IL-2 signaling pathway (Rattus norvegicus)

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Proteolytic cleavagePlasma membraneCytoplasmLigand(Protein-protein interaction)MitochondrionPMCY -> NUDemethylationNucleusNucleusGolgi apparatusAcetylationDeacetylationDPhosphorylationNURecruitmentCY -> NUDDCY -> NUDephosphorylationNUDCY -> NUUbiquitinationMTDeubiquitinationMTCYDECERPhosphorylationDGODDAccession Number: NetPath 14CY -> NUENGene SymbolCY -> PMControlPalmitolyationTranslocationCY -> NUDMolecule in the pathwayActivationDPM -> CYReactions through unknown mechanisms/moleculesProteins in a complex interactionReceptorDesumoylationDInhibitionCY -> NUMolecular associationSumoylationCY -> NUEndosomeAutophosphorylationExtracellularEndoplasmic reticulumMethylationDGlycosylationEnzyme complexStat5aJak3CblMapk1TertCreb1Nfkb1Mapk14RelaMapk3Il2Ptpn11Raf1Gab2Jak2Pik3r2CrklSocs1Ybx1Sos1Mknk1Vav1TertMap2k2Ptpn6Il2Mapk9Mapk3Ets2Mapk1CrkLynIL2RBNmiPik3cbPik3r1Cd53Akt1ChukPrkczNfkb1CishStat5bPIK3CAIl2Akt1Ets1Gnb2l1RelaKrasLckNr3c1Foxo3Eif3s9Grb2CrkSykPik3cgHsp90aa1Stat3IFNA1Ybx1MtorPlcb1Il2Shc1StamIl2Ptk2bAkt1Mapkapk2Bcl2FynStat1Jak1Irs1Itm2bEif4eRaf1Il2raPik3cdStam2Rps6kb1Socs3Stat5bMapk8Icam1SHBIl2rgStat5aMap2k1Irs2


Description

Interleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a common gamma chain (γc), which is shared by all members of this family of cytokines. Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_14

Comments

GenMAPP notes 
NetPath 14 - IL-2 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 95% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116982view10:44, 16 May 2021EweitzModified title
115905view09:20, 20 March 2021EgonwCopied the NetPath paper into the literature list
115898view22:51, 19 March 2021EgonwModified description
89844view12:15, 6 October 2016MkutmonRemove GenMAPP notes
89843view12:15, 6 October 2016MkutmonModified description
77327view17:43, 19 August 2014Mkutmonupdated schema
67370view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
41720view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
35781view06:19, 13 February 2010MaintBotAdded description
34097view19:18, 9 December 2009MaintBotAutomatic update of empty xrefs
31477view21:22, 13 August 2009MaintBotFixed text labels
30922view00:34, 30 July 2009MaintBotConverted from Homo sapiens
21878view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:IL-2 NetPath 14]] moved to [[Pathway:WP569]]: Moved to stable identifier
8168view13:46, 7 January 2008MaintBot[[Pathway:Rat:IL-2 NetPath 14]] moved to [[Pathway:Rattus norvegicus:IL-2 NetPath 14]]: Renaming species
7704view16:11, 18 December 2007MaintBotfixed category names
7243view12:41, 4 November 2007MaintBotAdded categories to GPML
6559view22:20, 22 May 2007A.Pandeygpml file for [[Rat:IL-2_NetPath_14]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
Bcl2GeneProduct24224 (Entrez Gene)
CblGeneProduct500985 (Entrez Gene)
Cd53GeneProduct24251 (Entrez Gene)
ChukGeneProduct309361 (Entrez Gene)
CishGeneProduct83681 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
CrkGeneProduct54245 (Entrez Gene)
CrklGeneProduct287942 (Entrez Gene)
Eif3s9GeneProduct288516 (Entrez Gene)
Eif4eGeneProduct117045 (Entrez Gene)
Ets1GeneProduct24356 (Entrez Gene)
Ets2GeneProduct304063 (Entrez Gene)
Foxo3GeneProduct294515 (Entrez Gene)
FynGeneProduct25150 (Entrez Gene)
Gab2GeneProduct84477 (Entrez Gene)
Gnb2l1GeneProduct83427 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Hsp90aa1GeneProduct299331 (Entrez Gene)
IFNA1GeneProduct298210 (Entrez Gene)
IL2RBGeneProduct25746 (Entrez Gene)
Icam1GeneProduct25464 (Entrez Gene)
Il2GeneProduct116562 (Entrez Gene)
Il2raGeneProduct25704 (Entrez Gene)
Il2rgGeneProduct140924 (Entrez Gene)
Irs1GeneProduct25467 (Entrez Gene)
Irs2GeneProduct29376 (Entrez Gene)
Itm2bGeneProduct290364 (Entrez Gene)
Jak1GeneProduct84598 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
Jak3GeneProduct25326 (Entrez Gene)
KrasGeneProduct24525 (Entrez Gene)
LckGeneProduct313050 (Entrez Gene)
LynGeneProduct81515 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
Mapkapk2GeneProduct289014 (Entrez Gene)
Mknk1GeneProduct500526 (Entrez Gene)
MtorGeneProduct56718 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
NmiGeneProduct311021 (Entrez Gene)
Nr3c1GeneProduct24413 (Entrez Gene)
PIK3CAGeneProduct170911 (Entrez Gene)
Pik3cbGeneProduct85243 (Entrez Gene)
Pik3cdGeneProduct366508 (Entrez Gene)
Pik3cgGeneProduct298947 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Plcb1GeneProduct24654 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Ptk2bGeneProduct50646 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
Ptpn6GeneProduct116689 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
RelaGeneProduct309165 (Entrez Gene)
Rps6kb1GeneProduct83840 (Entrez Gene)
SHBGeneProduct
Shc1GeneProduct85385 (Entrez Gene)
Socs1GeneProduct252971 (Entrez Gene)
Socs3GeneProduct89829 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
Stam2GeneProduct311030 (Entrez Gene)
StamGeneProduct498798 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
SykGeneProduct25155 (Entrez Gene)
TertGeneProduct301965 (Entrez Gene)
Vav1GeneProduct25156 (Entrez Gene)
Ybx1GeneProduct500538 (Entrez Gene)

Annotated Interactions

No annotated interactions
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