Transcriptional activation by Nfe2l2 in response to phytochemicals (Rattus norvegicus)
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1
Phase II enzymes
S-P
CCAAT/XRE
T-P
ARE
S-P
Nucleus
T-P
Maf
Hmox1
Nfe2l2
PI3K
Nqo1
GSTA2
6-HITC
Cebpb
Jtv1
Ephb2
Gclc
Prkca
Gclm
Sulforaphane
Mapk8
Keap1
Nfe2l2
Caffeic acid phenethyl ester
Curcumin
Nfe2l2
Cebpb
Keap1
Description
Based on
Surh, 2003, figure 4
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP3(r29720)
with a 88% conversion rate.
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Ontology Terms
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Bibliography
Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
117033
view
14:04, 16 May 2021
Eweitz
Modified title
106949
view
13:41, 17 September 2019
MaintBot
HMDB identifier normalization
69424
view
19:02, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67420
view
10:59, 26 June 2013
Ddigles
Ontology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
48260
view
21:58, 17 May 2012
MaintBot
Automatic update of PubChem xrefs
41747
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02:40, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34118
view
19:26, 9 December 2009
MaintBot
Automatic update of empty xrefs
31880
view
12:40, 14 August 2009
MaintBot
Fixed group labels
30935
view
00:38, 30 July 2009
MaintBot
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
6-HITC
Metabolite
Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
Caffeic acid phenethyl ester
Metabolite
Cebpb
GeneProduct
24253 (Entrez Gene)
Curcumin
Metabolite
HMDB02269 (HMDB)
Ephb2
GeneProduct
313633 (Entrez Gene)
GSTA2
GeneProduct
24422 (Entrez Gene)
Gclc
GeneProduct
25283 (Entrez Gene)
Gclm
GeneProduct
29739 (Entrez Gene)
Hmox1
GeneProduct
24451 (Entrez Gene)
Jtv1
GeneProduct
288480 (Entrez Gene)
Keap1
GeneProduct
117519 (Entrez Gene)
Maf
GeneProduct
54267 (Entrez Gene)
Mapk8
GeneProduct
116554 (Entrez Gene)
Nfe2l2
GeneProduct
83619 (Entrez Gene)
Nqo1
GeneProduct
24314 (Entrez Gene)
PI3K
GeneProduct
Prkca
GeneProduct
24680 (Entrez Gene)
Sulforaphane
Metabolite
5350 (PubChem)
Annotated Interactions
No annotated interactions
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Pathway
Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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No annotated interactions