SREBF and miR33 in cholesterol and lipid homeostasis (Homo sapiens)

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Bibliography

1. Rodgers JT, Puigserver P; ''Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
2. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM; ''An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.''; Nature, 2006 PubMed Europe PMC Scholia
3. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T; ''MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
4. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P; ''Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.''; EMBO J, 2007 PubMed Europe PMC Scholia
5. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P; ''mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.''; Nature, 2007 PubMed Europe PMC Scholia
6. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH; ''SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.''; EMBO J, 2007 PubMed Europe PMC Scholia
7. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM; ''Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.''; Genes Dev, 2010 PubMed Europe PMC Scholia
8. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT; ''Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
9. Joseph T Rodgers, Pere Puigserver; ''Receptor feasts on sugar and cholesterol''; Nature Medicine, 2007 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
ABCA1	GeneProduct	19 (Entrez Gene)
ALLC	GeneProduct	ENSG00000151360 (Ensembl Human)
HMGCR	GeneProduct	ENSG00000113161 (Ensembl Human)
HMGCS1	GeneProduct	ENSG00000112972 (Ensembl Human)
LDLR	GeneProduct	ENSG00000130164 (Ensembl Human)
MED15	GeneProduct	ENSG00000099917 (Ensembl Human)
MIR33A	GeneProduct	ENSG00000207932 (Ensembl Human)
MIR33B	GeneProduct	ENSG00000207839 (Ensembl Human)
MTOR	GeneProduct	ENSG00000198793 (Ensembl Human)
NR1H3	GeneProduct	ENSG00000025434 (Ensembl Human)
PAG1	GeneProduct	ENSG00000076641 (Ensembl Human)
PPARA	GeneProduct	ENSG00000186951 (Ensembl Human)
PPARGC1A	GeneProduct	ENSG00000109819 (Ensembl Human)
PRKAB1	GeneProduct	ENSG00000111725 (Ensembl Human)
SIRT1	GeneProduct	ENSG00000096717 (Ensembl Human)
SIRT6	GeneProduct	ENSG00000077463 (Ensembl Human)
SREBF1	GeneProduct	ENSG00000072310 (Ensembl Human)
SREBF2	GeneProduct	ENSG00000198911 (Ensembl Human)

Annotated Interactions