Folate-alcohol and cancer pathway hypotheses (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Hwang PH, Lian L, Zavras AI; ''Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.''; Med Hypotheses, 2012 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	141725	view	16:35, 22 November 2025	Eweitz	Standardize case
	136854	view	13:59, 24 February 2025	Eweitz	Standardize case
	136853	view	13:58, 24 February 2025	Eweitz	Economize layout
	126399	view	15:33, 26 April 2023	Egonw	License is CCZero
	122870	view	10:14, 27 May 2022	Egonw	Made a pathway clickable
	117726	view	12:34, 22 May 2021	Eweitz	Modified title
	106697	view	13:04, 17 September 2019	MaintBot	HMDB identifier normalization
	96101	view	23:23, 15 February 2018	AlexanderPico	Ontology Term : 'oral cavity cancer' added !
	96100	view	23:22, 15 February 2018	AlexanderPico	Modified description
	96099	view	23:15, 15 February 2018	AlexanderPico	Modified title
	96098	view	23:14, 15 February 2018	AlexanderPico	clarified layout and interations; added MTR
	92113	view	18:55, 28 April 2017	Egonw	Removed a lone metabolite node.
	87508	view	01:49, 25 July 2016	AlexanderPico	Ontology Term : 'cancer pathway' added !
	87507	view	01:49, 25 July 2016	AlexanderPico	Ontology Term : 'disease pathway' added !
	82223	view	03:26, 16 September 2015	AlexanderPico	fixed catalysis for biopax conversion
	78797	view	13:00, 30 January 2015	Egonw	Added missing metabolite identifiers.
	78796	view	12:51, 30 January 2015	Egonw	Connected dots.
	74018	view	13:36, 22 March 2014	Egonw	Added a few metabolite identifiers.
	62366	view	23:57, 27 April 2013	AlexanderPico	Fixed gene and metabolite annotations
	45285	view	19:11, 7 October 2011	AlexanderPico	added nucleus
	45284	view	19:10, 7 October 2011	AlexanderPico	fixed reactions
	45282	view	19:08, 7 October 2011	AlexanderPico	fixed gene labels
	41113	view	23:36, 1 March 2011	MaintBot	Removed redundant pathway information and comments
	38167	view	22:39, 20 August 2010	Khanspers	Added xrefs
	38166	view	22:24, 20 August 2010	Khanspers	Added xrefs
	38165	view	22:21, 20 August 2010	Khanspers	Periodical save, work in progress
	38164	view	22:11, 20 August 2010	Khanspers	Periodical save, work in progress
	38163	view	22:00, 20 August 2010	Khanspers	Periodical save, work in progress
	38147	view	19:01, 17 August 2010	Khanspers	Modified categories
	37896	view	19:18, 13 July 2010	Whom	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
5,10-Methylene-THF	Metabolite	HMDB01533 (HMDB)
5-Methyl THF	Metabolite
ADH	GeneProduct
ALDH1A1	GeneProduct	216 (Entrez Gene)
ALDH1L1	GeneProduct	10840 (Entrez Gene)
Acetate	Metabolite
CBS	GeneProduct	875 (Entrez Gene)
CYP2E1	GeneProduct	1571 (Entrez Gene)
Cystathionine	Metabolite	HMDB00099 (HMDB)
Cysteine	Metabolite	HMDB00574 (HMDB)
Ethanol	Metabolite	HMDB00108 (HMDB)
Folate	Metabolite
Homocysteine	Metabolite	HMDB00742 (HMDB)
MTHFR	GeneProduct	4524 (Entrez Gene)
Methionine	Metabolite	HMDB00696 (HMDB)
SAH	GeneProduct
SAM	GeneProduct
THF	GeneProduct
↑ALDH1A1	GeneProduct	216 (Entrez Gene)
↑ALDH1L1	GeneProduct	10840 (Entrez Gene)
↑Acetaldehyde	Metabolite	HMDB00990 (HMDB)
↑C/EBPB	GeneProduct	1051
↑CREB	GeneProduct

Annotated Interactions

No annotated interactions