Immunoregulatory interactions between lymphoid and non-lymphoid cells (Homo sapiens)

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20, 211, 9, 10191831-33281, 9, 1022, 231411-131, 9, 1052926, 27301, 9, 101, 9, 101, 9, 1024, 2515, 166-8171, 9, 104, 522, 23cellcellcellcellKIR2DS1 complexed with DAP12MHC Class I interacting with LILRsCytotoxic and regulatory T cell moleculeTCR interacting with antigen-bearing MHC Class INatural killer cells antigen CD94-1HLA-GE-cadherin bound to KLRG1VCAM1HLA-Bw4CD160 antigen precursorVLA-4CD40 complexed with CD40LKiller cell lectin-like receptor subfamily G member 1Antigen peptide bound class I MHCT-cell receptor complex with CD8Poliovirus receptor related protein 2 precursorComplex of CD19, CD81, CD225 and CD21 with C3d-bound AntigenKiller cell immunoglobulin-like receptor 2DL1 precursorCD226 bound to nectin-like 5Nectin-like 5 bound to CD96HLA Bw4 interacting with KIR3DL1L-selectinCoxsackievirus and adenovirus receptorNKG2D ligandHLA-C group-I-interacting KIRsLymphoid-expressed Fc-gamma receptorsHLA-C group 2 interacting with KIR2DS1Poliovirus receptor precursorIntegrin alpha4beta7KIR2DS2 complexed with DAP12Killer cell immunoglobulin-like receptor 3DL1 precursorCadherin-1L-selectin ligandsCD226 antigen precursorHLA-C group 2 interacting with KIR2DL1LILR setLFA-1:ICAM 1-4OX-2 membrane glycoprotein precursorKiller cell immunoglobulin-like receptor 2DL4 precursorHLA-C group 1 interacting with KIR2DL2/3Killer cell immunoglobulin-like receptor 3DL2 precursorHLA-C group 1 interacting with KIR2DS2Integrin alphaLbeta2 (LFA-1)CRTAM bound to NECL2NKG2D complexed with DAP10Complex of CD19, CD81, CD225 and CD21MHC Class I molecules interacting with CD160CXADR bound to JAMLLILR-interacting MHC Class I moleculesMADCAM1ICAM 1-4NKG2-A/NKG2-B type II integral membrane proteinIntegrin alpha4beta7:MADCAM1HLA-E interacting with NKG2A-CD94 heterdimerJunctional adhesion molecule-like precursorHLA-A3 interacting with KIR3DL2HLA-ET-cell surface protein tactile precursorCD226 bound to Nectin 2MHC Class I interacting with CD160Tumor necrosis factor receptor superfamily member 5HLA-A3C3d complexed with antigenAntigen-bound Ig G AntibodyL-selectin interacting with known ligandsHLA-C Cw4 (group I)HLA-G interacting with KIR2DL4Antigen-bound antibody bound to lymphoid Fc gamma receptorsCD200 bound to CD200RHLA-C Cw3 (group 2)Ligand interacting with NKG2DVLA-4:VCAM-1Tumor necrosis factor ligand superfamily member 5Cell surface glycoprotein OX2 receptor precursor1, 21, 21, 21, 23


Description

A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms.

<p>Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation. Somatic cells are also able to report internal functional impairment by displaying surface stress markers such as MICA. The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors.<p><p>Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation.<p><p>Furthermore, there are a number of avenues through which lymphoid cells may interact with antigen. This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. Activated complement factor C3d binds to both antigen and to cell surface receptor CD21. In such cases, the far-reaching influence of CD19 on B-lymphocyte function is tempered by its interaction with CD21.</div>

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Bibliography

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History

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CompareRevisionActionTimeUserComment
117760view12:54, 22 May 2021EweitzModified title
112459view15:41, 9 October 2020ReactomeTeamReactome version 73
101366view11:25, 1 November 2018ReactomeTeamreactome version 66
100904view21:00, 31 October 2018ReactomeTeamreactome version 65
100445view19:35, 31 October 2018ReactomeTeamreactome version 64
99994view16:18, 31 October 2018ReactomeTeamreactome version 63
99548view14:53, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99181view12:42, 31 October 2018ReactomeTeamreactome version 62
96981view18:21, 24 April 2018AlexanderPicoReverted to version '06:43, 16 August 2017' by AlexanderPico
96973view15:45, 24 April 2018WpblockedModified title
93898view13:43, 16 August 2017ReactomeTeamreactome version 61
93471view11:24, 9 August 2017ReactomeTeamreactome version 61
86567view09:21, 11 July 2016ReactomeTeamreactome version 56
83164view10:14, 18 November 2015ReactomeTeamVersion54
81523view13:03, 21 August 2015ReactomeTeamVersion53
76993view08:28, 17 July 2014ReactomeTeamFixed remaining interactions
76698view12:06, 16 July 2014ReactomeTeamFixed remaining interactions
76024view10:08, 11 June 2014ReactomeTeamRe-fixing comment source
75733view11:21, 10 June 2014ReactomeTeamReactome 48 Update
75083view14:03, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74730view08:48, 30 April 2014ReactomeTeamReactome46
68927view17:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
44851view09:50, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to immunity' added !
42000view21:22, 4 March 2011MaintBotAutomatic update
39855view05:53, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Antigen peptide

bound class I MHC

ComplexREACT_11766 (Reactome)
Antigen-bound

Ig G Antibody

ComplexREACT_11894 (Reactome) In view of the highly variable nature of antibody proteins, this biological object is an approximate and fragmented representation of an IgM/IgD antibody, given the limitations of Ig chain enumeration in UniProt. A single mRNA transcript is alternatively spliced to give either IgM or IgD. Thus unactivated B cells contain both classes of antibody.
Antigen-bound

antibody bound to lymphoid Fc gamma receptors

ComplexREACT_11822 (Reactome)
C3d

complexed with antigen

ComplexREACT_11562 (Reactome)
CD160 antigen

precursor

ProteinO95971 (UniProt)
CD200

bound to CD200R

ComplexREACT_11641 (Reactome)
CD226 antigen

precursor

ProteinQ15762 (UniProt)
CD226 bound

to Nectin 2

ComplexREACT_11703 (Reactome)
CD226 bound to

nectin-like 5

ComplexREACT_11602 (Reactome)
CD40

complexed with CD40L

ComplexREACT_11386 (Reactome)
CRTAM

bound to NECL2

ComplexREACT_11356 (Reactome)
CXADR

bound to JAML

ComplexREACT_11619 (Reactome)
Cadherin-1 ProteinP12830 (UniProt)
Cell surface

glycoprotein OX2 receptor precursor

ProteinQ8TD46 (UniProt)
Complex of

CD19, CD81, CD225 and CD21

ComplexREACT_11777 (Reactome)
Complex of

CD19, CD81, CD225 and CD21 with C3d-bound Antigen

ComplexREACT_11584 (Reactome)
Coxsackievirus and

adenovirus receptor

ProteinP78310 (UniProt)
Cytotoxic and

regulatory T cell molecule

ProteinO95727 (UniProt)
E-cadherin

bound to KLRG1

ComplexREACT_11260 (Reactome)
HLA Bw4

interacting with KIR3DL1

ComplexREACT_11950 (Reactome)
HLA-A3 ComplexREACT_11726 (Reactome)
HLA-A3 interacting

with KIR3DL2

ComplexREACT_11887 (Reactome)
HLA-Bw4 ComplexREACT_11642 (Reactome)
HLA-C

group 2 interacting with KIR2DL1

ComplexREACT_11338 (Reactome)
HLA-C

group-I- interacting KIRs

ProteinREACT_11748 (Reactome)
HLA-C Cw3

(group 2)

ComplexREACT_11404 (Reactome)
HLA-C Cw4

(group I)

ComplexREACT_11388 (Reactome)
HLA-C group 1

interacting with KIR2DL2/3

ComplexREACT_11577 (Reactome)
HLA-C group 1

interacting with KIR2DS2

ComplexREACT_11521 (Reactome)
HLA-C group 2

interacting with KIR2DS1

ComplexREACT_11864 (Reactome)
HLA-E ComplexREACT_11603 (Reactome)
HLA-E interacting

with NKG2A-CD94 heterdimer

ComplexREACT_11770 (Reactome)
HLA-G ComplexREACT_11699 (Reactome)
HLA-G

interacting with KIR2DL4

ComplexREACT_11741 (Reactome)
ICAM 1-4 ProteinREACT_11859 (Reactome)
Integrin

alpha4beta7

ComplexREACT_11974 (Reactome)
Integrin

alpha4beta7: MADCAM1

ComplexREACT_11447 (Reactome)
Integrin

alphaLbeta2 (LFA-1)

ComplexREACT_11837 (Reactome)
Junctional adhesion

molecule-like precursor

ProteinQ86YT9-1 (UniProt)
KIR2DS1

complexed with DAP12

ComplexREACT_11752 (Reactome)
KIR2DS2

complexed with DAP12

ComplexREACT_11717 (Reactome)
Killer cell

immunoglob ulin-like receptor 2DL1 precursor

ProteinP43626 (UniProt)
Killer cell

immunoglobulin- like receptor 2DL4 precursor

ProteinQ99706 (UniProt)
Killer cell

immunoglobulin- like receptor 3DL1 precursor

ProteinP43629 (UniProt)
Killer cell

immunoglobulin- like receptor 3DL2 precursor

ProteinP43630 (UniProt)
Killer cell lectin-

like receptor subfamily G member 1

ProteinQ96E93 (UniProt)
L-selectin ProteinP14151 (UniProt)
L-selectin

interacting with known ligands

ComplexREACT_11760 (Reactome)
L-selectin ligands ProteinREACT_11759 (Reactome)
LFA-1:ICAM 1-4 ComplexREACT_11942 (Reactome)
LILR set ProteinREACT_11576 (Reactome)
LILR-interacting

MHC Class I molecules

ComplexREACT_11528 (Reactome)
Ligand

interacting with NKG2D

ComplexREACT_11751 (Reactome)
Lymphoid-

expressed Fc- gamma receptors

ProteinREACT_11814 (Reactome)
MADCAM1 ProteinQ13477-1 (UniProt)
MHC Class I

interacting with CD160

ComplexREACT_11275 (Reactome)
MHC Class I

interacting with LILRs

ComplexREACT_11656 (Reactome)
MHC Class I

molecules interacting with CD160

ComplexREACT_11830 (Reactome)
NKG2-

A/NKG2-B type II integral membrane protein

ProteinP26715-1 (UniProt)
NKG2D

complexed with DAP10

ComplexREACT_11468 (Reactome)
NKG2D

ligand

ProteinREACT_11351 (Reactome)
Natural killer

cells antigen CD94-1

ProteinQ13241-1 (UniProt)
Nectin-like 5 bound

to CD96

ComplexREACT_11952 (Reactome)
OX-2 membrane

glycoprotein precursor

ProteinP41217 (UniProt)
Poliovirus

receptor related protein 2 precursor

ProteinQ92692-1 (UniProt)
Poliovirus receptor

precursor

ProteinP15151-1 (UniProt)
T-cell receptor

complex with CD8

ComplexREACT_11534 (Reactome)
T-cell surface

protein tactile precursor

ProteinP40200 (UniProt)
TCR interacting

with antigen- bearing MHC Class I

ComplexREACT_11723 (Reactome)
Tumor necrosis

factor ligand superfamily member 5

ProteinP29965 (UniProt)
Tumor necrosis

factor receptor superfamily member 5

ProteinP25942-1 (UniProt)
VCAM1 ProteinP19320 (UniProt)
VLA-4 ComplexREACT_11798 (Reactome)
VLA-4:VCAM-1 ComplexREACT_11750 (Reactome)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1829"
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