Eukaryotic transcription initiation (Rattus norvegicus)

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1, 2RNA polymerase ITATATFIIBTFIIFTATAPrimary RNA transcriptTFIIF5TFIIE53(small stable RNAs)Steps 3) DNA melting by association with TFIIHRNA polymerase IIITFIIATFIIHTFIIDTATA3(large ribosomal RNAs)55Steps 1) TBP binds TATA boxTFIIFcell growthSteps 2) Association of TIFs and RNA polymeraseTFIIA3Steps 4) Transcription elongation by NTPs3TATA Box bindingprotein5Gene Regulatory ProteinsRNA pol II53TFIIE5TFIIH355RNA polymerase II3TFIIB(recognize surface DNA geometry)dsDNASteps 5) RNA elongation with CDT phosphorylation33TFIIDTranscription Initiation Factors (TIFs)5(mRNA, snRNPs)Polr2eTaf13TbpTaf9Gtf2h4Ercc3IlkTaf7Taf5Polr2gPolr2jGtf2h1TAF12Gtf2f2Gtf2e2Polr2bPOLR2HTaf6Polr3dGtf2e1Gtf2a2Polr2fGstt2Polr3hPolr2iPOLR2KPolr1bPolr2cPolr3kPOLR1DGtf2h3Polr3eGtf2bMnat1Gtf2h2CcnhPolr3bPolr2aCdk7ERCC2Polr1a


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP405(r29565) with a 87% conversion rate.

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Bibliography

  1. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  2. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116960view10:09, 16 May 2021EweitzModified title
69450view19:06, 8 July 2013MaintBotUpdated to 2013 gpml schema
67214view10:22, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
47778view05:46, 6 April 2012Khanspersupdated xref
41779view02:42, 2 March 2011MaintBotRemoved redundant pathway information and comments
35532view14:03, 12 February 2010Thomasadded literature
35521view13:53, 12 February 2010ThomasModified description
34505view23:39, 16 December 2009KhanspersAdded connectors
34147view19:35, 9 December 2009MaintBotAutomatic update of empty xrefs
32446view17:20, 15 August 2009MaintBotFixed text labels
32120view13:51, 14 August 2009MaintBotFixed group labels
31465view21:17, 13 August 2009MaintBotFixed text labels
31008view01:04, 30 July 2009MaintBotConverted from Homo sapiens
21712view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:RNA transcription Reactome]] moved to [[Pathway:WP491]]: Moved to stable identifier
8370view13:46, 7 January 2008MaintBot[[Pathway:Rat:RNA transcription Reactome]] moved to [[Pathway:Rattus norvegicus:RNA transcription Reactome]]: Renaming species
7803view16:18, 18 December 2007MaintBotfixed category names
7288view12:41, 4 November 2007MaintBotAdded categories to GPML
6589view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:RNA_transcription_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CcnhGeneProduct84389 (Entrez Gene)
Cdk7GeneProduct171150 (Entrez Gene)
ERCC2GeneProduct308415 (Entrez Gene)
Ercc3GeneProduct291703 (Entrez Gene)
Gstt2GeneProduct29487 (Entrez Gene)
Gtf2a2GeneProduct83828 (Entrez Gene)
Gtf2bGeneProduct81673 (Entrez Gene)
Gtf2e1GeneProduct303918 (Entrez Gene)
Gtf2e2GeneProduct306516 (Entrez Gene)
Gtf2f2GeneProduct81674 (Entrez Gene)
Gtf2h1GeneProduct361580 (Entrez Gene)
Gtf2h2GeneProduct294693 (Entrez Gene)
Gtf2h3GeneProduct288651 (Entrez Gene)
Gtf2h4GeneProduct294236 (Entrez Gene)
IlkGeneProduct170922 (Entrez Gene)
Mnat1GeneProduct266713 (Entrez Gene)
POLR1DGeneProduct
POLR2HGeneProduct498109 (Entrez Gene)
POLR2KGeneProduct309224 (Entrez Gene)
Polr1aGeneProduct83581 (Entrez Gene)
Polr1bGeneProduct83582 (Entrez Gene)
Polr2aGeneProduct363633 (Entrez Gene)
Polr2bGeneProduct289561 (Entrez Gene)
Polr2cGeneProduct361365 (Entrez Gene)
Polr2eGeneProduct690966 (Entrez Gene)
Polr2fGeneProduct83503 (Entrez Gene)
Polr2gGeneProduct117017 (Entrez Gene)
Polr2iGeneProduct292778 (Entrez Gene)
Polr2jGeneProduct288588 (Entrez Gene)
Polr3bGeneProduct362858 (Entrez Gene)
Polr3dGeneProduct306012 (Entrez Gene)
Polr3eGeneProduct361640 (Entrez Gene)
Polr3hGeneProduct300088 (Entrez Gene)
Polr3kGeneProduct366277 (Entrez Gene)
TAF12GeneProduct682902 (Entrez Gene)
Taf13GeneProduct310784 (Entrez Gene)
Taf5GeneProduct294018 (Entrez Gene)
Taf6GeneProduct288533 (Entrez Gene)
Taf7GeneProduct307485 (Entrez Gene)
Taf9GeneProduct373541 (Entrez Gene)
TbpGeneProduct117526 (Entrez Gene)

Annotated Interactions

No annotated interactions
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