Prolactin signaling (Homo sapiens)

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ProteinPIK3CAPRLRPIK3R2PRegulation ofApoptosisCell proliferationCytoskeletonImmunoregulationProlactin Signaling PathwayCell survival(Endothelial cells)STAT5ASTAT5BRELANFKB1MAPK3SOCS2PAK1PIAS3CTSDPRLMYCFOSRPS6KA2PIK3CGCISHSTAT5ANOS2JAK1NFKBIBJUNPIK3CBAGAP2PTPN6PPIBPRLPPIBCASP3SH2B1STAT5ASOCS3NFKBIAPPPPPPPPPPPPPSTAT1PSTAT1PCBLPRELAPNEK3GAB2PCISHERRB2PMAPK1PITGB1VAV2PFLNAIRF1SIRPAPPIAPRLRPMAPK3PRAC1GTPMAPK1PMTORPAKT1PRPS6PMAPK9P MAPK8PGSK3BPMAPK14PEIF4EBP1PCYNUCYNUPRLSOCS3JAK2PVAV1PSTAT5ASTAT5BPSHC1PGRB2PPTPN11PSOCS2PIK3R1PFYNPIRS1IRS2PPZAP70PPTPN1RPS6KB1PPTK2PELK1PPXNPSTAT3PSTAT5APYWHAGYWHAZSOS1RAF1PHRASGTPMAP2K2PMAP2K1PSOCS1TECSRCPPMNUCYNUCYNUInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageProtein-protein dissociationmRNAReceptorLigandProteinEnzyme complexProtein16 KDa


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Bibliography

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History

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CompareRevisionActionTimeUserComment
129671view00:42, 22 May 2024EweitzModified title
126350view09:31, 23 April 2023EgonwLicense is CCZero
122570view10:37, 16 April 2022EgonwMade two pathways clickable
116779view09:50, 14 May 2021EweitzModified title
106530view23:50, 5 September 2019KhanspersModified description
105793view22:44, 15 August 2019KhanspersModified description
95112view14:47, 16 November 2017Mkutmonremove nested groups
90015view19:24, 8 October 2016AlexanderPicoModified description
89878view12:54, 6 October 2016MkutmonModified description
85569view11:18, 1 June 2016EgonwReplaced a mim-conversion with Arrow.
85553view08:29, 29 May 2016EgonwReplaced a mim-conversion with Arrow.
78501view10:28, 7 January 2015MaintBotadded missing graphIds
75382view21:19, 21 May 2014Khanspersupdating schema
67606view11:32, 26 June 2013DdiglesOntology Term : 'prolactin signaling pathway' added !
61683view21:55, 16 April 2013MaintBotadded data source where missing
48450view16:12, 24 May 2012NetPathModified description
48449view16:09, 24 May 2012NetPathModified description
47072view00:01, 15 March 2012KhanspersModified categories
46205view22:34, 3 January 2012KhanspersUpdating gpml
46067view19:56, 12 December 2011KhanspersUpdating gpml
45275view18:58, 7 October 2011KhanspersOntology Term : 'peptide and protein hormone signaling pathway' added !
44737view08:20, 29 September 2011JyotiModified description
44637view18:26, 22 September 2011KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
MAPK8Protein5599 (Entrez Gene)
AGAP2Protein116986 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CBLProtein867 (Entrez Gene)
CISHProtein1154 (Entrez Gene)
CTSDProtein1509 (Entrez Gene)
EIF4EBP1Protein1978 (Entrez Gene)
ELK1Protein2002 (Entrez Gene)
ERRB2Protein2064 (Entrez Gene)
FLNAProtein2316 (Entrez Gene)
FOSProtein2353 (Entrez Gene)
FYNProtein2534 (Entrez Gene)
GAB2Protein9846 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
GSK3BProtein2932 (Entrez Gene)
HRASProtein3265 (Entrez Gene)
IRF1Rna3659 (Entrez Gene)
IRS1Protein3667 (Entrez Gene)
IRS2Protein8660 (Entrez Gene)
ITGB1Protein3688 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
MYCProtein4609 (Entrez Gene)
NEK3Protein4752 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NFKBIBProtein4793 (Entrez Gene)
NOS2Rna4843 (Entrez Gene)
PAK1Protein5058 (Entrez Gene)
PIAS3Protein10401 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
PIK3CBProtein5291 (Entrez Gene)
PIK3CGProtein5294 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PPIAProtein5478 (Entrez Gene)
PPIBProtein5479 (Entrez Gene)
PRLProtein5617
PRLProtein5617 (Entrez Gene)
PRLRProtein5618 (Entrez Gene)
PTK2Protein5747 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PTPN1Protein5770 (Entrez Gene)
PTPN6Protein5777
PXNProtein5829 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KA2Protein6196 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
SH2B1Protein2316 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SIRPAProtein140885 (Entrez Gene)
SOCS1Protein8651 (Entrez Gene)
SOCS2Protein8835 (Entrez Gene)
SOCS3Rna9021
SOCS3Protein9021 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
TECProtein7006 (Entrez Gene)
VAV1Protein7409 (Entrez Gene)
VAV2Protein7410 (Entrez Gene)
YWHAGProtein7532 (Entrez Gene)
YWHAZProtein7534 (Entrez Gene)
ZAP70Protein7535 (Entrez Gene)

Annotated Interactions

No annotated interactions

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