Complement and coagulation cascades (Canis familiaris)
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Antibody/antigen
complex
Cell lysis
Clot
Fibrinolytic system
Coagulation Cascade
Muscle contraction,
Chemotaxis,
Phagocyte recruitment
Inflammation, etc.
Extrinsic pathway
Degredation
Mediators
C4b/2a
C3
Convertase
Kinin kallikrein system
C3a
Vascular injury
Cell adhesion,
migration,
profileration, etc
Complement Cascade
Zymosan,
insulin, etc.
C3b/Bb
C3b/4b, C3b, C3d
Classical Pathway
C4a
Cell adhesion,
migration,
profileration, etc
membrane attack complex
Collagen,
basement membrane,
activated platelets, etc.
C5a
Lectin Pathway
Thrombin
fibrin degredation
products
Alternative Pathway
C3b
Cross-linked
fibrin polymer
Platelet, monocyte,
lymphocyte,
endothelial cells,
smooth muscle cells
activation, etc
C6
PLG
F8
KLKB1
CFH
PLAU
F10
Daf1
C3AR1
MASP2
FGB
109821
CFI
A2M
PLAUR
F2
SERPING1
CD59A
C5AR1
F2R
PLAT
TFPI
MASP1
ADN
PROS1
F13B
Bradykinin
F7
C8G
VWF
C3
C4
PROC
KNG1
F9
SERPINE1
CR1
SERPINA1
F3
C4BP
LOC480771
SERPIND1
BDKRB1
F5
Hc
MBL1
C1R
CRRY
SERPINF2
SERPINA5
C1S
C1QC
C1QA
C9
Daf2
CPB2
C1QB
C2
Fibrin monomer
THBD
CR2
SERPINC1
F12
H2-BF
C7
Description
No description
Comments
GenMAPP notes
http://www.genome.jp/dbget-bin/get
pathway?org name=mmu&mapno=04610
GenMAPP remarks
Adapted from KEGG (see notes)
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP558(r22582)
with a 67% conversion rate.
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
''''; https://www.genome.jp/dbget-bin/www_bget?pathway+map04610,
History
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Compare
Revision
Action
Time
User
Comment
122648
view
04:15, 26 April 2022
Khanspers
updating with latest converted content
122581
view
09:59, 18 April 2022
Eweitz
Modified title
89195
view
03:58, 23 August 2016
Ariutta
Ontology Term : 'hemostasis pathway' added !
89194
view
03:58, 23 August 2016
Ariutta
Ontology Term : 'complement system pathway' added !
89193
view
03:56, 23 August 2016
Ariutta
Ontology Term : 'coagulation cascade pathway' added !
71454
view
19:16, 17 October 2013
MaintBot
Automated update of data sources
68513
view
21:57, 5 July 2013
MaintBot
Updated to 2013 gpml schema
40665
view
21:49, 1 March 2011
MaintBot
Removed redundant pathway information and comments
38706
view
19:28, 23 September 2010
AlexanderPico
33957
view
18:23, 9 December 2009
MaintBot
Automatic update of empty xrefs
32259
view
12:59, 15 August 2009
MaintBot
Fixed text labels
31783
view
12:12, 14 August 2009
MaintBot
Fixed group labels
31286
view
20:04, 13 August 2009
MaintBot
Fixed text labels
30741
view
23:03, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
A2M
GeneProduct
477699 (Entrez Gene)
ADN
GeneProduct
BDKRB1
GeneProduct
490847 (Entrez Gene)
Bradykinin
Metabolite
C1QA
GeneProduct
478194 (Entrez Gene)
C1QB
GeneProduct
487381 (Entrez Gene)
C1QC
GeneProduct
487382 (Entrez Gene)
C1R
GeneProduct
477707 (Entrez Gene)
C1S
GeneProduct
486714 (Entrez Gene)
C2
GeneProduct
C3
GeneProduct
476728 (Entrez Gene)
C3AR1
GeneProduct
486704 (Entrez Gene)
C4
GeneProduct
C4BP
GeneProduct
C5AR1
GeneProduct
442974 (Entrez Gene)
C6
GeneProduct
479348 (Entrez Gene)
C7
GeneProduct
489221 (Entrez Gene)
MGI:88235 LL:109828
C8G
GeneProduct
480672 (Entrez Gene)
C9
GeneProduct
479354 (Entrez Gene)
CD59A
GeneProduct
CFH
GeneProduct
478952 (Entrez Gene)
CFI
GeneProduct
478515 (Entrez Gene)
CPB2
GeneProduct
608910 (Entrez Gene)
CR1
GeneProduct
609328 (Entrez Gene)
CR2
GeneProduct
490269 (Entrez Gene)
CRRY
GeneProduct
Daf1
GeneProduct
Daf2
GeneProduct
F10
GeneProduct
476993 (Entrez Gene)
F12
GeneProduct
489090 (Entrez Gene)
F13B
GeneProduct
490261 (Entrez Gene)
F2
GeneProduct
F2R
GeneProduct
488942 (Entrez Gene)
F3
GeneProduct
490153 (Entrez Gene)
F5
GeneProduct
F7
GeneProduct
607661 (Entrez Gene)
F8
GeneProduct
403875 (Entrez Gene)
F9
GeneProduct
404015 (Entrez Gene)
FGB
GeneProduct
475472 (Entrez Gene)
Fibrin monomer
Metabolite
H2-BF
GeneProduct
Hc
GeneProduct
KLKB1
GeneProduct
475624 (Entrez Gene)
KNG1
GeneProduct
478666 (Entrez Gene)
LOC480771
GeneProduct
480771 (Entrez Gene)
MASP1
GeneProduct
488121 (Entrez Gene)
MASP2
GeneProduct
MBL1
GeneProduct
PLAT
GeneProduct
482840 (Entrez Gene)
PLAU
GeneProduct
403426 (Entrez Gene)
PLAUR
GeneProduct
476446 (Entrez Gene)
PLG
GeneProduct
403602 (Entrez Gene)
PROC
GeneProduct
476104 (Entrez Gene)
PROS1
GeneProduct
478529 (Entrez Gene)
SERPINA1
GeneProduct
480422 (Entrez Gene)
SERPINA5
GeneProduct
480424 (Entrez Gene)
SERPINC1
GeneProduct
480066 (Entrez Gene)
SERPIND1
GeneProduct
SERPINE1
GeneProduct
403476 (Entrez Gene)
SERPINF2
GeneProduct
611266 (Entrez Gene)
SERPING1
GeneProduct
475966 (Entrez Gene)
TFPI
GeneProduct
403921 (Entrez Gene)
THBD
GeneProduct
474355 (Entrez Gene)
VWF
GeneProduct
399544 (Entrez Gene)
109821
GeneProduct
Annotated Interactions
No annotated interactions
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Discussion
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No annotated interactions