TSH signaling pathway (Homo sapiens)

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CCND3CCND3MAP2K1PMAPK3PPIK3R2PIP2cAMPPIP3DAGIP3PKANUProteinCell proliferationTSH Signaling PathwayProteinReceptormRNALigandCYProtein - protein dissociationEnzyme ComplexProteinTTF1GNB1TSHBMYCKCNIP3STAT1 FOSGNG2RAF1BRAFCGAPAX8HRASTTF2EGR1SCRIBJUNE2F1PGTPTSHRSTAT3PPDPK1PIK3CAPPIK3R1CDK2PPSRCpMAP2K3MAP2K6PPAKT1PPRKCZRPS6KB1PMAPK1PRB1PCREB1PPDE4DPGNAI1GTPGNA13GNAI2GTPGNA12GTPGNAO1GTPGTPGNAQGTPGNAI3GTPMYL12BDePRALGDSGNASGTPJAK2PJAK1PRPS6MTORPADCY2ADCY3CDK2PCDK4PRPS6KA1PPLD1PLCB1RAP1BGTPRAP1AGTPRHOACCNE1MAPK14CDKN1BPCCND3CDK4RAP1GAPPPNUCYPKANUCYSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeAPEX1APEX1NUCY


Description

Human thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-thyroid by stimulating production and secretion of the thyroid hormone from the thyroid gland. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules.

Comments

GenMAPP notes 
NetPath_23 - TSH signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

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Bibliography


History

CompareRevisionActionTimeUserComment
44636view18:25, 22 September 2011KhanspersDeleted pathway: duplicate
44557view08:35, 20 September 2011JyotiModified description
44556view08:26, 20 September 2011JyotiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY2Protein108 (Entrez Gene)
ADCY3Protein109 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
APEX1Protein328 (Entrez Gene)
BRAFProtein673 (Entrez Gene)
CCND3Protein896 (Entrez Gene)
CCNE1Protein898 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
CDK4Protein1019 (Entrez Gene)
CDKN1BProtein1027 (Entrez Gene)
CGAProtein1081 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
E2F1Rna1869 (Entrez Gene)
EGR1Rna1958
FOSRna2353 (Entrez Gene)
GNA12Protein2768 (Entrez Gene)
GNA13Protein10672 (Entrez Gene)
GNAI1Protein2770 (Entrez Gene)
GNAI2Protein2771 (Entrez Gene)
GNAI3Protein2773 (Entrez Gene)
GNAO1Protein2775 (Entrez Gene)
GNAQProtein2776 (Entrez Gene)
GNASProtein2778 (Entrez Gene)
GNB1Protein2782 (Entrez Gene)
GNG2Protein54331 (Entrez Gene)
HRASProtein3265 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNRna3725 (Entrez Gene)
KCNIP3Protein30818 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K3Protein5606 (Entrez Gene)
MAP2K6Protein5608 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
MYCRna
MYL12BProtein103910 (Entrez Gene)
PAX8Rna7849 (Entrez Gene)
PDE4DProtein5144 (Entrez Gene)
PDPK1Protein5170 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PLCB1Protein23236 (Entrez Gene)
PLD1Protein5337 (Entrez Gene)
PRKCZProtein5934 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RALGDSProtein5900 (Entrez Gene)
RAP1AProtein5906 (Entrez Gene)
RAP1BProtein5908 (Entrez Gene)
RAP1GAPProtein5909 (Entrez Gene)
RB1Protein5925 (Entrez Gene)
RHOAProtein3480 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KA1Protein6195 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
SCRIBProtein23513 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1 Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
TSHBProtein7252 (Entrez Gene)
TSHRProtein7253 (Entrez Gene)
TTF1Rna7270 (Entrez Gene)
TTF2Rna8458 (Entrez Gene)

Annotated Interactions

No annotated interactions
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