Proteasome degradation (Rattus norvegicus)

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Activators of20S ComplexBeta subunitsDeubiquitinates proteinsProteins to be DegradedAMP Ubiquitin/E1 ComplexUbiquitin/ProteinAlpha subunitsOxidatively DamagedCytosolic ProteinsDegrades only PeptidesE3/ProteinLid subunitsProteasome 26 S(PA700) (ATP dependent)Unfolds and DegradesIntact ProteinsUbiquitin/E2 ComplexProteasome 20SCatalytic Core (p45)Presentation by MHC class 1p45 ATPase SubunitPsmb3PSMD10HLA-BPsmc6Uchl1Psma6Psma4Psmd2Psmd11HIST1H2ABIfngUBBHLA-JPsmb7Nedd4Psmd5Rpn1Psma2HLA-CH2afxH2-M3Psmd1Psmd7Psmb10Psmc2Psme3Psme2Psmb6UCHL3Psmd13Ube2d2Psma5Ube2d1Psmc1Psmb1Uba7HLA-HPsmd4Psmd9Rpn2UbiquitinPsmd6ATPPsmd8Psmb8Psmc3Psma7Psmc5PSMA3Psmb2Psma1RT1-M5UbcPsmb5Psmb4Ube2bHLA-APsmd12Psme1Psmd3Psmc5Uba1H2afzPsmc4H2-T23Psmb9UBE2D3


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP183(r29614) with a 80% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia
  2. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117012view11:22, 16 May 2021EweitzModified title
95795view14:41, 19 January 2018MkutmonHomology conversion update
72157view11:58, 25 October 2013EgonwAdded a metabolite ID.
71801view20:34, 17 October 2013MaintBotAutomated update of data sources
71306view16:59, 17 October 2013MaintBotAutomated update of data sources
69432view19:04, 8 July 2013MaintBotUpdated to 2013 gpml schema
67613view11:33, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
62852view05:06, 3 May 2013MaintBotUpdated UniProt data source
58967view18:39, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41756view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34126view19:28, 9 December 2009MaintBotAutomatic update of empty xrefs
32391view16:59, 15 August 2009MaintBotFixed text labels
32039view13:28, 14 August 2009MaintBotFixed group labels
31426view21:00, 13 August 2009MaintBotFixed text labels
31020view01:08, 30 July 2009MaintBotConverted from Homo sapiens
21315view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Proteasome Degradation]] moved to [[Pathway:WP302]]: Moved to stable identifier
8352view13:46, 7 January 2008MaintBot[[Pathway:Rat:Proteasome Degradation]] moved to [[Pathway:Rattus norvegicus:Proteasome Degradation]]: Renaming species
7794view16:18, 18 December 2007MaintBotfixed category names
7487view12:42, 4 November 2007MaintBotAdded categories to GPML
6588view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Proteasome_Degradation]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite
H2-M3GeneProduct24747 (Entrez Gene)
H2-T23GeneProduct294228 (Entrez Gene)
H2afxGeneProduct500987 (Entrez Gene)
H2afzGeneProduct58940 (Entrez Gene)
HIST1H2ABGeneProduct
HLA-AGeneProduct
HLA-BGeneProduct
HLA-CGeneProduct
HLA-HGeneProduct
HLA-JGeneProduct
IfngGeneProduct25712 (Entrez Gene)
Nedd4GeneProduct25489 (Entrez Gene)
PSMA3GeneProduct29670 (Entrez Gene)
PSMD10GeneProduct116722 (Entrez Gene)
Psma1GeneProduct29668 (Entrez Gene)
Psma2GeneProduct29669 (Entrez Gene)
Psma4GeneProduct29671 (Entrez Gene)
Psma5GeneProduct29672 (Entrez Gene)
Psma6GeneProduct29673 (Entrez Gene)
Psma7GeneProduct29674 (Entrez Gene)
Psmb10GeneProduct291983 (Entrez Gene)
Psmb1GeneProduct94198 (Entrez Gene)
Psmb2GeneProduct29675 (Entrez Gene)
Psmb3GeneProduct29676 (Entrez Gene)
Psmb4GeneProduct58854 (Entrez Gene)
Psmb5GeneProduct29425 (Entrez Gene)
Psmb6GeneProduct29666 (Entrez Gene) U13393
Psmb7GeneProduct85492 (Entrez Gene)
Psmb8GeneProduct24968 (Entrez Gene)
Psmb9GeneProduct24967 (Entrez Gene)
Psmc1GeneProduct117263 (Entrez Gene)
Psmc2GeneProduct25581 (Entrez Gene)
Psmc3GeneProduct29677 (Entrez Gene)
Psmc4GeneProduct117262 (Entrez Gene) PRS6 HUMAN
Psmc5GeneProduct81827 (Entrez Gene) PRS6 HUMAN
Psmc6GeneProduct289990 (Entrez Gene)
Psmd11GeneProduct303353 (Entrez Gene)
Psmd12GeneProduct287772 (Entrez Gene)
Psmd13GeneProduct365388 (Entrez Gene)
Psmd1GeneProduct83806 (Entrez Gene)
Psmd2GeneProduct287984 (Entrez Gene)
Psmd3GeneProduct287670 (Entrez Gene)
Psmd4GeneProduct83499 (Entrez Gene)
Psmd5GeneProduct296651 (Entrez Gene)
Psmd6GeneProduct289924 (Entrez Gene)
Psmd7GeneProduct307821 (Entrez Gene)
Psmd8GeneProduct292766 (Entrez Gene)
Psmd9GeneProduct161475 (Entrez Gene)
Psme1GeneProduct29630 (Entrez Gene)
Psme2GeneProduct29614 (Entrez Gene)
Psme3GeneProduct287716 (Entrez Gene)
RT1-M5GeneProduct499400 (Entrez Gene)
Rpn1GeneProduct25596 (Entrez Gene)
Rpn2GeneProduct64701 (Entrez Gene)
UBBGeneProduct192255 (Entrez Gene)
UBE2D3GeneProduct81920 (Entrez Gene)
UCHL3GeneProduct498560 (Entrez Gene)
Uba1GeneProduct314432 (Entrez Gene)
Uba7GeneProduct301000 (Entrez Gene)
UbcGeneProduct50522 (Entrez Gene)
Ube2bGeneProduct81816 (Entrez Gene)
Ube2d1GeneProduct361831 (Entrez Gene)
Ube2d2GeneProduct641452 (Entrez Gene)
UbiquitinProtein
Uchl1GeneProductENSRNOG00000002343 (Ensembl Rat)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP302"
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