miRNAs involved in DNA damage response (Mus musculus)

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161630221921, 281281516312067, 92731125291813204, 68142012, 17, 237, 93116531201415261615, 242215152810gene product used more than once in this pathwayactivationgene productmicroRNA clustermicroRNAconsistsofinhibitionhsa-mir-542hsa-mir-27bhsa-mir-27aMir34bMir203Cdkn1aMir497Mir29b-1hsa-let-7aMir195hsa-mir-421has-let-7a-2/100 clusterRAD52hsa-mir-371/373 clusterMir503hsa-mir-15b/16-2 clusterhsa-miR-106b/25 clusterMir222Creb1Mir290Mir17hsa-mir-15a/16-1 clusterMir291bMir181b-1Mir20ahas-miR-195/497 clusterhsa-mir-25hsa-mir-21hsa-mir-23a/24-2 clusterMir143CCND3Mir322has-mir-181a-2/181b-2 clusterMir23bc-MycMir223hsa-miR-449c/449a clusterMir23aH2AFXMir29ahsa-miR-424/450b clusterMir210hsa-miR-29b-1/29a clusterCcnd1Mir15bhsa-miR-210 geneMir19b-1Cdk6Ccne1Mir34chsa-mir-143/145 clusterE2f1Ccnd1Mir449bMir374hsa-mir-3074has-mir-181a-1/181b-1 clusterMir24-2Mir221hsa-mir-23b/24-1 clusterhsa-miR-222/221 clusterhsa-mir-373Mir93hsa-miR-29b-2/29c clusterMirlet7bhsa-mir-92ahsa-let-7a-1/7d clusterc-MycCdc25aAbl1hsa-mir-100Mir29cMir145Mir18hsa-mir-449chsa-let-7fhsa-miR-21genehsa-mir-330hsa-mir-374b/421 clusterE2f1Mirlet7dhsa-mir-450bATMhsa-miR-223 geneAC154660.1Mir450-2Trp53Mir181a-1hsa-let-7a-3/7b clusterhsa-miR-330 geneMir19aMir449aCdkn1bhsa-miR-203 geneMir106bAC154660.2hsa-miR-17/92a-1 clusterhsa-mir-34b/34c cluster


Description

MicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo sapiens)". More info can be found there.

Comments

 
This pathway show all microRNA gene cluster involed in the wikipathway pathway "DNA damage response (Homo sapiens)". More info can be found there.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1545(r45378) with a 52% conversion rate.

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Ontology Terms

 

Bibliography

View all...
  1. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM; ''MicroRNA regulation of DNA repair gene expression in hypoxic stress.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  2. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D; ''miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  3. Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Børresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V; ''p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.''; Mol Syst Biol, 2008 PubMed Europe PMC Scholia
  4. Woods K, Thomson JM, Hammond SM; ''Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  5. Yamakuchi M, Lowenstein CJ; ''MiR-34, SIRT1 and p53: the feedback loop.''; Cell Cycle, 2009 PubMed Europe PMC Scholia
  6. Quintavalle M, Elia L, Condorelli G, Courtneidge SA; ''MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro.''; J Cell Biol, 2010 PubMed Europe PMC Scholia
  7. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT; ''c-Myc-regulated microRNAs modulate E2F1 expression.''; Nature, 2005 PubMed Europe PMC Scholia
  8. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q; ''miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.''; Genes Dev, 2009 PubMed Europe PMC Scholia
  9. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT; ''Widespread microRNA repression by Myc contributes to tumorigenesis.''; Nat Genet, 2008 PubMed Europe PMC Scholia
  10. Yu Z, Wang C, Wang M, Li Z, Casimiro MC, Liu M, Wu K, Whittle J, Ju X, Hyslop T, McCue P, Pestell RG; ''A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.''; J Cell Biol, 2008 PubMed Europe PMC Scholia
  11. Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, Lu PJ; ''MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.''; Oncogene, 2009 PubMed Europe PMC Scholia
  12. Ivanovska I, Ball AS, Diaz RL, Magnus JF, Kibukawa M, Schelter JM, Kobayashi SV, Lim L, Burchard J, Jackson AL, Linsley PS, Cleary MA; ''MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  13. Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, Xing R, Sun Z, Zheng X; ''miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes.''; Nucleic Acids Res, 2008 PubMed Europe PMC Scholia
  14. Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML; ''The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.''; Cancer Res, 2010 PubMed Europe PMC Scholia
  15. Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA; ''ATM is down-regulated by N-Myc-regulated microRNA-421.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  16. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia
  17. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P; ''An E2F/miR-20a autoregulatory feedback loop.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  18. Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N; ''MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  19. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY; ''MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  20. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY; ''p53 represses c-Myc through induction of the tumor suppressor miR-145.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  21. Pigazzi M, Manara E, Baron E, Basso G; ''miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  22. Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández-Piqueras J, Zubiaga AM, Malumbres M; ''Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  23. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M; ''MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.''; Oncogene, 2008 PubMed Europe PMC Scholia
  24. Cuesta R, Martínez-Sánchez A, Gebauer F; ''miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia
  25. Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J; ''microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.''; Cancer Res, 2009 PubMed Europe PMC Scholia
  26. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G; ''Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.''; Blood, 2010 PubMed Europe PMC Scholia
  27. Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM, Dejean A; ''miR-221 overexpression contributes to liver tumorigenesis.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  28. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, MacDougald OA, Cho KR, Fearon ER; ''p53-mediated activation of miRNA34 candidate tumor-suppressor genes.''; Curr Biol, 2007 PubMed Europe PMC Scholia
  29. Pothof J, Verkaik NS, van IJcken W, Wiemer EA, Ta VT, van der Horst GT, Jaspers NG, van Gent DC, Hoeijmakers JH, Persengiev SP; ''MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.''; EMBO J, 2009 PubMed Europe PMC Scholia
  30. Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M; ''p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  31. Bueno MJ, Pérez de Castro I, Gómez de Cedrón M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernández-Piqueras J, Malumbres M; ''Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.''; Cancer Cell, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
89982view18:57, 6 October 2016Mkutmonfixed unconnected lines
78406view10:25, 7 January 2015MaintBotadded missing graphIds
74241view14:24, 9 April 2014EgonwFixed a character encoding issue in author names in references.
74240view14:22, 9 April 2014EgonwRemoved a data source where no ID was given.
71762view20:27, 17 October 2013MaintBotremoved data source from nodes without identifier
59079view21:49, 21 February 2013MaintBotModified title
59078view21:48, 21 February 2013MaintBotUpdated Ensembl data source
45987view21:19, 1 December 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AC154660.1GeneProductENSMUSG00000092995 (Ensembl Mouse)
AC154660.2GeneProductENSMUSG00000093007 (Ensembl Mouse)
ATMGeneProduct
Abl1GeneProduct11350 (Entrez Gene)
CCND3GeneProduct
Ccnd1GeneProduct12443 (Entrez Gene)
Ccne1GeneProduct12447 (Entrez Gene)
Cdc25aGeneProduct12530 (Entrez Gene)
Cdk6GeneProduct12571 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn1bGeneProduct12576 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
E2f1GeneProduct13555 (Entrez Gene)
H2AFXGeneProduct
Mir106bGeneProductENSMUSG00000065514 (Ensembl Mouse)
Mir143GeneProductENSMUSG00000065445 (Ensembl Mouse)
Mir145GeneProductENSMUSG00000065592 (Ensembl Mouse)
Mir15bGeneProductENSMUSG00000065580 (Ensembl Mouse)
Mir17GeneProductENSMUSG00000065508 (Ensembl Mouse)
Mir181a-1GeneProductENSMUSG00000065565 (Ensembl Mouse)
Mir181b-1GeneProductENSMUSG00000065458 (Ensembl Mouse)
Mir18GeneProductENSMUSG00000065403 (Ensembl Mouse)
Mir195GeneProductENSMUSG00000065411 (Ensembl Mouse)
Mir19aGeneProductENSMUSG00000065416 (Ensembl Mouse)
Mir19b-1GeneProductENSMUSG00000076256 (Ensembl Mouse)
Mir203GeneProductENSMUSG00000065574 (Ensembl Mouse)
Mir20aGeneProductENSMUSG00000065442 (Ensembl Mouse)
Mir210GeneProductENSMUSG00000065551 (Ensembl Mouse)
Mir221GeneProductENSMUSG00000065422 (Ensembl Mouse)
Mir222GeneProductENSMUSG00000065471 (Ensembl Mouse)
Mir223GeneProductENSMUSG00000076066 (Ensembl Mouse)
Mir23aGeneProductENSMUSG00000065611 (Ensembl Mouse)
Mir23bGeneProductENSMUSG00000065599 (Ensembl Mouse)
Mir24-2GeneProductENSMUSG00000065541 (Ensembl Mouse)
Mir290GeneProductENSMUSG00000077815 (Ensembl Mouse)
Mir291bGeneProductENSMUSG00000078032 (Ensembl Mouse)
Mir29aGeneProductENSMUSG00000065610 (Ensembl Mouse)
Mir29b-1GeneProductENSMUSG00000065604 (Ensembl Mouse)
Mir29cGeneProductENSMUSG00000065548 (Ensembl Mouse)
Mir322GeneProductENSMUSG00000065418 (Ensembl Mouse)
Mir34bGeneProductENSMUSG00000065492 (Ensembl Mouse)
Mir34cGeneProductENSMUSG00000065587 (Ensembl Mouse)
Mir374GeneProductENSMUSG00000076269 (Ensembl Mouse)
Mir449aGeneProductENSMUSG00000065575 (Ensembl Mouse)
Mir449bGeneProductENSMUSG00000078027 (Ensembl Mouse)
Mir450-2GeneProductENSMUSG00000076399 (Ensembl Mouse)
Mir497GeneProductENSMUSG00000070109 (Ensembl Mouse)
Mir503GeneProductENSMUSG00000076122 (Ensembl Mouse)
Mir93GeneProductENSMUSG00000065527 (Ensembl Mouse)
Mirlet7bGeneProductENSMUSG00000065564 (Ensembl Mouse)
Mirlet7dGeneProductENSMUSG00000065453 (Ensembl Mouse)
RAD52GeneProduct
Trp53GeneProduct22059 (Entrez Gene)
c-MycGeneProduct
has-let-7a-2/100 clusterGeneProduct
has-miR-195/497 clusterGeneProduct
has-mir-181a-1/181b-1 clusterGeneProduct
has-mir-181a-2/181b-2 clusterGeneProduct
hsa-let-7aGeneProduct
hsa-let-7a-1/7d clusterGeneProduct
hsa-let-7a-3/7b clusterGeneProduct
hsa-let-7fGeneProduct
hsa-miR-106b/25 clusterGeneProduct
hsa-miR-17/92a-1 clusterGeneProduct
hsa-miR-203 geneGeneProduct
hsa-miR-210 geneGeneProduct
hsa-miR-21geneGeneProduct
hsa-miR-222/221 clusterGeneProduct
hsa-miR-223 geneGeneProduct
hsa-miR-29b-1/29a clusterGeneProduct
hsa-miR-29b-2/29c clusterGeneProduct
hsa-miR-330 geneGeneProduct
hsa-miR-424/450b clusterGeneProduct
hsa-miR-449c/449a clusterGeneProduct
hsa-mir-100GeneProduct
hsa-mir-143/145 clusterGeneProduct
hsa-mir-15a/16-1 clusterGeneProduct
hsa-mir-15b/16-2 clusterGeneProduct
hsa-mir-21GeneProduct
hsa-mir-23a/24-2 clusterGeneProduct
hsa-mir-23b/24-1 clusterGeneProduct
hsa-mir-25GeneProduct
hsa-mir-27aGeneProduct
hsa-mir-27bGeneProduct
hsa-mir-3074GeneProduct
hsa-mir-330GeneProduct
hsa-mir-34b/34c clusterGeneProduct
hsa-mir-371/373 clusterGeneProduct
hsa-mir-373GeneProduct
hsa-mir-374b/421 clusterGeneProduct
hsa-mir-421GeneProduct
hsa-mir-449cGeneProduct
hsa-mir-450bGeneProduct
hsa-mir-542GeneProduct
hsa-mir-92aGeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2085"
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