Nuclear receptors (Danio rerio)

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1NR1 SUPERFAMILYOrphan Nuclear ReceptorNR0 SUPERFAMILYNR5 SUPERFAMILYAndrogen ReceptorHepatocyte Nuclear FactorOrphan NuclearRetinoic Acid Receptor RXRNR4 SUPERFAMILYGlucocorticoid ReceptorReceptorSteroidogenic ReceptorOrphan ReceptorOrphan ReceptorActivated ReceptorVitamin D3 ReceptorEstrogen ReceptorNR3 SUPERFAMILYPeroxisome ProliferatorNuclear receptor TLXSteroid Hormone ReceptorOxysterols ReceptorNuclear Receptor RORRetinoic Acid ReceptorCoup Transcription FactorThyroid ReceptorProgesterone ReceptorNR2 SUPERFAMILYsi:dkey-209n16.1RXRGrargaRARAESR2hnf4aesrranr2c2thrbppargNR2F6nr2e1rxraaesr1NR1H2NR1I3nr2f2rargbppardbnr1i2thrbnr2f1arargbTHRAESRRBroraaNR5A1vdrbnr1d2bnr4a1ppargRXRBRORCnr3c1nr1h3arnr0b1nr5a2nr4a2apparabPGR


Description

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a ligand—a molecule which affects the receptor's behavior—is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. As discussed in more detail below, nuclear receptors may be classified either according to mechanism or homology. Source: Wikipedia (wikipedia:Nuclear_receptor)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP170(r21037) with a 70% conversion rate.

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Bibliography

  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118089view10:46, 24 May 2021EweitzModified title
89862view12:33, 6 October 2016MkutmonModified description
89861view12:32, 6 October 2016MkutmonModified description
69975view21:16, 11 July 2013MaintBot
69974view21:16, 11 July 2013MaintBotupdating to 2013 schema
67530view11:21, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
40840view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35775view00:13, 13 February 2010AlexanderPico
34223view21:35, 9 December 2009MaintBotAutomatic update of empty xrefs
31960view13:05, 14 August 2009MaintBotFixed group labels
31097view01:40, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ESR2GeneProduct
ESRRBGeneProduct407693 (Entrez Gene)
NR1H2GeneProduct
NR1I3GeneProduct
NR2F6GeneProduct
NR5A1GeneProduct
PGRGeneProduct569575 (Entrez Gene)
RARAGeneProduct
RORCGeneProduct
RXRBGeneProduct
RXRGGeneProduct
THRAGeneProduct
arGeneProduct100005148 (Entrez Gene)
esr1GeneProduct259252 (Entrez Gene)
esrraGeneProduct405891 (Entrez Gene)
hnf4aGeneProduct322358 (Entrez Gene)
nr0b1GeneProduct100001692 (Entrez Gene)
nr1d2bGeneProduct30271 (Entrez Gene)
nr1h3GeneProduct548341 (Entrez Gene)
nr1i2GeneProduct565875 (Entrez Gene)
nr2c2GeneProduct569321 (Entrez Gene)
nr2e1GeneProduct445214 (Entrez Gene)
nr2f1aGeneProduct30418 (Entrez Gene)
nr2f2GeneProduct30424 (Entrez Gene)
nr3c1GeneProduct553740 (Entrez Gene)
nr4a1GeneProduct431720 (Entrez Gene)
nr4a2aGeneProduct100008101 (Entrez Gene)
nr5a2GeneProduct30749 (Entrez Gene)
pparabGeneProduct557714 (Entrez Gene)
ppardbGeneProduct30754 (Entrez Gene)
ppargGeneProduct557037 (Entrez Gene)
rargaGeneProduct30606 (Entrez Gene)
rargbGeneProduct100034753 (Entrez Gene)
roraaGeneProduct564951 (Entrez Gene)
rxraaGeneProduct555578 (Entrez Gene)
si:dkey-209n16.1GeneProduct568282 (Entrez Gene)
thrbGeneProduct30607 (Entrez Gene)
vdrbGeneProduct564511 (Entrez Gene)

Annotated Interactions

No annotated interactions
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