G1 to S cell cycle control (Canis familiaris)

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pE2fG1/S transition CyclinDependent Kinasesdp1DNA replicationTTTCC/GCGCinactiveCyclin EspCyclin DspRbpG2 Phase-M phaseG1/S Cell CycleG1 PhaseuepG1/S transition Phasephosphorylation of proteinsinvolved in G1/S transitionbCheckpointuCell cycle DNA replication genesecakborigin recognition complexDegradationpDNA polymerasesuG1 CyclinDependant CyclasesE2fCDKN1BCDKN2ACdkE2F1CDK6MYT1CCNA1E2F4RPA2ORC3LTFDP1ORC5LCCND3RPA1RBL1CCNG2MCM6E2F3CDKORC4LCREB3L3CCND1CCNE1MYCTFDP1CDKCCNB1CCNHCDC25ACdkCDKN2CCDKN2DCyclinDRPA3CCND2ORC6LMCM4CREB3L1POLECDK4E2F2CDKN1CCCNE2WEE1PCNATP53CDK2E2F5MCM5CDK7POLA2MDM2CDKN1ACyclinDRB1CDK4GADD45ACREB3L4MCM7POLE2CDKN2BCCNE1CDC45LRB1PRIM2CCNE1PRIM1ATF6BCREB3ORC1LE2fCDK6E2F6MCM2RHOXF2CREB1RB1MCM3TP53ORC2LRHOXF2TFDP2CDK7ATMMNAT1


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP45(r20771) with a 82% conversion rate.

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Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95748view13:54, 19 January 2018MkutmonHomology conversion update
68574view23:00, 5 July 2013MaintBotUpdated to 2013 gpml schema
67266view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
48155view18:50, 9 May 2012MaintBotUpdating from human to fix xrefs
40732view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35826view22:00, 17 February 2010KhanspersModified description
34010view18:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32271view13:05, 15 August 2009MaintBotFixed text labels
31805view12:19, 14 August 2009MaintBotFixed group labels
31299view20:10, 13 August 2009MaintBotFixed text labels
30764view23:13, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF6BGeneProduct474855 (Entrez Gene)
ATMGeneProduct479450 (Entrez Gene)
CCNA1GeneProduct477302 (Entrez Gene)
CCNB1GeneProduct
CCND1GeneProduct449028 (Entrez Gene)
CCND2GeneProduct611782 (Entrez Gene)
CCND3GeneProduct608847 (Entrez Gene)
CCNE1GeneProduct484610 (Entrez Gene)
CCNE2GeneProduct487057 (Entrez Gene)
CCNG2GeneProduct478442 (Entrez Gene)
CCNHGeneProduct479156 (Entrez Gene)
CDC25AGeneProduct484780 (Entrez Gene)
CDC45LGeneProduct486421 (Entrez Gene)
CDKGeneProduct
CDK2GeneProduct606931 (Entrez Gene)
CDK4GeneProduct481131 (Entrez Gene)
CDK6GeneProduct609920 (Entrez Gene)
CDK7GeneProduct608441 (Entrez Gene)
CDKN1AGeneProduct474890 (Entrez Gene)
CDKN1BGeneProduct403429 (Entrez Gene)
CDKN1CGeneProduct
CDKN2AGeneProduct100271861 (Entrez Gene)
CDKN2BGeneProduct481563 (Entrez Gene)
CDKN2CGeneProduct475359 (Entrez Gene)
CDKN2DGeneProduct611216 (Entrez Gene)
CREB1GeneProduct607922 (Entrez Gene)
CREB3GeneProduct611934 (Entrez Gene)
CREB3L1GeneProduct483636 (Entrez Gene)
CREB3L3GeneProduct485046 (Entrez Gene)
CREB3L4GeneProduct612303 (Entrez Gene)
CdkGeneProduct
CyclinDGeneProduct
E2F1GeneProduct485839 (Entrez Gene)
E2F2GeneProduct
E2F3GeneProduct488239 (Entrez Gene)
E2F4GeneProduct611243 (Entrez Gene)
E2F5GeneProduct611103 (Entrez Gene)
E2F6GeneProduct609996 (Entrez Gene)
E2fGeneProduct
GADD45AGeneProduct
MCM2GeneProduct484622 (Entrez Gene)
MCM3GeneProduct481839 (Entrez Gene)
MCM4GeneProduct477871 (Entrez Gene)
MCM5GeneProduct610519 (Entrez Gene)
MCM6GeneProduct476131 (Entrez Gene)
MCM7GeneProduct479737 (Entrez Gene)
MDM2GeneProduct403693 (Entrez Gene)
MNAT1GeneProduct480346 (Entrez Gene)
MYCGeneProduct403924 (Entrez Gene)
MYT1GeneProduct485987 (Entrez Gene)
ORC1LGeneProduct475351 (Entrez Gene)
ORC2LGeneProduct478868 (Entrez Gene)
ORC3LGeneProduct474991 (Entrez Gene)
ORC4LGeneProduct476141 (Entrez Gene)
ORC5LGeneProduct609937 (Entrez Gene)
ORC6LGeneProduct482492 (Entrez Gene)
PCNAGeneProduct477166 (Entrez Gene)
POLA2GeneProduct476025 (Entrez Gene)
POLE2GeneProduct608973 (Entrez Gene)
POLEGeneProduct486223 (Entrez Gene)
PRIM1GeneProduct607309 (Entrez Gene)
PRIM2GeneProduct474950 (Entrez Gene)
RB1GeneProduct476915 (Entrez Gene)
RBL1GeneProduct477221 (Entrez Gene)
RHOXF2GeneProduct611154 (Entrez Gene)
RPA1GeneProduct491196 (Entrez Gene)
RPA2GeneProduct487339 (Entrez Gene)
RPA3GeneProduct481449 (Entrez Gene)
TFDP1GeneProduct607720 (Entrez Gene)
TFDP2GeneProduct477099 (Entrez Gene)
TP53GeneProduct403869 (Entrez Gene)
WEE1GeneProduct476847 (Entrez Gene)

Annotated Interactions

No annotated interactions
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