Cell surface interactions at the vascular wall (Homo sapiens)

From WikiPathways

Revision as of 21:50, 4 March 2011 by MaintBot (Talk | contribs)
Jump to: navigation, search
1-64, 37-394, 35462, 634, 5166, 671464, 657928, 321917, 259, 59, 6071617869775, 504, 3422, 237052, 5317, 185457, 5880-82754, 40-426918, 2124197226-2955, 5618, 2048, 498330, 3112, 13683318, 2118, 22, 2345-47734, 43, 446074764, 36plasma membraneplasma membraneGolgi lumenGolgi membranecytosolMERTK ligandsMonocarboxylate Transporter Set (MCT)JAM2ADPCyP60 complexed with BasiginpTie2:Ang-1VLA-4SOS-1 bound to Tie2:Grb2Integrin alpha5beta1Collagen IGrb2 bound to Tie2Basigin:Mannose-carrying cell recognition moleculesP-selectin glycoprotein ligand 1 precursorTie2/Ang1 dimerPeptidyl-prolyl cis-trans isomerase like 2p21 RAS:GTPGTPMannose-carrying cell recognition moleculesOxidized low-density lipoprotein receptor 1Heparan SulphateAngiopoietin-4Integrin alphaMbeta2:JAM3Complex of Tie2:Ang2Son of sevenless protein homolog 1Basigin:CD98hc complexp85 bound to Tie2ADPP-selectin bound to its ligandPI3KCD98hc complexGrb14Ligand to TREM-1 on the platelet membraneTie2 and Grb14 complexGPVI:FceRI gamma:FYN:LYN:Collagen IAngiopoietin 1 receptor precursorpTie2 and SHP2 complexCD47Integrin alphaVbeta3:PECAM-1SHIP1activated thrombin:thrombomodulinIntegrin alphaXbeta2Tie2:Grb7 complexphosphorylated PECAM-1Basigin:MMP1LFA-1:JAM-ABasigin bound to MCTsBasigin bound to CyPAcaveolin-1Angiopoietin-1SHC1VLA-4: JAM-BCD84 HomodimerTie2 and Dok-2 complexJAM3Coxsackievirus and adenovirus receptorATPAngiopoietin-2Integrin alpha5beta1:FibronectinCD84Junctional adhesion molecule-like precursorTriggering receptor expressed on myeloid cells 1 precursorpTie2:SHC1 complexATPManganeseCD48 bound to CD244Neutrophil CEACAMs affecting integrin binding to fibronectinJAM-C homodimerSrc family tyrosine kinasesPhosphorylated Tie2 in Tie2/Akt dimerPECAM-1:SHP-2 complexPECAM-1:PECAM-1Caveolin-1 bound to BasiginTREM-1 bound to its ligandPECAM-1:PLC gamma1 complexGRB2JAM-A HomodimerGrb7CEACAM heterodimerPECAM-1:SHIP1 complexBasigin bound to CD43activated protein CCXADR bound to JAMLMERTK bound to its ligandLeukosialin precursorIntegrin alphaXbeta2:JAMLprotein C heavy chain activation peptidePECAM-1 bound to CD177PECAM-1:SHP-1 complexLDLMatrix metalloproteinase-1Platelet Factor 4JAM-AGDPIntegrin alphaVbeta3SHP1CD58 bound to CD2Basigin-binding integrinsPhospholipase C gamma 1B-lymphocyte activation marker BLAST-1 precursorSelectinDocking protein 2protein CT-cell surface antigen CD2 precursorPECAM-1CD47-binding SIRPsGPVI:FceRI gamma:FYN:LYNSHP2Proto-oncogene tyrosine-protein kinase MER precursorNatural killer cell receptor 2B4 precursorCD47 bound to its ligandJunctional adhesion molecule-like (JAML)Lymphocyte function-associated antigen 3 precursorIntegrin alphaMbeta2CypA proteinJAM-B homodimerBasigin homodimerTie2 and Ang4 complexp-PECAM1:p-PECAM1CD177 antigen precursorFibronectin dimerBasigin precursorOLR1 bound to oxidized LDLComplex of Tie2:Ang-1JAM-B bound to JAM-Cp21 RAS:GDPBasigin precursorBasigin bound to integrinsIntegrin alphaLbeta2 (LFA-1)10, 111598141610-1279131610-12


Description

Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates.

Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established.<p>

This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury.</div>

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Jones N, Dumont DJ.; ''The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.''; PubMed Europe PMC Scholia
  2. Huang H, Cruz F, Bazzoni G.; ''Junctional adhesion molecule-A regulates cell migration and resistance to shear stress.''; PubMed Europe PMC Scholia
  3. Hafizi S, Dahlbäck B.; ''Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.''; PubMed Europe PMC Scholia
  4. Yan Q, Malashkevich VN, Fedorov A, Fedorov E, Cao E, Lary JW, Cole JL, Nathenson SG, Almo SC.; ''Structure of CD84 provides insight into SLAM family function.''; PubMed Europe PMC Scholia
  5. Hua CT, Gamble JR, Vadas MA, Jackson DE.; ''Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates.''; PubMed Europe PMC Scholia
  6. Esmon CT.; ''The roles of protein C and thrombomodulin in the regulation of blood coagulation.''; PubMed Europe PMC Scholia
  7. Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R.; ''MIF signal transduction initiated by binding to CD74.''; PubMed Europe PMC Scholia
  8. Guo H, Li R, Zucker S, Toole BP.; ''EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface.''; PubMed Europe PMC Scholia
  9. Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP.; ''CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.''; PubMed Europe PMC Scholia
  10. Wanaguru M, Crosnier C, Johnson S, Rayner JC, Wright GJ.; ''Biochemical analysis of the Plasmodium falciparum erythrocyte-binding antigen-175 (EBA175)-glycophorin-A interaction: implications for vaccine design.''; PubMed Europe PMC Scholia
  11. Litvinov SV, Balzar M, Winter MJ, Bakker HA, Briaire-de Bruijn IH, Prins F, Fleuren GJ, Warnaar SO.; ''Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins.''; PubMed Europe PMC Scholia
  12. Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM.; ''An antagonist decoy receptor and a death domain-containing receptor for TRAIL.''; PubMed Europe PMC Scholia
  13. Kontos CD, Stauffer TP, Yang WP, York JD, Huang L, Blanar MA, Meyer T, Peters KG.; ''Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.''; PubMed Europe PMC Scholia
  14. Messmer B, Eissmann P, Stark S, Watzl C.; ''CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells.''; PubMed Europe PMC Scholia
  15. Kalinowska A, Losy J.; ''PECAM-1, a key player in neuroinflammation.''; PubMed Europe PMC Scholia
  16. Xu Y, Yu Q.; ''Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region.''; PubMed Europe PMC Scholia
  17. Pumphrey NJ, Taylor V, Freeman S, Douglas MR, Bradfield PF, Young SP, Lord JM, Wakelam MJ, Bird IN, Salmon M, Buckley CD.; ''Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31.''; PubMed Europe PMC Scholia
  18. Yoshida S, Shibata M, Yamamoto S, Hagihara M, Asai N, Takahashi M, Mizutani S, Muramatsu T, Kadomatsu K.; ''Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain.''; PubMed Europe PMC Scholia
  19. Trzpis M, McLaughlin PM, de Leij LM, Harmsen MC.; ''Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule.''; PubMed Europe PMC Scholia
  20. Huang L, Turck CW, Rao P, Peters KG.; ''GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.''; PubMed Europe PMC Scholia
  21. Blois SM, Sulkowski G, Tirado-González I, Warren J, Freitag N, Klapp BF, Rifkin D, Fuss I, Strober W, Dveksler GS.; ''Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice.''; PubMed Europe PMC Scholia
  22. Lisboa FA, Warren J, Sulkowski G, Aparicio M, David G, Zudaire E, Dveksler GS.; ''Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans.''; PubMed Europe PMC Scholia
  23. Hafizi S, Dahlbäck B.; ''Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily.''; PubMed Europe PMC Scholia
  24. Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M, Aurrand-Lions M, Imhof BA.; ''JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.''; PubMed Europe PMC Scholia
  25. Haselmayer P, Grosse-Hovest L, von Landenberg P, Schild H, Radsak MP.; ''TREM-1 ligand expression on platelets enhances neutrophil activation.''; PubMed Europe PMC Scholia
  26. Jackson SP, Mistry N, Yuan Y.; ''Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton.''; PubMed Europe PMC Scholia
  27. Farias E, Lu M, Li X, Schnapp LM.; ''Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.''; PubMed Europe PMC Scholia
  28. Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO.; ''Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule.''; PubMed Europe PMC Scholia
  29. Mayer DC, Cofie J, Jiang L, Hartl DL, Tracy E, Kabat J, Mendoza LH, Miller LH.; ''Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1.''; PubMed Europe PMC Scholia
  30. Ordonez C, Zhai AB, Camacho-Leal P, Demarte L, Fan MM, Stanners CP.; ''GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction.''; PubMed Europe PMC Scholia
  31. Melchers F, Karasuyama H, Haasner D, Bauer S, Kudo A, Sakaguchi N, Jameson B, Rolink A.; ''The surrogate light chain in B-cell development.''; PubMed Europe PMC Scholia
  32. Tang W, Hemler ME.; ''Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering.''; PubMed Europe PMC Scholia
  33. Bradfield PF, Nourshargh S, Aurrand-Lions M, Imhof BA.; ''JAM family and related proteins in leukocyte migration (Vestweber series).''; PubMed Europe PMC Scholia
  34. Weber C, Fraemohs L, Dejana E.; ''The role of junctional adhesion molecules in vascular inflammation.''; PubMed Europe PMC Scholia
  35. Yurchenko V, Zybarth G, O'Connor M, Dai WW, Franchin G, Hao T, Guo H, Hung HC, Toole B, Gallay P, Sherry B, Bukrinsky M.; ''Active site residues of cyclophilin A are crucial for its signaling activity via CD147.''; PubMed Europe PMC Scholia
  36. Berditchevski F, Chang S, Bodorova J, Hemler ME.; ''Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6.''; PubMed Europe PMC Scholia
  37. Foster DC, Sprecher CA, Holly RD, Gambee JE, Walker KM, Kumar AA.; ''Endoproteolytic processing of the dibasic cleavage site in the human protein C precursor in transfected mammalian cells: effects of sequence alterations on efficiency of cleavage.''; PubMed Europe PMC Scholia
  38. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y.; ''CATs and HATs: the SLC7 family of amino acid transporters.''; PubMed Europe PMC Scholia
  39. Ostermann G, Weber KS, Zernecke A, Schröder A, Weber C.; ''JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.''; PubMed Europe PMC Scholia
  40. Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD.; ''Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.''; PubMed Europe PMC Scholia
  41. Woodfin A, Reichel CA, Khandoga A, Corada M, Voisin MB, Scheiermann C, Haskard DO, Dejana E, Krombach F, Nourshargh S.; ''JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.''; PubMed Europe PMC Scholia
  42. McMullen BA, Fujikawa K, Kisiel W.; ''The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens.''; PubMed Europe PMC Scholia
  43. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD.; ''Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.''; PubMed Europe PMC Scholia
  44. Furie B, Furie BC.; ''The molecular basis of platelet and endothelial cell interaction with neutrophils and monocytes: role of P-selectin and the P-selectin ligand, PSGL-1.''; PubMed Europe PMC Scholia
  45. Jones N, Dumont DJ.; ''Tek/Tie2 signaling: new and old partners.''; PubMed Europe PMC Scholia
  46. Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD.; ''Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.''; PubMed Europe PMC Scholia
  47. Tangye SG, Phillips JH, Lanier LL.; ''The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells.''; PubMed Europe PMC Scholia
  48. Seitz HM, Camenisch TD, Lemke G, Earp HS, Matsushima GK.; ''Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells.''; PubMed Europe PMC Scholia
  49. Wilson MC, Meredith D, Halestrap AP.; ''Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ.''; PubMed Europe PMC Scholia
  50. Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, Zimmerman PA, Cowman AF.; ''Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.''; PubMed Europe PMC Scholia
  51. McDonald KJ, Cameron AJ, Allen JM, Jardine AG.; ''Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy.''; PubMed Europe PMC Scholia
  52. da Costa Martins P, García-Vallejo JJ, van Thienen JV, Fernandez-Borja M, van Gils JM, Beckers C, Horrevoets AJ, Hordijk PL, Zwaginga JJ.; ''P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium.''; PubMed Europe PMC Scholia
  53. Newton JP, Buckley CD, Jones EY, Simmons DL.; ''Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31.''; PubMed Europe PMC Scholia
  54. Loughna S, Sato TN.; ''Angiopoietin and Tie signaling pathways in vascular development.''; PubMed Europe PMC Scholia
  55. Wilkins AL, Yang W, Yang JJ.; ''Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design.''; PubMed Europe PMC Scholia
  56. Langer HF, Daub K, Braun G, Schönberger T, May AE, Schaller M, Stein GM, Stellos K, Bueltmann A, Siegel-Axel D, Wendel HP, Aebert H, Roecken M, Seizer P, Santoso S, Wesselborg S, Brossart P, Gawaz M.; ''Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro.''; PubMed Europe PMC Scholia
  57. Tsuji M, Ezumi Y, Arai M, Takayama H.; ''A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.''; PubMed Europe PMC Scholia
  58. Newton JP, Hunter AP, Simmons DL, Buckley CD, Harvey DJ.; ''CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylated.''; PubMed Europe PMC Scholia
  59. Xu D, Hemler ME.; ''Metabolic activation-related CD147-CD98 complex.''; PubMed Europe PMC Scholia
  60. Khunkaewla P, Schiller HB, Paster W, Leksa V, Cermák L, Andera L, Horejsí V, Stockinger H.; ''LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147.''; PubMed Europe PMC Scholia
  61. Han DC, Shen TL, Guan JL.; ''The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions.''; PubMed Europe PMC Scholia
  62. Piali L, Hammel P, Uherek C, Bachmann F, Gisler RH, Dunon D, Imhof BA.; ''CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.''; PubMed Europe PMC Scholia
  63. Schröder AK, Uciechowski P, Fleischer D, Rink L.; ''Crosslinking of CD66B on peripheral blood neutrophils mediates the release of interleukin-8 from intracellular storage.''; PubMed Europe PMC Scholia
  64. Bayas MV, Kearney A, Avramovic A, van der Merwe PA, Leckband DE.; ''Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58.''; PubMed Europe PMC Scholia
  65. Ward NL, Dumont DJ.; ''The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.''; PubMed Europe PMC Scholia
  66. Brakebusch C, Fässler R.; ''beta 1 integrin function in vivo: adhesion, migration and more.''; PubMed Europe PMC Scholia
  67. Ostermann G, Fraemohs L, Baltus T, Schober A, Lietz M, Zernecke A, Liehn EA, Weber C.; ''Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A.''; PubMed Europe PMC Scholia
  68. Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ.; ''Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.''; PubMed Europe PMC Scholia
  69. Barton WA, Tzvetkova D, Nikolov DB.; ''Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.''; PubMed Europe PMC Scholia
  70. Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Esplugues E, Pizcueta P, Bosch J, Engel P.; ''CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.''; PubMed Europe PMC Scholia
  71. Neumann S, Hasenauer J, Pollak N, Scheurich P.; ''Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes.''; PubMed Europe PMC Scholia
  72. Deora AA, Philp N, Hu J, Bok D, Rodriguez-Boulan E.; ''Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia.''; PubMed Europe PMC Scholia
  73. DiScipio RG, Davie EW.; ''Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma.''; PubMed Europe PMC Scholia
  74. Sachs UJ, Andrei-Selmer CL, Maniar A, Weiss T, Paddock C, Orlova VV, Choi EY, Newman PJ, Preissner KT, Chavakis T, Santoso S.; ''The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).''; PubMed Europe PMC Scholia
  75. Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J.; ''The structural basis of the activation of Ras by Sos.''; PubMed Europe PMC Scholia
  76. Moriwaki H, Kume N, Sawamura T, Aoyama T, Hoshikawa H, Ochi H, Nishi E, Masaki T, Kita T.; ''Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein.''; PubMed Europe PMC Scholia
  77. Pushkarsky T, Yurchenko V, Vanpouille C, Brichacek B, Vaisman I, Hatakeyama S, Nakayama KI, Sherry B, Bukrinsky MI.; ''Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60.''; PubMed Europe PMC Scholia
  78. Xie Q, Matsunaga S, Niimi S, Ogawa S, Tokuyasu K, Sakakibara Y, Machida S.; ''Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells.''; PubMed Europe PMC Scholia
  79. Cartron JP, Rahuel C.; ''Human erythrocyte glycophorins: protein and gene structure analyses.''; PubMed Europe PMC Scholia
  80. Merzaban JS, Burdick MM, Gadhoum SZ, Dagia NM, Chu JT, Fuhlbrigge RC, Sackstein R.; ''Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells.''; PubMed Europe PMC Scholia
  81. Kisiel W.; ''Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin.''; PubMed Europe PMC Scholia
  82. Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE.; ''Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene.''; PubMed Europe PMC Scholia
  83. Barclay AN, Brown MH.; ''The SIRP family of receptors and immune regulation.''; PubMed Europe PMC Scholia
  84. Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, Bussolino F.; ''Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.''; PubMed Europe PMC Scholia
  85. Foster D, Davie EW.; ''Characterization of a cDNA coding for human protein C.''; PubMed Europe PMC Scholia
  86. Peters KG, Kontos CD, Lin PC, Wong AL, Rao P, Huang L, Dewhirst MW, Sankar S.; ''Functional significance of Tie2 signaling in the adult vasculature.''; PubMed Europe PMC Scholia
  87. Buckley CD, Doyonnas R, Newton JP, Blystone SD, Brown EJ, Watt SM, Simmons DL.; ''Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1.''; PubMed Europe PMC Scholia
  88. Becker BF, Heindl B, Kupatt C, Zahler S.; ''Endothelial function and hemostasis.''; PubMed Europe PMC Scholia
  89. Ludwig RJ, Zollner TM, Santoso S, Hardt K, Gille J, Baatz H, Johann PS, Pfeffer J, Radeke HH, Schön MP, Kaufmann R, Boehncke WH, Podda M.; ''Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation.''; PubMed Europe PMC Scholia
  90. Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, Daly R, Alitalo K, Dumont DJ.; ''Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.''; PubMed Europe PMC Scholia
  91. Mandicourt G, Iden S, Ebnet K, Aurrand-Lions M, Imhof BA.; ''JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration.''; PubMed Europe PMC Scholia
  92. Moore KL, Eaton SF, Lyons DE, Lichenstein HS, Cummings RD, McEver RP.; ''The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine.''; PubMed Europe PMC Scholia
  93. Santoso S, Sachs UJ, Kroll H, Linder M, Ruf A, Preissner KT, Chavakis T.; ''The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1.''; PubMed Europe PMC Scholia
  94. Yoshida H, Kondratenko N, Green S, Steinberg D, Quehenberger O.; ''Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor.''; PubMed Europe PMC Scholia
  95. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T.; ''An endothelial receptor for oxidized low-density lipoprotein.''; PubMed Europe PMC Scholia
  96. Jackson DE, Ward CM, Wang R, Newman PJ.; ''The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling.''; PubMed Europe PMC Scholia
  97. Cicmil M, Thomas JM, Sage T, Barry FA, Leduc M, Bon C, Gibbins JM.; ''Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.''; PubMed Europe PMC Scholia
  98. Heller M, von der Ohe M, Kleene R, Mohajeri MH, Schachner M.; ''The immunoglobulin-superfamily molecule basigin is a binding protein for oligomannosidic carbohydrates: an anti-idiotypic approach.''; PubMed Europe PMC Scholia
  99. Schober A, Weber C.; ''Mechanisms of monocyte recruitment in vascular repair after injury.''; PubMed Europe PMC Scholia
  100. Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA.; ''JAM2 interacts with alpha4beta1. Facilitation by JAM3.''; PubMed Europe PMC Scholia
  101. Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, Presky DH, Familletti PC, Wolitzky BA, Burns DK.; ''Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.''; PubMed Europe PMC Scholia
  102. Bos MP, Grunert F, Belland RJ.; ''Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae.''; PubMed Europe PMC Scholia
  103. Zen K, Liu Y, McCall IC, Wu T, Lee W, Babbin BA, Nusrat A, Parkos CA.; ''Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils.''; PubMed Europe PMC Scholia
  104. Shi X, Niimi S, Ohtani T, Machida S.; ''Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor.''; PubMed Europe PMC Scholia
  105. Popp A, Dehio C, Grunert F, Meyer TF, Gray-Owen SD.; ''Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding.''; PubMed Europe PMC Scholia
  106. Zhang Z, Morla AO, Vuori K, Bauer JS, Juliano RL, Ruoslahti E.; ''The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin.''; PubMed Europe PMC Scholia
  107. Balzar M, Winter MJ, de Boer CJ, Litvinov SV.; ''The biology of the 17-1A antigen (Ep-CAM).''; PubMed Europe PMC Scholia
  108. Bogdanovic E, Nguyen VP, Dumont DJ.; ''Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization.''; PubMed Europe PMC Scholia
  109. Fraemohs L, Koenen RR, Ostermann G, Heinemann B, Weber C.; ''The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain.''; PubMed Europe PMC Scholia
  110. da Costa Martins P, van den Berk N, Ulfman LH, Koenderman L, Hordijk PL, Zwaginga JJ.; ''Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
112591view15:56, 9 October 2020ReactomeTeamReactome version 73
101507view11:37, 1 November 2018ReactomeTeamreactome version 66
101043view21:18, 31 October 2018ReactomeTeamreactome version 65
100574view19:51, 31 October 2018ReactomeTeamreactome version 64
100123view16:37, 31 October 2018ReactomeTeamreactome version 63
99673view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99268view12:45, 31 October 2018ReactomeTeamreactome version 62
94057view13:54, 16 August 2017ReactomeTeamreactome version 61
93737view13:25, 16 August 2017ReactomeTeamreactome version 61
93686view11:31, 9 August 2017ReactomeTeamreactome version 61
87157view19:14, 18 July 2016MkutmonOntology Term : 'hemostasis pathway' added !
86809view09:27, 11 July 2016ReactomeTeamreactome version 56
83824view13:10, 13 December 2015EgonwMarked heparan sulfate (HS) as a metabolite.
83200view10:21, 18 November 2015ReactomeTeamVersion54
81579view13:07, 21 August 2015ReactomeTeamVersion53
77039view08:33, 17 July 2014ReactomeTeamFixed remaining interactions
76744view12:10, 16 July 2014ReactomeTeamFixed remaining interactions
76069view10:13, 11 June 2014ReactomeTeamRe-fixing comment source
75779view11:29, 10 June 2014ReactomeTeamReactome 48 Update
75129view14:07, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74859view15:22, 2 May 2014EgonwMarked a metabolite as a DataNode type="Metabolite"...
74776view08:51, 30 April 2014ReactomeTeamReactome46
42017view21:50, 4 March 2011MaintBotAutomatic update
39820view05:51, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Angiopoietin 1

receptor precursor

ProteinQ02763 (UniProt)
Angiopoietin-1 ProteinQ15389 (UniProt)
Angiopoietin-2 ProteinO15123 (UniProt)
Angiopoietin-4 ProteinQ9Y264 (UniProt)
B-lymphocyte

activation marker BLAST-1 precursor

ProteinP09326 (UniProt)
Basigin bound to

CD43

ComplexREACT_18170 (Reactome)
Basigin bound to

CyPA

ComplexREACT_12714 (Reactome)
Basigin bound to

MCTs

ComplexREACT_15052 (Reactome)
Basigin bound to

integrins

ComplexREACT_14081 (Reactome)
Basigin homodimer ComplexREACT_13277 (Reactome)
Basigin precursor ProteinP35613 (UniProt)
Basigin-binding

integrins

ComplexREACT_14484 (Reactome)
Basigin:CD98hc

complex

ComplexREACT_17413 (Reactome)
Basigin:MMP1 ComplexREACT_17528 (Reactome)
Basigin:Mannose-

carrying cell recognition molecules

ComplexREACT_18084 (Reactome)
CD177 antigen

precursor

ProteinQ8N6Q3 (UniProt)
CD47 ProteinQ08722 (UniProt)
CD47 bound to its

ligand

ComplexREACT_12217 (Reactome)
CD47-binding SIRPs ProteinREACT_12311 (Reactome)
CD48 bound to

CD244

ComplexREACT_12345 (Reactome)
CD58 bound to CD2 ComplexREACT_12230 (Reactome)
CD84 ProteinQ9UIB8-1 (UniProt)
CD84 Homodimer ComplexREACT_12135 (Reactome)
CD98hc complex ComplexREACT_18154 (Reactome)
CEACAM

heterodimer

ComplexREACT_12134 (Reactome)
CXADR bound to

JAML

ComplexREACT_11619 (Reactome)
Caveolin-1 bound to

Basigin

ComplexREACT_13130 (Reactome)
Collagen I ComplexREACT_2739 (Reactome)
Complex of Tie2:

Ang-1

ComplexREACT_12688 (Reactome)
Complex of Tie2:

Ang2

ComplexREACT_12895 (Reactome)
Coxsackievirus and

adenovirus receptor

ProteinP78310 (UniProt)
CyP60 complexed

with Basigin

ComplexREACT_12835 (Reactome)
CypA protein ProteinP62937 (UniProt)
Docking protein 2 ProteinO60496 (UniProt)
Fibronectin dimer ComplexREACT_14040 (Reactome)
GDP Metabolite17552 (ChEBI)
GPVI:FceRI

gamma:FYN:LYN

ComplexREACT_20322 (Reactome)
GPVI:FceRI gamma:

FYN:LYN:Collagen I

ComplexREACT_20373 (Reactome)
GRB2 ProteinP62993-1 (UniProt)
GTP Metabolite15996 (ChEBI)
Grb14 ProteinQ14449 (UniProt)
Grb2 bound to Tie2 ComplexREACT_12659 (Reactome)
Grb7 ProteinQ14451 (UniProt)
Heparan Sulphate Unknown35721 (ChEBI)
Integrin

alphaLbeta2 (LFA-1)

ComplexREACT_11837 (Reactome)
Integrin

alphaMbeta2

ComplexREACT_12291 (Reactome)
Integrin

alphaMbeta2: JAM3

ComplexREACT_12228 (Reactome)
Integrin

alphaVbeta3

ComplexREACT_13287 (Reactome)
Integrin

alphaVbeta3: PECAM-1

ComplexREACT_13361 (Reactome)
Integrin

alphaXbeta2

ComplexREACT_12091 (Reactome)
Integrin alpha5beta1 ComplexREACT_12335 (Reactome)
Integrin alpha5beta1:

Fibronectin

ComplexREACT_12353 (Reactome)
Integrin alphaXbeta2:

JAML

ComplexREACT_12224 (Reactome)
JAM-A ProteinQ9Y624 (UniProt)
JAM-A Homodimer ComplexREACT_12319 (Reactome)
JAM-B bound to

JAM-C

ComplexREACT_12255 (Reactome)
JAM-B homodimer ComplexREACT_12209 (Reactome)
JAM-C homodimer ComplexREACT_12100 (Reactome)
JAM2 ProteinP57087 (UniProt)
JAM3 ProteinQ9BX67 (UniProt)
Junctional adhesion

molecule-like precursor

ProteinQ86YT9-1 (UniProt)
Junctional adhesion

molecule-like (JAML)

ProteinQ86YT9 (UniProt)
LDL ComplexREACT_7774 (Reactome) LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
LFA-1:JAM-A ComplexREACT_12182 (Reactome)
Leukosialin

precursor

ProteinP16150 (UniProt)
Ligand to TREM-1

on the platelet membrane

UnknownREACT_12176 (Reactome)
Lymphocyte function-

associated antigen 3 precursor

ProteinP19256 (UniProt)
MERTK bound to its

ligand

ComplexREACT_12164 (Reactome)
MERTK ligands ProteinREACT_12235 (Reactome)
Manganese Metabolite18291 (ChEBI)
Mannose-carrying

cell recognition molecules

ComplexREACT_18192 (Reactome)
Matrix

metalloproteinase-1

ProteinP03956 (UniProt)
Monocarboxylate

Transporter Set (MCT)

ProteinREACT_17955 (Reactome)
Natural killer cell

receptor 2B4 precursor

ProteinQ9BZW8 (UniProt)
Neutrophil CEACAMs

affecting integrin binding to fibronectin

ProteinREACT_12292 (Reactome)
OLR1 bound to

oxidized LDL

ComplexREACT_12181 (Reactome)
Oxidized low-density

lipoprotein receptor 1

ProteinP78380 (UniProt)
P-selectin

glycoprotein ligand 1 precursor

ProteinQ14242 (UniProt)
P-selectin bound to

its ligand

ComplexREACT_12193 (Reactome)
PECAM-1 ProteinP16284 (UniProt)
PECAM-1 bound to

CD177

ComplexREACT_12173 (Reactome)
PECAM-1:PECAM-1 ComplexREACT_13059 (Reactome)
PECAM-1:PLC

gamma1 complex

ComplexREACT_13045 (Reactome)
PECAM-1:SHIP1

complex

ComplexREACT_13027 (Reactome)
PECAM-1:SHP-1

complex

ComplexREACT_13228 (Reactome)
PECAM-1:SHP-2

complex

ComplexREACT_13041 (Reactome)
PI3K ComplexREACT_4240 (Reactome)
Peptidyl-prolyl cis-

trans isomerase like 2

ProteinQ13356 (UniProt)
Phospholipase C

gamma 1

ProteinP19174 (UniProt)
Phosphorylated

Tie2 in Tie2/Akt dimer

ComplexREACT_13046 (Reactome)
Platelet Factor 4 UnknownREACT_12205 (Reactome)
Proto-oncogene

tyrosine-protein kinase MER precursor

ProteinQ12866 (UniProt)
SHC1 ProteinP29353 (UniProt)
SHIP1 ProteinQ92835 (UniProt)
SHP1 ProteinP29350 (UniProt)
SHP2 ProteinQ06124 (UniProt)
SOS-1 bound to

Tie2:Grb2

ComplexREACT_13320 (Reactome)
Selectin ProteinREACT_12297 (Reactome)
Son of sevenless

protein homolog 1

ProteinQ07889 (UniProt)
Src family tyrosine

kinases

UnknownREACT_13328 (Reactome)
T-cell surface

antigen CD2 precursor

ProteinP06729 (UniProt)
TREM-1 bound to its

ligand

ComplexREACT_12367 (Reactome)
Tie2 and Ang4

complex

ComplexREACT_12703 (Reactome)
Tie2 and Dok-2

complex

ComplexREACT_13019 (Reactome)
Tie2 and Grb14

complex

ComplexREACT_18185 (Reactome)
Tie2/Ang1 dimer ComplexREACT_13336 (Reactome)
Tie2:Grb7 complex ComplexREACT_18058 (Reactome)
Triggering receptor

expressed on myeloid cells 1 precursor

ProteinQ9NP99 (UniProt)
VLA-4 ComplexREACT_11798 (Reactome)
VLA-4: JAM-B ComplexREACT_12179 (Reactome)
activated protein C ComplexREACT_2599 (Reactome)
activated thrombin:

thrombomodulin

ComplexREACT_5904 (Reactome)
caveolin-1 ProteinQ03135 (UniProt)
p-PECAM1:p-

PECAM1

ComplexREACT_12801 (Reactome)
p21 RAS:GDP ComplexREACT_2657 (Reactome)
p21 RAS:GTP ComplexREACT_4782 (Reactome)
p85 bound to Tie2 ComplexREACT_13298 (Reactome)
pTie2 and SHP2

complex

ComplexREACT_17975 (Reactome)
pTie2:Ang-1 ComplexREACT_13342 (Reactome)
pTie2:SHC1

complex

ComplexREACT_12988 (Reactome)
phosphorylated

PECAM-1

ProteinP16284 (UniProt)
protein C ComplexREACT_4912 (Reactome)
protein C heavy

chain activation peptide

ProteinP04070 (UniProt)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1794"
Personal tools