Combined Pathways (Network) for Cellulose Digestion (Clostridium thermocellum)

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1ABC Transporter3L-Lactate Dehydrogenase PyruvateLactateAcetylCoACelluloseCellobioseD-GlucoseGlucose-6-PhosphateFructose-6-PhosphateFructose-1,6-BiphosphateGlyceraldehyde 3-phosphateDihydroxyacetone phosphateBisphosphoglyceric acid3-Phosphoglyceric acid2-Phosphoglyceric acidphosphoenolpyruvateEndoglucanase2Cellobiose PhosphorylaseGlucokinaseGlucose-6-phosphate Isomerase6-PhosphofructokinaseFructose-bisphosphate AldolaseGlyceraldehyde-3-Phosphate DehydrogenseTriosephosphate IsomerasePhosphoglycerate mutasePyruvate:fd Oxioreductase ɤAMP-dependent synthetase and ligaseEthanolAcetaldhyde Dehydrogenase/Alcohol DehydrogenaseFerredoxin - OxFerodoxin - ReFerrodoxinH2NADH dehydrogenase (ubquinone)H+NADP+NADPHFormateFormate acetyltransferaseNADP+NADP+NADPHNADPHATPADPATPADPNAD+NADHATPADPAcetateATPAMPPiα-D-glucose 1-phosphateα-PhosphoglucomutaseCellotrioseD-CellotetraoseCellobioseCellotrioseD-CellotetraoseInnermembrane TranslocatorInner-membrane translocatorbinding-proteinbinding-proteinbinding-proteinbinding-proteinABC-type sugarextracellular solute-binding proteinextracellular solute-binding proteinATPasephosphoglycerate mutaseABC transporter-like proteinABC transporterABC transporter-like proteinABC transporter-like protein(ATPase component)ATPADPPhosphoglyceromutasePhosphoglycerare mutasePhosphoglycerate mutaseEno Phosphopyruvate HydrataseOxaloacetic AcidPhosphoenolpyruvate CarboxykinaseCarboxyl transferaseBiotin/lipoyl attachment proteinOxaloacetate DecarboxylaseC02MalateMalate Dehydrogenase (NAD) NAD+NADHMalate DehydrogenasePhosphoenolpyruvate Synthase Pyruvate:fd Oxidoreductase δPyruvate:fd Oxioreductase αPeptide Chain Release Factor 1Pyruvate:fl/fd Oxioreductase-LikePyruvate:fl/fd Oxioreductase-likeIndolepyruvate oxidoreductase subunit ɗPyruvate formate-lyase activating enzymeC02AcetaldehydeFe-Containing ADHFe-Containing ADHNADPHNADP+PiiGlycogen, StarchGlycogen Debranching EnzymeGlycogen, Amylase (1,4-α)1,4-α-Branching Enzymeα-Glucan PhosphorylasePiADP-GlucoseGlucose-1-phosphate adenylyltransferaseGlgD subunit ADP-glucose type glycogen/starch synthaseADP-glucose type glycogen/starch synthaseADPATPGlycosyltransferaseGlycosyltransferasePPiPPiPi6-PhosphofructokinasePfkBNADH dehydrogenase (quinone)hydrogenase, Fe-onlyNADH dehydrogenase (quinone)Hydrogenase, Fe-onlyNAD+NADHFerredoxin - OxFerodoxin - ReNADH:Fd Oxioreductase


Description

No description

Comments

 
Metabolically deduced pathway of pyruvate catabolism in Clositridium thermocellum ATCC 27405.

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Bibliography


History

View all...
CompareRevisionActionTimeUserComment
50507view19:36, 16 August 2012MaintBotDeleted pathway: request by author; she plans to resubmit after publication
47939view20:38, 19 April 2012BjorklundFxing ABC transporter
47938view20:31, 19 April 2012BjorklundPeriodical save, work in progress
47937view20:28, 19 April 2012BjorklundFixing the ABC transporter
47735view17:45, 4 April 2012BjorklundAdded a reference to alpha phosphoglucomutase
47730view16:49, 4 April 2012BjorklundModified title
47673view19:14, 2 April 2012BjorklundModified description
47672view19:12, 2 April 2012BjorklundModified description
47662view18:20, 2 April 2012BjorklundModified title
46993view16:31, 9 March 2012BjorklundAdded missing Phosphoglycerate kinase
46976view18:44, 8 March 2012BjorklundPeriodical save, work in progress
46975view18:33, 8 March 2012BjorklundPeriodical save, work in progress
46883view20:45, 5 March 2012BjorklundTouchup
46882view20:42, 5 March 2012BjorklundPathway Completed First Draft
46872view18:55, 5 March 2012BjorklundPeriodical save, work in progress
46871view18:45, 5 March 2012BjorklundPeriodical save, work in progress
46870view18:28, 5 March 2012BjorklundPeriodical save, work in progress
46868view18:18, 5 March 2012BjorklundPeriodical save, work in progress
46867view18:08, 5 March 2012BjorklundPeriodical save, work in progress
46866view17:57, 5 March 2012BjorklundPeriodical save, work in progress
46865view17:47, 5 March 2012BjorklundPeriodical save, work in progress
46864view17:37, 5 March 2012BjorklundPeriodical save, work in progress
46863view17:17, 5 March 2012BjorklundPeriodical save, work in progress
46843view02:26, 3 March 2012AlexanderPicoReverted to version '12:19, 2 March 2012' by AlexanderPico
46842view02:18, 3 March 2012AlexanderPicoReverted to version '12:29, 2 March 2012' by AlexanderPico
46837view19:34, 2 March 2012BjorklundMore undating
46836view19:29, 2 March 2012BjorklundPeriodical save, work in progress
46835view19:19, 2 March 2012BjorklundPeriodical save, work in progress
46834view19:09, 2 March 2012BjorklundPeriodical save, work in progress
46833view18:59, 2 March 2012BjorklundPeriodical save, work in progress
46832view18:48, 2 March 2012BjorklundPeriodical save, work in progress
46831view18:38, 2 March 2012BjorklundPeriodical save, work in progress
46830view18:28, 2 March 2012BjorklundPeriodical save, work in progress
46829view18:18, 2 March 2012BjorklundPeriodical save, work in progress
46828view18:08, 2 March 2012BjorklundPeriodical save, work in progress
46827view17:37, 2 March 2012BjorklundPeriodical save, work in progress
46826view17:27, 2 March 2012BjorklundPeriodical save, work in progress
46825view17:17, 2 March 2012BjorklundPeriodical save, work in progress
46824view17:07, 2 March 2012BjorklundPeriodical save, work in progress
46823view16:45, 2 March 2012BjorklundPeriodical save, work in progress
46814view03:35, 2 March 2012BjorklundPeriodical save, work in progress
46809view00:03, 2 March 2012BjorklundContinuing to work on the pathways
46808view23:54, 1 March 2012BjorklundPeriodical save, work in progress
46807view23:43, 1 March 2012BjorklundPeriodical save, work in progress
46806view23:33, 1 March 2012BjorklundPeriodical save, work in progress
46805view23:23, 1 March 2012BjorklundPeriodical save, work in progress
46804view23:13, 1 March 2012BjorklundPeriodical save, work in progress
46803view23:03, 1 March 2012BjorklundPeriodical save, work in progress
46802view22:53, 1 March 2012BjorklundPeriodical save, work in progress
46801view22:43, 1 March 2012BjorklundPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,4-α-Branching EnzymeGeneProduct4810907 (Entrez Gene) Cthe 2191, 1,4-α-Debranching Enzyme
2-Phosphoglyceric acidMetabolite2553-59-5 (CAS)
3-Phosphoglyceric acidMetabolite17794 (ChEBI)
6-PhosphofructokinaseGeneProduct4808496 (Entrez Gene) Cthe 0347
6-PhosphofructokinaseGeneProduct4809766 (Entrez Gene) Cthe 1261
ABC transporter-like protein (ATPase component)Protein4809413 (Entrez Gene) Cthe 2128 (sugar binding periplasmic protein
ABC transporter-like proteinProtein4809826 (Entrez Gene) Cthe 2447
ABC transporter-like proteinProtein4811175 (Entrez Gene) Cthe 0391 ABC transporter-like protein putative sugar ABC transporter ATP-binding protein
ABC transporterProtein4808396 (Entrez Gene) Cthe 0393 sugar ABC transporter sugar-binding protein
ABC-type sugarProtein4809825 (Entrez Gene) Cthe 2446 ABC-type sugar transport system periplasmic component-like protein (D-ribose transport system ATP-binding protein)
ADP-GlucoseMetabolite15751 (ChEBI)
ADP-glucose type glycogen/starch synthaseGeneProduct4808565 (Entrez Gene) Cthe 0282, ADP-glucose type glycogen/starch synthase
ADP-glucose type glycogen/starch synthaseGeneProduct4809536 (Entrez Gene) Cthe 1284, ADP-glucose type glycogen/starch synthase
ADPMetabolite58-64-0 (ChEBI)
AMP-dependent synthetase and ligaseProtein19926-71-7 (CAS) Cthe 0551, Acetate Thiokinase
AMPMetabolite61-19-8 (CAS)
ATPMetabolite56-65-5 (ChEBI)
ATPaseProtein4811174 (Entrez Gene) MoxR-like ATPases
AcetaldehydeMetabolite75-07-0 (CAS)
Acetaldhyde Dehydrogenase/Alcohol DehydrogenaseGeneProduct4808426 (Entrez Gene) Cthe 0423
AcetateMetabolite758-12-3 (CAS)
AcetylCoAMetabolite72-89-9 (CAS)
Biotin/lipoyl attachment proteinProtein4810318 (Entrez Gene) Cthe 0700
Bisphosphoglyceric acidMetabolite1981-49-3 (CAS)
C02Metabolite124-38-9 (CAS)
Carboxyl transferaseProtein4810317 (Entrez Gene) Cthe 0699
Cellobiose PhosphorylaseGeneProduct4808558 (Entrez Gene) Cthe 0275
CellobioseMetabolite17057 (ChEBI)
CellotrioseMetabolite33404-34-1 (CAS)
CelluloseMetabolite18246 (ChEBI)
D-CellotetraoseMetabolite38819-01-1 (CAS)
D-GlucoseMetabolite4146 (ChEBI)
Dihydroxyacetone phosphateMetabolite57-04-5 (CAS)
EndoglucanaseGeneProduct4808805 (Entrez Gene)
Eno Phosphopyruvate HydrataseGeneProduct4808701 (Entrez Gene) Enolase Cthe 0143
EthanolMetabolite64-17-5 (CAS)
Fe-Containing ADHGeneProduct4808397 (Entrez Gene) Cthe 0394, iron-containing alcohol dehydrogenase
Fe-Containing ADHGeneProduct4808725 (Entrez Gene) Cthe 0101, iron-containing alcohol dehydrogenase
Ferodoxin - ReGeneProduct4810104 (Entrez Gene) Enolase
Ferredoxin - OxGeneProduct4810104 (Entrez Gene) Enolase
FerrodoxinGeneProduct4808489 (Entrez Gene) Cthe 0340,
Formate acetyltransferaseGeneProduct4808305 (Entrez Gene) Cthe 0505, Pyruvate:Formate Lyase (& AE)
FormateMetabolite15740 (ChEBI)
Fructose-1,6-BiphosphateMetabolite488-69-7 (CAS)
Fructose-6-PhosphateMetabolite643-13-0 (CAS)
Fructose-bisphosphate AldolaseGeneProduct4808498 (Entrez Gene) Cthe 0349, (Cthe 2938 no protein detected)
GlgD subunit GeneProduct4809617 (Entrez Gene) Cthe_3167, glucose-1-phosphate adenylyltransferase, GlgD subunit
GlucokinaseGeneProduct4810221 (Entrez Gene) hexokinase, Cthe 2938, (Cthe 0390 no dectable protein)
Glucose-1-phosphate adenylyltransferaseGeneProduct4809616 (Entrez Gene) Cthe 3166, glgC glucose-1-phosphate adenylyltransferase
Glucose-6-PhosphateMetabolite4170 (ChEBI)
Glucose-6-phosphate IsomeraseGeneProduct4808635 (Entrez Gene) Cthe 0217
Glyceraldehyde 3-phosphateMetabolite142-10-9 (CAS)
Glyceraldehyde-3-Phosphate DehydrogenseGeneProduct4808695 (Entrez Gene) Cthe 0137
Glycogen Debranching EnzymeGeneProduct4808741 (Entrez Gene) Cthe 0115, 1,4-a-Debranching Enzyme
Glycogen, Amylase (1,4-α)Metabolite9014-71-5 (CAS)
Glycogen, StarchMetaboliteHMDB00757 (HMDB)
GlycosyltransferaseGeneProduct4809913 (Entrez Gene) Cthe 1221
GlycosyltransferaseGeneProduct4811137 (Entrez Gene) Cthe 2989
H+ Metabolite12408-02-5 (CAS)
H2Metabolite1333-74-0 (CAS)
Hydrogenase, Fe-onlyGeneProduct4808491 (Entrez Gene) Cthe 0342
Indolepyruvate oxidoreductase subunit ɗGeneProduct4808216 (Entrez Gene) Cthe 0614, indolepyruvate oxidoreductase subunit beta
Inner-membrane translocatorProtein4808395 (Entrez Gene)
Innermembrane TranslocatorProtein4809827 (Entrez Gene) Cthe 2448
L-Lactate Dehydrogenase GeneProduct4811351 (Entrez Gene) Cthe 1053
LactateMetabolite16651 (ChEBI)
Malate Dehydrogenase (NAD) GeneProduct4808494 (Entrez Gene) Cthe 0345
Malate DehydrogenaseGeneProduct4808493 (Entrez Gene) Cthe 0344
MalateMetabolite6915-15-7 (CAS)
NAD+Metabolite53-54-9 (CAS)
NADH dehydrogenase (quinone)GeneProduct4808357 (Entrez Gene) Cthe 0429
NADH dehydrogenase (quinone)GeneProduct4808490 (Entrez Gene) Cthe 0341
NADH dehydrogenase (ubquinone)GeneProduct4808431 (Entrez Gene) Cthe 0428, NADH dehydrogenase (ubiquinone), 24 kDa subunit
NADHMetabolite53-68-4 (CAS)
NADH:Fd OxioreductaseGeneProduct4808490 (Entrez Gene) Cthe 2430
NADP+Metabolite53-59-8 (CAS)
NADPHMetabolite53-59-8 (CAS)
Oxaloacetate DecarboxylaseProtein4810319 (Entrez Gene) Cthe 0701
Oxaloacetic AcidMetabolite328-42-7 (CAS)
PPiMetabolite18361 (ChEBI)
Peptide Chain Release Factor 1GeneProduct4809015 (Entrez Gene) Cthe 2593
PfkBGeneProduct4808466 (Entrez Gene) Cthe 0389,
Phosphoenolpyruvate CarboxykinaseProtein4809154 (Entrez Gene) Cthe 2874
Phosphoenolpyruvate Synthase Protein4809758 (Entrez Gene) Cthe 1253
Phosphoglycerare mutaseGeneProduct4810325 (Entrez Gene) Cthe 707
Phosphoglycerate mutaseGeneProduct4809544 (Entrez Gene) Cthe 1292
Phosphoglycerate mutaseGeneProduct4811239 (Entrez Gene) Cthe 0946
PhosphoglyceromutaseGeneProduct4808698 (Entrez Gene) Cthe 0140
PiMetabolite14265-44-2 (CAS)
PiiMetabolite14265-44-2 (CAS)
Pyruvate formate-lyase activating enzymeGeneProduct4808306 (Entrez Gene) Cthe 0505, Pyruvate formate-lyase activating enzyme
PyruvateMetabolite127-17-3 (CAS)
Pyruvate:fd Oxidoreductase δGeneProduct4811043 (Entrez Gene) Cthe 2392
Pyruvate:fd Oxioreductase ɤGeneProduct4811042 (Entrez Gene) Cthe 2390
Pyruvate:fd Oxioreductase αGeneProduct4811044 (Entrez Gene) Cthe 2392
Pyruvate:fl/fd Oxioreductase-LikeGeneProduct4809683 (Entrez Gene) Cthe 3120, pyruvate flavodoxin/ferredoxin oxidoreductase-like protein
Pyruvate:fl/fd Oxioreductase-likeGeneProduct4810484 (Entrez Gene) Cthe 0866, pyruvate flavodoxin/ferredoxin oxidoreductase-like protein
Triosephosphate IsomeraseGeneProduct4808697 (Entrez Gene) Cthe 0347
binding-proteinProtein4811172 (Entrez Gene)
  • Cthe 2125, binding-protein-dependent transport systems inner membrane component (permease component)
  • Type your comment here
binding-proteinProtein4811173 (Entrez Gene) Cthe 2126, binding-protein-dependent transport systems inner membrane component (permease component)
binding-proteinProtein4811312 (Entrez Gene)
  • Cthe 1018, binding-protein-dependent transport systems inner membrane component (sugar ABC transporter, permease protein)
  • Type your comment here
binding-proteinProtein4811313 (Entrez Gene)
  • Cthe 1019, binding-protein-dependent transport systems inner membrane component, putative transmembrane sugar transport protein
  • Type your comment here
extracellular solute-binding proteinProtein4811175 (Entrez Gene) Cthe 2128 (sugar binding periplasmic protein
extracellular solute-binding proteinMetabolite4811314 (ChEBI) Cthe 1020
hydrogenase, Fe-onlyGeneProduct4808358 (Entrez Gene) Cthe 0430
phosphoenolpyruvateMetabolite138-08-9 (CAS)
phosphoglycerate mutase Protein4809828 (Entrez Gene) Location in ABC Transporter not specified.
α-D-glucose 1-phosphateMetabolite59-56-3 (CAS)
α-Glucan PhosphorylaseGeneProduct4808434 (Entrez Gene) Cthe 0357, alpha-glucan phosphorylases
α-PhosphoglucomutaseGeneProduct4809770 (Entrez Gene)

Annotated Interactions

No annotated interactions
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