Transcriptional activation by nfe2l2 in response to phytochemicals (Danio rerio)
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1
S-P
Phase II enzymes
Nucleus
T-P
T-P
CCAAT/XRE
S-P
ARE
hmox1
Caffeic acid phenethyl ester
keap1b
zgc:172209
nfe2l2
nfe2l2
cebpb
MAF
LOC100149498
nqo1
6-HITC
Sulforaphane
cebpb
LOC562176
nfe2l2
zgc:63976
LOC561737
Curcumin
gclc
keap1b
gclm
GSTA2
Description
Based on
Surh, 2003, figure 4
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP3(r29720)
with a 88% conversion rate.
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Ontology Terms
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Bibliography
Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
116897
view
11:27, 15 May 2021
Eweitz
Modified title
106069
view
11:58, 16 August 2019
MaintBot
HMDB identifier normalization
88687
view
15:49, 12 August 2016
Jmelius
Ontology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
88686
view
15:49, 12 August 2016
Jmelius
Ontology Term : 'oxidative stress response pathway' added !
71507
view
19:21, 17 October 2013
MaintBot
Automated update of data sources
68628
view
04:40, 6 July 2013
MaintBot
Updated to 2013 gpml schema
46422
view
20:47, 27 January 2012
MaintBot
Automatic update of PubChem xrefs
40793
view
22:16, 1 March 2011
MaintBot
Removed redundant pathway information and comments
34183
view
21:22, 9 December 2009
MaintBot
Automatic update of empty xrefs
31921
view
12:53, 14 August 2009
MaintBot
Fixed group labels
31042
view
01:19, 30 July 2009
MaintBot
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
6-HITC
Metabolite
Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
Caffeic acid phenethyl ester
Metabolite
Curcumin
Metabolite
HMDB02269 (HMDB)
GSTA2
GeneProduct
LOC100149498
GeneProduct
100149498 (Entrez Gene)
LOC561737
GeneProduct
561737 (Entrez Gene)
LOC562176
GeneProduct
562176 (Entrez Gene)
MAF
GeneProduct
114467 (Entrez Gene)
Sulforaphane
Metabolite
5350 (PubChem)
cebpb
GeneProduct
140814 (Entrez Gene)
gclc
GeneProduct
326857 (Entrez Gene)
gclm
GeneProduct
333974 (Entrez Gene)
hmox1
GeneProduct
791518 (Entrez Gene)
keap1b
GeneProduct
100003679 (Entrez Gene)
nfe2l2
GeneProduct
360149 (Entrez Gene)
nqo1
GeneProduct
322506 (Entrez Gene)
zgc:172209
GeneProduct
562720 (Entrez Gene)
zgc:63976
GeneProduct
406647 (Entrez Gene)
Annotated Interactions
No annotated interactions
Views
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Discussion
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