Complement and coagulation cascades (Mus musculus)
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Extrinsic pathway
Lectin Pathway
fibrin polymer
C5a
C3
Convertase
Phagocyte recruitment
Thrombin
Cell adhesion,
migration,
proliferation, etc.
Clot
C4a
fibrin degradation
products
C3b/4b, C3b, C3d
Chemotaxis,
Inflammation, etc.
Fibrin
monomer
Complement Cascade
Degradation
Platelet, monocyte,
lymphocyte,
endothelial cells,
smooth muscle cells,
activation, etc.
Collagen,
basement membrane,
activated platelets etc.
Zymosan
insulin etc.
Kinin kallikrein system
Fibrinolytic system
Antibody/antigen
complex
C3a
Classical Pathway
Cross-linked
Muscle contraction,
C4b/2a
Cell lysis
Cell adhesion,
migration,
proliferation, etc.
C3b
Vascular injury
Alternative Pathway
Mediators
Coagulation Cascade
C3b/Bb
membrane attack complex
Proc
Cr2
C1qb
C3
F13b
Serpinf2
Plg
Daf1
Plaur
Crry
Cfi
Klkb1
Plau
C2
Daf2
Bdkrb1
C1r
Plat
C1qa
F8
Vwf
Serpina5
Cd59a
Serpinc1
C4
1700013L23Rik
C9
A2m
F10
F11
C1s
Kng1
H2-Bf
Thbd
Hc
Serpina1
C6
F12
C3ar1
Serpind1
Cfh
Serpine1
F9
Cr1
Mbl1
C5r1
F3
Cpb2
Fgb
Adn
C1qg
F2
Pros1
Tfpi
Mcp
F5
Serping1
C4bp
F2r
C7
Masp1
Bradykinin
Masp2
F7
Description
No description
Comments
GenMAPP notes
http://www.genome.jp/dbget-bin/get
pathway?org name=mmu&mapno=04610
GenMAPP remarks
Adapted from KEGG (see notes)
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
No bibliography
History
View all...
Compare
Revision
Action
Time
User
Comment
122582
view
10:00, 18 April 2022
Eweitz
Modified title
114008
view
14:51, 17 December 2020
Fehrhart
connected lines
109409
view
18:14, 16 March 2020
L Dupuis
Fixed interactions
106896
view
13:37, 17 September 2019
MaintBot
HMDB identifier normalization
104990
view
04:21, 28 June 2019
Khanspers
removed KEGG comments
71733
view
20:17, 17 October 2013
MaintBot
Automated update of data sources
69115
view
18:13, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67784
view
15:12, 26 June 2013
Ddigles
Ontology Term : 'complement system pathway' added !
67124
view
10:09, 26 June 2013
Christine Chichester
Ontology Term : 'coagulation cascade pathway' added !
41301
view
00:23, 2 March 2011
MaintBot
Removed redundant pathway information and comments
38703
view
19:27, 23 September 2010
AlexanderPico
33690
view
22:22, 3 December 2009
Khanspers
Added connectors
33689
view
22:17, 3 December 2009
Khanspers
Periodical save, work in progress
33688
view
22:06, 3 December 2009
Khanspers
Periodical save, work in progress
33687
view
21:56, 3 December 2009
Khanspers
Periodical save, work in progress
22601
view
13:45, 14 November 2008
Thomas
Changed pathway title (was duplicate of WP200)
21624
view
11:32, 14 November 2008
MaintBot
[[Pathway:Mus musculus:Complement and Coagulation Cascades KEGG]] moved to [[Pathway:WP449]]: Moved to stable identifier
7974
view
13:46, 7 January 2008
MaintBot
[[Pathway:Mouse:Complement and Coagulation Cascades KEGG]] moved to [[Pathway:Mus musculus:Complement and Coagulation Cascades KEGG]]: Renaming species
7611
view
16:04, 18 December 2007
MaintBot
fixed category names
7468
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
6428
view
22:18, 22 May 2007
169.230.77.174
gpml file for [[Mouse:Complement_and_Coagulation_Cascades_KEGG]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
1700013L23Rik
GeneProduct
69379 (Entrez Gene)
A2m
GeneProduct
232345 (Entrez Gene)
Adn
GeneProduct
11537 (Entrez Gene)
Bdkrb1
GeneProduct
12061 (Entrez Gene)
Bradykinin
Metabolite
HMDB04246 (HMDB)
C1qa
GeneProduct
12259 (Entrez Gene)
C1qb
GeneProduct
12260 (Entrez Gene)
C1qg
GeneProduct
12262 (Entrez Gene)
C1r
GeneProduct
50909 (Entrez Gene)
C1s
GeneProduct
50908 (Entrez Gene)
C2
GeneProduct
12263 (Entrez Gene)
C3
GeneProduct
12266 (Entrez Gene)
C3ar1
GeneProduct
12267 (Entrez Gene)
C4
GeneProduct
12268 (Entrez Gene)
C4bp
GeneProduct
12269 (Entrez Gene)
C5r1
GeneProduct
12273 (Entrez Gene)
C6
GeneProduct
12274 (Entrez Gene)
C7
GeneProduct
109828 (Entrez Gene)
MGI:88235 LL:109828
C9
GeneProduct
12279 (Entrez Gene)
Cd59a
GeneProduct
12509 (Entrez Gene)
Cfh
GeneProduct
12628 (Entrez Gene)
Cfi
GeneProduct
12630 (Entrez Gene)
Cpb2
GeneProduct
56373 (Entrez Gene)
Cr1
GeneProduct
Cr2
GeneProduct
12902 (Entrez Gene)
Crry
GeneProduct
12946 (Entrez Gene)
Daf1
GeneProduct
13136 (Entrez Gene)
Daf2
GeneProduct
13137 (Entrez Gene)
F10
GeneProduct
14058 (Entrez Gene)
F11
GeneProduct
109821 (Entrez Gene)
F12
GeneProduct
58992 (Entrez Gene)
F13b
GeneProduct
14060 (Entrez Gene)
F2
GeneProduct
14061 (Entrez Gene)
F2r
GeneProduct
14062 (Entrez Gene)
F3
GeneProduct
14066 (Entrez Gene)
F5
GeneProduct
14067 (Entrez Gene)
F7
GeneProduct
14068 (Entrez Gene)
F8
GeneProduct
14069 (Entrez Gene)
F9
GeneProduct
14071 (Entrez Gene)
Fgb
GeneProduct
110135 (Entrez Gene)
H2-Bf
GeneProduct
14962 (Entrez Gene)
Hc
GeneProduct
15139 (Entrez Gene)
Klkb1
GeneProduct
16621 (Entrez Gene)
Kng1
GeneProduct
16644 (Entrez Gene)
Masp1
GeneProduct
17174 (Entrez Gene)
Masp2
GeneProduct
17175 (Entrez Gene)
Mbl1
GeneProduct
17194 (Entrez Gene)
Mcp
GeneProduct
17221 (Entrez Gene)
Plat
GeneProduct
18791 (Entrez Gene)
Plau
GeneProduct
18792 (Entrez Gene)
Plaur
GeneProduct
18793 (Entrez Gene)
Plg
GeneProduct
18815 (Entrez Gene)
Proc
GeneProduct
19123 (Entrez Gene)
Pros1
GeneProduct
19128 (Entrez Gene)
Serpina1
GeneProduct
20699 (Entrez Gene)
Serpina5
GeneProduct
268591 (Entrez Gene)
Serpinc1
GeneProduct
11905 (Entrez Gene)
Serpind1
GeneProduct
15160 (Entrez Gene)
Serpine1
GeneProduct
18787 (Entrez Gene)
Serpinf2
GeneProduct
18816 (Entrez Gene)
Serping1
GeneProduct
12258 (Entrez Gene)
Tfpi
GeneProduct
21788 (Entrez Gene)
Thbd
GeneProduct
21824 (Entrez Gene)
Vwf
GeneProduct
22371 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Discussion
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DataNodes
Annotated Interactions
No annotated interactions