Apoptosis (Pan troglodytes)

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MitochondrionbDNA FragmentationFas LigandIGF1R signaling pathwayeInhibitor of Cell DeathpeActivator of Cell DeathInterferon regulatory factorsApoptosisDegradationp53 RelatedbpCaspbTP53CHUKRHOXF2IRF6MDM2CASP8IGF1RTRAF1CASP7NFKBIBCASP2MAP3K1BIRC5TNFRSF25NFKBIATRAF3BIRC3RHOXF2CYCSCASP3DFFARELAJUNNFKBIBCASP1BOKRELABIDMYCTRAF2AKT1BCL2FADDPIK3R1BNIP3LIRF4TNFSF10CASP9IGF2CDKN2ANFKBIEGZMBIRF1APAF1CFLARRIPK1BCL2L1BAK1TNFRSF21TNFRSF1ARIPK1BCL2L2TNFRSF10BFASLGDFFBLTABIRC2DIABLOBAXTNFRSF1BTP73NFKBIAFASMCL1NFKB1IKBKGHRKCASP10XIAPCRADDNFKBIEIRF2TNFRSF1APMAIP1TRADDTRADDMAP2K4CASP4IKBKBBCL2L11MAPK10PRF1CASP6RHOXF2IGF1IRF5IRF7BADIRF3BBC3TNFNFKB1BADHELLS


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP254(r29955) with a 88% conversion rate.

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Ontology Terms

 

Bibliography

  1. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia
  2. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
87013view14:45, 15 July 2016MkutmonOntology Term : 'apoptotic cell death pathway' added !
69320view18:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
48144view18:35, 9 May 2012MaintBotUpdating from human to fix xrefs
41630view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
34357view22:24, 9 December 2009MaintBotAutomatic update of empty xrefs
33561view09:43, 1 December 2009MaintBotRemoved group label
30470view21:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene)
APAF1GeneProduct452153 (Entrez Gene)
BADGeneProduct
BAK1GeneProduct462616 (Entrez Gene)
BAXGeneProduct747093 (Entrez Gene)
BBC3GeneProduct746617 (Entrez Gene)
BCL2GeneProduct738409 (Entrez Gene)
BCL2L11GeneProduct459487 (Entrez Gene)
BCL2L1GeneProduct458156 (Entrez Gene)
BCL2L2GeneProduct
BIDGeneProduct458635 (Entrez Gene)
BIRC2GeneProduct451508 (Entrez Gene)
BIRC3GeneProduct451507 (Entrez Gene)
BIRC5GeneProduct455276 (Entrez Gene)
BNIP3LGeneProduct464069 (Entrez Gene)
BOKGeneProduct
CASP10GeneProduct
CASP1GeneProduct451519 (Entrez Gene)
CASP2GeneProduct463804 (Entrez Gene)
CASP3GeneProduct461669 (Entrez Gene)
CASP4GeneProduct451518 (Entrez Gene)
CASP6GeneProduct736606 (Entrez Gene)
CASP7GeneProduct450745 (Entrez Gene)
CASP8GeneProduct746477 (Entrez Gene)
CASP9GeneProduct456457 (Entrez Gene)
CDKN2AGeneProduct465021 (Entrez Gene)
CFLARGeneProduct459872 (Entrez Gene)
CHUKGeneProduct450673 (Entrez Gene)
CRADDGeneProduct452128 (Entrez Gene)
CYCSGeneProduct744779 (Entrez Gene)
DFFAGeneProduct457928 (Entrez Gene)
DFFBGeneProduct744932 (Entrez Gene)
DIABLOGeneProduct745126 (Entrez Gene)
FADDGeneProduct451389 (Entrez Gene)
FASGeneProduct738331 (Entrez Gene)
FASLGGeneProduct469584 (Entrez Gene)
GZMBGeneProduct452825 (Entrez Gene)
HELLSGeneProduct450624 (Entrez Gene)
HRKGeneProduct
IGF1GeneProduct741055 (Entrez Gene)
IGF1RGeneProduct453676 (Entrez Gene)
IGF2GeneProduct742381 (Entrez Gene)
IKBKBGeneProduct472749 (Entrez Gene)
IKBKGGeneProduct743415 (Entrez Gene)
IRF1GeneProduct745042 (Entrez Gene)
IRF2GeneProduct461629 (Entrez Gene)
IRF3GeneProduct747565 (Entrez Gene)
IRF4GeneProduct462386 (Entrez Gene)
IRF5GeneProduct472512 (Entrez Gene)
IRF6GeneProduct457701 (Entrez Gene)
IRF7GeneProduct450927 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
LTAGeneProduct744443 (Entrez Gene)
MAP2K4GeneProduct455065 (Entrez Gene)
MAP3K1GeneProduct471543 (Entrez Gene)
MAPK10GeneProduct461358 (Entrez Gene)
MCL1GeneProduct457274 (Entrez Gene)
MDM2GeneProduct742141 (Entrez Gene)
MYCGeneProduct464393 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
NFKBIAGeneProduct467426 (Entrez Gene)
NFKBIBGeneProduct456014 (Entrez Gene)
NFKBIEGeneProduct462730 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PMAIP1GeneProduct737247 (Entrez Gene)
PRF1GeneProduct450512 (Entrez Gene)
RELAGeneProduct466665 (Entrez Gene)
RHOXF2GeneProduct473763 (Entrez Gene)
RIPK1GeneProduct462397 (Entrez Gene)
TNFGeneProduct744399 (Entrez Gene)
TNFRSF10BGeneProduct742898 (Entrez Gene)
TNFRSF1AGeneProduct466934 (Entrez Gene)
TNFRSF1BGeneProduct457968 (Entrez Gene)
TNFRSF21GeneProduct462749 (Entrez Gene)
TNFRSF25GeneProduct749145 (Entrez Gene)
TNFSF10GeneProduct460852 (Entrez Gene)
TP53GeneProduct455214 (Entrez Gene)
TP73GeneProduct
TRADDGeneProduct454154 (Entrez Gene)
TRAF1GeneProduct743748 (Entrez Gene)
TRAF2GeneProduct
TRAF3GeneProduct453178 (Entrez Gene)
XIAPGeneProduct473765 (Entrez Gene)

Annotated Interactions

No annotated interactions
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