Hypothetical network for drug addiction (Pan troglodytes)

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1Gap junctionNeuroactive ligand-receptorinteractionNMDARAMPARStrong depolarizationLong-term potentiationMAPK signaling pathwayGonadotropins gene expression & secretionRegulation of gap junctionLocal TranslationmGluRRegulation of actin cytoskeletonGnRH Signal pathwayGRIA4CAMK2MAPK3DRD1GRIA3PKCCa++GRIN2BGJB7NR1MAPK1CAMK4MAP2K1PRKACAZHX2D-GlutamateGRIN2ADRD4GiGRIA1PPA1GJB7MAP2K2I-1RAP1GsDRD2GRIA2ADCY1GRM1CREB1GRIN2CGRIN2DPRKACAKRIT1GRM5ADCY1ADCY8ACTA1Cyclic AMP


Description

Adapted from figure 2 in Li et al..

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 70% conversion rate.

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Ontology Terms

 

Bibliography

  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118081view10:44, 24 May 2021EweitzModified title
107223view14:31, 17 September 2019MaintBotChEBI identifier normalization
102312view13:33, 18 December 2018EgonwFixed the ChEBI identifier for Ca2+
88659view15:15, 12 August 2016JmeliusOntology Term : 'substance dependence disease pathway' added !
69323view18:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
41633view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
34360view22:26, 9 December 2009MaintBotAutomatic update of empty xrefs
33537view09:36, 1 December 2009MaintBotRemoved group label
31571view21:59, 13 August 2009MaintBotFixed text labels
30442view21:23, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA1GeneProduct
ADCY1GeneProduct463392 (Entrez Gene)
ADCY8GeneProduct464400 (Entrez Gene)
CAMK2GeneProduct
CAMK4GeneProduct461992 (Entrez Gene)
CREB1GeneProduct459901 (Entrez Gene)
Ca++Metabolite29320 (ChEBI)
Cyclic AMPMetabolite17489 (ChEBI)
D-GlutamateMetabolite15966 (ChEBI)
DRD1GeneProduct
DRD2GeneProduct451553 (Entrez Gene)
DRD4GeneProduct449578 (Entrez Gene)
GJB7GeneProduct742067 (Entrez Gene)
GRIA1GeneProduct471714 (Entrez Gene)
GRIA2GeneProduct461570 (Entrez Gene)
GRIA3GeneProduct
GRIA4GeneProduct466768 (Entrez Gene)
GRIN2AGeneProduct454396 (Entrez Gene)
GRIN2BGeneProduct473373 (Entrez Gene)
GRIN2CGeneProduct454868 (Entrez Gene)
GRIN2DGeneProduct456180 (Entrez Gene)
GRM1GeneProduct463049 (Entrez Gene)
GRM5GeneProduct451472 (Entrez Gene)
GiGeneProduct
GsGeneProduct
I-1GeneProduct
KRIT1GeneProduct463528 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K2GeneProduct456390 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
NR1GeneProduct
PKCGeneProduct
PPA1GeneProduct748973 (Entrez Gene)
PRKACAGeneProduct455776 (Entrez Gene)
RAP1GeneProduct
ZHX2GeneProduct464363 (Entrez Gene)

Annotated Interactions

No annotated interactions
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