IL3 signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Name: New Pathway


Description

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15

Comments

GenMAPP notes 
NetPath:15 - IL-3 Signaling Pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

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View approved pathways at the new wikipathways.org.

Quality Tags

Image:Curated.pngReview changes for Approved
Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137586
Approved
view07:31, 5 March 2025EgonwModified description
129666view00:40, 22 May 2024EweitzModified title
129665view00:39, 22 May 2024EweitzModified title
126282view04:33, 20 April 2023EgonwLicense is CCZero
120663view23:29, 22 December 2021EweitzStandardize font
116632view11:21, 9 May 2021EweitzModified title
115919view16:58, 20 March 2021EgonwCopied the NetPath paper into the literature list
115914view14:27, 20 March 2021EgonwModified description
108324view21:02, 6 December 2019L DupuisConverted interactions to graphical lines in legend
78583view14:50, 7 January 2015MaintBotadded missing graphIds
72139view09:43, 25 October 2013Mkutmonadded datasources to some proteins
67374view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-3 signaling pathway' added !
63210view20:57, 8 May 2013MaintBotUpdating gpml version
61833view17:22, 19 April 2013MaintBotfixed xrefs
61676view21:17, 16 April 2013MaintBotAdded missing Data Source
48436view14:30, 24 May 2012NetPathModified description
44845view09:46, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44623view18:01, 22 September 2011KhanspersUpdating content to NetSlim
44107view20:30, 24 August 2011KhanspersReverted to version '23:43, 1 March 2011' by Khanspers
44027view22:56, 22 August 2011KhanspersAdded category
44026view22:55, 22 August 2011KhanspersModified description
44025view22:53, 22 August 2011KhanspersUpdating pathway from NetSlim
41196view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
35642view21:30, 12 February 2010KhanspersModified description
21281view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-3 NetPath 15]] moved to [[Pathway:WP286]]: Moved to stable identifier
8170view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-3 NetPath 15]] moved to [[Pathway:Homo sapiens:IL-3 NetPath 15]]: Renaming species
7705view16:11, 18 December 2007MaintBotfixed category names
7244view12:41, 4 November 2007MaintBotAdded categories to GPML
6336view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-3_NetPath_15]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProduct207 (Entrez Gene)
ATF1GeneProduct466 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BCL2L11GeneProduct10018 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
BIRC5GeneProduct332 (Entrez Gene)
BMXGeneProduct660 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene)
CISHGeneProduct1154 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CSF2RBGeneProduct1439 (Entrez Gene)
DNM1GeneProduct1759 (Entrez Gene)
FCER2GeneProduct2208 (Entrez Gene)
FESGeneProduct2242 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GAB2GeneProduct9846 (Entrez Gene)
GATA1GeneProduct2623 (Entrez Gene)
GATA2GeneProduct2624 (Entrez Gene)
GNB2L1GeneProduct10399 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct3055 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
HSPB1GeneProduct3315 (Entrez Gene)
ID1GeneProduct3397 (Entrez Gene)
IL3GeneProduct3562 (Entrez Gene)
IL3RAGeneProduct3563 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
KCNIP3GeneProduct30818 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
MATKGeneProduct4145 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
MRASGeneProduct22808 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PILRBGeneProduct29990 (Entrez Gene)
PPP2CAGeneProduct5515 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RARAGeneProduct5914 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
SELPGeneProduct6403 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SLC2A1GeneProduct6513 (Entrez Gene)
SOCS2GeneProduct8835 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SPI1GeneProduct6688 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
STAT6GeneProduct6778 (Entrez Gene)
SYKGeneProduct6850 (Entrez Gene)
TECGeneProduct7006 (Entrez Gene)
TNFRSF1BGeneProduct7133 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
VCLGeneProduct7414 (Entrez Gene)
YWHABGeneProduct7529 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene)
YWHAZGeneProduct7534 (Entrez Gene)

Annotated Interactions

No annotated interactions
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