EGF Receptor Signaling Pathway (Homo sapiens)

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Revision as of 20:30, 22 August 2011 by Khanspers (Talk | contribs)
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SHC1PIP3PIP2Internalization, degradation and recycling of EGFRPIP2DAGIP3actinCYCYNUNUCYEGFR signal transduction pathwayReleaseRegulation ofPathwayNUNUCa2+NFKBCYpolymerizationNUSTAT1AP2A1HRASIQGAP1COX2EPS8GRB2SOS2TNK2NCOA3PRKCZJAK2RIN1MAPK8PLSCR1RPS6KA1PLD2ABI1ATXN2STAT5ASHC1STAMBPMAPK14PCNAMAP3K1PRKCISTAT3VAV1NCK1PTPN11CREB1STAM2MEF2DCAV2NCK2PTENCRKMAP2K2GJA1SH3GL3PLCE1EIF4EBP1CAMK2ASYNJ1EPN1MAPK3PLSCR1PTPN5ERBB2NEDD4FOXO4E2F1GAB1EGFREGFPTPRRINPP5DUSP6NLCSKPEBP1KRASRPS6KB1PIAS3EGFRRAB5ARAC1BRAFMAPK1PRKCABCAR1PLCG1FOXO1DOK2RALBMAP3K4VAV2EGFRELK1RASA1RPS6KA5MYBL2RICTORATF1CRKLSH3GL2JAK1INPPL1PRKCDVAV3PIK3R1ARF6MAP3K3SRCMAP2K5JUNDAP2S1PRKCBPTK6EPS15L1MAP2K1HGSSOS1REPS2ELK4FOSBERRFI1AKT1JUNIQSEC1USP8SH3KBP1PTK2BSTMN1SH2D2APTPN12RPS6KA3RALASTAMMAP4K1ROCK1CAV1LIMK2MAPK7STXBP1STAT5BRALGDSRAP1AMAPK9SPRY2AP2B1CDC42PLD1PDPK1ABL1PIK3R2MTORASAP1ITCHGRIM19TWIST1DNM1AURKAGRB10MAP3K2RALBP1SP1RPS6KA2NEDD8GAB2PIK3C2BEPS15NOS3FOSRAF1ARHGEF1PUbPPPPPPPPPPPPPPGTPpPGTPGTPPGTPPPPPPPPPPGTPPGTPPPPPPGTPPUbPPGTPPPPPPPPPPPPPPPEGFREGFRCBLBCBLCBLCSRCPGRB2PSOS1RALBP1CBLBCBLCBLCPPLD1PAK1PSTAT3STAT1PSTAT5BPPSTAT5APCFL1PTK2PEGFAP2M1PIAS3MEF2ASRCPXNEndosome/Multivesicular bodies/LysozomeHRASGTPVAV2PSP1PEPS8MEF2CRPS6KA3MAPK3MAPK1MAPK9MAPK8PPMAPK7MAP2K2MAP2K1NUCYCYNUNUNUCYNUCYCYEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinmRNAProteinReceptorLigandDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage


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History

CompareRevisionActionTimeUserComment
44083view21:00, 23 August 2011KhanspersDeleted pathway: duplicate
43999view20:30, 22 August 2011KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABI1GeneProduct10006 (Entrez Gene)
ABL1GeneProduct25 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
AP2A1Protein160 (Entrez Gene)
AP2B1Protein163 (Entrez Gene)
AP2M1Protein1173 (Entrez Gene)
AP2S1Protein1175 (Entrez Gene)
ARF6GeneProduct382 (Entrez Gene)
ARHGEF1Protein9138 (Entrez Gene)
ASAP1GeneProduct50807
ATF1GeneProduct466 (Entrez Gene)
ATXN2GeneProduct6311 (Entrez Gene)
AURKAGeneProduct6790 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
CAV1Protein857 (Entrez Gene)
CAV2GeneProduct858
CBLGeneProduct867
CBLBGeneProduct868 (Enzyme Nomenclature)
CBLCGeneProduct23624 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CFL1Protein1072 (Entrez Gene)
COX2GeneProduct
CREB1GeneProduct1385 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CSKGeneProduct1445 (Entrez Gene)
DNM1Protein1759 (Entrez Gene)
DOK2Protein9046 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956
EGFRGeneProduct1956 (Entrez Gene)
EIF4EBP1GeneProduct1978
ELK1GeneProduct2002 (Entrez Gene)
ELK4GeneProduct2005 (Entrez Gene)
EPN1Protein29924 (Entrez Gene)
EPS15GeneProduct2060 (Entrez Gene)
EPS15L1Protein58513 (Entrez Gene)
EPS8GeneProduct2059 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
ERRFI1GeneProduct54206 (Entrez Gene)
FOSProtein2353 (Entrez Gene)
FOSBProtein2354 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO4GeneProduct4303 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GAB2GeneProduct9846 (Entrez Gene)
GJA1GeneProduct2697 (Entrez Gene)
GRB10GeneProduct2887
GRB2Protein2885 (Entrez Gene)
GRIM19GeneProduct51079 (Entrez Gene)
HGSGeneProduct9146 (Entrez Gene)
HRASGeneProduct3265
INPP5DProtein3635 (Entrez Gene)
INPPL1Protein3636 (Entrez Gene)
IQGAP1GeneProduct8826 (Entrez Gene)
IQSEC1GeneProduct9922 (Entrez Gene)
ITCHProtein83737 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
JUNDProtein3727 (Entrez Gene)
KRASProtein3845 (Entrez Gene)
LIMK2Protein3985 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP4K1Protein11184 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5596 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MEF2AProtein207 (Entrez Gene)
MEF2CProtein5605 (Entrez Gene)
MEF2DGeneProduct160 (Entrez Gene)
MTORProtein207 (Entrez Gene)
MYBL2GeneProduct4605 (Entrez Gene)
NCK1GeneProduct4690 (Entrez Gene)
NCK2GeneProduct8440 (Entrez Gene)
NCOA3GeneProduct
NEDD4GeneProduct4737
NEDD8GeneProduct4738 (Entrez Gene)
NOS3GeneProduct
PAK1GeneProduct5338
PCNAGeneProduct5111 (Entrez Gene)
PDPK1Protein5170 (Entrez Gene)
PEBP1GeneProduct5037 (Entrez Gene)
PIAS3GeneProduct10401 (Entrez Gene)
PIK3C2BGeneProduct5287 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PLCE1Protein51196 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PLD1Protein5337 (Entrez Gene)
PLD2GeneProduct5338
PLSCR1GeneProduct5359 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCBGeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PTENGeneProduct5728 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTK6GeneProduct5753 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN12GeneProduct5782 (Entrez Gene)
PTPN5GeneProduct84867 (Entrez Gene)
PTPRRGeneProduct5801
PXNGeneProduct38326 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
RAB5AProtein5868 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RALAProtein5898 (Entrez Gene)
RALBProtein5899 (Entrez Gene)
RALBP1Protein10928 (Entrez Gene)
RALGDSProtein5900 (Entrez Gene)
RAP1AProtein5906 (Entrez Gene)
RASA15921 (Entrez Gene)
REPS2Protein9185 (Entrez Gene)
RICTORGeneProduct253260 (Entrez Gene)
RIN1Protein9610 (Entrez Gene)
ROCK1Protein
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
SH2D2AGeneProduct9047 (Entrez Gene)
SH3GL2GeneProduct6456 (Entrez Gene)
SH3GL3GeneProduct6457 (Entrez Gene)
SH3KBP1Protein30011 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
SPRY2GeneProduct10253 (Entrez Gene)
SRCGeneProduct6714
STAM2Protein10254 (Entrez Gene)
STAMProtein8027 (Entrez Gene)
STAMBPGeneProduct10617 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
STXBP1GeneProduct6812 (Entrez Gene)
SYNJ1GeneProduct8867 (Entrez Gene)
TNK2GeneProduct10188 (Entrez Gene)
TWIST1GeneProduct7291 (Entrez Gene)
USP6NLProtein9712 (Entrez Gene)
USP8GeneProduct9101 (Entrez Gene)
VAV1Protein7409 (Entrez Gene)
VAV2Protein7410 (Entrez Gene)
VAV3Protein10451 (Entrez Gene)
mRNAProtein

Annotated Interactions

No annotated interactions

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