IL-2 signaling pathway (Gallus gallus)

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DephosphorylationReactions through unknown mechanisms/moleculesPMDNucleusGolgi apparatusMTCY -> NUMethylationPlasma membraneNUEndosome(Protein-protein interaction)AcetylationDPalmitolyationMitochondrionSumoylationDPM -> CYDCY -> NUPhosphorylationNUDCY -> PMDesumoylationGOUbiquitinationNucleusControlMolecule in the pathwayCYENAutophosphorylationDERDDGene SymbolCY -> NUECDCY -> NURecruitmentDemethylationMolecular associationCY -> NUDReceptorInhibitionActivationCY -> NUEnzyme complexAccession Number: NetPath 14LigandProteolytic cleavageDPhosphorylationMTCY -> NUDeubiquitinationCY -> NUEndoplasmic reticulumTranslocationCytoplasmExtracellularGlycosylationDDeacetylationProteins in a complex interactionVAV1JAK1CRKLSTAT5BYBX1EIF4EMAPK3MAPK8NFKB1MAPK1IL2LYNAKT1MAPK3JAK3PIK3R1GNB2L1SOS1RELAICAM1HSPCAMAP2K2FOXO3MAP2K1PIK3R2IL2MAPKAPK2MAPK1ETS1PTPN6RCJMB04_17i9TERTCRKPIK3CALCKPTK2BEIF3S9MAPK9NR3C1YBX1SOCS1STAT5ARCJMB04_4j14CRKTERTNMICISHIL2RGNFKB1RAF1JAK2ETS2AKT1RCJMB04_19h23RAF1SHBGAB2PIK3CDFRAP1AKT1BCL2RELAIFNA1SOCS3IL2RAPTPN11STAM2IL2IL2GRB2FYNMAPK14ITM2BPIK3CGSTAT5BIL2RCJMB04_19o18PRKCZMKNK1SHC1IL2RBPIK3CBIRS2PLCB1STAMSTAT5AKRASCD53CBLSTAT3CREB1IRS1


Description

Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_14

Comments

GenMAPP notes 
NetPath 14 - IL-2 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 75% conversion rate.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
118760view11:32, 1 June 2021EgonwModified description
118005view11:30, 23 May 2021EweitzModified title
89850view12:17, 6 October 2016Mkutmonremove GenMAPP notes
89846view12:16, 6 October 2016MkutmonModified description
73858view00:58, 26 February 2014MaintBotupdated schema
67371view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
40924view22:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
35782view06:20, 13 February 2010MaintBotAdded description
33855view17:43, 9 December 2009MaintBotAutomatic update of empty xrefs
31491view21:29, 13 August 2009MaintBotFixed text labels
30316view20:41, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene)
BCL2GeneProduct396282 (Entrez Gene)
CBLGeneProduct374038 (Entrez Gene)
CD53GeneProduct
CISHGeneProduct395335 (Entrez Gene)
CREB1GeneProduct395099 (Entrez Gene)
CRKGeneProduct417553 (Entrez Gene)
CRKLGeneProduct416939 (Entrez Gene)
EIF3S9GeneProduct
EIF4EGeneProduct422703 (Entrez Gene)
ETS1GeneProduct768354 (Entrez Gene)
ETS2GeneProduct396250 (Entrez Gene)
FOXO3GeneProduct421769 (Entrez Gene)
FRAP1GeneProduct419455 (Entrez Gene)
FYNGeneProduct396294 (Entrez Gene)
GAB2GeneProduct419027 (Entrez Gene)
GNB2L1GeneProduct417044 (Entrez Gene)
GRB2GeneProduct386572 (Entrez Gene)
HSPCAGeneProduct
ICAM1GeneProduct
IFNA1GeneProduct
IL2GeneProduct373958 (Entrez Gene)
IL2RAGeneProduct395294 (Entrez Gene)
IL2RBGeneProduct
IL2RGGeneProduct395199 (Entrez Gene)
IRS1GeneProduct429126 (Entrez Gene)
IRS2GeneProduct428017 (Entrez Gene)
ITM2BGeneProduct395969 (Entrez Gene)
JAK1GeneProduct395681 (Entrez Gene)
JAK2GeneProduct374199 (Entrez Gene)
JAK3GeneProduct395845 (Entrez Gene)
KRASGeneProduct418207 (Entrez Gene)
LCKGeneProduct
LYNGeneProduct421127 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MAPK14GeneProduct421183 (Entrez Gene)
MAPK3GeneProduct
MAPK8GeneProduct423778 (Entrez Gene)
MAPK9GeneProduct395983 (Entrez Gene)
MAPKAPK2GeneProduct419847 (Entrez Gene)
MKNK1GeneProduct771961 (Entrez Gene)
NFKB1GeneProduct396033 (Entrez Gene)
NMIGeneProduct424314 (Entrez Gene)
NR3C1GeneProduct416343 (Entrez Gene)
PIK3CAGeneProduct424971 (Entrez Gene)
PIK3CBGeneProduct424826 (Entrez Gene)
PIK3CDGeneProduct419444 (Entrez Gene)
PIK3CGGeneProduct417706 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PIK3R2GeneProduct771142 (Entrez Gene)
PLCB1GeneProduct427687 (Entrez Gene)
PRKCZGeneProduct419399 (Entrez Gene)
PTK2BGeneProduct421998 (Entrez Gene)
PTPN11GeneProduct395815 (Entrez Gene)
PTPN6GeneProduct427947 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_19h23GeneProduct423669 (Entrez Gene)
RCJMB04_19o18GeneProduct427272 (Entrez Gene)
RCJMB04_4j14GeneProduct417637 (Entrez Gene)
RELAGeneProduct
SHBGeneProduct427280 (Entrez Gene)
SHC1GeneProduct395934 (Entrez Gene)
SOCS1GeneProduct416630 (Entrez Gene)
SOCS3GeneProduct395299 (Entrez Gene)
SOS1GeneProduct425964 (Entrez Gene)
STAM2GeneProduct424317 (Entrez Gene)
STAMGeneProduct420517 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)
STAT5AGeneProduct
STAT5BGeneProduct395556 (Entrez Gene)
TERTGeneProduct420972 (Entrez Gene)
VAV1GeneProduct
YBX1GeneProduct386575 (Entrez Gene)

Annotated Interactions

No annotated interactions
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