TNF-alpha NF-kB signaling pathway (Canis familiaris)

From WikiPathways

Revision as of 21:53, 1 March 2011 by MaintBot (Talk | contribs)
Jump to: navigation, search
Endoplasmic reticulumGolgi apparatusReaction through unknown mechanisms/moleculesGOControlGlycosylationPalmitoylationUbiquitinationEnzyme complexDeubiquitinationERCY ->NUSumoylationCY ->NUMolecular associationAutophosphorylationActivationNucleusProteins in a complex interactionPhosphorylationMolecule in the pathwayDeacetylationCY ->NUCytoplasmCY ->NUExtracellular(Protein-protein interaction)MethylationInhibitionCY ->NUTranslocationCYDemethylationPMAcetylationENMTLigandDesumoylationNUEndosomeDReceptorMitochondrionProteolytic cleavageAccession Number: NetPath 9; cellmap:9Plasma membraneRecruitmentDephosphorylationECGLG1RELAMAP3K3MAP3K2CASP2TNFAIP3MAP3K7IP1NFKB1TNFRSF1BPOLR1EAKAP8PMLCD3EAPMAP3K7IP2AZI2ZFAND5NKIRAS1TRAF2MAP3K1BIRC2RELBNFKBIANALP4GeneCDC37RASAL2RPL6NFKB1MARK2HIST3H3SMARCA4CUL1HSPB1BIRC2POLR2HMAP3K7IP3RELAPSMD13RPL4TRAF4CFLARUBCH5CPOLR1BTNFYWHAHMCM5COPS3SKP1NFKBIAPSMC1COMMD1GeneCDC34TIFATNFRSF1ALOC475035POLR1APOLR1CRELBPTPN11TNIP2PDCD2PSMD3TRAF2KPNA2MCM7MCCPSMC3TBK1CHUKPEBP1RPS6KB1EIF4A3PPP2CARELATNFRSF11ACAPN3CASP10TNFTNFWDR68Gene SymbolCAV1RIPK2CHUKPSMB5AKT1NFKBIECASP3TRAF5TANKSMARCC2PEG3IKBKGAKT2GAB1PSMD1RELTRAF6GeneTRADDYWHAESMARCB1KTN1NFKBIAMAP3K3YWHABGNB2L1PFDN2RIPK1CRADDTRAF2CSNK2A1FAF1FBLIKBKGCASP8KPNA6PSMC2DDX3XTRAIPSTAT1TNFKPNA3CSNK2BSRCHSP90AB1RNF216BIRC3RELDAPRPS6KA5YWHAZNKIRAS2TRADDLOC487309PSMD6MAP2K5RELAUSP11LOC486122TNFBIRC3KCNQ1PIAS3GSK3BFKBP5TBK1LOC480907MTIF2BCL3PRKCZBCL7AYWHAGSMARCC1TXLNASUMO1CASP8AP2NFKBIZMAP3K14CSNK2A2NR2C2NSMAFUBE2IFANCD2UNC5CLPRKACATRAF1RPL8FLNAIKBKETNFRSF8UBE2D2RNF25TRPC4APRPS13RIPK3CREBBPPSMD12GTF2INFKB1PSMD7BTRCRIPK1IKBKAPLOC612286NFKBIBPTK2YWHAQBAG4MAP3K8GeneDPF2TNFUSP2TRAF3FADDPOLR1DALPLTRAF4TNFRSF1APOLR2LPAPOLACYLDLRPPRCTNFRSF1BTRAF1TNFRSF1BRPL30ACTL6AIQGAP2FBXW11IKBKBNR2C2NFKB2RPS11SMARCE1PKN1TNFRSF1ALOC480438TNIP1G3BP2CASP7


Description

No description

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 87% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
118009view11:31, 23 May 2021EweitzModified title
108149view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87779view11:09, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87778view11:08, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68568view22:53, 5 July 2013MaintBotUpdated to 2013 gpml schema
40726view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
34005view18:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32256view12:58, 15 August 2009MaintBotFixed text labels
31777view12:10, 14 August 2009MaintBotFixed group labels
31281view20:02, 13 August 2009MaintBotFixed text labels
30732view23:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTL6AGeneProduct478637 (Entrez Gene)
AKAP8GeneProduct474362 (Entrez Gene)
AKT1GeneProduct490878 (Entrez Gene)
AKT2GeneProduct449021 (Entrez Gene)
ALPLGeneProduct403548 (Entrez Gene)
AZI2GeneProduct485632 (Entrez Gene)
BAG4GeneProduct607954 (Entrez Gene)
BCL3GeneProduct612349 (Entrez Gene)
BCL7AGeneProduct486256 (Entrez Gene)
BIRC2GeneProduct479464 (Entrez Gene)
BIRC3GeneProduct489433 (Entrez Gene)
BTRCGeneProduct486851 (Entrez Gene)
CAPN3GeneProduct487518 (Entrez Gene)
CASP10GeneProduct488472 (Entrez Gene)
CASP2GeneProduct482737 (Entrez Gene)
CASP3GeneProduct403567 (Entrez Gene)
CASP7GeneProduct486896 (Entrez Gene)
CASP8GeneProduct488473 (Entrez Gene)
CASP8AP2GeneProduct481921 (Entrez Gene)
CAV1GeneProduct403980 (Entrez Gene)
CD3EAPGeneProduct612284 (Entrez Gene)
CDC34GeneProduct476759 (Entrez Gene)
CDC37GeneProduct484955 (Entrez Gene)
CFLARGeneProduct488471 (Entrez Gene)
CHUKGeneProduct477796 (Entrez Gene)
COMMD1GeneProduct403590 (Entrez Gene)
COPS3GeneProduct479528 (Entrez Gene)
CRADDGeneProduct482604 (Entrez Gene)
CREBBPGeneProduct479866 (Entrez Gene)
CSNK2A1GeneProduct477185 (Entrez Gene)
CSNK2A2GeneProduct478108 (Entrez Gene)
CSNK2BGeneProduct474844 (Entrez Gene)
CUL1GeneProduct475512 (Entrez Gene)
CYLDGeneProduct611649 (Entrez Gene)
DAPGeneProduct607300 (Entrez Gene)
DDX3XGeneProduct480886 (Entrez Gene)
DPF2GeneProduct483743 (Entrez Gene)
EIF4A3GeneProduct475922 (Entrez Gene)
FADDGeneProduct
FAF1GeneProduct608231 (Entrez Gene)
FANCD2GeneProduct484659 (Entrez Gene)
FBLGeneProduct476460 (Entrez Gene)
FBXW11GeneProduct479291 (Entrez Gene)
FKBP5GeneProduct481759 (Entrez Gene)
FLNAGeneProduct481084 (Entrez Gene)
G3BP2GeneProduct478429 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
GLG1GeneProduct479654 (Entrez Gene)
GNB2L1GeneProduct480818 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
GTF2IGeneProduct479714 (Entrez Gene)
GeneGeneProduct
Gene SymbolGeneProduct
HIST3H3GeneProduct
HSP90AB1GeneProduct
HSPB1GeneProduct403979 (Entrez Gene)
IKBKAPGeneProduct612455 (Entrez Gene)
IKBKBGeneProduct482839 (Entrez Gene)
IKBKEGeneProduct478950 (Entrez Gene)
IKBKGGeneProduct
IQGAP2GeneProduct479177 (Entrez Gene)
KCNQ1GeneProduct483669 (Entrez Gene)
KPNA2GeneProduct
KPNA3GeneProduct476909 (Entrez Gene)
KPNA6GeneProduct487314 (Entrez Gene)
KTN1GeneProduct480332 (Entrez Gene)
LOC475035GeneProduct475035 (Entrez Gene)
LOC480438GeneProduct480438 (Entrez Gene)
LOC480907GeneProduct480907 (Entrez Gene)
LOC486122GeneProduct486122 (Entrez Gene)
LOC487309GeneProduct487309 (Entrez Gene)
LOC612286GeneProduct612286 (Entrez Gene)
LRPPRCGeneProduct474572 (Entrez Gene)
MAP2K5GeneProduct
MAP3K14GeneProduct490926 (Entrez Gene)
MAP3K1GeneProduct478061 (Entrez Gene)
MAP3K2GeneProduct612902 (Entrez Gene)
MAP3K3GeneProduct480481 (Entrez Gene)
MAP3K7IP1GeneProduct481245 (Entrez Gene)
MAP3K7IP2GeneProduct484028 (Entrez Gene)
MAP3K7IP3GeneProduct491807 (Entrez Gene)
MAP3K8GeneProduct487085 (Entrez Gene)
MARK2GeneProduct483769 (Entrez Gene)
MCCGeneProduct611208 (Entrez Gene)
MCM5GeneProduct610519 (Entrez Gene)
MCM7GeneProduct479737 (Entrez Gene)
MTIF2GeneProduct474600 (Entrez Gene)
NALP4GeneProduct
NFKB1GeneProduct442859 (Entrez Gene)
NFKB2GeneProduct486858 (Entrez Gene)
NFKBIAGeneProduct480291 (Entrez Gene)
NFKBIBGeneProduct484519 (Entrez Gene)
NFKBIEGeneProduct609647 (Entrez Gene)
NFKBIZGeneProduct478549 (Entrez Gene)
NKIRAS1GeneProduct477047 (Entrez Gene)
NKIRAS2GeneProduct480518 (Entrez Gene)
NR2C2GeneProduct484641 (Entrez Gene)
NSMAFGeneProduct477892 (Entrez Gene)
PAPOLAGeneProduct480430 (Entrez Gene)
PDCD2GeneProduct475041 (Entrez Gene)
PEBP1GeneProduct477501 (Entrez Gene)
PEG3GeneProduct476371 (Entrez Gene)
PFDN2GeneProduct488648 (Entrez Gene)
PIAS3GeneProduct483160 (Entrez Gene)
PKN1GeneProduct484903 (Entrez Gene)
PMLGeneProduct
POLR1AGeneProduct475766 (Entrez Gene)
POLR1BGeneProduct
POLR1CGeneProduct474912 (Entrez Gene)
POLR1DGeneProduct
POLR1EGeneProduct474767 (Entrez Gene)
POLR2HGeneProduct478656 (Entrez Gene)
POLR2LGeneProduct
PPP2CAGeneProduct403608 (Entrez Gene)
PRKACAGeneProduct403556 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PSMB5GeneProduct480246 (Entrez Gene)
PSMC1GeneProduct478703 (Entrez Gene)
PSMC2GeneProduct475896 (Entrez Gene)
PSMC3GeneProduct475980 (Entrez Gene)
PSMD1GeneProduct
PSMD12GeneProduct480465 (Entrez Gene)
PSMD13GeneProduct475934 (Entrez Gene)
PSMD3GeneProduct491018 (Entrez Gene)
PSMD6GeneProduct484700 (Entrez Gene)
PSMD7GeneProduct479671 (Entrez Gene)
PTK2GeneProduct475108 (Entrez Gene)
PTPN11GeneProduct477488 (Entrez Gene)
RASAL2GeneProduct480056 (Entrez Gene)
RELGeneProduct474606 (Entrez Gene)
RELAGeneProduct483729 (Entrez Gene)
RELBGeneProduct484454 (Entrez Gene)
RIPK1GeneProduct488195 (Entrez Gene)
RIPK2GeneProduct477936 (Entrez Gene)
RIPK3GeneProduct608486 (Entrez Gene)
RNF216GeneProduct479760 (Entrez Gene)
RNF25GeneProduct478912 (Entrez Gene)
RPL30GeneProduct480751 (Entrez Gene)
RPL4GeneProduct
RPL6GeneProduct612604 (Entrez Gene)
RPL8GeneProduct475130 (Entrez Gene)
RPS11GeneProduct403684 (Entrez Gene)
RPS13GeneProduct610820 (Entrez Gene)
RPS6KA5GeneProduct490831 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
SKP1GeneProduct474682 (Entrez Gene)
SMARCA4GeneProduct476710 (Entrez Gene)
SMARCB1GeneProduct486407 (Entrez Gene)
SMARCC1GeneProduct476640 (Entrez Gene)
SMARCC2GeneProduct481107 (Entrez Gene)
SMARCE1GeneProduct608250 (Entrez Gene)
SRCGeneProduct485864 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
SUMO1GeneProduct478874 (Entrez Gene)
TANKGeneProduct608092 (Entrez Gene)
TBK1GeneProduct481145 (Entrez Gene)
TIFAGeneProduct487905 (Entrez Gene)
TNFGeneProduct403922 (Entrez Gene)
TNFAIP3GeneProduct484006 (Entrez Gene)
TNFRSF11AGeneProduct483957 (Entrez Gene)
TNFRSF1AGeneProduct403634 (Entrez Gene)
TNFRSF1BGeneProduct487437 (Entrez Gene)
TNFRSF8GeneProduct487438 (Entrez Gene)
TNIP1GeneProduct489178 (Entrez Gene)
TNIP2GeneProduct488798 (Entrez Gene)
TRADDGeneProduct611262 (Entrez Gene)
TRAF1GeneProduct612709 (Entrez Gene)
TRAF2GeneProduct480673 (Entrez Gene)
TRAF3GeneProduct490867 (Entrez Gene)
TRAF4GeneProduct
TRAF5GeneProduct480019 (Entrez Gene)
TRAF6GeneProduct
TRAIPGeneProduct608724 (Entrez Gene)
TRPC4APGeneProduct477207 (Entrez Gene)
TXLNAGeneProduct487313 (Entrez Gene)
UBCH5CGeneProduct
UBE2D2GeneProduct612742 (Entrez Gene)
UBE2IGeneProduct491332 (Entrez Gene)
UNC5CLGeneProduct481786 (Entrez Gene)
USP11GeneProduct404014 (Entrez Gene)
USP2GeneProduct608188 (Entrez Gene)
WDR68GeneProduct612958 (Entrez Gene)
YWHABGeneProduct477237 (Entrez Gene)
YWHAEGeneProduct480645 (Entrez Gene)
YWHAGGeneProduct489818 (Entrez Gene)
YWHAHGeneProduct
YWHAQGeneProduct607060 (Entrez Gene)
YWHAZGeneProduct475864 (Entrez Gene)
ZFAND5GeneProduct476324 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools