Alzheimer's disease (Mus musculus)

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Calcium overloadalpha-SecretaseC83MicrogliaAggr. amyloidsAPP-alphaAICDOligomeric intracellular ABp-(Tau-P)nATP depletionMitochondiral dysfunctionNeuronAmyloid Beta (AB)Endoplasmic reticulum (ER)p+Cell DeathProtein oxidationNae1AppNOIronOxidative PhosphorylationIP3ApoptosisCalciumCalcium Signaling PathwayCopperHydrogen peroxideInduction of ApoptosisNeuronal InjuryModulation of gene expressionApbb1Gm2221Adam10Bace1PsenenPsen1NcstnAph1aIdeMmeLplApoeLrp1FasTnfrsf1aFaddCasp8Cx ICx IICx IIICx IVCx VAPP processingLower energy production?beta-Secretasegamma-SecretaseHsd17b10Fall in mitochondrialsAPP-betaC99membrane potentialIncreased ROSDegredationInactivationBidGm10121Calm21500003O03RikBadCALM2CALM3Calml3Calm4Ppp3caPpp3cbPpp3ccPpp3r1Ppp3r22010110P09RikAdam17Psen2Apaf1Casp9Casp3AB AggregationOligomeric ABalpha-synucleinSncaSenileplaqueNACGPCRGrin1Cacna1cGrin2aGrin2bGrin2cGrin2dCacna1dCacna1fCacna1sGnaqPlcb1Plcb2Plcb3Plcb4TnfIl1bMapk1Mapk3Casp12ApoptosisRyr3PsenenAtp2a2Atp2a1Atp2a3Eif2ak3Ern1Atf6Itpr1Itpr2Itpr3CalciumCalciumER stressCapn1Capn2Trp53Cdk5r1Nos1Cdk5MaptGsk3bCasp3Casp7Paired helical filaments (PHFs)Neurofibrillarytangles (NFTs)p+ABMitochondrial dysfunctionApoptosisDNA damageInflammationLipid peroxidationONOO-


Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information. Source: KEGG (http://www.genome.jp/kegg/pathway/hsa/hsa05010.html)

Comments

 
Adapted from KEGG
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2059(r45384) with a 90% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A; ''Presenilin-mediated signal transduction.''; Physiol Behav, 2007 PubMed Europe PMC Scholia
  2. Shen Y, He P, Zhong Z, McAllister C, Lindholm K; ''Distinct destructive signal pathways of neuronal death in Alzheimer's disease.''; Trends Mol Med, 2006 PubMed Europe PMC Scholia
  3. Hölscher C; ''Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.''; Neurobiol Dis, 1998 PubMed Europe PMC Scholia
  4. Takuma K, Yan SS, Stern DM, Yamada K; ''Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.''; J Pharmacol Sci, 2005 PubMed Europe PMC Scholia
  5. Mattson MP; ''Pathways towards and away from Alzheimer's disease.''; Nature, 2004 PubMed Europe PMC Scholia
  6. Dickson DW; ''Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?''; J Clin Invest, 2004 PubMed Europe PMC Scholia
  7. Small DH, Mok SS, Bornstein JC; ''Alzheimer's disease and Abeta toxicity: from top to bottom.''; Nat Rev Neurosci, 2001 PubMed Europe PMC Scholia
  8. Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Müller WE; ''Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.''; Exp Gerontol, 2006 PubMed Europe PMC Scholia
  9. Parihar MS, Hemnani T; ''Alzheimer's disease pathogenesis and therapeutic interventions.''; J Clin Neurosci, 2004 PubMed Europe PMC Scholia
  10. Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G; ''Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.''; Aging Cell, 2008 PubMed Europe PMC Scholia
  11. Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M; ''Induction of neuronal death by ER stress in Alzheimer's disease.''; J Chem Neuroanat, 2004 PubMed Europe PMC Scholia
  12. Gandy S; ''The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease.''; J Clin Invest, 2005 PubMed Europe PMC Scholia
  13. Avila J; ''Tau phosphorylation and aggregation in Alzheimer's disease pathology.''; FEBS Lett, 2006 PubMed Europe PMC Scholia
  14. Ivins KJ, Thornton PL, Rohn TT, Cotman CW; ''Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.''; Neurobiol Dis, 1999 PubMed Europe PMC Scholia
  15. Bojarski L, Herms J, Kuznicki J; ''Calcium dysregulation in Alzheimer's disease.''; Neurochem Int, 2008 PubMed Europe PMC Scholia
  16. Bezprozvanny I, Mattson MP; ''Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.''; Trends Neurosci, 2008 PubMed Europe PMC Scholia
  17. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH; ''Neurotoxicity induces cleavage of p35 to p25 by calpain.''; Nature, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116517view10:58, 7 May 2021EweitzModified title
115746view11:10, 9 March 2021EgonwReplaced the WP ids of human pathways with the matching mouse pathway identifiers
115734view09:46, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
115413view11:57, 18 February 2021EgonwMade a few more pathways clickable
114028view15:38, 17 December 2020LaurentConnected lines
108253view13:51, 3 December 2019L DupuisConnected unconnected lines
108215view11:19, 29 November 2019FehrhartOntology Term : 'disease pathway' added !
106866view13:34, 17 September 2019MaintBotHMDB identifier normalization
104989view04:20, 28 June 2019Khanspersremoved KEGG comment
104988view04:19, 28 June 2019KhanspersModified description
97336view12:18, 10 May 2018EgonwUndo revision 97322 by [[Special:Contributions/Lovnish.thakur|Lovnish.thakur]] ([[User talk:Lovnish.thakur|Talk]])
97322view17:31, 9 May 2018Lovnish.thakurModified title
85337view16:16, 7 May 2016EgonwReplaced a mim-conversion with Arrow.
78427view10:26, 7 January 2015MaintBotadded missing graphIds
75216view20:19, 9 May 2014Khanspersadded lit refs
75213view20:13, 9 May 2014Khanspersadded states, changed some pathway nodes to labels
71747view20:19, 17 October 2013MaintBotAutomated update of data sources
69161view18:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
59061view21:01, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
45977view20:57, 1 December 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1500003O03RikGeneProduct56398 (Entrez Gene)
2010110P09RikGeneProduct70261 (Entrez Gene)
APP processingPathway
Adam10GeneProductENSMUSG00000054693 (Ensembl Mouse)
Adam17GeneProductENSMUSG00000052593 (Ensembl Mouse)
Apaf1GeneProductENSMUSG00000019979 (Ensembl Mouse)
Apbb1GeneProductENSMUSG00000037032 (Ensembl Mouse)
Aph1aGeneProductENSMUSG00000015750 (Ensembl Mouse)
ApoeGeneProductENSMUSG00000002985 (Ensembl Mouse)
ApoptosisPathwayWP254 (WikiPathways)
AppGeneProductENSMUSG00000022892 (Ensembl Mouse)
Atf6GeneProductENSMUSG00000026663 (Ensembl Mouse)
Atp2a1GeneProductENSMUSG00000030730 (Ensembl Mouse)
Atp2a2GeneProductENSMUSG00000029467 (Ensembl Mouse)
Atp2a3GeneProductENSMUSG00000020788 (Ensembl Mouse)
Bace1GeneProductENSMUSG00000032086 (Ensembl Mouse)
BadGeneProductENSMUSG00000024959 (Ensembl Mouse)
BidGeneProductENSMUSG00000004446 (Ensembl Mouse)
CALM2GeneProduct
CALM3GeneProduct
Cacna1cGeneProductENSMUSG00000051331 (Ensembl Mouse)
Cacna1dGeneProductENSMUSG00000015968 (Ensembl Mouse)
Cacna1fGeneProductENSMUSG00000031142 (Ensembl Mouse)
Cacna1sGeneProductENSMUSG00000026407 (Ensembl Mouse)
Calcium Signaling PathwayPathway
CalciumMetaboliteHMDB00464 (HMDB)
Calm2GeneProductENSMUSG00000036438 (Ensembl Mouse)
Calm4GeneProductENSMUSG00000033765 (Ensembl Mouse)
Calml3GeneProductENSMUSG00000063130 (Ensembl Mouse)
Capn1GeneProductENSMUSG00000024942 (Ensembl Mouse)
Capn2GeneProductENSMUSG00000026509 (Ensembl Mouse)
Casp12GeneProductENSMUSG00000025887 (Ensembl Mouse)
Casp3GeneProductENSMUSG00000031628 (Ensembl Mouse)
Casp7GeneProductENSMUSG00000025076 (Ensembl Mouse)
Casp8GeneProductENSMUSG00000026029 (Ensembl Mouse)
Casp9GeneProductENSMUSG00000028914 (Ensembl Mouse)
Cdk5GeneProductENSMUSG00000028969 (Ensembl Mouse)
Cdk5r1GeneProductENSMUSG00000048895 (Ensembl Mouse)
Cell DeathPathway
CopperMetaboliteHMDB00657 (HMDB)
Cx IGeneProduct
Cx IIGeneProduct
Cx IIIGeneProduct
Cx IVGeneProduct
Cx VGeneProduct
DNA damagePathway
Eif2ak3GeneProductENSMUSG00000031668 (Ensembl Mouse)
Ern1GeneProductENSMUSG00000020715 (Ensembl Mouse)
FaddGeneProductENSMUSG00000031077 (Ensembl Mouse)
FasGeneProductENSMUSG00000024778 (Ensembl Mouse)
GPCRGeneProduct
Gm10121GeneProductENSMUSG00000062813 (Ensembl Mouse)
Gm2221GeneProductENSMUSG00000090825 (Ensembl Mouse)
GnaqGeneProductENSMUSG00000024639 (Ensembl Mouse)
Grin1GeneProductENSMUSG00000026959 (Ensembl Mouse)
Grin2aGeneProductENSMUSG00000059003 (Ensembl Mouse)
Grin2bGeneProductENSMUSG00000030209 (Ensembl Mouse)
Grin2cGeneProductENSMUSG00000020734 (Ensembl Mouse)
Grin2dGeneProductENSMUSG00000002771 (Ensembl Mouse)
Gsk3bGeneProductENSMUSG00000022812 (Ensembl Mouse)
Hsd17b10GeneProductENSMUSG00000025260 (Ensembl Mouse)
Hydrogen peroxideMetaboliteHMDB03125 (HMDB)
IP3MetaboliteHMDB01498 (HMDB)
IdeGeneProductENSMUSG00000056999 (Ensembl Mouse)
Il1bGeneProductENSMUSG00000027398 (Ensembl Mouse)
Induction of ApoptosisPathwayWP1896 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
IronMetaboliteHMDB00692 (HMDB)
Itpr1GeneProductENSMUSG00000030102 (Ensembl Mouse)
Itpr2GeneProductENSMUSG00000030287 (Ensembl Mouse)
Itpr3GeneProductENSMUSG00000042644 (Ensembl Mouse)
Lipid peroxidationPathwayWP1878 (WikiPathways)
Lower energy production?Pathway
LplGeneProductENSMUSG00000015568 (Ensembl Mouse)
Lrp1GeneProductENSMUSG00000040249 (Ensembl Mouse)
Mapk1GeneProductENSMUSG00000063358 (Ensembl Mouse)
Mapk3GeneProductENSMUSG00000063065 (Ensembl Mouse)
MaptGeneProductENSMUSG00000018411 (Ensembl Mouse)
Mitochondrial dysfunctionPathway
MmeGeneProductENSMUSG00000027820 (Ensembl Mouse)
Modulation of gene expressionPathwayWP1821 (WikiPathways)
NOMetaboliteHMDB03378 (HMDB)
Nae1GeneProductENSMUSG00000031878 (Ensembl Mouse)
NcstnGeneProductENSMUSG00000003458 (Ensembl Mouse)
Neuronal InjuryPathway
Nos1GeneProductENSMUSG00000029361 (Ensembl Mouse)
ONOO-MetaboliteHMDB02179 (HMDB)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
Plcb1GeneProductENSMUSG00000051177 (Ensembl Mouse)
Plcb2GeneProductENSMUSG00000040061 (Ensembl Mouse)
Plcb3GeneProductENSMUSG00000024960 (Ensembl Mouse)
Plcb4GeneProductENSMUSG00000039943 (Ensembl Mouse)
Ppp3caGeneProductENSMUSG00000028161 (Ensembl Mouse)
Ppp3cbGeneProductENSMUSG00000021816 (Ensembl Mouse)
Ppp3ccGeneProductENSMUSG00000022092 (Ensembl Mouse)
Ppp3r1GeneProductENSMUSG00000033953 (Ensembl Mouse)
Ppp3r2GeneProductENSMUSG00000028310 (Ensembl Mouse)
Protein oxidationPathway
Psen1GeneProductENSMUSG00000019969 (Ensembl Mouse)
Psen2GeneProductENSMUSG00000010609 (Ensembl Mouse)
PsenenGeneProductENSMUSG00000036835 (Ensembl Mouse)
Ryr3GeneProductENSMUSG00000057378 (Ensembl Mouse)
SncaGeneProductENSMUSG00000025889 (Ensembl Mouse)
TnfGeneProductENSMUSG00000024401 (Ensembl Mouse)
Tnfrsf1aGeneProductENSMUSG00000030341 (Ensembl Mouse)
Trp53GeneProductENSMUSG00000059552 (Ensembl Mouse)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2075"
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