Neural crest differentiation (Homo sapiens)

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3DifferentiationBMP7RHOBMYBITGB1WNT1TFAP2AZIC1PAX3PAX7DLX5MSX1MSX2FOXD3SNAI1SNAI2Snail/SlugWNT3AFZD3GSK3BCTNNB1TCF7L1TCF4GBX2AXIN2AXIN1DVL3DVL2DVL1BMP4SMAD1ID1NOTCH1DLL3NOTCH4NOTCH2DLL4NOTCH3DLL1DeltaHEY2TWIST1SOX10FGF2HES5HES1RBPJHES5HES1(high)(intermed)FGFR1FGFR2FGFR3Nuclear TFsZIC5MYCSOX9SOX10ISL1CDH6CDH2CDH1SOX5ETS1EpidermisMesodermNeural plate borderNeuralplatePAX3PAX7NFKB1CDH7TFAP2ASNAI1SNAI2Snail/SlugFOXD3ID1SOX9NFKB2Premigratory CNCCNEUROG1SOX10PHOX2BGFAPOLIG1OLIG2GJB1ASCL1MITFPMP22MPZMBPFOXD3PAX3LHX1LHX2BMP4FGF8FGF19Neurons/gliaMelanocytesChondrocytesAutonomicNervousSystemSensoryNeuronsGliaSOX10PAX3PAX7SOX5MITFHDAC1HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HDAC10HDAC11CTBP2DCTSOX5SOX9COL2A1COL11A2MIAMigratory CNCCWNT8AHOXB152PRTG6OLIG3Other Implicated1TBX6HOXA147LHX5


Description

Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143 When citing thies pathway, please reference the source publication (PMID: 19575671).

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Bibliography

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  1. Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, Sakai H; ''Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.''; BMC Dev Biol, 2010 PubMed Europe PMC Scholia
  2. Betancur P, Bronner-Fraser M, Sauka-Spengler T; ''Assembling neural crest regulatory circuits into a gene regulatory network.''; Annu Rev Cell Dev Biol, 2010 PubMed Europe PMC Scholia
  3. Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, Ravazzolo R, Ceccherini I; ''''; , PubMed Europe PMC Scholia
  4. Callery EM, Thomsen GH, Smith JC; ''A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.''; Dev Biol, 2010 PubMed Europe PMC Scholia
  5. Makki N, Capecchi MR; ''Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.''; Dev Biol, 2011 PubMed Europe PMC Scholia
  6. Filippi A, Tiso N, Deflorian G, Zecchin E, Bortolussi M, Argenton F; ''The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  7. Ohtoshi A, Bradley A, Behringer RR, Nishijima I; ''Generation and maintenance of Dmbx1 gene-targeted mutant alleles.''; Mamm Genome, 2006 PubMed Europe PMC Scholia
  8. Arenkiel BR, Gaufo GO, Capecchi MR; ''Hoxb1 neural crest preferentially form glia of the PNS.''; Dev Dyn, 2003 PubMed Europe PMC Scholia
  9. Lewis JL, Bonner J, Modrell M, Ragland JW, Moon RT, Dorsky RI, Raible DW; ''Reiterated Wnt signaling during zebrafish neural crest development.''; Development, 2004 PubMed Europe PMC Scholia
  10. Knight RD, Javidan Y, Zhang T, Nelson S, Schilling TF; ''AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo.''; Development, 2005 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117162view09:48, 18 May 2021EweitzModified title
106662view21:21, 12 September 2019KhanspersModified description
105663view05:18, 10 August 2019KhanspersModified description
101922view15:32, 17 November 2018EgonwRemoved whitespace in PubMed identifiers.
79263view18:42, 19 March 2015ZariChange Identifier for LHX1 gene
68974view17:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
59181view18:44, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
47071view00:00, 15 March 2012KhanspersModified categories
45837view05:53, 17 November 2011NsalomonisAdded other implicated genes
45836view05:51, 17 November 2011NsalomonisSpecify description
45835view05:40, 17 November 2011NsalomonisPeriodical save, work in progress
45834view05:30, 17 November 2011NsalomonisPeriodical save, work in progress
45833view05:17, 17 November 2011NsalomonisPeriodical save, work in progress
45832view04:51, 17 November 2011NsalomonisPeriodical save, work in progress
45831view01:01, 17 November 2011NsalomonisSpecify description
45830view01:01, 17 November 2011NsalomonisSpecify description
45829view00:43, 17 November 2011NsalomonisPeriodical save, work in progress
45633view23:18, 25 October 2011NsalomonisModified description
45584view20:45, 17 October 2011NsalomonisOntology Term : 'neuron neural crest derived' added !
45583view20:45, 17 October 2011NsalomonisOntology Term : 'regulatory pathway' added !
45582view20:44, 17 October 2011NsalomonisOntology Term : 'cranial neural crest cell' added !
45581view20:43, 17 October 2011NsalomonisModified description
45580view18:38, 17 October 2011NsalomonisModified description
45579view18:31, 17 October 2011NsalomonisPeriodical save, work in progress
45578view18:24, 17 October 2011NsalomonisSpecify description
45577view18:21, 17 October 2011NsalomonisPeriodical save, work in progress
45576view18:00, 17 October 2011NsalomonisSpecify description
45575view17:55, 17 October 2011NsalomonisSpecify description
45574view17:50, 17 October 2011NsalomonisPeriodical save, work in progress
45573view17:40, 17 October 2011NsalomonisPeriodical save, work in progress
45567view06:15, 17 October 2011NsalomonisSpecify description
45566view06:11, 17 October 2011NsalomonisModified description
45565view06:06, 17 October 2011NsalomonisSpecify description
45564view06:06, 17 October 2011NsalomonisSpecify description
45563view06:03, 17 October 2011NsalomonisPeriodical save, work in progress
45562view05:45, 17 October 2011NsalomonisSpecify description
45561view05:43, 17 October 2011NsalomonisPeriodical save, work in progress
45560view05:21, 17 October 2011NsalomonisSpecify description
45559view05:13, 17 October 2011NsalomonisPeriodical save, work in progress
45558view05:09, 17 October 2011NsalomonisSpecify description
45557view05:01, 17 October 2011NsalomonisSpecify description
45556view04:56, 17 October 2011NsalomonisPeriodical save, work in progress
45555view04:46, 17 October 2011NsalomonisPeriodical save, work in progress
45554view04:36, 17 October 2011NsalomonisPeriodical save, work in progress
45553view04:26, 17 October 2011NsalomonisPeriodical save, work in progress
45552view04:23, 17 October 2011NsalomonisSpecify description
45551view04:16, 17 October 2011NsalomonisPeriodical save, work in progress
45550view04:05, 17 October 2011NsalomonisPeriodical save, work in progress
45549view03:55, 17 October 2011NsalomonisPeriodical save, work in progress
45548view03:53, 17 October 2011NsalomonisSpecify description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASCL1GeneProductENSG00000139352 (Ensembl Human)
AXIN1GeneProduct8312 (Entrez Gene)
AXIN2GeneProduct8313 (Entrez Gene)
BMP4GeneProductENSG00000125378 (Ensembl Human)
BMP7GeneProductENSG00000101144 (Ensembl Human)
CDH1GeneProductENSG00000039068 (Ensembl Human)
CDH2GeneProductENSG00000170558 (Ensembl Human)
CDH6GeneProductENSG00000113361 (Ensembl Human)
CDH7GeneProductENSG00000081138 (Ensembl Human)
COL11A2GeneProductENSG00000204248 (Ensembl Human)
COL2A1GeneProductENSG00000139219 (Ensembl Human)
CTBP2GeneProductENSG00000175029 (Ensembl Human)
CTNNB1GeneProductENSG00000168036 (Ensembl Human)
DCTGeneProductENSG00000080166 (Ensembl Human)
DLL1GeneProductENSG00000198719 (Ensembl Human)
DLL3GeneProductENSG00000090932 (Ensembl Human)
DLL4GeneProductENSG00000128917 (Ensembl Human)
DLX5GeneProductENSG00000105880 (Ensembl Human)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
DifferentiationPathway
ETS1GeneProductENSG00000134954 (Ensembl Human)
FGF19GeneProductENSG00000162344 (Ensembl Human)
FGF2GeneProductENSG00000138685 (Ensembl Human)
FGF8GeneProductENSG00000107831 (Ensembl Human)
FGFR1GeneProductENSG00000077782 (Ensembl Human)
FGFR2GeneProductENSG00000066468 (Ensembl Human)
FGFR3GeneProductENSG00000068078 (Ensembl Human)
FOXD3GeneProductENSG00000187140 (Ensembl Human)
FZD3GeneProductENSG00000104290 (Ensembl Human)
GBX2GeneProductENSG00000168505 (Ensembl Human)
GFAPGeneProductENSG00000131095 (Ensembl Human)
GJB1GeneProductENSG00000169562 (Ensembl Human)
GSK3BGeneProductENSG00000082701 (Ensembl Human)
HDAC10GeneProductENSG00000100429 (Ensembl Human)
HDAC11GeneProductENSG00000163517 (Ensembl Human)
HDAC1GeneProductENSG00000116478 (Ensembl Human)
HDAC2GeneProductENSG00000196591 (Ensembl Human)
HDAC3GeneProductENSG00000171720 (Ensembl Human)
HDAC4GeneProductENSG00000068024 (Ensembl Human)
HDAC5GeneProductENSG00000108840 (Ensembl Human)
HDAC6GeneProductENSG00000094631 (Ensembl Human)
HDAC7GeneProductENSG00000061273 (Ensembl Human)
HDAC8GeneProductENSG00000147099 (Ensembl Human)
HDAC9GeneProductENSG00000048052 (Ensembl Human)
HES1GeneProductENSG00000114315 (Ensembl Human)
HES5GeneProductENSG00000197921 (Ensembl Human)
HEY2GeneProductENSG00000135547 (Ensembl Human)
HOXA1GeneProductENSG00000105991 (Ensembl Human)
HOXB1GeneProductENSG00000120094 (Ensembl Human)
ID1GeneProductENSG00000125968 (Ensembl Human)
ISL1GeneProductENSG00000016082 (Ensembl Human)
ITGB1GeneProductENSG00000150093 (Ensembl Human)
LHX1GeneProductENSG00000132130 (Ensembl Human)
LHX2GeneProductENSG00000106689 (Ensembl Human)
LHX5GeneProductENSG00000089116 (Ensembl Human)
MBPGeneProductENSG00000197971 (Ensembl Human)
MIAGeneProduct8190 (Entrez Gene)
MITFGeneProductENSG00000187098 (Ensembl Human)
MPZGeneProductENSG00000158887 (Ensembl Human)
MSX1GeneProductENSG00000163132 (Ensembl Human)
MSX2GeneProductENSG00000120149 (Ensembl Human)
MYBGeneProductENSG00000118513 (Ensembl Human)
MYCGeneProductENSG00000136997 (Ensembl Human)
NEUROG1GeneProductENSG00000181965 (Ensembl Human)
NFKB1GeneProductENSG00000109320 (Ensembl Human)
NFKB2GeneProductENSG00000077150 (Ensembl Human)
NOTCH1GeneProductENSG00000148400 (Ensembl Human)
NOTCH2GeneProductENSG00000134250 (Ensembl Human)
NOTCH3GeneProductENSG00000074181 (Ensembl Human)
NOTCH4GeneProductENSG00000204301 (Ensembl Human)
OLIG1GeneProductENSG00000184221 (Ensembl Human)
OLIG2GeneProductENSG00000205927 (Ensembl Human)
OLIG3GeneProductENSG00000177468 (Ensembl Human)
PAX3GeneProductENSG00000135903 (Ensembl Human)
PAX7GeneProductENSG00000009709 (Ensembl Human)
PHOX2BGeneProductENSG00000109132 (Ensembl Human)
PMP22GeneProductENSG00000109099 (Ensembl Human)
PRTGGeneProductENSG00000166450 (Ensembl Human)
RBPJGeneProductENSG00000168214 (Ensembl Human)
RHOBGeneProductENSG00000143878 (Ensembl Human)
SMAD1GeneProductENSG00000170365 (Ensembl Human)
SNAI1GeneProductENSG00000124216 (Ensembl Human)
SNAI2GeneProductENSG00000019549 (Ensembl Human)
SOX10GeneProductENSG00000100146 (Ensembl Human)
SOX5GeneProductENSG00000134532 (Ensembl Human)
SOX9GeneProductENSG00000125398 (Ensembl Human)
TBX6GeneProductENSG00000149922 (Ensembl Human)
TCF4GeneProductENSG00000196628 (Ensembl Human)
TCF7L1GeneProductENSG00000152284 (Ensembl Human)
TFAP2AGeneProductENSG00000137203 (Ensembl Human)
TWIST1GeneProductENSG00000122691 (Ensembl Human)
WNT1GeneProductENSG00000125084 (Ensembl Human)
WNT3AGeneProductENSG00000154342 (Ensembl Human)
WNT8AGeneProductENSG00000061492 (Ensembl Human)
ZIC1GeneProductENSG00000152977 (Ensembl Human)
ZIC5GeneProductENSG00000139800 (Ensembl Human)

Annotated Interactions

No annotated interactions

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