Splicing factor NOVA regulated synaptic proteins (Mus musculus)

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1LegendPost-synaptic neuronCav2.24.1GNIK/Mapk4N-CadherinLARSKIPMAP4AGRINCalsynteninEphrinA5RGIRK2PIP2Clasp1SloCASKneurochondrinGlyRa2GABAARg2JNK2PMCA1Syntaxin1Plcb4Rap1gapSyntaxin 2Camk2ga-cateninIgsf4aNeogeninnAChRa2Cav2.2CaskGephrinCASKDab1Aplp2Kcnq2Munc184.1R4.1BChl1Netrin G1Rap1EphrinA5NMDAR2BNMDAR1Chl1N-CadherinAnkyrin GCASKDab1a-cateninLARGluR6CaskPKCzGABAB2RnAChRa4Plcb4PIP2Ankyrin GAnkyrin GJNK24.1R4.1RGluR6SloPKCzGABAB2RGephrinPre-synaptic neuronPlcb44.1NIgsf4bIntegrin a2validated targetCLIP predicted targetvalidated target - predicted by bioinformaticsvalidated target - predicted by splicing microarrayvalidated target - predicted by CLIP


Description

Neuron-specific splicing factor NOVA dependent splicing regulation at the synapse

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Ontology Terms

 

Bibliography

  1. Ule J, Ule A, Spencer J, Williams A, Hu JS, Cline M, Wang H, Clark T, Fraser C, Ruggiu M, Zeeberg BR, Kane D, Weinstein JN, Blume J, Darnell RB; ''Nova regulates brain-specific splicing to shape the synapse.''; Nat Genet, 2005 PubMed Europe PMC Scholia
  2. J. Ule, G. Stefani, A. Mele, M. Ruggiu, X. Wang, B. Taneri, T. Gaasterland, B.J. Blencowe, R.B. Darnell; ''An RNA map predicting Nova-dependent splicing regulation.''; Nature, 2006 PubMed Europe PMC Scholia

History

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123566view10:02, 4 August 2022EgonwConverted legend content to shapes.
123565view09:58, 4 August 2022EgonwRemoved redundant whitespace in labels
123564view09:53, 4 August 2022EgonwConverted into a text box
106863view13:34, 17 September 2019MaintBotHMDB identifier normalization
89961view18:11, 6 October 2016Mkutmonfix unconnected lines
88456view11:57, 9 August 2016MkutmonModified title
78426view10:26, 7 January 2015MaintBotadded missing graphIds
71717view20:15, 17 October 2013MaintBotAutomated update of data sources
71310view17:14, 17 October 2013MaintBotAutomated update of data sources
69063view18:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
67652view11:44, 26 June 2013DdiglesOntology Term : 'cadherin mediated signaling pathway' added !
59012view20:33, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
42575view16:58, 5 April 2011MkutmonModified categories
42574view16:56, 5 April 2011MkutmonModified description
42573view14:17, 5 April 2011Mkutmonnew literature reference
42572view12:01, 5 April 2011B.taneriModified description
42511view09:49, 31 March 2011Mkutmonconnect missing lines and form complexes + new legend
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External references

DataNodes

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NameTypeDatabase referenceComment
4.1BGeneProduct13823 (Entrez Gene) Validated target - predicted by splicing microarray
4.1GGeneProduct13822 (Entrez Gene) Validated target - predicted by splicing microarray
4.1NGeneProduct13821 (Entrez Gene) Validated target - predicted by bioinformatics
4.1RGeneProduct269587 (Entrez Gene) Validated target - predicted by splicing microarray
AGRINProteinA2ASQ1 (Uniprot/TrEMBL) Validated target - predicted by splicing microarray
Ankyrin GGeneProduct11735 (Entrez Gene) Validated target - predicted by splicing microarray
Aplp2GeneProductENSMUSG00000031996 (Ensembl Mouse) Validated target - predicted by splicing microarray
CASK GeneProductENSMUSG00000031012 (Ensembl Mouse) Validated target - predicted by splicing microarray
CASK ProteinP06796 (Uniprot/TrEMBL) Validated target - predicted by splicing microarray
CLIP predicted targetCLIP predicted target
CalsynteninGeneProduct65945 (Entrez Gene) Validated target - predicted by splicing microarray
Camk2gGeneProductENSMUSG00000021820 (Ensembl Mouse) Validated target - predicted by splicing microarray
CaskGeneProductENSMUSG00000031012 (Ensembl Mouse) Validated target - predicted by splicing microarray
Cav2.2 GeneProductENSMUSG00000000058 (Ensembl Mouse) Validated target - predicted by splicing microarray
Cav2.2GeneProductENSMUSG00000000058 (Ensembl Mouse) Validated target - predicted by splicing microarray
Chl1GeneProductENSMUSG00000030077 (Ensembl Mouse) Validated target - predicted by splicing microarray
Clasp1GeneProductENSMUSG00000064302 (Ensembl Mouse) Validated target - predicted by splicing microarray
Dab1GeneProductENSMUSG00000028519 (Ensembl Mouse) Validated target - predicted by bioinformatics
EphrinA5GeneProduct13640 (Entrez Gene) Validated target - predicted by splicing microarray
EphrinA5RGeneProductValidated target - predicted by splicing microarray
GABAARg2GeneProduct14406 (Entrez Gene) Validated target
GABAB2RGeneProduct242425 (Entrez Gene) CLIP predicted target
GIRK2GeneProduct16522 (Entrez Gene) CLIP predicted target
GephrinGeneProduct268566 (Entrez Gene) Validated target - predicted by splicing microarray
GluR6GeneProduct14806 (Entrez Gene) Validated target - predicted by splicing microarray
GlyRa2GeneProductValidated target
Igsf4aGeneProduct54725 (Entrez Gene) Validated target - predicted by splicing microarray
Igsf4bGeneProduct94332 (Entrez Gene) Validated target - predicted by bioinformatics
Integrin a2 GeneProductValidated target - predicted by bioinformatics
JNK2GeneProduct26420 (Entrez Gene) Validated target - predicted by CLIP
Kcnq2GeneProductENSMUSG00000016346 (Ensembl Mouse) Validated target - predicted by splicing microarray
LAR GeneProductValidated target - predicted by splicing microarray
MAP4ProteinP27546 (Uniprot/TrEMBL) Validated target - predicted by bioinformatics
Munc18GeneProduct20911 (Entrez Gene) Validated target - predicted by splicing microarray
N-CadherinGeneProduct12558 (Entrez Gene)
NIK/Mapk4 GeneProductENSMUSG00000024558 (Ensembl Mouse) Validated target - predicted by splicing microarray
NMDAR1GeneProduct14810 (Entrez Gene) Validated target - predicted by splicing microarray
NMDAR2BGeneProduct14812 (Entrez Gene) CLIP predicted target
NeogeninGeneProduct18007 (Entrez Gene) Validated target - predicted by CLIP
Netrin G1GeneProduct80883 (Entrez Gene) Validated target - predicted by splicing microarray
PIP2 MetaboliteHMDB10032 (HMDB)
PKCzGeneProduct18762 (Entrez Gene) CLIP predicted target
PMCA1GeneProduct67972 (Entrez Gene) Validated target - predicted by splicing microarray
Plcb4GeneProductENSMUSG00000039943 (Ensembl Mouse) Validated target - predicted by splicing microarray
Rap1GeneProduct57321 (Entrez Gene)
Rap1gapGeneProduct110351 (Entrez Gene) Validated target - predicted by splicing microarray
SKIPGeneProduct66354 (Entrez Gene) Validated target - predicted by splicing microarray
SloGeneProduct16531 (Entrez Gene) Validated target - predicted by splicing microarray
Syntaxin 2GeneProduct13852 (Entrez Gene) Validated target - predicted by splicing microarray
Syntaxin1GeneProduct
a-catenin GeneProductValidated target - predicted by splicing microarray
nAChRa2GeneProductCLIP predicted target
nAChRa4GeneProductCLIP predicted target
neurochondrinGeneProduct26562 (Entrez Gene) Validated target - predicted by splicing microarray
validated targetValidated target
validated target - predicted by CLIPValidated target - predicted by CLIP
validated target - predicted by bioinformaticsValidated target - predicted by bioinformatics
validated target - predicted by splicing microarrayValidated target - predicted by splicing microarray

Annotated Interactions

No annotated interactions

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