Nodal signaling pathway (Danio rerio)
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1
BMP
NODAL genes
EGF
IFN-
g
TGF-beta
cofactors
type I
endoderm
related
double unigenes
type II
nodal
responsive genes
mesoderm
nucleus
coactivators
TNF-alpha
lef1
p300b - Dr.53214
junb
oep
BAMBI
cat
runx2b/cbfa3
oep
smad3b
smad5
neurog1
smad2
dharma / boz
cyc / foxa / ndr2
smad2
NFkB1#
sox32 / cas
bon / mixer
acvr2b
smad5
dharma / boz
men1
smad2
ntl
neurog1
stat1
vent
ved
pcdh8 / papc
smad2
Foxh1 / sur
runx2a/cbfa1
smad3b
sqt / foxa3 / ndr1#
flh
p300 - Dr.69707
acvr2a
MITFa
cyc / foxa /ndr2#
myoD
Foxh1 / sur
smad5
snip1
bhik
tcf7/tcf1#
smad2
smad5
tcfl1b
sox17
cyc / foxa / ndr2
smad3a
cyc / foxa /ndr2#
taf5l
Ras*
bon / mixer
lft1 / antivin
cyc / foxa / ndr2
smad5
sox32 / cas
axial / FOXA2
p300 - similar
lft1 / antivin
Foxh1 / sur
smad4#
runx2b/cbfa1
lim1 / lhx1a
smad7
tcfl1a
p300 - pred.
dlx1a
stat3
lft2
cyc / foxa /ndr2
myoD
smad2
pax6a
lft2
smad2
lft2
p300a - Dr.67573
ERK2 / mapk1
p300
p300 - similar
ERK1 / mapk3
foxh1 / sur
tbx16 / spt
lft1 / antivin
cdx4
smad6#
smurf1*
smad3a
CBP / crebbp*
skiB
lft1 / antivin
gata5 / fau
neurog1
acvr1b / TARAMA
sqt / foxa3 / ndr1#
vox
ube2d1
junbl
p300 - Dr.69584
jun
oep#
sox32 / cas
bon / mixer
foxg1
cldnd
NFkB2
sqt / foxa3 / ndr1
smad1
neurog1
TGIF
smad4#
Description
No description
Comments
GenMAPP notes
* = gene not present in GenMAPP gene database
GenMAPP remarks
# = gene not represented in Agilent zebrafish 22k oligo set
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Quality Tags
Ontology Terms
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Bibliography
Krens SF, Corredor-Adamez M, He S, Snaar-Jagalska BE, Spaink HP; ''ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis.''; BMC Genomics, 2008
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
118480
view
05:45, 28 May 2021
Egonw
Replaced UniGene with Ensembl IDs
116893
view
11:20, 15 May 2021
Eweitz
Modified title
95702
view
19:56, 18 January 2018
AlexanderPico
fixed xref
95700
view
19:55, 18 January 2018
AlexanderPico
fixed xref
95699
view
19:54, 18 January 2018
AlexanderPico
fixed xref
95698
view
19:53, 18 January 2018
AlexanderPico
updated retired unigene id
95697
view
19:51, 18 January 2018
AlexanderPico
fixed xref
95696
view
19:49, 18 January 2018
AlexanderPico
fixed xref
95692
view
19:48, 18 January 2018
AlexanderPico
fixed xref
95691
view
19:47, 18 January 2018
AlexanderPico
fixed xref
95690
view
19:45, 18 January 2018
AlexanderPico
fixed xref
95689
view
19:43, 18 January 2018
AlexanderPico
fixed xref
95688
view
19:41, 18 January 2018
AlexanderPico
fixed xref
95687
view
19:38, 18 January 2018
AlexanderPico
Removed stray characters and updated xref
95686
view
19:31, 18 January 2018
AlexanderPico
updated retired entrez id
95685
view
19:26, 18 January 2018
AlexanderPico
updated retired unigene ids
71978
view
00:27, 24 October 2013
MaintBot
removed data source from nodes without identifier
70244
view
21:32, 15 July 2013
MaintBot
upated to 2013 schema
70193
view
01:59, 13 July 2013
AlexanderPico
Modified title
67512
view
11:19, 26 June 2013
Ddigles
Ontology Term : 'Nodal signaling pathway' added !
58800
view
22:53, 20 February 2013
MaintBot
Updated Ensembl data source
52980
view
11:41, 25 October 2012
Fredp
added lft1/antivin with correct mapping
40857
view
22:20, 1 March 2011
MaintBot
Removed redundant pathway information and comments
34975
view
09:01, 9 February 2010
Danio368
correct ectoderm to endoderm
29185
view
18:26, 9 April 2009
Khanspers
Changes pathway name: removed "zebrafish"
21395
view
11:31, 14 November 2008
MaintBot
[[Pathway:Danio rerio:Nodal Signaling]] moved to [[Pathway:WP341]]: Moved to stable identifier
16296
view
20:44, 17 June 2008
Khanspers
[[Pathway:Danio rerio:Dr Nodal-signaling]] moved to [[Pathway:Danio rerio:Nodal Signaling]]: Removed species code prefix from pathway name
14278
view
07:48, 22 May 2008
SFGKrens
Modified categories
14047
view
08:24, 21 May 2008
SFGKrens
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
BAMBI
GeneProduct
83496 (Entrez Gene)
CBP / crebbp*
GeneProduct
GENE-050208-439 (Other)
ERK1 / mapk3
GeneProduct
399480 (Entrez Gene)
ERK2 / mapk1
GeneProduct
360144 (Entrez Gene)
Foxh1 / sur
GeneProduct
327135 (Entrez Gene)
FAST1 (fast1) (foxh1)
Foxh1 / sur
GeneProduct
337369 (Entrez Gene)
âForkhead box H1, mRNA (cDNA clone MGC:55221 IMAGE:2639305) (foxh1)â
Foxh1 / sur
GeneProduct
Dr.18760 (UniGene)
âForkhead box H1 (foxh1), mRNA (foxh1) - forkhead box H1 / schmalspur (sur)â
MITFa
GeneProduct
30080 (Entrez Gene)
NFkB1#
GeneProduct
Dr.47468 (UniGene)
NFkB2
GeneProduct
Dr.13012 (UniGene)
Ras*
GeneProduct
TGIF
GeneProduct
321756 (Entrez Gene)
acvr1b / TARAMA
GeneProduct
30183 (Entrez Gene)
acvr2a
GeneProduct
338214 (Entrez Gene)
Activin receptor IIA (acvr2a)
acvr2b
GeneProduct
80357 (Entrez Gene)
âActivin receptor IIb (acvr2b), mRNA (acvr2b)â
axial / FOXA2
GeneProduct
30126 (Entrez Gene)
bhik
GeneProduct
64281 (Entrez Gene)
âBhikhari (bhik), mRNA (bhik)â
bon / mixer
GeneProduct
336263 (Entrez Gene)
Homeodomain transcription factor Mixer (mix) (bon)
bon / mixer
GeneProduct
492490 (Entrez Gene)
Homeodomain transcription factor Mixer (mix) (bon)
bon / mixer
GeneProduct
Dr.81305 (UniGene)
cat
GeneProduct
368234 (Entrez Gene)
Catalase (cat)
cdx4
GeneProduct
30330 (Entrez Gene)
cldnd
GeneProduct
286779 (Entrez Gene)
âClaudin-like gene, clone ZF-A89 (cldnd) - anosmin1 precursorâ
cyc / foxa / ndr2
GeneProduct
195823 (Entrez Gene)
cyc / foxa / ndr2
GeneProduct
30292 (Entrez Gene)
cyc / foxa / ndr2
GeneProduct
492721 (Entrez Gene)
cyc / foxa /ndr2#
GeneProduct
564119 (Entrez Gene)
cyc / foxa /ndr2
GeneProduct
30292 (Entrez Gene)
dharma / boz
GeneProduct
30170 (Entrez Gene)
dlx1a
GeneProduct
30216 (Entrez Gene)
Dlx1 (dlx1a)
flh
GeneProduct
30260 (Entrez Gene)
âflh: Floating head (flh), mRNAâ
foxg1
GeneProduct
Dr.75832 (UniGene)
foxg1 / BF1
foxh1 / sur
GeneProduct
57930 (Entrez Gene)
gata5 / fau
GeneProduct
30482 (Entrez Gene)
jun
GeneProduct
Dr.1064 (UniGene)
junb
GeneProduct
407086 (Entrez Gene)
junbl
GeneProduct
Dr.737 (UniGene)
lef1
GeneProduct
Dr.78861 (UniGene)
lft1 / antivin
GeneProduct
114417 (Entrez Gene)
lft1 / antivin
GeneProduct
327065 (Entrez Gene)
lft2
GeneProduct
30146 (Entrez Gene)
âLefty2 (lft2), mRNA (lft2)â
lft2
GeneProduct
336233 (Entrez Gene)
Signaling molecule lefty2 (lft2) (lft2)
lft2
GeneProduct
393724 (Entrez Gene)
âLefty2 (lft2), mRNA (lft2)â
lim1 / lhx1a
GeneProduct
30463 (Entrez Gene)
men1
GeneProduct
321622 (Entrez Gene)
Menin (men1 gene) (men1)
myoD
GeneProduct
30513 (Entrez Gene)
myoD
GeneProduct
664740 (Entrez Gene)
neurog1
GeneProduct
30269 (Entrez Gene)
âNeurogenin 1, mRNA (cDNA clone MGC:76812 IMAGE:6963393) (neurog1)â
neurog1
GeneProduct
30475 (Entrez Gene)
âNeurogenin 1, mRNA (cDNA clone MGC:76812 IMAGE:6963393) (neurog1)â
neurog1
GeneProduct
393697 (Entrez Gene)
âNeurogenin 1 (neurog1), mRNA (neurog1)â
neurog1
GeneProduct
58121 (Entrez Gene)
Neurogenin (neurog1)
ntl
GeneProduct
30399 (Entrez Gene)
ântl: No tail (ntl), mRNAâ
oep#
GeneProduct
30406 (Entrez Gene)
One-eyed pinhead short form protein (oep)
oep
GeneProduct
30346 (Entrez Gene)
One-eyed pinhead long form protein (oep)
oep
GeneProduct
386614 (Entrez Gene)
âOne-eyed pinhead (oep), mRNA (oep)â
p300 - Dr.69584
GeneProduct
Dr.69584 (UniGene)
p300 - Dr.69707
GeneProduct
Dr.69707 (UniGene)
p300 - pred.
GeneProduct
327385 (Entrez Gene)
p300 - similar
GeneProduct
337477 (Entrez Gene)
p300 - similar
GeneProduct
337578 (Entrez Gene)
p300
GeneProduct
Dr.15367 (UniGene)
p300a - Dr.67573
GeneProduct
p300b - Dr.53214
GeneProduct
Dr.53214 (UniGene)
pax6a
GeneProduct
30567 (Entrez Gene)
pcdh8 / papc
GeneProduct
Dr.75833 (UniGene)
runx2a/cbfa1
GeneProduct
405784 (Entrez Gene)
runx2b/cbfa1
GeneProduct
Dr.30423 (UniGene)
runx2b/cbfa3
GeneProduct
Dr.82593 (UniGene)
skiB
GeneProduct
30113 (Entrez Gene)
smad1
GeneProduct
30628 (Entrez Gene)
smad2
GeneProduct
30639 (Entrez Gene)
smad2
GeneProduct
323832 (Entrez Gene)
Transcription factor Smad2 (smad2)
smad2
GeneProduct
324790 (Entrez Gene)
Smad2 protein (smad2) (smad2)
smad2
GeneProduct
326879 (Entrez Gene)
âMAD homolog 2 (Drosophila), mRNA (cDNA clone MGC:113963 IMAGE:7395088) (smad2)â
smad2
GeneProduct
393344 (Entrez Gene)
âMAD homolog 2 (Drosophila) (smad2), mRNA (smad2)â
smad3a
GeneProduct
58092 (Entrez Gene)
smad3b
GeneProduct
326283 (Entrez Gene)
smad4#
GeneProduct
30640 (Entrez Gene)
smad4#
GeneProduct
Dr.8327 (UniGene)
smad5
GeneProduct
30641 (Entrez Gene)
smad5
GeneProduct
393459 (Entrez Gene)
âMAD homolog 5 (Drosophila), mRNAâ
smad5
GeneProduct
415211 (Entrez Gene)
Mad-related protein Smad5 (smad5) (smad5)
smad5
GeneProduct
553171 (Entrez Gene)
âMAD homolog 5 (Drosophila) (smad5), mRNA (smad5)â
smad5
GeneProduct
58093 (Entrez Gene)
âMAD homolog 5 (Drosophila), mRNAâ
smad6#
GeneProduct
Dr.4888 (UniGene)
smad7
GeneProduct
Dr.52521 (UniGene)
smurf1*
GeneProduct
snip1
GeneProduct
474374 (Entrez Gene)
sox17
GeneProduct
30544 (Entrez Gene)
âsox17: SRY-box containing gene 17, mRNA (cDNA clone MGC:91776 â
sox32 / cas
GeneProduct
116990 (Entrez Gene)
âsox32: SRY-box containing gene 32, mRNA (cDNA clone MGC:114019)â
sox32 / cas
GeneProduct
322641 (Entrez Gene)
Sox transcription factor 226D7 (sox32)
sox32 / cas
GeneProduct
664758 (Entrez Gene)
âSRY-box containing gene 32, mRNA (cDNA clone MGC:114019 IMAGE:7450460) (sox32)â
sqt / foxa3 / ndr1#
GeneProduct
Dr.81188 (UniGene)
sqt / foxa3 / ndr1#
GeneProduct
sqt / foxa3 / ndr1
GeneProduct
336281 (Entrez Gene)
stat1
GeneProduct
30768 (Entrez Gene)
stat3
GeneProduct
30767 (Entrez Gene)
taf5l
GeneProduct
334055 (Entrez Gene)
tbx16 / spt
GeneProduct
Dr.75456 (UniGene)
tcf7/tcf1#
GeneProduct
Dr.38863 (UniGene)
tcfl1a
GeneProduct
Dr.79155 (UniGene)
tcfl1b
GeneProduct
Dr.8108 (UniGene)
ube2d1
GeneProduct
324015 (Entrez Gene)
ved
GeneProduct
368201 (Entrez Gene)
vent
GeneProduct
64810 (Entrez Gene)
vox
GeneProduct
64807 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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External references
DataNodes
Annotated Interactions
No annotated interactions