entrez Gene)
VIL1
GeneProduct
281573 (Entrez Gene)
WAS
GeneProduct
WASF1
GeneProduct
531488 (Entrez Gene)
WASF2
GeneProduct
504482 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
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