Mouse ESC Pluripotency Pathways (Mus musculus)

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R-Smad/ Co-SmadInhibits self-renewal (promotes differentiation)Self-renewalbWnt signalingSelf-renewal+p+pSelf-renewalbTcf/Lef+pG12 SignalingPKCGi SignalingSelf-renewalnon-canonical pathwayMEKBMP signalingRas-GDPTRb Binding+pNucleus+pFrizzled ligandsCa++Ras/ERK pathwaybTR Transcriptional Regulation+pPIP2+p PhosphorylationPromotes self-renewal (inhibits differentiation)+pR-Smad / Co-Smad complexERKRas-GTPLIF Signaling+p-pPIP3JNK+pDegradation of beta-catenin-p DephosphorylationNucleusPIP2+pGPCR-Arrestin SignalsPI3 Kinase / Akt signalingPDETRRAFPI3 kinaseStat3Tcf4Fgf22Smad5Sos1Fgf3Mapk7Grb2Fgf8Fzd7Fzd6Akt1Mapk12Ctnnb1Smad9Akt2Fgf5LifrFzd4Smad1Smad9Wnt7bMap2k3Lrp6Il6stMycWnt10aEgfrLrp5Fgfr4Fgf21Wnt1Smad7Wnt4Ctnnb1Wnt2Stat3Smad1LifMap2k5Fgf18Wnt6Dvl2Dvl1PdgfrbGab1Tcf2NlkSmad6Lef1Stat3ErasSox2FosFgf10Oct3/4Mapk4Jak1Fgf16Fgf2Gsk3bWnt10bSmad5Bmpr1aWnt2bArafCtnnb1Map3k7Jak1Fgf7Smad1Smad9Fgf4Arrb2Wnt9bMapk1Map2k1Fzd8Akt3PdgfbFgf1Arrb1PdgfraPik3r2Fgf14IkbkgBmp4Tcf1Fgf13Raf1Dvl3Fgf20Smad5Map2k2Wnt16Fgfr1Fzd9Wnt5bMapk6JunFgfr3Pik3cdPdgfaPtenStat3Fgf17Bmpr2BrafNanogAcvr1Bmpr1bFzd5Fzd2Fgf12Tcf3Wnt7aactr2bFgf9Fgf23Fgf11Fzd3Fgfr2Smad4Frap1EgfWnt5aWnt3Wnt3aWnt11ElkFgf15actr2Ptpn11Fzd1Smad4Mdm2ApcMap2k6Fgf6Axin1


Description

No description

Comments

GenMAPP notes 
Based on Intracellular Signaling Pathways Regulating Pluripotency of Embryonic Stem Cells, Okita et al, Current Stem Cell Research and Therapy, 2006, 1, 103-111

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Bibliography


History

CompareRevisionActionTimeUserComment
42944view07:25, 23 May 2011ThomasDeleted pathway: Duplicate of WP339, no response from author on why this version has additional value.
41268view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
39569view15:08, 23 December 2010SaibrahiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acvr1GeneProduct11477 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Akt2GeneProduct11652 (Entrez Gene)
Akt3GeneProduct23797 (Entrez Gene)
ApcGeneProduct11789 (Entrez Gene)
ArafGeneProduct11836 (Entrez Gene)
Arrb1GeneProduct109689 (Entrez Gene)
Arrb2GeneProduct216869 (Entrez Gene)
Axin1GeneProduct12005 (Entrez Gene)
Bmp4GeneProduct12159 (Entrez Gene)
Bmpr1aGeneProduct12166 (Entrez Gene)
Bmpr1bGeneProduct12167 (Entrez Gene)
Bmpr2GeneProduct12168 (Entrez Gene)
BrafGeneProduct109880 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Dvl1GeneProduct13542 (Entrez Gene)
Dvl2GeneProduct13543 (Entrez Gene)
Dvl3GeneProduct13544 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
ElkGeneProduct270190 (Entrez Gene)
ErasGeneProduct353283 (Entrez Gene)
Fgf10GeneProduct14165 (Entrez Gene)
Fgf11GeneProduct14166 (Entrez Gene)
Fgf1GeneProduct14164 (Entrez Gene)
Fgf12GeneProduct14167 (Entrez Gene)
Fgf13GeneProduct14168 (Entrez Gene)
Fgf14GeneProduct14169 (Entrez Gene)
Fgf15GeneProduct14170 (Entrez Gene)
Fgf16GeneProduct80903 (Entrez Gene)
Fgf17GeneProduct14171 (Entrez Gene)
Fgf18GeneProduct14172 (Entrez Gene)
Fgf20GeneProduct80857 (Entrez Gene)
Fgf2GeneProduct14173 (Entrez Gene)
Fgf21GeneProduct56636 (Entrez Gene)
Fgf22GeneProduct67112 (Entrez Gene)
Fgf23GeneProduct64654 (Entrez Gene)
Fgf3GeneProduct14174 (Entrez Gene)
Fgf4GeneProduct14175 (Entrez Gene)
Fgf5GeneProduct14176 (Entrez Gene)
Fgf6GeneProduct14177 (Entrez Gene)
Fgf7GeneProduct14178 (Entrez Gene)
Fgf8GeneProduct14179 (Entrez Gene)
Fgf9GeneProduct14180 (Entrez Gene)
Fgfr1GeneProduct14182 (Entrez Gene)
Fgfr2GeneProduct14183 (Entrez Gene)
Fgfr3GeneProduct14184 (Entrez Gene)
Fgfr4GeneProduct14186 (Entrez Gene)
FosGeneProduct14281 (Entrez Gene)
Frap1GeneProduct56717 (Entrez Gene)
Fzd1GeneProduct14362 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
Fzd3GeneProduct14365 (Entrez Gene)
Fzd4GeneProduct14366 (Entrez Gene)
Fzd5GeneProduct14367 (Entrez Gene)
Fzd6GeneProduct14368 (Entrez Gene)
Fzd7GeneProduct14369 (Entrez Gene)
Fzd8GeneProduct14370 (Entrez Gene)
Fzd9GeneProduct14371 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Il6stGeneProduct16195 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Lef1GeneProduct21405 (Entrez Gene)
LifGeneProduct16878 (Entrez Gene)
LifrGeneProduct16880 (Entrez Gene)
Lrp5GeneProduct16973 (Entrez Gene)
Lrp6GeneProduct16974 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map2k3GeneProduct26397 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
Map2k6GeneProduct26399 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Mapk12GeneProduct29857 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk4GeneProduct225724 (Entrez Gene)
Mapk6GeneProduct50772 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Mdm2GeneProduct17246 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
NanogGeneProduct71950 (Entrez Gene)
NlkGeneProduct18099 (Entrez Gene)
Oct3/4GeneProduct18999 (Entrez Gene)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
PdgfraGeneProduct18595 (Entrez Gene)
PdgfrbGeneProduct18596 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
PtenGeneProduct19211 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
Smad1GeneProduct17125 (Entrez Gene)
Smad4GeneProduct17128 (Entrez Gene)
Smad5GeneProduct17129 (Entrez Gene)
Smad6GeneProduct17130 (Entrez Gene)
Smad7GeneProduct17131 (Entrez Gene)
Smad9GeneProduct55994 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
Sox2GeneProduct20674 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Tcf1GeneProduct21405 (Entrez Gene)
Tcf2GeneProduct21410 (Entrez Gene)
Tcf3GeneProduct21415 (Entrez Gene)
Tcf4GeneProduct21413 (Entrez Gene)
Wnt10aGeneProduct22409 (Entrez Gene)
Wnt10bGeneProduct22410 (Entrez Gene)
Wnt11GeneProduct22411 (Entrez Gene)
Wnt1GeneProduct22408 (Entrez Gene)
Wnt16GeneProduct93735 (Entrez Gene)
Wnt2GeneProduct22413 (Entrez Gene)
Wnt2bGeneProduct22414 (Entrez Gene)
Wnt3GeneProduct22415 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
Wnt4GeneProduct22417 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
Wnt5bGeneProduct22419 (Entrez Gene)
Wnt6GeneProduct22420 (Entrez Gene)
Wnt7aGeneProduct22421 (Entrez Gene)
Wnt7bGeneProduct22422 (Entrez Gene)
Wnt9bGeneProduct22412 (Entrez Gene)
actr2GeneProduct
actr2bGeneProduct

Annotated Interactions

No annotated interactions
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