Sterol regulatory element-binding proteins (SREBP) signaling (Homo sapiens)

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ERNucleus10, 24819Golgi COPII coated vesicleLipogenic enzymes7Negative effectCholesterol synthesisstimulationUp regulation CleavagePositive effectCofactorLegendSREInhibitionExact mechanism unknownTranscription-TranslationCatalysisnSREBPSCAPTRC8GlucoseATF6LXROxysterolsmTOR complex 1SREBP2importin betaPUFAsS1PINSIG1NFYHMG CoA reductaseCholesterolGSK3GlutamineInsulin181611252, 6, 23173SCAP15, 201SCAPINSIG2INSIG1INSIG2SREBP1a,-c13, 22SREBP2SREBP1a,-cSREBP2SREBP1a,-cSAR1ASCAPSREBP2SREBP1a,-cSAR1BSAR1ASAR1BSEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSEC13SEC31ASEC31BSEC13SEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSAR1ASCAPSREBF2SREBP1a,-cSAR1BSEC31ASEC31BS2P9SCAPSREBP2SREBP1a,-cnSREBP1a,-cGeneSREnSREBP2GeneCholesterogenic enzymesLipoprotein metabolismSREBP2SREBP1a,-cCholesterol uptakeInsig1Insig2CofactorCREBSP121NFYCREBSP1YY14, 12YY1PGC-1betaARC514ARCLanosterol synthaseHMG CoA synthasemevalonate (diphospho) decarboxylase isopentenyl-diphosphate isomerasefarnesyl diphosphate synthasefarnesyl-diphosphate farnesyltransferasesqualene epoxidase lanosterol demethylaseLipoprotein lipaseLDL receptorHDL receptoracetyl-CoA carboxylaseglycerol-3-phosphate acyltransferasefatty acid synthaseAcyl-CoA binding proteinATP citrate lyasemalate dehydrogenase PPAR-gammaacetyl CoA synthetasestearoyl-CoA desaturase


Description

Sterol regulatory element-binding protein (SREBP) are membrane-bound proteins that act as transcription factors. They regulate cholesterol biosynthesis and uptake, at a transcriptional level, to maintain cellular cholesterol homeostasis.

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Bibliography

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  4. Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB; ''Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
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  42. Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, Manning BD; ''Activation of a metabolic gene regulatory network downstream of mTOR complex 1.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  43. Sun LP, Li L, Goldstein JL, Brown MS; ''Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
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  45. Sakai J, Nohturfft A, Goldstein JL, Brown MS; ''Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  46. Bengoechea-Alonso MT, Ericsson J; ''A phosphorylation cascade controls the degradation of active SREBP1.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  47. Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J; ''Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.''; J Biol Chem, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135870view04:21, 20 November 2024EweitzIncrease font size
135869view04:15, 20 November 2024EweitzRefine legend
135868view04:10, 20 November 2024EweitzEconomize layout
127880view02:01, 6 January 2024EweitzModified description
116442view09:47, 7 May 2021EweitzModified title
110111view12:30, 17 April 2020FehrhartConnected lines and converted graphical lines
106704view13:13, 17 September 2019MaintBotHMDB identifier normalization
105824view23:03, 15 August 2019KhanspersModified description
90425view18:38, 13 November 2016EgonwAdded two references about the cholesterol-SCAP interaction.
90350view13:37, 6 November 2016EgonwFixed weird chars in several references.
86074view08:50, 29 June 2016MirellaKalafatiModified title
79943view09:38, 28 April 2015Zariadded anotation for AMPK
78494view10:28, 7 January 2015MaintBotadded missing graphIds
73382view05:26, 25 January 2014MaintBotremoved newlines from datanode labels
71987view11:08, 24 October 2013MkutmonChanged Unknown -> RNA for miRNA33a
71698view19:46, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
68403view09:40, 5 July 2013EveloModified description
68402view09:39, 5 July 2013EveloModified description
68401view09:32, 5 July 2013EveloAdded reference for review paper.
67653view11:44, 26 June 2013DdiglesOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
63160view20:19, 8 May 2013MaintBotUpdating gpml version
59430view09:37, 27 February 2013SabinedaemenModified description
59171view18:35, 22 February 2013MaintBotUpdated Ensembl data source
58748view12:15, 20 February 2013Sabinedaemenannotations
58745view09:56, 20 February 2013Sabinedaemenannotations
58744view09:52, 20 February 2013Sabinedaemenannotations
58743view09:01, 20 February 2013Sabinedaemenannotations
58578view10:43, 16 February 2013SabinedaemenModified description
58567view16:25, 15 February 2013Sabinedaemenliterature added
58566view16:21, 15 February 2013Sabinedaemenupdate
58565view10:58, 15 February 2013SabinedaemenRBP4
58564view08:59, 15 February 2013SabinedaemenFGF21
55311view15:16, 13 December 2012SabinedaemenUpdate
55303view15:07, 13 December 2012SabinedaemenPeriodical save, work in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARCComplexactivator recruited cofactor (ARC)-mediator activator complex
ATF6GeneProductENSG00000118217 (Ensembl Human)
ATP citrate lyase GeneProductENSG00000131473 (Ensembl Human)
Acyl-CoA binding proteinGeneProductENSG00000155368 (Ensembl Human)
CREBGeneProductENSG00000118260 (Ensembl Human)
CholesterolMetaboliteHMDB00067 (HMDB)
GSK3GeneProductENSG00000105723 (Ensembl Human)
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamineMetaboliteHMDB00641 (HMDB)
HDL receptorGeneProductENSG00000073060 (Ensembl Human)
HMG CoA reductaseGeneProductENSG00000113161 (Ensembl Human)
HMG CoA synthaseGeneProductENSG00000112972 (Ensembl Human)
INSIG1GeneProductENSG00000186480 (Ensembl Human)
INSIG2GeneProductENSG00000125629 (Ensembl Human)
InsulinProteinP01308 (Uniprot/TrEMBL)
LDL receptorGeneProductENSG00000130164 (Ensembl Human)
LXRENSG00000131408 (Ensembl Human)
Lanosterol synthaseGeneProductENSG00000160285 (Ensembl Human)
Lipoprotein lipase GeneProductENSG00000175445 (Ensembl Human)
NFYGeneProductENSG00000001167 (Ensembl Human)
OxysterolsMetaboliteOxysterols (Wikipedia)
PGC-1betaGeneProductENSG00000155846 (Ensembl Human)
PPAR-gammaGeneProductENSG00000132170 (Ensembl Human)
PUFAsMetaboliteInhibition of SREBP1 processing
S1PGeneProductENSG00000140943 (Ensembl Human)
S2PGeneProductENSG00000012174 (Ensembl Human)
SAR1AGeneProductENSG00000079332 (Ensembl Human)
SAR1BGeneProductENSG00000152700 (Ensembl Human)
SCAPGeneProductENSG00000114650 (Ensembl Human)
SEC13GeneProductENSG00000157020 (Ensembl Human)
SEC23AGeneProductENSG00000100934 (Ensembl Human)
SEC23BGeneProductENSG00000101310 (Ensembl Human)
SEC24AGeneProductENSG00000113615 (Ensembl Human)
SEC24BGeneProductENSG00000138802 (Ensembl Human)
SEC24CGeneProductENSG00000176986 (Ensembl Human)
SEC24DGeneProductENSG00000150961 (Ensembl Human)
SEC31AGeneProductENSG00000138674 (Ensembl Human)
SEC31BGeneProductENSG00000075826 (Ensembl Human)
SP1GeneProductENSG00000185591 (Ensembl Human)
SREBF2GeneProductENSG00000198911 (Ensembl Human)
SREBP1a,-cGeneProductENSG00000072310 (Ensembl Human)
SREBP2GeneProductENSG00000198911 (Ensembl Human)
TRC8GeneProduct
YY1GeneProductENSG00000100811 (Ensembl Human)
acetyl CoA synthetase GeneProductENSG00000154930 (Ensembl Human)
acetyl-CoA carboxylaseGeneProductENSG00000132142 (Ensembl Human)
farnesyl diphosphate synthaseGeneProductENSG00000160752 (Ensembl Human)
farnesyl-diphosphate farnesyltransferaseGeneProductENSG00000079459 (Ensembl Human)
fatty acid synthase GeneProductENSG00000169710 (Ensembl Human)
glycerol-3-phosphate acyltransferase GeneProductENSG00000119927 (Ensembl Human)
importin betaGeneProductENSG00000108424 (Ensembl Human)
isopentenyl-diphosphate isomeraseGeneProductENSG00000067064 (Ensembl Human)
lanosterol demethylaseGeneProductENSG00000001630 (Ensembl Human)
mTOR complex 1GeneProductENSG00000198793 (Ensembl Human)
malate dehydrogenase GeneProductENSG00000146701 (Ensembl Human)
mevalonate (diphospho) decarboxylase GeneProductENSG00000167508 (Ensembl Human)
nSREBPGeneProduct
nSREBP1a,-cGeneProduct
nSREBP2GeneProduct
squalene epoxidase GeneProductENSG00000104549 (Ensembl Human)
stearoyl-CoA desaturase GeneProductENSG00000099194 (Ensembl Human)

Annotated Interactions

No annotated interactions

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