Leptin-insulin signaling overlap (Mus musculus)

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11IRSPI3KDNAIRSIRSAkt1/PKBPDK1Irs2Stat3InsulinPKCP85Irs4Stat3PIP3Stat3P110Jak2Irs3P110Socs1Irs1InsrLeprPIP2Socs3LeptinSocs2Jak2Jak2


Description

Overlap of cellular insulin and leptin signaling

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Quality Tags

Ontology Terms

 

Bibliography

  1. Numan S, Russell DS; ''Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain.''; Brain Res Mol Brain Res, 1999 PubMed Europe PMC Scholia
  2. Banks AS, Davis SM, Bates SH, Myers MG Jr; ''Activation of downstream signals by the long form of the leptin receptor.''; J Biol Chem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140639view06:42, 24 September 2025EgonwLonger description
139887view19:35, 9 July 2025EgonwRemoved duplicate BioPax fields
116798view10:02, 14 May 2021EweitzModified title
116796view10:01, 14 May 2021EweitzModified title
107211view14:30, 17 September 2019MaintBotChEBI identifier normalization
89977view18:44, 6 October 2016Mkutmonfix unconnected lines
72579view16:05, 23 November 2013EgonwReplace a revoked HMDB id with a ChEBI id.
71323view17:17, 17 October 2013MaintBotAutomated update of data sources
69134view18:15, 8 July 2013MaintBotUpdated to 2013 gpml schema
62835view04:55, 3 May 2013MaintBotUpdated UniProt data source
59046view20:48, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
45175view08:52, 7 October 2011ThomasOntology Term : 'leptin system pathway' added !
43785view20:58, 27 July 2011Samuel SklarSpecify description
41321view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
39408view19:19, 23 November 2010MartijnVanIerselOntology Term : 'insulin signaling pathway' added !
32155view14:03, 14 August 2009MaintBotFixed group labels
29902view12:10, 9 June 2009Thomasupdated ensembl references
21896view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Insulin Leptin Overlap]] moved to [[Pathway:WP578]]: Moved to stable identifier
19750view20:09, 10 October 2008MartijnVanIerselConnected lines
19748view20:07, 10 October 2008MartijnVanIerselFixed PIP2 reference
19614view13:55, 9 October 2008EveloAdded leptin backpage
19611view12:34, 9 October 2008EveloModified description
16144view08:13, 12 June 2008SusanModified categories
16142view08:12, 12 June 2008SusanModified categories
16124view12:36, 11 June 2008SusanAdding ID's
15886view12:52, 6 June 2008SusanAdding connections
15880view12:40, 6 June 2008SusanNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1/PKBGeneProduct11651 (Entrez Gene)
InsrGeneProduct16337 (Entrez Gene)
InsulinGeneProduct16333 (Entrez Gene)
Irs1GeneProduct16367 (Entrez Gene)
Irs2GeneProduct384783 (Entrez Gene)
Irs3GeneProduct16369 (Entrez Gene)
Irs4GeneProduct16370 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
LeprGeneProduct16847 (Entrez Gene)
LeptinGeneProductP41160 (SwissProt)
P110GeneProductENSMUSG00000020573 (Ensembl Mouse)
P85GeneProductENSMUSG00000028698 (Ensembl Mouse)
PDK1GeneProduct18607 (Entrez Gene)
PIP2MetaboliteHMDB06811 (HMDB)
PIP3Metabolite16618 (ChEBI)
PKCGeneProductENSMUSG00000040479 (Ensembl Mouse)
Socs1GeneProduct12703 (Entrez Gene)
Socs2GeneProduct216233 (Entrez Gene)
Socs3GeneProduct12702 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP578"
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