Hedgehog signaling pathway (Bos taurus)

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1, 2PMExtracellularCYAcetylationERControlEnzyme complexGene SymbolProteolytic cleavageCY->NUInhibitionPhosphorylationGO(Protein-protein interaction)Golgi apparatusDemethylationECPlasma membraneMethylationMitochondrionDRecruitmentLigandEndosomeNucleusEndoplasmic reticulumAccession Number: NetPath 10; cellmap:10DeubiquitinationCytoplasmProteins in a complex interactionMolecular AssociationCY->NUReceptorPM->ENCY->NUGlycosylationActivationDeacetylationUbiquitinationAutophosphorylationMTCY->PMCY->NUCY->NUDPalmitoylationENDMolecule in the pathwayDephosphorylationSumoylationNUPM->ENDesumoylationTranslocationReaction through unknown mechanisms/moleculesHHIPIHHSKIGLI2SMOSAP18GLI1SIN3ASUFUDYRK1APTCH2PTCH2PTCH1GLI3SUFULOC525833HHIPLOC618588PTCH1GAS1SMOSHHSTK36HHIPCREBBPCDC2IHHSUFUPTCH1LOC618588SHHGLI1CDC2SHHSHHLOC525833GLI2IGF2LOC525833PTCH1GLI3CCNB1PTCH2CCNB1IHH


Description

The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Comments

GenMAPP notes 
NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP47(r20775) with a 91% conversion rate.

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117535view11:14, 21 May 2021EweitzModified title
115958view08:24, 22 March 2021EgonwCopied the NetPath paper into the literature list
115948view07:12, 22 March 2021EgonwModified description
111050view12:39, 3 July 2020L DupuisConverted interactions to graphical lines in legend
80656view15:20, 30 June 2015Mkutmonhomology conversion
79162view05:14, 6 March 2015MaintBotUpdated conversion from Hs
67325view10:37, 26 June 2013Christine ChichesterOntology Term : 'Hedgehog signaling pathway' added !
63470view17:19, 10 May 2013MaintBotUpdated to 2013 gpml schema
40606view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35744view23:53, 12 February 2010AlexanderPico
33843view00:33, 9 December 2009MaintBotAutomatic update of empty xrefs
32496view12:47, 17 August 2009MaintBotFixed text labels
31194view19:31, 13 August 2009MaintBotFixed text labels
30591view22:12, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCNB1GeneProduct327679 (Entrez Gene)
CDC2GeneProduct281061 (Entrez Gene)
CREBBPGeneProduct505453 (Entrez Gene)
DYRK1AGeneProduct532989 (Entrez Gene)
GAS1GeneProduct540336 (Entrez Gene)
GLI1GeneProduct517588 (Entrez Gene)
GLI2GeneProduct510255 (Entrez Gene)
GLI3GeneProduct785371 (Entrez Gene)
HHIPGeneProduct540830 (Entrez Gene)
IGF2GeneProduct281240 (Entrez Gene)
IHHGeneProduct522714 (Entrez Gene)
LOC525833GeneProduct525833 (Entrez Gene)
LOC618588GeneProduct618588 (Entrez Gene)
PTCH1GeneProduct520994 (Entrez Gene)
PTCH2GeneProduct507948 (Entrez Gene)
SAP18GeneProduct615692 (Entrez Gene)
SHHGeneProduct286821 (Entrez Gene)
SIN3AGeneProduct518504 (Entrez Gene)
SKIGeneProduct506127 (Entrez Gene)
SMOGeneProduct539308 (Entrez Gene)
STK36GeneProduct508408 (Entrez Gene)
SUFUGeneProduct535067 (Entrez Gene)

Annotated Interactions

No annotated interactions
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