Opioid signaling (Homo sapiens)

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18, 30, 3220, 373528, 314, 40, 5123, 291, 2522, 34193, 10, 21, 52122517, 19, 3941272244625471525214, 48382526, 33, 44114342132556, 945, 508, 1649, 531536endoplasmic reticulum lumennucleoplasmcytosolG-protein alpha (i): GTPCalcium3',5'-Cyclic AMPOpioid peptideactive Cam-PDE 1Adenylate cyclase (Mg2+ cofactor)ADPG protein-GDP complexphospho-CREBPP2B catalytic (Fe3+, Zn2+):Active CalmodulinOrthophosphatePP2B complexH2OIP3 receptor homotetramer1D-myo-Inositol 1,4,5-trisphosphateG alpha-olf:GTP:Adenylate cyclase (active) complexH2ODARPP-32 phosphorylated on Thr75phospho-CREBcAMP-specific 3',5'-cyclic phosphodiesterase 4BADPphospho-GRK2PLC-betaATPOrthophosphateCalmodulin:CaMK IVG-protein alpha (i/o/z/t) subunitDARPP-32 (for CDK5 phosphorylation)Phosphatidyl cholineATPCam-PDE 1 homodimerATP1-Phosphatidyl-D-myo-inositol 4,5-bisphosphateAMPcAMP-dependent protein kinase, alpha-catalytic subunitOpioid:MOR:G protein-GTP complexDARPP-32 (and/or phosphorylated)Adenylate cyclase (Mg2+ cofactor)(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)ATPOpioid:MOR:G protein-GDP complexIP3 receptor:IP3 complexPP2A-ABdeltaC complexProtein Kinase A, catalytic subunitsADPPKA catalytic subunitOrthophosphatecAMP:PKA regulatory subunitCREBphospho-CREB dimerGRK2DARPP-32 phosporylated on T34phospho-cPLA2ADP3',5'-Cyclic AMPcPLA2G-protein alpha (i):GTP:Adenylate cyclaseG alpha-olf:GDP:Adenylate cyclase (active) complexactive PKC (alpha, gamma, delta)Calmodulin:CaMK IVOrthophosphateATPGDP3',5'-Cyclic AMPOpioid:MORGDPSerine/threonine protein phosphatase PP1-alpha 1 catalytic subunitactive CalmodulinG alpha-olf:GTPADPAdenylate cyclase (Mg2+ cofactor)PKA tetramer3',5'-Cyclic AMPGTPActivated PLC beta 1/4ATPATPH2OG-protein alpha:GDPPKA catalytic subunitCalciumpyrophosphateCaMKIVPhosphorylated cAMP-specific 3',5'-cyclic phosphodiesterase 4BAdenylate cyclase (Mg2+ cofactor)G-protein beta-gamma complexADPG alpha-olf:GDP complexATPPDE 4OrthophosphateCalmodulindiacylglycerolspyrophosphateCREBH2OCDK5PhosphatidylcholinePhosphorylated (T34) DARPP-32:PP1AH2OActive CalmodulinArachidonateOpioid:MOR:G-protein complexGRK2:calmodulinG alpha-olf:GDP complexG protein alpha:GTP complexActive PLA2:phosphatidylcholine(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)Activated ERK2H2O2-LysophosphatidylcholineADPATPPP2B catalytic (Fe3+, Zn2+)phospho-CaMK IV:CalmodulinG-protein alpha (i):GDPPhosphorylated (Thr75) DARPP-32:PKAMu-type opioid receptor(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)AMPGTP7


Description

Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP).

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116415view09:08, 7 May 2021EweitzModified title
115086view17:03, 25 January 2021ReactomeTeamReactome version 75
113528view12:00, 2 November 2020ReactomeTeamReactome version 74
112726view16:12, 9 October 2020ReactomeTeamReactome version 73
101642view11:50, 1 November 2018ReactomeTeamreactome version 66
101178view21:37, 31 October 2018ReactomeTeamreactome version 65
100704view20:10, 31 October 2018ReactomeTeamreactome version 64
100254view16:55, 31 October 2018ReactomeTeamreactome version 63
99807view15:20, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99353view12:48, 31 October 2018ReactomeTeamreactome version 62
93848view13:40, 16 August 2017ReactomeTeamreactome version 61
93406view11:22, 9 August 2017ReactomeTeamreactome version 61
88062view14:04, 25 July 2016RyanmillerOntology Term : 'chemical compound signaling pathway' added !
88061view14:04, 25 July 2016RyanmillerOntology Term : 'signaling pathway' added !
86494view09:19, 11 July 2016ReactomeTeamreactome version 56
83304view10:42, 18 November 2015ReactomeTeamVersion54
81440view12:58, 21 August 2015ReactomeTeamVersion53
76919view08:19, 17 July 2014ReactomeTeamFixed remaining interactions
76624view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75955view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75657view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75012view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74656view08:43, 30 April 2014ReactomeTeamReactome46
56299view16:38, 5 January 2013EgonwData typed a ChEBI metabolite as such.
42186view23:51, 4 March 2011MaintBotModified categories
42185view23:51, 4 March 2011MaintBot
42184view23:50, 4 March 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Gi alpha1:GDP:

Adenylate cyclase): (G alpha-olf:GDP)

ComplexREACT_15896 (Reactome)
(Gi alpha1:GTP:

Adenylate cyclase): (G alpha-olf:GDP)

ComplexREACT_15853 (Reactome)
(Gi alpha1:GTP:

Adenylate cyclase): (G alpha-olf:GTP)

ComplexREACT_15996 (Reactome)
1-Phosphatidyl-

D-myo-inositol 4,5-bisphosphate

18348 (ChEBI)
1D-myo-Inositol

1,4,5-trisphosphate

Metabolite16595 (ChEBI)
2-

Lysophosphatidylcholi ne

17504 (ChEBI)
3',5'-Cyclic AMP Metabolite17489 (ChEBI)
ADP Metabolite16761 (ChEBI)
AMP Metabolite16027 (ChEBI)
ATP Metabolite15422 (ChEBI)
Activated ERK2 ProteinP28482 (UniProt)
Activated PLC beta

1/4

ComplexREACT_15568 (Reactome)
Active

Calmodulin

ComplexREACT_3178 (Reactome)
Active PLA2:

phosphatidylcholine

ComplexREACT_15631 (Reactome)
Adenylate cyclase

(Mg2+ cofactor)

ComplexREACT_17689 (Reactome)
Arachidonate Metabolite15843 (ChEBI)
CDK5 ProteinQ00535 (UniProt)
CREB ProteinP16220 (UniProt)
CaMKIV ProteinQ16566 (UniProt)
Calcium Metabolite29108 (ChEBI)
Calmodulin ProteinP62158 (UniProt)
Calmodulin:CaMK IV ComplexREACT_15739 (Reactome)
Calmodulin:CaMK IV ComplexREACT_15747 (Reactome)
Cam-PDE 1

homodimer

ComplexREACT_5507 (Reactome)
DARPP-32

phosphorylated on Thr75

ProteinREACT_16096 (Reactome)
DARPP-32

phosporylated on T34

ProteinREACT_15578 (Reactome)
DARPP-32 (and/or

phosphorylated)

ProteinREACT_17763 (Reactome)
DARPP-32 (for CDK5

phosphorylation)

ProteinREACT_17935 (Reactome)
G alpha-olf:GDP

complex

ComplexREACT_17352 (Reactome)
G alpha-olf:GDP:

Adenylate cyclase (active) complex

ComplexREACT_15796 (Reactome)
G alpha-olf:GTP ComplexREACT_16015 (Reactome)
G alpha-olf:GTP:

Adenylate cyclase (active) complex

ComplexREACT_17212 (Reactome)
G protein alpha:GTP

complex

ComplexREACT_17389 (Reactome)
G protein-GDP

complex

ComplexREACT_15793 (Reactome)
G-protein alpha

(i):GDP

ComplexREACT_19806 (Reactome)
G-protein alpha

(i):GTP:Adenylate cyclase

ComplexREACT_19914 (Reactome)
G-protein alpha

(i/o/z/t) subunit

ProteinREACT_16054 (Reactome)
G-protein alpha (i):

GTP

ComplexREACT_19580 (Reactome)
G-protein alpha:GDP ComplexREACT_17952 (Reactome)
G-protein beta-

gamma complex

ComplexREACT_15674 (Reactome)
GDP Metabolite17552 (ChEBI)
GRK2 ProteinP25098 (UniProt)
GRK2:

calmodulin

ComplexREACT_17570 (Reactome)
GTP Metabolite15996 (ChEBI)
H2O Metabolite15377 (ChEBI)
IP3 receptor

homotetramer

ComplexREACT_12247 (Reactome)
IP3 receptor:IP3

complex

ComplexREACT_12249 (Reactome)
Mu-type opioid

receptor

ProteinP35372 (UniProt)
Opioid peptide ProteinREACT_15976 (Reactome)
Opioid:MOR ComplexREACT_15680 (Reactome)
Opioid:MOR:G

protein-GDP complex

ComplexREACT_15815 (Reactome)
Opioid:MOR:G

protein-GTP complex

ComplexREACT_15831 (Reactome)
Opioid:MOR:G-protein

complex

ComplexREACT_15585 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PDE 4 REACT_5541 (Reactome) cAMP selective hydrolase
PKA catalytic subunit ProteinREACT_3031 (Reactome)
PKA tetramer ComplexREACT_5749 (Reactome)
PLC-beta ProteinREACT_15673 (Reactome)
PP2A-ABdeltaC

complex

ComplexREACT_5648 (Reactome)
PP2B catalytic (Fe3+,

Zn2+)

ComplexREACT_18243 (Reactome)
PP2B catalytic (Fe3+,

Zn2+):Active Calmodulin

ComplexREACT_17373 (Reactome)
PP2B complex ComplexREACT_17149 (Reactome)
Phosphatidyl choline Metabolite16110 (ChEBI)
Phosphatidylcholine 16110 (ChEBI)
Phosphorylated

(Thr75) DARPP- 32:PKA

ComplexREACT_17157 (Reactome)
Phosphorylated

cAMP-specific 3',5'- cyclic phosphodiesterase 4B

ProteinQ07343 (UniProt)
Phosphorylated (T34)

DARPP-32:PP1A

ComplexREACT_17348 (Reactome)
Protein Kinase A,

catalytic subunits

ProteinREACT_2480 (Reactome)
Serine/threonine

protein phosphatase PP1-alpha 1 catalytic subunit

ProteinP62136 (UniProt)
active

Calmodulin

ComplexREACT_10340 (Reactome)
active Cam-PDE 1 ComplexREACT_3728 (Reactome)
active PKC

(alpha, gamma, delta)

ComplexREACT_16103 (Reactome)
cAMP-dependent

protein kinase, alpha-catalytic subunit

ProteinP17612 (UniProt)
cAMP-specific 3',5'-

cyclic phosphodiesterase 4B

ProteinQ07343 (UniProt)
cAMP:PKA regulatory

subunit

ComplexREACT_4571 (Reactome)
cPLA2 ProteinP47712 (UniProt)
diacylglycerols Metabolite18035 (ChEBI)
phospho-CREB ProteinP16220 (UniProt)
phospho-CREB dimer ComplexREACT_17630 (Reactome)
phospho-CaMK IV:

Calmodulin

ComplexREACT_15743 (Reactome)
phospho-GRK2 ProteinP25098 (UniProt)
phospho-cPLA2 ProteinP47712 (UniProt)
pyrophosphate Metabolite29888 (ChEBI)

Annotated Interactions

No annotated interactions

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