Eukaryotic transcription initiation (Canis familiaris)

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1, 2TFIIB(small stable RNAs)5Gene Regulatory Proteins5(mRNA, snRNPs)3RNA pol II335RNA polymerase III53TFIIERNA polymerase IIdsDNATATAPrimary RNA transcript5TFIIATFIIF3TFIIE55(recognize surface DNA geometry)TFIIF5(large ribosomal RNAs)TATA33Steps 1) TBP binds TATA box5TFIIBTATATFIIFTFIIDSteps 4) Transcription elongation by NTPsTFIID3TFIIHSteps 2) Association of TIFs and RNA polymeraseSteps 5) RNA elongation with CDT phosphorylation3TFIIHTFIIARNA polymerase ITATA Box bindingproteinSteps 3) DNA melting by association with TFIIH5cell growthTranscription Initiation Factors (TIFs)POLR2IPOLR3KPOLR2FTAF7GTF2E2ERCC2POLR1BPOLR2ECDK7TAF12POLR2GPOLR2HPOLR2CPOLR1DRHOXF2POLR2AMNAT1GTF2BPOLR3HPOLR3DPOLR2JTBPGTF2H4TAF9GTF2H2GTF2H1POLR3EILKGTF2H3GTF2F2POLR2KERCC3TAF13CCNHPOLR2BPOLR1AGTF2E1TAF6POLR3BGTF2A2TAF5


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP405(r29565) with a 85% conversion rate.

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Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117449view10:52, 21 May 2021EweitzModified title
68516view21:59, 5 July 2013MaintBotUpdated to 2013 gpml schema
67209view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
48167view20:27, 9 May 2012MaintBotUpdating from human to fix xrefs
40669view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
35524view13:55, 12 February 2010Thomasadded literature
35513view13:49, 12 February 2010ThomasModified description
35511view13:48, 12 February 2010ThomasModified description
32265view13:02, 15 August 2009MaintBotFixed text labels
31792view12:15, 14 August 2009MaintBotFixed group labels
31293view20:08, 13 August 2009MaintBotFixed text labels
30751view23:07, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCNHGeneProduct479156 (Entrez Gene)
CDK7GeneProduct608441 (Entrez Gene)
ERCC2GeneProduct493995 (Entrez Gene)
ERCC3GeneProduct476105 (Entrez Gene)
GTF2A2GeneProduct478327 (Entrez Gene)
GTF2BGeneProduct479960 (Entrez Gene)
GTF2E1GeneProduct488002 (Entrez Gene)
GTF2E2GeneProduct475597 (Entrez Gene)
GTF2F2GeneProduct609164 (Entrez Gene)
GTF2H1GeneProduct476881 (Entrez Gene)
GTF2H2GeneProduct478089 (Entrez Gene)
GTF2H3GeneProduct477446 (Entrez Gene)
GTF2H4GeneProduct606988 (Entrez Gene)
ILKGeneProduct476836 (Entrez Gene)
MNAT1GeneProduct480346 (Entrez Gene)
POLR1AGeneProduct475766 (Entrez Gene)
POLR1BGeneProduct
POLR1DGeneProduct
POLR2AGeneProduct479483 (Entrez Gene)
POLR2BGeneProduct475152 (Entrez Gene)
POLR2CGeneProduct478109 (Entrez Gene)
POLR2EGeneProduct611859 (Entrez Gene)
POLR2FGeneProduct474512 (Entrez Gene)
POLR2GGeneProduct476052 (Entrez Gene)
POLR2HGeneProduct478656 (Entrez Gene)
POLR2IGeneProduct476476 (Entrez Gene)
POLR2JGeneProduct
POLR2KGeneProduct
POLR3BGeneProduct474531 (Entrez Gene)
POLR3DGeneProduct609056 (Entrez Gene)
POLR3EGeneProduct608689 (Entrez Gene)
POLR3HGeneProduct607850 (Entrez Gene)
POLR3KGeneProduct611625 (Entrez Gene)
RHOXF2GeneProduct611154 (Entrez Gene)
TAF12GeneProduct
TAF13GeneProduct476973 (Entrez Gene)
TAF5GeneProduct
TAF6GeneProduct489846 (Entrez Gene)
TAF7GeneProduct487180 (Entrez Gene)
TAF9GeneProduct480815 (Entrez Gene)
TBPGeneProduct611193 (Entrez Gene)

Annotated Interactions

No annotated interactions
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