Neural crest differentiation (Homo sapiens)
From WikiPathways
Description
Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143
When citing thies pathway, please reference the source publication (PMID: 19575671).
Quality Tags
Ontology Terms
Bibliography
View all... |
- Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, Sakai H; ''Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.''; BMC Dev Biol, 2010 PubMed Europe PMC Scholia
- Betancur P, Bronner-Fraser M, Sauka-Spengler T; ''Assembling neural crest regulatory circuits into a gene regulatory network.''; Annu Rev Cell Dev Biol, 2010 PubMed Europe PMC Scholia
- Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, Ravazzolo R, Ceccherini I; ''''; , PubMed Europe PMC Scholia
- Callery EM, Thomsen GH, Smith JC; ''A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.''; Dev Biol, 2010 PubMed Europe PMC Scholia
- Makki N, Capecchi MR; ''Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.''; Dev Biol, 2011 PubMed Europe PMC Scholia
- Filippi A, Tiso N, Deflorian G, Zecchin E, Bortolussi M, Argenton F; ''The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
- Ohtoshi A, Bradley A, Behringer RR, Nishijima I; ''Generation and maintenance of Dmbx1 gene-targeted mutant alleles.''; Mamm Genome, 2006 PubMed Europe PMC Scholia
- Arenkiel BR, Gaufo GO, Capecchi MR; ''Hoxb1 neural crest preferentially form glia of the PNS.''; Dev Dyn, 2003 PubMed Europe PMC Scholia
- Lewis JL, Bonner J, Modrell M, Ragland JW, Moon RT, Dorsky RI, Raible DW; ''Reiterated Wnt signaling during zebrafish neural crest development.''; Development, 2004 PubMed Europe PMC Scholia
- Knight RD, Javidan Y, Zhang T, Nelson S, Schilling TF; ''AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo.''; Development, 2005 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
ASCL1 | GeneProduct | ENSG00000139352 (Ensembl Human) | |
AXIN1 | GeneProduct | 8312 (Entrez Gene) | |
AXIN2 | GeneProduct | 8313 (Entrez Gene) | |
BMP4 | GeneProduct | ENSG00000125378 (Ensembl Human) | |
BMP7 | GeneProduct | ENSG00000101144 (Ensembl Human) | |
CDH1 | GeneProduct | ENSG00000039068 (Ensembl Human) | |
CDH2 | GeneProduct | ENSG00000170558 (Ensembl Human) | |
CDH6 | GeneProduct | ENSG00000113361 (Ensembl Human) | |
CDH7 | GeneProduct | ENSG00000081138 (Ensembl Human) | |
COL11A2 | GeneProduct | ENSG00000204248 (Ensembl Human) | |
COL2A1 | GeneProduct | ENSG00000139219 (Ensembl Human) | |
CTBP2 | GeneProduct | ENSG00000175029 (Ensembl Human) | |
CTNNB1 | GeneProduct | ENSG00000168036 (Ensembl Human) | |
DCT | GeneProduct | ENSG00000080166 (Ensembl Human) | |
DLL1 | GeneProduct | ENSG00000198719 (Ensembl Human) | |
DLL3 | GeneProduct | ENSG00000090932 (Ensembl Human) | |
DLL4 | GeneProduct | ENSG00000128917 (Ensembl Human) | |
DLX5 | GeneProduct | ENSG00000105880 (Ensembl Human) | |
DVL1 | GeneProduct | 1855 (Entrez Gene) | |
DVL2 | GeneProduct | 1856 (Entrez Gene) | |
DVL3 | GeneProduct | 1857 (Entrez Gene) | |
Differentiation | Pathway | ||
ETS1 | GeneProduct | ENSG00000134954 (Ensembl Human) | |
FGF19 | GeneProduct | ENSG00000162344 (Ensembl Human) | |
FGF2 | GeneProduct | ENSG00000138685 (Ensembl Human) | |
FGF8 | GeneProduct | ENSG00000107831 (Ensembl Human) | |
FGFR1 | GeneProduct | ENSG00000077782 (Ensembl Human) | |
FGFR2 | GeneProduct | ENSG00000066468 (Ensembl Human) | |
FGFR3 | GeneProduct | ENSG00000068078 (Ensembl Human) | |
FOXD3 | GeneProduct | ENSG00000187140 (Ensembl Human) | |
FZD3 | GeneProduct | ENSG00000104290 (Ensembl Human) | |
GBX2 | GeneProduct | ENSG00000168505 (Ensembl Human) | |
GFAP | GeneProduct | ENSG00000131095 (Ensembl Human) | |
GJB1 | GeneProduct | ENSG00000169562 (Ensembl Human) | |
GSK3B | GeneProduct | ENSG00000082701 (Ensembl Human) | |
HDAC10 | GeneProduct | ENSG00000100429 (Ensembl Human) | |
HDAC11 | GeneProduct | ENSG00000163517 (Ensembl Human) | |
HDAC1 | GeneProduct | ENSG00000116478 (Ensembl Human) | |
HDAC2 | GeneProduct | ENSG00000196591 (Ensembl Human) | |
HDAC3 | GeneProduct | ENSG00000171720 (Ensembl Human) | |
HDAC4 | GeneProduct | ENSG00000068024 (Ensembl Human) | |
HDAC5 | GeneProduct | ENSG00000108840 (Ensembl Human) | |
HDAC6 | GeneProduct | ENSG00000094631 (Ensembl Human) | |
HDAC7 | GeneProduct | ENSG00000061273 (Ensembl Human) | |
HDAC8 | GeneProduct | ENSG00000147099 (Ensembl Human) | |
HDAC9 | GeneProduct | ENSG00000048052 (Ensembl Human) | |
HES1 | GeneProduct | ENSG00000114315 (Ensembl Human) | |
HES5 | GeneProduct | ENSG00000197921 (Ensembl Human) | |
HEY2 | GeneProduct | ENSG00000135547 (Ensembl Human) | |
HOXB1 | GeneProduct | ENSG00000120094 (Ensembl Human) | |
ID1 | GeneProduct | ENSG00000125968 (Ensembl Human) | |
ISL1 | GeneProduct | ENSG00000016082 (Ensembl Human) | |
ITGB1 | GeneProduct | ENSG00000150093 (Ensembl Human) | |
LHX1 | GeneProduct | ENSG00000132130 (Ensembl Human) | |
LHX2 | GeneProduct | ENSG00000106689 (Ensembl Human) | |
MBP | GeneProduct | ENSG00000197971 (Ensembl Human) | |
MIA | GeneProduct | 8190 (Entrez Gene) | |
MITF | GeneProduct | ENSG00000187098 (Ensembl Human) | |
MPZ | GeneProduct | ENSG00000158887 (Ensembl Human) | |
MSX1 | GeneProduct | ENSG00000163132 (Ensembl Human) | |
MSX2 | GeneProduct | ENSG00000120149 (Ensembl Human) | |
MYB | GeneProduct | ENSG00000118513 (Ensembl Human) | |
MYC | GeneProduct | ENSG00000136997 (Ensembl Human) | |
NEUROG1 | GeneProduct | ENSG00000181965 (Ensembl Human) | |
NFKB1 | GeneProduct | ENSG00000109320 (Ensembl Human) | |
NFKB2 | GeneProduct | ENSG00000077150 (Ensembl Human) | |
NOTCH1 | GeneProduct | ENSG00000148400 (Ensembl Human) | |
NOTCH2 | GeneProduct | ENSG00000134250 (Ensembl Human) | |
NOTCH3 | GeneProduct | ENSG00000074181 (Ensembl Human) | |
NOTCH4 | GeneProduct | ENSG00000204301 (Ensembl Human) | |
OLIG1 | GeneProduct | ENSG00000184221 (Ensembl Human) | |
OLIG2 | GeneProduct | ENSG00000205927 (Ensembl Human) | |
OLIG3 | GeneProduct | ENSG00000177468 (Ensembl Human) | |
PAX3 | GeneProduct | ENSG00000135903 (Ensembl Human) | |
PAX7 | GeneProduct | ENSG00000009709 (Ensembl Human) | |
PHOX2B | GeneProduct | ENSG00000109132 (Ensembl Human) | |
PMP22 | GeneProduct | ENSG00000109099 (Ensembl Human) | |
PRTG | GeneProduct | ENSG00000166450 (Ensembl Human) | |
RBPJ | GeneProduct | ENSG00000168214 (Ensembl Human) | |
RHOB | GeneProduct | ENSG00000143878 (Ensembl Human) | |
SMAD1 | GeneProduct | ENSG00000170365 (Ensembl Human) | |
SNAI1 | GeneProduct | ENSG00000124216 (Ensembl Human) | |
SNAI2 | GeneProduct | ENSG00000019549 (Ensembl Human) | |
SOX10 | GeneProduct | ENSG00000100146 (Ensembl Human) | |
SOX5 | GeneProduct | ENSG00000134532 (Ensembl Human) | |
SOX9 | GeneProduct | ENSG00000125398 (Ensembl Human) | |
TBX6 | GeneProduct | ENSG00000149922 (Ensembl Human) | |
TCF4 | GeneProduct | ENSG00000196628 (Ensembl Human) | |
TCF7L1 | GeneProduct | ENSG00000152284 (Ensembl Human) | |
TFAP2A | GeneProduct | ENSG00000137203 (Ensembl Human) | |
TWIST1 | GeneProduct | ENSG00000122691 (Ensembl Human) | |
WNT1 | GeneProduct | ENSG00000125084 (Ensembl Human) | |
WNT3A | GeneProduct | ENSG00000154342 (Ensembl Human) | |
WNT8A | GeneProduct | ENSG00000061492 (Ensembl Human) | |
ZIC1 | GeneProduct | ENSG00000152977 (Ensembl Human) | |
ZIC5 | GeneProduct | ENSG00000139800 (Ensembl Human) |
Annotated Interactions
No annotated interactions