Oxidative stress response (Danio rerio)
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TF activation
Immediate-early
gene induction
Stress-regulated MAP kinase
Induction of
antioxidant genes
Inhibition of oxidases
Repression of ROS-
producing systems
Activation
TF inhibition
Reactive Oxygen Species
Adaptive response
Repression
UGT1A6
sod2
MGST1
JUNB
cyba
sod1
mapk10
NFKB1
LOC791504
sp1
fos
cat
mapk14a
MAOA
GPX3
zgc:110010
xdh
TXNRD2
si:dkey-117m1.6
nqo1
hmox1
gclc
MT1X
GPX1
cyp1a
GSTT2
LOC555669
Nrf2
TXNRD1
Description
No description
Comments
GenMAPP notes
Adapted from Biochem J 1999 Sep 15;342 Pt 3:481-96 Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999 Sep 15;342 Pt 3:481-96
GenMAPP remarks
Adapted from rat by GenMAPP.org
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP408(r21540)
with a 58% conversion rate.
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Bibliography
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History
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Compare
Revision
Action
Time
User
Comment
116901
view
11:31, 15 May 2021
Eweitz
Modified title
91955
view
13:58, 6 April 2017
LWackers
Updated annotations. Split GSTT2 into its zebrafish orthologues.
88284
view
14:42, 1 August 2016
Fehrhart
Ontology Term : 'oxidative stress response pathway' added !
71514
view
19:22, 17 October 2013
MaintBot
Automated update of data sources
68644
view
04:58, 6 July 2013
MaintBot
Updated to 2013 gpml schema
40812
view
22:17, 1 March 2011
MaintBot
Removed redundant pathway information and comments
34200
view
21:28, 9 December 2009
MaintBot
Automatic update of empty xrefs
32338
view
13:32, 15 August 2009
MaintBot
Fixed text labels
31951
view
13:01, 14 August 2009
MaintBot
Fixed group labels
31382
view
20:41, 13 August 2009
MaintBot
Fixed text labels
31084
view
01:34, 30 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
GPX1
GeneProduct
GPX3
GeneProduct
798788 (Entrez Gene)
GSTT2
GeneProduct
JUNB
GeneProduct
407086 (Entrez Gene)
LOC555669
GeneProduct
555669 (Entrez Gene)
LOC791504
GeneProduct
791504 (Entrez Gene)
MAOA
GeneProduct
MGST1
GeneProduct
449784 (Entrez Gene)
MT1X
GeneProduct
NFKB1
GeneProduct
565756 (Entrez Gene)
Nrf2
GeneProduct
TXNRD1
GeneProduct
352924 (Entrez Gene)
TXNRD2
GeneProduct
UGT1A6
GeneProduct
cat
GeneProduct
30068 (Entrez Gene)
cyba
GeneProduct
393551 (Entrez Gene)
Probe set ID: u18729
cyp1a
GeneProduct
140634 (Entrez Gene)
fos
GeneProduct
394198 (Entrez Gene)
gclc
GeneProduct
326857 (Entrez Gene)
hmox1
GeneProduct
791518 (Entrez Gene)
mapk10
GeneProduct
569698 (Entrez Gene)
mapk14a
GeneProduct
65237 (Entrez Gene)
nqo1
GeneProduct
322506 (Entrez Gene)
si:dkey-117m1.6
GeneProduct
794006 (Entrez Gene)
sod1
GeneProduct
30553 (Entrez Gene)
sod2
GeneProduct
335799 (Entrez Gene)
sp1
GeneProduct
324109 (Entrez Gene)
xdh
GeneProduct
560486 (Entrez Gene)
zgc:110010
GeneProduct
553575 (Entrez Gene)
Annotated Interactions
No annotated interactions
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