Neurotransmitter clearance (Homo sapiens)

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13245, 6cytosolmitochondrial matrixCatechol O-methyltransferaseNH3Noradrenaline uptake transporterNoradrenalinesodium ionMAOA-FAD complexAcetatesodium ionHomocysteineNoradrenalineSodium dpendent Dopamine transporterSerotonin5-HydroxytryptamineH2OSodium dependent Serotonin transporterH2O2S-adenosylmethionineO-acetylcholineDopaminesodium ionAcetylcholinesterase5-hydroxytryptamine N-methyl conjugatesodium ion5-hydroxyindole acetaldehydeOxygenNH3S-adenosylhomocysteineNADHS-adenosylmethionineOxygenH2ONAD+5-hydroxytryptamine N-methyl conjugateH+1-chloro-2,4-dinitrobenzenealdehyde dehydrogenase, mitochondrial, tetramerCholineDopamine5-Hydroxyindole acetic acid


Description

Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter.
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Bibliography

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  1. Stahl SM.; ''The new cholinesterase inhibitors for Alzheimer's disease, Part 2: illustrating their mechanisms of action.''; PubMed Europe PMC Scholia
  2. DEEDS F, BOOTH AN, JONES FT.; ''Methylation and dehydroxylation of phenolic compounds by rats and rabbits.''; PubMed Europe PMC Scholia
  3. Beck O, Helander A, Carlsson S, Borg S.; ''Changes in serotonin metabolism during treatment with the aldehyde dehydrogenase inhibitors disulfiram and cyanamide.''; PubMed Europe PMC Scholia
  4. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melén K, Julkunen I, Taskinen J.; ''Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme.''; PubMed Europe PMC Scholia
  5. Canli T, Lesch KP.; ''Long story short: the serotonin transporter in emotion regulation and social cognition.''; PubMed Europe PMC Scholia
  6. Vandenbergh DJ, Thompson MD, Cook EH, Bendahhou E, Nguyen T, Krasowski MD, Zarrabian D, Comings D, Sellers EM, Tyndale RF, George SR, O'Dowd BF, Uhl GR.; ''Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations.''; PubMed Europe PMC Scholia
  7. Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Müller U, Beutler B.; ''A catechol-O-methyltransferase that is essential for auditory function in mice and humans.''; PubMed Europe PMC Scholia
  8. Lambert GW, Eisenhofer G, Jennings GL, Esler MD.; ''Regional homovanillic acid production in humans.''; PubMed Europe PMC Scholia
  9. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H.; ''Cloning and characterization of two human polyspecific organic cation transporters.''; PubMed Europe PMC Scholia
  10. Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL.; ''Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.''; PubMed Europe PMC Scholia
  11. O'Carroll AM, Fowler CJ, Phillips JP, Tobbia I, Tipton KF.; ''The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions.''; PubMed Europe PMC Scholia
  12. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD.; ''Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.''; PubMed Europe PMC Scholia
  13. Ahmed ZM, Masmoudi S, Kalay E, Belyantseva IA, Mosrati MA, Collin RW, Riazuddin S, Hmani-Aifa M, Venselaar H, Kawar MN, Tlili A, van der Zwaag B, Khan SY, Ayadi L, Riazuddin SA, Morell RJ, Griffith AJ, Charfedine I, Caylan R, Oostrik J, Karaguzel A, Ghorbel A, Riazuddin S, Friedman TB, Ayadi H, Kremer H.; ''Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans.''; PubMed Europe PMC Scholia
  14. Lanier M, Ambrus G, Cole DC, Davenport R, Ellery J, Fosbeary R, Jennings AJ, Kadotani A, Kamada Y, Kamran R, Matsumoto S, Mizukami A, Okubo S, Okada K, Saikatendu K, Walsh L, Wu H, Hixon MS.; ''A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).''; PubMed Europe PMC Scholia
  15. Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, Flashner Y, Marcus D, Cohen S, Shafferman A.; ''The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant.''; PubMed Europe PMC Scholia
  16. Brenner B, Harney JT, Ahmed BA, Jeffus BC, Unal R, Mehta JL, Kilic F.; ''Plasma serotonin levels and the platelet serotonin transporter.''; PubMed Europe PMC Scholia
  17. Hempel J, Kaiser R, Jörnvall H.; ''Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations.''; PubMed Europe PMC Scholia
  18. Fernandez E, Koek W, Ran Q, Gerhardt GA, France CP, Strong R.; ''Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice.''; PubMed Europe PMC Scholia
  19. Guldberg HC, Sharman DF, Tegerdine PR.; ''Some observations on the estimation of 3-methoxytyramine in brain tissue.''; PubMed Europe PMC Scholia
  20. Weyler W.; ''Monoamine oxidase A from human placenta and monoamine oxidase B from bovine liver both have one FAD per subunit.''; PubMed Europe PMC Scholia
  21. Greenfield NJ, Pietruszko R.; ''Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.''; PubMed Europe PMC Scholia
  22. Sotnikova TD, Beaulieu JM, Espinoza S, Masri B, Zhang X, Salahpour A, Barak LS, Caron MG, Gainetdinov RR.; ''The dopamine metabolite 3-methoxytyramine is a neuromodulator.''; PubMed Europe PMC Scholia
  23. Weinstock M, Groner E.; ''Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114635view16:09, 25 January 2021ReactomeTeamReactome version 75
113083view11:14, 2 November 2020ReactomeTeamReactome version 74
112317view15:23, 9 October 2020ReactomeTeamReactome version 73
101216view11:11, 1 November 2018ReactomeTeamreactome version 66
100754view20:36, 31 October 2018ReactomeTeamreactome version 65
100298view19:13, 31 October 2018ReactomeTeamreactome version 64
99844view15:57, 31 October 2018ReactomeTeamreactome version 63
99401view14:34, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99092view12:39, 31 October 2018ReactomeTeamreactome version 62
94498view09:04, 14 September 2017Mkutmonreactome version 61
87768view10:01, 25 July 2016RyanmillerOntology Term : 'signaling pathway' added !
87767view10:00, 25 July 2016RyanmillerOntology Term : 'signaling pathway pertinent to the brain and nervous system' added !
86397view09:17, 11 July 2016ReactomeTeamreactome version 56
83079view09:53, 18 November 2015ReactomeTeamVersion54
81400view12:55, 21 August 2015ReactomeTeamVersion53
76869view08:14, 17 July 2014ReactomeTeamFixed remaining interactions
76574view11:55, 16 July 2014ReactomeTeamFixed remaining interactions
75907view09:56, 11 June 2014ReactomeTeamRe-fixing comment source
75607view10:46, 10 June 2014ReactomeTeamReactome 48 Update
74962view13:48, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74606view08:39, 30 April 2014ReactomeTeamReactome46
58006view22:02, 5 February 2013AriuttaPeriodical save, work in progress
42088view21:56, 4 March 2011MaintBotAutomatic update
39896view05:55, 21 January 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1-chloro-2,4-

dinitrobenzene

MetaboliteREACT_7022 (Reactome)
5-Hydroxyindole

acetic acid

MetaboliteREACT_17511 (Reactome)
5-Hydroxytryptamine Metabolite28790 (ChEBI)
5-hydroxyindole

acetaldehyde

MetaboliteREACT_17970 (Reactome)
5-hydroxytryptamine

N-methyl conjugate

MetaboliteREACT_15971 (Reactome)
Acetate Metabolite15366 (ChEBI)
Acetylcholinesterase ProteinP22303 (UniProt)
Catechol O-

methyltransferase

ProteinP21964 (UniProt)
Choline Metabolite15354 (ChEBI)
Dopamine Metabolite18243 (ChEBI)
H+ Metabolite15378 (ChEBI)
H2O Metabolite15377 (ChEBI)
H2O2 Metabolite16240 (ChEBI)
Homocysteine Metabolite17230 (ChEBI)
MAOA-FAD complex ComplexREACT_5113 (Reactome)
NAD+ Metabolite15846 (ChEBI)
NADH Metabolite16908 (ChEBI)
NH3 Metabolite16134 (ChEBI)
Noradrenaline Metabolite18357 (ChEBI)
Noradrenaline

uptake transporter

ProteinO15244 (UniProt)
O-acetylcholine Metabolite15355 (ChEBI)
Oxygen Metabolite15379 (ChEBI)
S-

adenosylhomocysteine

Metabolite16680 (ChEBI)
S-adenosylmethionine Metabolite15414 (ChEBI)
Serotonin Metabolite28790 (ChEBI)
Sodium dependent

Serotonin transporter

UnknownREACT_15766 (Reactome)
Sodium dpendent

Dopamine transporter

ProteinQ01959 (UniProt)
aldehyde

dehydrogenase, mitochondrial, tetramer

ComplexREACT_2466 (Reactome)
sodium ion Metabolite29101 (ChEBI)

Annotated Interactions

No annotated interactions

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