IL-4 signaling pathway (Bos taurus)

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ReceptorDDCYECSumoylationCY -> PMGlycosylationDCY -> PMTranslocationMethylationCY -> PMRecruitmentCytoplasmGolgi apparatusDemethylationMolecular associationCY -> NUDEndosomeMolecule in the pathwayDDesumoylationDEnzyme complexENUbiquitination(Protein-protein interaction)DDephosphorylationPhosphorylationProteins in a complex interactionReaction through unknown mechanisms/moleculesExtracellularAccession Number: NetPath 16ControlMTNucleusPalmitoylationGOEndoplasmic reticulumMitochondrionDProteolytic cleavageERInhibitionAcetylationCY -> PMDeubiquitinationPMNUDPlasma membraneActivationLigandAutophosphorylationCY -> NUDeacetylationPRKCIJAK1RASA1PRKD3STAT6ELK1PRKCZNFKB1JAK1INPP5DMAPK11Gene SymbolPIK3R1IRS1IL13RA1DOK2MAPK1STAMSTAT6STAT1PRKD3EP300PRKCDJAK2PTPN6PRKCIPIK3CATYK2MAPK14IL4RBADADRBK2IL4RSTAT5ABCL2L1LCKMAPK3CXCR4JAK2NCF1MAPK14FYNIL4PIK3CDCREBBPSTAT6RELAPIK3R2SHC1SOCS3HMGA1SPI1ETS1GRB2FESATF2IRS2STAT6HIST2H3CRPS6KB1PLCG1PTPN11PRKCZSOCS1SRCCBLIL4PTK2LOC532789SOS1JAK3PRKCDSOCS5NFKB1IL2RGAKT1STAT6


Description

No description

Comments

GenMAPP notes 
NetPath 16 - IL-4 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP395(r28126) with a 87% conversion rate.

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117539view11:15, 21 May 2021EweitzModified title
115963view08:31, 22 March 2021EgonwCopied the NetPath paper into the literature list
115953view07:18, 22 March 2021EgonwModified description
89831view12:07, 6 October 2016MkutmonOntology Term : 'Interleukin mediated signaling pathway' added !
89830view12:07, 6 October 2016MkutmonOntology Term : 'interleukin-4 signaling pathway' added !
89829view12:06, 6 October 2016MkutmonModified description
80839view15:28, 30 June 2015Mkutmonhomology conversion
63474view17:20, 10 May 2013MaintBotUpdated to 2013 gpml schema
40610view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
33847view00:34, 9 December 2009MaintBotAutomatic update of empty xrefs
32516view12:54, 17 August 2009MaintBotFixed text labels
31214view19:38, 13 August 2009MaintBotFixed text labels
30624view22:23, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADRBK2GeneProduct282136 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
ATF2GeneProduct509827 (Entrez Gene)
BADGeneProduct615013 (Entrez Gene)
BCL2L1GeneProduct282152 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CREBBPGeneProduct505453 (Entrez Gene)
CXCR4GeneProduct281736 (Entrez Gene)
DOK2GeneProduct514616 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
EP300GeneProduct
ETS1GeneProduct540313 (Entrez Gene)
FESGeneProduct507304 (Entrez Gene)
FYNGeneProduct527263 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
Gene SymbolGeneProduct
HIST2H3CGeneProduct
HMGA1GeneProduct618849 (Entrez Gene)
IL13RA1GeneProduct407110 (Entrez Gene)
IL2RGGeneProduct281862 (Entrez Gene)
IL4GeneProduct280824 (Entrez Gene)
IL4RGeneProduct404154 (Entrez Gene)
INPP5DGeneProduct507329 (Entrez Gene)
IRS1GeneProduct538598 (Entrez Gene)
IRS2GeneProduct
JAK1GeneProduct537201 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
JAK3GeneProduct
LCKGeneProduct508890 (Entrez Gene)
LOC532789GeneProduct532789 (Entrez Gene)
MAPK11GeneProduct618906 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
NCF1GeneProduct281345 (Entrez Gene)
NFKB1GeneProduct616115 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PLCG1GeneProduct281987 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCIGeneProduct528478 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PRKD3GeneProduct538447 (Entrez Gene)
PTK2GeneProduct506270 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
RASA1GeneProduct282032 (Entrez Gene)
RELAGeneProduct508233 (Entrez Gene)
RPS6KB1GeneProduct404181 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SOCS1GeneProduct518795 (Entrez Gene)
SOCS3GeneProduct282081 (Entrez Gene)
SOCS5GeneProduct514773 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SPI1GeneProduct507100 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
STAMGeneProduct512734 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT6GeneProduct353105 (Entrez Gene)
TYK2GeneProduct512484 (Entrez Gene)

Annotated Interactions

No annotated interactions
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