Estrogen metabolism (Canis familiaris)

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2, 5, 847662671777616473466777671476777676166DNA adductsDNA adductsDNA adductsDNA adductsST1A1_CANFACYP3A4UGT1A8UGT1A1NP_001004074.1NQO1CYP3A42-HydroxyestroneUGT1A8STSUGT1A8UGT1A816a-HydroxyestroneCP1A2_CANFACP1A2_CANFAEstradiol-17-glucuronideCP1A1_CANFAEstradiol-3,4-semiquinone4-hydroxyestrone-3-glucuronideUGT1A1Q2VB21_CANFA4-hydroxy-estradiol-4-glucuronide2-Methoxyestradiol-3-glucuronideST1A1_CANFANP_001004074.1UGT1A8UGT1A12-Hydroxyestradiol2-hydroxy-estradiol-sulfateQ32KI1_CANFAEstradiolCYP1B1SuperoxideUGT1A8OxygenQ32KI2_CANFAOxygenUGT2B7EstroneOxygenEstradiol-2,3-quinoneNP_001004074.12-Hydroxyestrone-3-glucuronideUGT1A8UGT1A1UGT1A9UGT1A82-hydroxyestradiol-3-glucuronide2-hydroxy-estradiol-2-glucuronideUGT2B7UGT2B7OxygenSuperoxideSULT1E1UGT1A94-hydroxy-estradiol-sulfateGSTM1NP_001004074.1UGT1A8Estrone-17-glucuronideEstradiol sulfateEstrone-3-glucuronideST1A1_CANFA2-Methoxyestrone 3-glucuronide4-Methoxyestradiol-3-glucuronideNQO1UGT2B7Estradiol-3,4-quinone4-hydroxyestroneSuperoxideEstrone-3,4-quinone2-MethoxyestroneEstrone-2,3-semiquinoneEstrone sulfateEstrone-3,4-semiquinoneEstradiol-2,3-semiquinone4-MethoxyestradiolEstrone-2,3-quinone4-hydroxyestradiolUGT1A8CP1A1_CANFAUGT1A34-Methoxyestrone-3-glucuronide4-MethoxyestroneSuperoxide4-Hydroxyestradiol-3-glucuronideEstradiol-3-glucuronide2-MethoxyestradiolUGT1A1UGT1A1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP697(r30275) with a 60% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL; ''Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.''; Breast Cancer Res, 2005 PubMed Europe PMC Scholia
  2. Lakhani NJ, Sarkar MA, Venitz J, Figg WD; ''2-Methoxyestradiol, a promising anticancer agent.''; Pharmacotherapy, 2003 PubMed Europe PMC Scholia
  3. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG; ''Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC Scholia
  4. Guillemette C, Belanger A, Lepine J; ''Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.''; Breast Cancer Res, 2004 PubMed Europe PMC Scholia
  5. Raftogianis R, Creveling C, Weinshilboum R, Weisz J; ''Estrogen metabolism by conjugation.''; J Natl Cancer Inst Monogr, 2000 PubMed Europe PMC Scholia
  6. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM; ''Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.''; Mol Endocrinol, 2003 PubMed Europe PMC Scholia
  7. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL; ''Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.''; Carcinogenesis, 2003 PubMed Europe PMC Scholia
  8. Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL; ''Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.''; Chem Biol Interact, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106057view11:57, 16 August 2019MaintBotHMDB identifier normalization
88023view13:32, 25 July 2016SusanOntology Term : 'steroid metabolic pathway' added !
74174view15:37, 2 April 2014EgonwUpdated the PubChem-compound data source.
72041view13:56, 24 October 2013SusanConnected lines
68556view22:41, 5 July 2013MaintBotUpdated to 2013 gpml schema
58847view23:34, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40712view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
33991view18:35, 9 December 2009MaintBotAutomatic update of empty xrefs
31782view12:11, 14 August 2009MaintBotFixed group labels
30738view23:02, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
16a-HydroxyestroneMetaboliteHMDB00335 (HMDB)
2-HydroxyestradiolMetaboliteHMDB00338 (HMDB)
2-Hydroxyestrone-3-glucuronideMetabolite
2-HydroxyestroneMetaboliteHMDB00343 (HMDB)
2-Methoxyestradiol-3-glucuronideMetabolite
2-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
2-Methoxyestrone 3-glucuronideMetaboliteHMDB04482 (HMDB)
2-MethoxyestroneMetaboliteHMDB00010 (HMDB)
2-hydroxy-estradiol-2-glucuronideMetabolite
2-hydroxy-estradiol-sulfateMetabolite
2-hydroxyestradiol-3-glucuronideMetabolite
4-Hydroxyestradiol-3-glucuronideMetabolite
4-Methoxyestradiol-3-glucuronideMetabolite
4-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
4-MethoxyestroneMetabolite
4-Methoxyestrone-3-glucuronideMetabolite
4-hydroxy-estradiol-4-glucuronideMetabolite
4-hydroxy-estradiol-sulfateMetabolite
4-hydroxyestradiolMetabolite
4-hydroxyestroneMetabolite
4-hydroxyestrone-3-glucuronideMetabolite
CP1A1_CANFAGeneProductENSCAFG00000017937 (Ensembl Dog)
CP1A2_CANFAGeneProductENSCAFG00000017941 (Ensembl Dog)
CYP1B1GeneProductENSCAFG00000006164 (Ensembl Dog)
CYP3A4GeneProduct
EstradiolMetabolite
Estradiol sulfateMetabolite
Estradiol-17-glucuronideMetabolite
Estradiol-2,3-quinoneMetabolite
Estradiol-2,3-semiquinoneMetabolite
Estradiol-3,4-quinoneMetabolite
Estradiol-3,4-semiquinoneMetabolite
Estradiol-3-glucuronideMetaboliteHMDB06224 (HMDB)
Estrone sulfateMetaboliteHMDB01425 (HMDB)
Estrone-17-glucuronideMetaboliteHMDB04483 (HMDB)
Estrone-2,3-quinoneMetabolite148381 (PubChem)
Estrone-2,3-semiquinoneMetabolite
Estrone-3,4-quinoneMetabolite114862 (PubChem)
Estrone-3,4-semiquinoneMetabolite
Estrone-3-glucuronideMetaboliteHMDB04483 (HMDB)
EstroneMetaboliteHMDB00145 (HMDB)
GSTM1GeneProduct
NP_001004074.1GeneProductENSCAFG00000014253 (Ensembl Dog)
NQO1GeneProduct610935 (Entrez Gene)
OxygenMetaboliteHMDB01377 (HMDB)
Q2VB21_CANFAGeneProductENSCAFG00000002230 (Ensembl Dog)
Q32KI1_CANFAGeneProductENSCAFG00000025078 (Ensembl Dog)
Q32KI2_CANFAGeneProductENSCAFG00000011139 (Ensembl Dog)
ST1A1_CANFAGeneProductENSCAFG00000017122 (Ensembl Dog)
STSGeneProduct491727 (Entrez Gene)
SULT1E1GeneProductENSCAFG00000002878 (Ensembl Dog)
SuperoxideMetaboliteHMDB02168 (HMDB)
UGT1A1GeneProduct
UGT1A3GeneProduct
UGT1A8GeneProductENSCAFG00000015350 (Ensembl Dog)
UGT1A9GeneProduct
UGT2B7GeneProduct

Annotated Interactions

No annotated interactions
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