B cell receptor signaling (Homo sapiens)

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CytoplasmUbiquitinationPMAutophosphorylationDCY->PMCY->NUNucleusMitochondriaARP2/3SumoylationNUDCY->PMCY->PMCY->PM(Protein-protein interaction)CYPhosphorylationDDCY->PMCY->MTCY->PMMolecule in the pathwayDEndoplasmic reticulumDInhibitionLigandAccesion Number: NetPath 12DMethylationRecruitmentCY->PMCY->PMPM->CYDComplexDemethylationECDEnzyme ComplexTranslocationCY->NUGOCY->NUDephosphorylationDCY->NUMT->CYPlasma membraneCY->PMCY->PMDCY->PMNU->CYCY->PMCY->PMDGlycosylationProteolytic cleavageDActivationEndosomeDAcetylationDesumoylationControlDeacetylationCY->NUNU->CYDMolecular associationGolgi apparatusReaction through unknown mechanisms/moleculesCY->PMCY->NUPM->CYReceptorDeubiquitinationCY->PMCY->NUMTCY->NUENMAPalmitoylationExtracellularProteins in a complex interactionCY->PMCY->PMDERCY->PMCCNE1DOK3BRAGCDK4ITKMAPK14SHC1PRKCECCND2PTPN6CRKHDAC7ARB1PIP5K1BSOS2SH3BP2LCP2PIP5K2BRAPGEF1SLA2PLEKHA1BRDG1CYCSMAP4K1PLCG1GTF2IRELPIP5K1CCD5RHOAPDK2LYNCBLMAPK1PIP5K2AGene SymbolLAT2PIK3AP1NFATC2BCL2CASP7MAPKAPK2HDAC5LYNPTPN6NCK1SYKPRKD1SYKZAP70CDK6PLEKHA1PLCG2PLEKHA2MAPK3RAPGEF1HCKIKBKBBLNKCYCSPIP5K1BGSK3BAKT1BAXVAV1DUSP4CSKGAB1NEDD9FCGR2BARPC4FYNPIK3R1NFATC3PRKCDBRAFRASA1CMTM3BANK1PTPN18PIK3CGPRKCB1ELK1CCNA2LAT2CD79BPIK3AP1ARPC3AKT1HNRPKPIP5K2BLIME1CDK2DAPP1PTK2BMAPK8CTNNB1BTKBTKCD79APLEKHA2PIP5K1APIP5K2CFOXO1AHDAC7ABCL2L11GAB2PRKCQBLKCRKLCHUKIKBKGSYKSOS1MAP2K1RPS6KA1PRKCEBCL10PTPRCLYNRPS6KB1CD81PIP5K2BBCAR1PTK2HCLS1CTNNB1CASP9PRKCDAPSRELAPPP3CBSHC1RASGRP3DUSP6PTPN11CRKDOK1CD22ARPC1BINPP5DCR2ARP2GSK3ARPS6CARD11JUNMAPK4RAP2APLCG2BLNKBCL6STAT1GRB2RPS6KA1CHUKPILRBPPP3CAGRB2MAP3K7ATF2PDPK1IKBKBRELCD79AIGHMPRKCB1PTPN6CDK7ITPR2GAB1CBLBNFATC3CD19ITPR1RASGRP3ARPC5CARD11WASGTF2IRAF1ARPC2CD72MAP2K2ARP3NFATC1HCLS1PPP3R1TECPIP5K1BCCND3ATP2B4STAT3PIK3R2INPP5DLCKRELADAPP1BAXCREB1HDAC5VAV2NFATC2NFKBIAHCLS1


Description

The B cell receptor includes membrane μ heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_12

Comments

GenMAPP notes 
NetPath 12 - B Cell Receptor Signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135864view03:38, 20 November 2024EweitzClear cache
135863view02:00, 20 November 2024EweitzEconomize layout
135862view01:52, 20 November 2024EweitzClear cache to tailor board dimensions
135861view01:50, 20 November 2024EweitzEconomize layout, standardize nucleus representation
135859view22:25, 19 November 2024EweitzRemove graphical blemish
135532view22:55, 22 September 2024EweitzEconomize layout
135531view22:50, 22 September 2024EweitzEconomize layout
135530view03:42, 22 September 2024EweitzRefine legend
135529view03:41, 22 September 2024EweitzRefine legend
135528view03:32, 22 September 2024EweitzFix interaction modeling, thin interactions for discernibility
135527view03:24, 22 September 2024EweitzFix interaction modeling
135526view03:18, 22 September 2024EweitzThin interactions, for discernible ends
135525view03:08, 22 September 2024EweitzRefine legend
135524view03:03, 22 September 2024EweitzEconomize layout, improve alignment
135523view02:58, 22 September 2024EweitzAlign translocations
135522view02:50, 22 September 2024EweitzEconomize layout
135521view02:49, 22 September 2024EweitzThin lines for translocation, for discernible ends
135520view02:44, 22 September 2024EweitzEconomize layout
135495view12:54, 20 September 2024EweitzConnect source node in branching interactions, refine receptor graphic
135494view12:49, 20 September 2024EweitzConnect source node in branching interactions
135493view12:43, 20 September 2024EweitzConnect source node in branching interactions, refine legend
135492view02:40, 20 September 2024EweitzEconomize layout
135488view00:05, 20 September 2024EweitzRemove errant nodes shown in Kaavio / Pvjs, but not PathVisio
129688view00:47, 22 May 2024EweitzModified title
126262view05:57, 19 April 2023EgonwLicense is CCZero
120701view13:17, 23 December 2021EweitzStandardize font, weight, case
117659view11:52, 22 May 2021EweitzModified title
115881view12:33, 19 March 2021EgonwCopied the NetPath reference into the literature list
115879view12:30, 19 March 2021EgonwModified description
108321view20:51, 6 December 2019L DupuisConverted interactions to graphical lines in legend
106310view17:47, 20 August 2019KhanspersModified description
105541view06:07, 9 August 2019KhanspersModified description
92558view00:23, 16 June 2017AlexanderPicoFixed 0 widths and heights by removing "hidden" elements
89900view13:18, 6 October 2016MkutmonModified description
89899view13:17, 6 October 2016MkutmonModified description
79985view16:20, 29 April 2015Zariannotated PDPK2, CD79B ,CD79A, CD19 and LCK
78566view14:50, 7 January 2015MaintBotadded missing graphIds
72101view21:43, 24 October 2013Mkutmonadded datasource for "GSK3A" and "CD81"
71524view19:22, 17 October 2013MaintBotremoved data source from nodes without identifier
67071view10:02, 26 June 2013Christine ChichesterOntology Term : 'B cell receptor signaling pathway' added !
63145view20:12, 8 May 2013MaintBotUpdating GPML version
47980view14:44, 23 April 2012NetPathModified description
44975view14:24, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to immunity' added !
44972view14:22, 6 October 2011MartijnVanIerselOntology Term : 'B cell' added !
44829view07:29, 6 October 2011Mkutmonconnected some lines
44620view17:50, 22 September 2011KhanspersUpdating content to NetSlim
44113view20:38, 24 August 2011KhanspersReverted to version '23:43, 1 March 2011' by Khanspers
44035view23:18, 22 August 2011KhanspersModified description
44034view23:16, 22 August 2011KhanspersUpdating pathway from NetSlim
41190view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
APSGeneProduct10603 (Entrez Gene)
ARP2GeneProduct10097 (Entrez Gene)
ARP3GeneProduct10096 (Entrez Gene)
ARPC1BGeneProduct10095 (Entrez Gene)
ARPC2GeneProduct10109 (Entrez Gene)
ARPC3GeneProduct10094 (Entrez Gene)
ARPC4GeneProduct10093 (Entrez Gene)
ARPC5GeneProduct10092 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
ATP2B4GeneProduct493 (Entrez Gene)
BANK1GeneProduct55024 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
BCL10GeneProduct8915 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BCL2L11GeneProduct10018 (Entrez Gene)
BCL6GeneProduct604 (Entrez Gene)
BLKGeneProduct640 (Entrez Gene)
BLNKGeneProduct29760 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
BRAGGeneProduct51363 (Entrez Gene)
BRDG1GeneProduct26228 (Entrez Gene)
BTKGeneProduct695 (Entrez Gene)
CARD11GeneProduct84433 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CD19GeneProduct930 (Entrez Gene)
CD22GeneProduct933 (Entrez Gene)
CD5GeneProduct921 (Entrez Gene)
CD72GeneProduct971 (Entrez Gene)
CD79AGeneProduct973 (Entrez Gene)
CD79BGeneProduct974 (Entrez Gene)
CD81GeneProduct975 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
CHUKGeneProduct1147 (Entrez Gene)
CMTM3GeneProduct123920 (Entrez Gene)
CR2GeneProduct1380 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CSKGeneProduct1445 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CYCSGeneProduct54205 (Entrez Gene)
DAPP1GeneProduct27071 (Entrez Gene)
DOK1GeneProduct1796 (Entrez Gene)
DOK3GeneProduct79930 (Entrez Gene)
DUSP4GeneProduct1846 (Entrez Gene)
DUSP6GeneProduct1848 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
FCGR2BGeneProduct2213 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GAB2GeneProduct9846 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
GTF2IGeneProduct2969 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct3055 (Entrez Gene)
HCLS1GeneProduct3059 (Entrez Gene)
HDAC5GeneProduct10014 (Entrez Gene)
HDAC7AGeneProduct51564 (Entrez Gene)
HNRPKGeneProduct3190 (Entrez Gene)
IGHMGeneProduct3507 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
ITKGeneProduct3702 (Entrez Gene)
ITPR1GeneProduct3708 (Entrez Gene)
ITPR2GeneProduct3709 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LAT2GeneProduct7462 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
LCP2GeneProduct3937 (Entrez Gene)
LIME1GeneProduct54923 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
NCK1GeneProduct4690 (Entrez Gene)
NEDD9GeneProduct4739 (Entrez Gene)
NFATC1GeneProduct4772 (Entrez Gene)
NFATC2GeneProduct4773 (Entrez Gene)
NFATC3GeneProduct4775 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene)
PDK2GeneProduct5164 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PIK3AP1GeneProduct118788 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PILRBGeneProduct29990 (Entrez Gene)
PIP5K1AGeneProduct8394 (Entrez Gene)
PIP5K1BGeneProduct8395 (Entrez Gene)
PIP5K1CGeneProduct23396 (Entrez Gene)
PIP5K2AGeneProduct5305 (Entrez Gene)
PIP5K2BGeneProduct8396 (Entrez Gene)
PIP5K2CGeneProduct79837 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PLCG2GeneProduct5336 (Entrez Gene)
PLEKHA1GeneProduct59338 (Entrez Gene)
PLEKHA2GeneProduct59339 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCEGeneProduct5581 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PRKD1GeneProduct5587 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN18GeneProduct26469 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
PTPRCGeneProduct5788 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAP2AGeneProduct5911 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RASGRP3GeneProduct25780 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RELGeneProduct5966 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
RPS6GeneProduct6194 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
SH3BP2GeneProduct6452 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SLA2GeneProduct84174 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
SYKGeneProduct6850 (Entrez Gene)
TECGeneProduct7006 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
VAV2GeneProduct7410 (Entrez Gene)
WASGeneProduct7454 (Entrez Gene)
ZAP70GeneProduct7535 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP23"
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