DNA replication (Rattus norvegicus)

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1-3Mcm4DNA polymerase alpha:primase: origin complexMcm10Mcm7Mcm6Degraded by proteasome in cytosolPrimasePhosphorylation ofMcm 2-7 complexMcm10Orc complexp70Cdt1Orc3Cdt1Mcm 4,6,7 trimer forms andassociates with the replication forkProcessive complexOrc4Orc3Mcm4Pre-replicative complexp180Pre-replicative complexOrc5Cdt1RFC36DNAPolymerase AMcm62. Activation of the pre-replicative complexOrc complexRFC37p49Cdc6Orc complexMcm5Ubiquitinated Cdc6RNA primer-DNA primer4. Switching of origins to post-replicative stateOrc complexUbiquitinated Orc1Orc2GemininUbiquitinOrc1Mcm7Orc3Phosphorylated Orc1UbiquitinOriginMcm3Orc2RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimer1. Assembly of the pre-replicative complexOrc5Mcm3RNA PrimerOrc complexCdc6RNA primer-DNA primer:origin duplex:PCNARFC140Orc2Cdt1Orc5Degraded byproteasomein cytosolRFC Heteropentamer:RNA primer-DNA primerPhosphorylated Cdc6DNA polymerase alpha:primase: origin complexCdt1Mcm55. Leading/lagging strand synthesisMcm2RNA primer-DNA primerCdc6RFC38p58Mcm2RFC40Orc23. DNA replication initiationCdc6Orc4Orc3Mcm5PoleOrc2lUbcPOLAMcm10Rpa2UTPPole2Rfc5RPA4Rpa3Cdc7ADPUba52GmnnOrc5lMcm7Prim2dCTPATPMcm2dGTPPola2Pold3Rfc3Orc1lADPdATPMcm3Mcm6ATPPcnaCTPATPOrc4lCdc6Pold2Cdk2ATPPold1Rfc2Dbf4Mcm4Cdc45lRpa1Cdt1Pold4PRIM1Rfc4Rfc1GTPdUTPOrc3lOrc6l


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 70% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116954view10:07, 16 May 2021EweitzModified title
71773view20:30, 17 October 2013MaintBotAutomated update of data sources
69342view18:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
67163view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41654view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
35215view15:47, 11 February 2010Thomasadded literature
35214view15:46, 11 February 2010ThomasModified description
35200view15:39, 11 February 2010ThomasModified description
34052view19:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32445view17:19, 15 August 2009MaintBotFixed text labels
32119view13:51, 14 August 2009MaintBotFixed group labels
31462view21:16, 13 August 2009MaintBotFixed text labels
30930view00:37, 30 July 2009MaintBotConverted from Homo sapiens
21698view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:DNA replication Reactome]] moved to [[Pathway:WP484]]: Moved to stable identifier
10211view18:29, 16 January 2008MaintBotSpecify description
10047view15:05, 11 January 2008MaintBot
7994view13:46, 7 January 2008MaintBot[[Pathway:Rat:DNA replication Reactome]] moved to [[Pathway:Rattus norvegicus:DNA replication Reactome]]: Renaming species
7211view12:33, 4 November 2007MaintBotAdded categories to GPML
19419view22:19, 22 May 2007D.Korengpml file for [[Rat:DNA_replication_Reactome]]
6530view22:19, 22 May 2007Kdahlquistgpml file for [[Rat:DNA_replication_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CTPMetabolite
Cdc45lGeneProduct287961 (Entrez Gene)
Cdc6GeneProduct360621 (Entrez Gene)
Cdc7GeneProduct360908 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene)
Cdt1GeneProduct292071 (Entrez Gene)
Dbf4GeneProduct312046 (Entrez Gene)
GTPMetabolite
GmnnGeneProduct291137 (Entrez Gene)
Mcm10GeneProduct307126 (Entrez Gene)
Mcm2GeneProduct312538 (Entrez Gene)
Mcm3GeneProduct316273 (Entrez Gene)
Mcm4GeneProduct29728 (Entrez Gene)
Mcm5GeneProduct291885 (Entrez Gene)
Mcm6GeneProduct29685 (Entrez Gene)
Mcm7GeneProduct288532 (Entrez Gene)
Orc1lGeneProduct313479 (Entrez Gene)
Orc2lGeneProduct301430 (Entrez Gene)
Orc3lGeneProduct313138 (Entrez Gene)
Orc4lGeneProduct295596 (Entrez Gene)
Orc5lGeneProduct362304 (Entrez Gene)
Orc6lGeneProduct291927 (Entrez Gene)
POLAGeneProduct
PRIM1GeneProduct246327 (Entrez Gene)
PcnaGeneProduct25737 (Entrez Gene)
Pola2GeneProduct85242 (Entrez Gene)
Pold1GeneProduct59294 (Entrez Gene)
Pold2GeneProduct289758 (Entrez Gene)
Pold3GeneProduct293144 (Entrez Gene)
Pold4GeneProduct361698 (Entrez Gene)
Pole2GeneProduct299112 (Entrez Gene)
PoleGeneProduct304573 (Entrez Gene)
Prim2GeneProduct301323 (Entrez Gene)
RPA4GeneProduct
Rfc1GeneProduct89809 (Entrez Gene)
Rfc2GeneProduct116468 (Entrez Gene)
Rfc3GeneProduct288414 (Entrez Gene)
Rfc4GeneProduct288003 (Entrez Gene)
Rfc5GeneProduct304528 (Entrez Gene)
Rpa1GeneProduct287524 (Entrez Gene)
Rpa2GeneProduct59102 (Entrez Gene)
Rpa3GeneProduct296883 (Entrez Gene)
UTPMetabolite
Uba52GeneProduct64156 (Entrez Gene)
UbcGeneProduct50522 (Entrez Gene)
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP484"
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